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Mishima Takayasu  三嶋 崇靖

… Alternative Names

三嶋 崇靖  ミシマ タカヤス

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Researcher Number 00600602
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-4649-0434
Affiliation (Current) 2025: 東邦大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2023: 福岡大学, 医学部, 准教授
2021: 福岡大学, 医学部, 講師
2016 – 2020: 福岡大学, 医学部, 助教
2014 – 2015: 福岡大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 52020:Neurology-related / Neurology
Keywords
Principal Investigator
TDP-43 / DCTN1 / Perry症候群 / Perry病 / iPS細胞 / 動物モデル / 疾患モデル / パーキンソン病 / 家族性パーキンソン病 / ダイナクチン / トランスジェニックマウス / 診断基準 / モデルマウス
  • Research Projects

    (3 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (6 People)
  •  Generation of novel mouse models for elucidating the pathogenesis of Perry disease and drug discoveryPrincipal Investigator

    • Principal Investigator
      三嶋 崇靖
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Fukuoka University
  •  Establishment of a Perry syndrome disease model using human induced pluripotent stem cellsPrincipal Investigator

    • Principal Investigator
      Mishima Takayasu
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Fukuoka University
  •  A pathogenesis study of Perry syndromePrincipal Investigator

    • Principal Investigator
      Mishima Takayasu
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Fukuoka University

All 2024 2023 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Perry Disease: Bench to Bedside Circulation and a Team Approach2024

    • Author(s)
      Mishima Takayasu、Yuasa-Kawada Junichi、Fujioka Shinsuke、Tsuboi Yoshio
    • Journal Title

      Biomedicines

      Volume: 12 Issue: 1 Pages: 113-113

    • DOI

      10.3390/biomedicines12010113

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K06937
  • [Journal Article] DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation2021

    • Author(s)
      Deshimaru M, Kinoshita-Kawada M, Kubota K, Watanabe T, Tanaka Y, Hirano S, Ishidate F, Hiramoto M, Ishikawa M, Uehara Y, Okano H, Hirose S, Fujioka S, Iwasaki K, Yuasa-Kawada J, Mishima T, Tsuboi Y
    • Journal Title

      Int J Mol Sci

      Volume: 22 Issue: 8 Pages: 3985-3985

    • DOI

      10.3390/ijms22083985

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15471, KAKENHI-PROJECT-20K22663, KAKENHI-PROJECT-18K11009, KAKENHI-PROJECT-21K06205
  • [Journal Article] Behavioral profile in a Dctn1 G71A knock-in mouse model of Perry disease2021

    • Author(s)
      Deshimaru M, Mishima T, Watanabe T, Kubota K, Hosoi M, Kinoshita-Kawada M, Yuasa-Kawada J, Ikeda M, Mori M, Murata Y, Abe T, Enjoji M, Kiyonari H, Kodama S, Fujioka S, Iwasaki K, Tsuboi Y
    • Journal Title

      Neurosci Lett

      Volume: 764 Pages: 136234-136234

    • DOI

      10.1016/j.neulet.2021.136234

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15471, KAKENHI-PROJECT-20K22663, KAKENHI-PROJECT-21K06205, KAKENHI-PROJECT-20K16657
  • [Journal Article] Meta-iodobenzylguanidine myocardial scintigraphy in Perry disease2021

    • Author(s)
      Mishima T, Fujioka S, Nishioka K, Li Y, Sato K, Houzen H, Yabe I, Shiomi K, Eriguchi M, Hara H, Hattori N, Tsuboi Y.
    • Journal Title

      Parkinsonism and related disorders

      Volume: In press Pages: 49-53

    • DOI

      10.1016/j.parkreldis.2020.12.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-18K15471, KAKENHI-PROJECT-20K07890
  • [Journal Article] A crucial role for Arf6 in the response of commissural axons to Slit.2019

    • Author(s)
      Kinoshita-Kawada M, Hasegawa H, Hongu T, Yanagi S, Kanaho Y, Masai I, Mishima T, Chen X, Tsuboi Y, Rao Y, Yuasa-Kawada J, Wu JY.
    • Journal Title

      Development

      Volume: 146 Issue: 3 Pages: 1-9

    • DOI

      10.1242/dev.172106

    • NAID

      120007127965

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K06988, KAKENHI-PROJECT-18K15471
  • [Journal Article] Perry disease: recent advances and perspectives2019

