Mishima Takayasu 三嶋崇靖

Researcher Number	00600602
Other IDs	https://orcid.org/0000-0002-4649-0434
Affiliation (Current)	2024: 東邦大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023: 福岡大学, 医学部, 准教授 2021: 福岡大学, 医学部, 講師 2016 – 2020: 福岡大学, 医学部, 助教 2014 – 2015: 福岡大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology
Keywords	Principal Investigator TDP-43 / DCTN1 / Perry症候群 / Perry病 / iPS細胞 / 動物モデル / 疾患モデル / パーキンソン病 / 家族性パーキンソン病 / ダイナクチン / トランスジェニックマウス / 診断基準 / モデルマウス

Generation of novel mouse models for elucidating the pathogenesis of Perry disease and drug discoveryPrincipal Investigator
- Principal Investigator
  
  三嶋崇靖
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Fukuoka University
Establishment of a Perry syndrome disease model using human induced pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  Mishima Takayasu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Fukuoka University
A pathogenesis study of Perry syndromePrincipal Investigator
- Principal Investigator
  
  Mishima Takayasu
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Fukuoka University

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation2021
- Author(s)
  Deshimaru M, Kinoshita-Kawada M, Kubota K, Watanabe T, Tanaka Y, Hirano S, Ishidate F, Hiramoto M, Ishikawa M, Uehara Y, Okano H, Hirose S, Fujioka S, Iwasaki K, Yuasa-Kawada J, Mishima T, Tsuboi Y
- Journal Title
  
  Int J Mol Sci
  
  Volume: 22 Issue: 8 Pages: 3985-3985
- DOI
  10.3390/ijms22083985
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15471, KAKENHI-PROJECT-20K22663, KAKENHI-PROJECT-18K11009, KAKENHI-PROJECT-21K06205
[Journal Article] Behavioral profile in a Dctn1 G71A knock-in mouse model of Perry disease2021
- Author(s)
  Deshimaru M, Mishima T, Watanabe T, Kubota K, Hosoi M, Kinoshita-Kawada M, Yuasa-Kawada J, Ikeda M, Mori M, Murata Y, Abe T, Enjoji M, Kiyonari H, Kodama S, Fujioka S, Iwasaki K, Tsuboi Y
- Journal Title
  
  Neurosci Lett
  
  Volume: 764 Pages: 136234-136234
- DOI
  10.1016/j.neulet.2021.136234
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15471, KAKENHI-PROJECT-20K22663, KAKENHI-PROJECT-21K06205, KAKENHI-PROJECT-20K16657
[Journal Article] Meta-iodobenzylguanidine myocardial scintigraphy in Perry disease2021
- Author(s)
  Mishima T, Fujioka S, Nishioka K, Li Y, Sato K, Houzen H, Yabe I, Shiomi K, Eriguchi M, Hara H, Hattori N, Tsuboi Y.
- Journal Title
  
  Parkinsonism and related disorders
  
  Volume: In press Pages: 49-53
- DOI
  10.1016/j.parkreldis.2020.12.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-18K15471, KAKENHI-PROJECT-20K07890
[Journal Article] A crucial role for Arf6 in the response of commissural axons to Slit.2019
- Author(s)
  Kinoshita-Kawada M, Hasegawa H, Hongu T, Yanagi S, Kanaho Y, Masai I, Mishima T, Chen X, Tsuboi Y, Rao Y, Yuasa-Kawada J, Wu JY.
- Journal Title
  
  Development
  
  Volume: 146 Issue: 3 Pages: 1-9
- DOI
  10.1242/dev.172106
- NAID
  120007127965
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K06988, KAKENHI-PROJECT-18K15471
[Journal Article] Perry disease: recent advances and perspectives2019
- Author(s)
  Mishima T, Fujioka S, Tsuboi Y.
- Journal Title
  
  Expert Opinion on Orphan Drugs
  
  Volume: 7 Issue: 5 Pages: 253-259
- DOI
  10.1080/21678707.2019.1625766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15471
[Journal Article] Establishing diagnostic criteria for Perry syndrome2018
- Author(s)
  Mishima T, Fujioka S, Tomiyama H, Yabe I, Kurisaki R, Fujii N, Neshige R, Ross OA, Farrer MJ, Dickson DW, Wszolek ZK, Hattori N, Tsuboi Y
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 89 Issue: 5 Pages: 482-487
- DOI
  10.1136/jnnp-2017-316864
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860678
[Journal Article] Modeling Parkinson's Disease and Atypical Parkinsonian Syndromes Using Induced Pluripotent Stem Cells.2018
- Author(s)
  Mishima T, Fujioka S, Fukae J, Yuasa-Kawada J, Tsuboi Y.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 19 Pages: 3870-3870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15471
[Journal Article] Behavioral defects in a DCTN1 G71A transgenic mouse model of Perry syndrome2018
- Author(s)
  Mishima T, Deshimaru M, Watanabe T, Kubota K, Kinoshita-Kawada M, Yuasa-Kawada J, Takasaki K, Uehara Y, Jinno S, Iwasaki K, Tsuboi Y
- Journal Title
  
  Neurosci Lett
  
  Volume: 666 Pages: 98-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860678
[Journal Article] Perry症候群2018
- Author(s)
  三嶋崇靖，坪井義夫
- Journal Title
  
  Frontiers in Parkinson Disease
  
  Volume: 11 Pages: 28-31
- Data Source
  KAKENHI-PROJECT-26860678
[Journal Article] Perry Syndrome: A Distinctive type of TDP-43 Proteinopathy2017
- Author(s)
  Mishima T, Koga S, Lin WL, Kasanuki K, Castanedes-Casey M, Wszolek ZK, Oh SJ, Tsuboi Y, Dickson DW
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 76 Issue: 8 Pages: 676-682
- DOI
  10.1093/jnen/nlx049
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860678
[Journal Article] Reduced orexin immunoreactivity in Perry syndrome and multiple system atrophy2017
- Author(s)
  Mishima T, Kasanuki K, Koga S, Castanedes-Casey M, Wszolek ZK, Tsuboi Y, Dickson DW
- Journal Title
  
  Parkinsonism Relat Disord
  
  Volume: 42 Pages: 85-89
- DOI
  10.1016/j.parkreldis.2017.06.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860678
[Journal Article] Dysphagia in Perry syndrome: pharyngeal pressure of two cases2017
- Author(s)
  Umemoto G, Tsuboi Y, Furuya H, Mishima T, Fujioka S, Fujii N, Arahata H, Sugahara M, Sakai M
- Journal Title
  
  Case report in Neurology
  
  Volume: 9 Issue: 2 Pages: 161-167
- DOI
  10.1159/000457900
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25463276, KAKENHI-PROJECT-17K12069, KAKENHI-PROJECT-26860678
[Journal Article] Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome2016
- Author(s)
  Mishima T, Ishikawa T, Imamura K, Kondo T, Koshiba Y, Takahashi R, Takahashi J, Watanabe A, Fujii N, Tsuboi Y, Inoue H
- Journal Title
  
  Parkinsonism & Related Disorders
  
  Volume: 30 Pages: 67-72
- DOI
  10.1016/j.parkreldis.2016.06.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860678
[Journal Article] Impulse control disorders and punding in Perry syndrome.2015
- Author(s)
  Mishima T, Fujioka S, Kurisaki R, Yanamoto S, Higuchi MA, Tsugawa J, Fukae J, Neshige R, Tsuboi Y
- Journal Title
  