    • Author(s)
      Mishima T, Fujioka S, Tsuboi Y.
    • Journal Title

      Expert Opinion on Orphan Drugs

      Volume: 7 Issue: 5 Pages: 253-259

    • DOI

      10.1080/21678707.2019.1625766

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K15471
  • [Journal Article] Establishing diagnostic criteria for Perry syndrome2018

    • Author(s)
      Mishima T, Fujioka S, Tomiyama H, Yabe I, Kurisaki R, Fujii N, Neshige R, Ross OA, Farrer MJ, Dickson DW, Wszolek ZK, Hattori N, Tsuboi Y
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 89 Issue: 5 Pages: 482-487

    • DOI

      10.1136/jnnp-2017-316864

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Journal Article] Modeling Parkinson's Disease and Atypical Parkinsonian Syndromes Using Induced Pluripotent Stem Cells.2018

    • Author(s)
      Mishima T, Fujioka S, Fukae J, Yuasa-Kawada J, Tsuboi Y.
    • Journal Title

      Int J Mol Sci.

      Volume: 19 Pages: 3870-3870

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15471
  • [Journal Article] Behavioral defects in a DCTN1 G71A transgenic mouse model of Perry syndrome2018

    • Author(s)
      Mishima T, Deshimaru M, Watanabe T, Kubota K, Kinoshita-Kawada M, Yuasa-Kawada J, Takasaki K, Uehara Y, Jinno S, Iwasaki K, Tsuboi Y
    • Journal Title

      Neurosci Lett

      Volume: 666 Pages: 98-103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Journal Article] Perry症候群2018

    • Author(s)
      三嶋崇靖,坪井義夫
    • Journal Title

      Frontiers in Parkinson Disease

      Volume: 11 Pages: 28-31

    • Data Source
      KAKENHI-PROJECT-26860678
  • [Journal Article] Perry Syndrome: A Distinctive type of TDP-43 Proteinopathy2017

    • Author(s)
      Mishima T, Koga S, Lin WL, Kasanuki K, Castanedes-Casey M, Wszolek ZK, Oh SJ, Tsuboi Y, Dickson DW
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 76 Issue: 8 Pages: 676-682

    • DOI

      10.1093/jnen/nlx049

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Journal Article] Reduced orexin immunoreactivity in Perry syndrome and multiple system atrophy2017

    • Author(s)
      Mishima T, Kasanuki K, Koga S, Castanedes-Casey M, Wszolek ZK, Tsuboi Y, Dickson DW
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 42 Pages: 85-89

    • DOI

      10.1016/j.parkreldis.2017.06.003

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Journal Article] Dysphagia in Perry syndrome: pharyngeal pressure of two cases2017

    • Author(s)
      Umemoto G, Tsuboi Y, Furuya H, Mishima T, Fujioka S, Fujii N, Arahata H, Sugahara M, Sakai M
    • Journal Title

      Case report in Neurology

      Volume: 9 Issue: 2 Pages: 161-167

    • DOI

      10.1159/000457900

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25463276, KAKENHI-PROJECT-17K12069, KAKENHI-PROJECT-26860678
  • [Journal Article] Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome2016

    • Author(s)
      Mishima T, Ishikawa T, Imamura K, Kondo T, Koshiba Y, Takahashi R, Takahashi J, Watanabe A, Fujii N, Tsuboi Y, Inoue H
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 30 Pages: 67-72

    • DOI

      10.1016/j.parkreldis.2016.06.007

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Journal Article] Impulse control disorders and punding in Perry syndrome.2015

    • Author(s)
      Mishima T, Fujioka S, Kurisaki R, Yanamoto S, Higuchi MA, Tsugawa J, Fukae J, Neshige R, Tsuboi Y
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 21 Issue: 11 Pages: 1381-1382

    • DOI

      10.1016/j.parkreldis.2015.09.037

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Presentation] Perry病の臨床とモデル動物・細胞を用いた病態解明2023

    • Author(s)
      三嶋崇靖, 坪井義夫
    • Organizer
      第53回日本神経精神薬理学会年会
    • Data Source
      KAKENHI-PROJECT-23K06937
  • [Presentation] Update on Perry disease in Japan: analysis of long-term survivors and genetic counseling2023

    • Author(s)
      MishimaT, Fujioka S, Watanabe A, Kuratomi A, Honda H, Sasagasako N, Tsuboi Y
    • Organizer
      第64回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-23K06937
  • [Presentation] DCTN1 G71A変異Perry病ノックインマウスにおける黒質・線条体のtyrosine hydroxylase染色性低下2021