  Parkinsonism & Related Disorders
  
  Volume: ２１ Issue: 11 Pages: 1381-1382
- DOI
  10.1016/j.parkreldis.2015.09.037
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860678
[Presentation] DCTN1 G71A変異Perry病ノックインマウスにおける黒質・線条体のtyrosine hydroxylase染色性低下2021
- Author(s)
  三嶋崇靖
- Organizer
  第14回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-18K15471
[Presentation] Behavioral defects in a Dctn1 G71A knock-in mouse model of Perry disease2021
- Author(s)
  三嶋崇靖，弟子丸眞実，池田茉偉子，河田真理子，河田純一，藤岡伸助，窪田香織，渡辺拓也，清成寛，岩崎克典，坪井義夫
- Organizer
  第15回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-18K15471
[Presentation] Characteristic of Perry disease in Japan2020
- Author(s)
  三嶋崇靖
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K15471
[Presentation] Perry病におけるMIBG心筋シンチグラフィー低下の頻度2019
- Author(s)
  三嶋崇靖、藤岡伸助、坪井義夫
- Organizer
  第13回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-18K15471
[Presentation] Proposal of international diagnostic criteria and a new disease concept2018
- Author(s)
  Takayasu Mishima, Fujioka S, Tomiyama H, Yabe I, Kurisaki R, Fujii N, Neshige R, Ross OA, Farrer MJ, Dickson DW, Wszolek ZK, Hattori N, Tsuboi Y
- Organizer
  International Congress of Parkinson’s Disease and Movement Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15471
[Presentation] Perry症候群国際診断基準の確立2018
- Author(s)
  三嶋崇靖、藤岡伸助、富山弘幸、矢部一郎、栗﨑玲一、藤井直樹、音成龍司、Ross OA、 Farrer MJ、Dickson DW、Wszolek ZK、服部信孝、坪井義夫
- Organizer
  第59回日本神経学会
- Data Source
  KAKENHI-PROJECT-18K15471
[Presentation] DCTN1 G71A変異Perry症候群トランスジェニックマウスにおける行動障害2018
- Author(s)
  三嶋崇靖、弟子丸眞実、渡辺拓也、窪田香織、河田真理子、河田純一、高崎浩太郎、上原吉就、神野尚三、岩崎克典、坪井義夫
- Organizer
  第12回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-18K15471
[Presentation] Disease modeling for Perry syndrome using patient induced pluripotent stem cells2017
- Author(s)
  Mishima T, Ishikawa T, Imamura K, Kondo T, Koshiba Y, Takahashi R, Takahashi J, Watanabe A, Fujii N, Tsuboi Y, Inoue H
- Organizer
  21th International Congress of Parkinson's Disease and Movement Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860678
[Presentation] Perry症候群におけるマイネルト基底核のオレキシン染色性の低下2017
- Author(s)
  三嶋崇靖, 笠貫浩史, 古賀俊輔, Monica Castanedes-Casey, Zbigniew K. Wszolek, 坪井義夫, Dennis W. Dickson
- Organizer
  第11回パーキンソン病運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-26860678
[Presentation] Human iPSC disease modeling of Perry syndrome2017
- Author(s)
  Mishima T, Ishikawa T, Imamura K, Kondo T, Koshiba Y, Takahashi R, Takahashi J, Watanabe A, Fujii N, Tsuboi Y, Inoue H
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860678
[Presentation] Perry syndrome is a distinctive type of TDP-43 proteinopathy2017
- Author(s)
  Mishima T, Koga S, Lin WL, Kasanuki K, Castanedes-Casey M, Wszolek ZK, Oh SJ, Tsuboi Y, Dickson DW
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860678
[Presentation] A cellular model for Perry syndrome using patient iPSCs2016
- Author(s)
  Mishima T, Ishikawa T, Imamura K, Kondo T, Koshiba Y, Takahashi R, Takahashi J, Watanabe A, Fujii N, Tsuboi Y, Inoue H
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター(兵庫・神戸市)
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26860678
[Presentation] Impulse control disorders and punding in Perry syndrome2015
- Author(s)
  Mishima T, Fujioka S, Kurisaki R, Yanamoto S, Higuchi MA, Tsugawa J, Fukae J, Neshige R, Tsuboi Y
- Organizer
  XXI Word Congress on Parkinson’s disease and Related Disorders
- Place of Presentation
  イタリア
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860678

1. 河田純一 (00312207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 坪井義夫 (90291822)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. HASEGAWA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. UMEMOTO George

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 古谷博和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 西岡健弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mishima Takayasu 三嶋 崇靖

Research Projects

Research Products

Co-Researchers

Generation of novel mouse models for elucidating the pathogenesis of Perry disease and drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a Perry syndrome disease model using human induced pluripotent stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A pathogenesis study of Perry syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Behavioral profile in a Dctn1 G71A knock-in mouse model of Perry disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Meta-iodobenzylguanidine myocardial scintigraphy in Perry disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A crucial role for Arf6 in the response of commissural axons to Slit.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Perry disease: recent advances and perspectives2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishing diagnostic criteria for Perry syndrome2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modeling Parkinson's Disease and Atypical Parkinsonian Syndromes Using Induced Pluripotent Stem Cells.2018

Author(s)

Journal Title

Data Source

[Journal Article] Behavioral defects in a DCTN1 G71A transgenic mouse model of Perry syndrome2018

Author(s)

Journal Title

Data Source

[Journal Article] Perry症候群2018

Author(s)

Journal Title

Data Source

[Journal Article] Perry Syndrome: A Distinctive type of TDP-43 Proteinopathy2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced orexin immunoreactivity in Perry syndrome and multiple system atrophy2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysphagia in Perry syndrome: pharyngeal pressure of two cases2017

Author(s)

Journal Title

DOI

Data Source

Mishima Takayasu 三嶋崇靖