    • Author(s)
      三嶋崇靖
    • Organizer
      第14回パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-18K15471
  • [Presentation] Behavioral defects in a Dctn1 G71A knock-in mouse model of Perry disease2021

    • Author(s)
      三嶋崇靖,弟子丸眞実,池田茉偉子,河田真理子,河田純一,藤岡伸助,窪田香織,渡辺拓也,清成寛,岩崎克典,坪井義夫
    • Organizer
      第15回パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-18K15471
  • [Presentation] Characteristic of Perry disease in Japan2020

    • Author(s)
      三嶋崇靖
    • Organizer
      第61回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K15471
  • [Presentation] Perry病におけるMIBG心筋シンチグラフィー低下の頻度2019

    • Author(s)
      三嶋崇靖、藤岡伸助、坪井義夫
    • Organizer
      第13回パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-18K15471
  • [Presentation] Proposal of international diagnostic criteria and a new disease concept2018

    • Author(s)
      Takayasu Mishima, Fujioka S, Tomiyama H, Yabe I, Kurisaki R, Fujii N, Neshige R, Ross OA, Farrer MJ, Dickson DW, Wszolek ZK, Hattori N, Tsuboi Y
    • Organizer
      International Congress of Parkinson’s Disease and Movement Disorders
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15471
  • [Presentation] Perry症候群国際診断基準の確立2018

    • Author(s)
      三嶋崇靖、藤岡伸助、富山弘幸、矢部一郎、栗﨑玲一、藤井直樹、音成龍司、Ross OA、 Farrer MJ、Dickson DW、Wszolek ZK、服部信孝、坪井義夫
    • Organizer
      第59回日本神経学会
    • Data Source
      KAKENHI-PROJECT-18K15471
  • [Presentation] DCTN1 G71A変異Perry症候群トランスジェニックマウスにおける行動障害2018

    • Author(s)
      三嶋崇靖、弟子丸眞実、渡辺拓也、窪田香織、河田真理子、河田純一、高崎浩太郎、上原吉就、神野尚三、岩崎克典、坪井義夫
    • Organizer
      第12回パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-18K15471
  • [Presentation] Disease modeling for Perry syndrome using patient induced pluripotent stem cells2017

    • Author(s)
      Mishima T, Ishikawa T, Imamura K, Kondo T, Koshiba Y, Takahashi R, Takahashi J, Watanabe A, Fujii N, Tsuboi Y, Inoue H
    • Organizer
      21th International Congress of Parkinson's Disease and Movement Disorders
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Presentation] Perry症候群におけるマイネルト基底核のオレキシン染色性の低下2017

    • Author(s)
      三嶋 崇靖, 笠貫 浩史, 古賀 俊輔, Monica Castanedes-Casey, Zbigniew K. Wszolek, 坪井 義夫, Dennis W. Dickson
    • Organizer
      第11回パーキンソン病運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Presentation] Human iPSC disease modeling of Perry syndrome2017

    • Author(s)
      Mishima T, Ishikawa T, Imamura K, Kondo T, Koshiba Y, Takahashi R, Takahashi J, Watanabe A, Fujii N, Tsuboi Y, Inoue H
    • Organizer
      XXIII World Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Presentation] Perry syndrome is a distinctive type of TDP-43 proteinopathy2017

    • Author(s)
      Mishima T, Koga S, Lin WL, Kasanuki K, Castanedes-Casey M, Wszolek ZK, Oh SJ, Tsuboi Y, Dickson DW
    • Organizer
      XXIII World Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Presentation] A cellular model for Perry syndrome using patient iPSCs2016

    • Author(s)
      Mishima T, Ishikawa T, Imamura K, Kondo T, Koshiba Y, Takahashi R, Takahashi J, Watanabe A, Fujii N, Tsuboi Y, Inoue H
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫・神戸市)
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26860678
  • [Presentation] Impulse control disorders and punding in Perry syndrome2015

    • Author(s)
      Mishima T, Fujioka S, Kurisaki R, Yanamoto S, Higuchi MA, Tsugawa J, Fukae J, Neshige R, Tsuboi Y
    • Organizer
      XXI Word Congress on Parkinson’s disease and Related Disorders
    • Place of Presentation
      イタリア
    • Year and Date
      2015-12-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860678
  • 1.  河田 純一 (00312207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  坪井 義夫 (90291822)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 3.  HASEGAWA Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  UMEMOTO George
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  古谷 博和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  西岡 健弥
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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