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OTSUBO Takeshi  大坪 武史

ORCIDConnect your ORCID iD *help
Researcher Number 00623034
Other IDs
Affiliation (based on the past Project Information) *help 2013: 国立国際医療研究センター研究所肝炎・免疫研究センター, 消化器疾患研究部, 特任研究員
2012 – 2013: 独立行政法人国立国際医療研究センター, 消化器疾患研究部, 特任研究員
Review Section/Research Field
Principal Investigator
Gastroenterology
Except Principal Investigator
Gastroenterology
Keywords
Principal Investigator
上部消化管学(食道、胃、十二指腸) / エピゲノム / 上部消化管学(食道、胃、 十二指腸)
Except Principal Investigator
TNFSP / レトロトランスポジション / TNFSF / 消化管炎症 / 炎症 / DNA傷害 / Fn14 / TWEAK / 消化管上皮細胞
  • Research Projects

    (2 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (7 People)
  •  Epigenomic analysis for Barrette's esophagus and carcinomasPrincipal Investigator

    • Principal Investigator
      OTSUBO Takeshi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      独立行政法人国立国際医療研究センター
  •  TWEAK is involved in DNA damage in intestinal epithelial cells

    • Principal Investigator
      DOHI Taeko
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Research Institute, International Medical Center of Japan

All 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.2014

    • Author(s)
      Obata, Y., Furusawa, Y., Endo, T. A., Sharif, J., Takahashi, D., Atarasho, K., Nakayama, M., Onawa, S., Fujimura, Y., Takahashi, M., Ikawa, T., Otsubo, T., Kawamura, Y. I., Dohi, T., Tajima, S., Masumoto, H., Ohara, O., Honda, K., Hori, S., Ohno, H., Koseki, H., Hase, K
    • Journal Title

      Nat Immunol

      Volume: 15(6) Pages: 571-579

    • Data Source
      KAKENHI-PROJECT-24790729
  • [Journal Article] A. Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice2014

    • Author(s)
      Inagaki-Ohara, K., Mayuzumi, H., Kato, S., Minokoshi, Y., Otsubo, T., Kawamura, Y. I., Dohi, T., Matsuzaki, G., Yoshimura
    • Journal Title

      Oncogene

      Volume: 33(1) Pages: 74-84

    • Data Source
      KAKENHI-PROJECT-24790729
  • [Journal Article] Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.2014

    • Author(s)
      Inagaki-Ohara K, Mayuzumi H, Kato S, Minokoshi Y, Otsubo T, Kawamura YI, Dohi T, Matsuzaki G, Yoshimura A.
    • Journal Title

      Oncogene

      Volume: 33 Issue: 1 Pages: 74-84

    • DOI

      10.1038/onc.2012.540

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22126005, KAKENHI-PROJECT-23590272, KAKENHI-PROJECT-23590955, KAKENHI-PROJECT-24390058
  • [Journal Article] Retrotransposition of long interspersed element-1 by viral protein R of human immunodeficiency virus type-12013

    • Author(s)
      Kenta Iijima, Noriyuki Okudaira, Masato Tamura, Akihiro Doi, Yoshikazu Saito, Mari Shimura, Motohito Goto, Akihiro Matsunaga, Yuki Kawamura, Takeshi Otsubo, Taeko Dohi, Shigeki Hoshino, Shigeyuki Kano, Shotaro Hagiwara, Junko Tanuma, Hiroyuki Gatanaga, Masanori Baba, Taku Iguchi, Motoko Yanagita, Shin-ichi Oka Tadashi Okamura and Yukihito Ishizaka
    • Journal Title

      Retrovirology

      Volume: 10 Issue: 1 Pages: 83-83

    • DOI

      10.1186/1742-4690-10-83

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J10677, KAKENHI-PROJECT-23590955
  • [Journal Article] Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice2013

    • Author(s)
      Okada T
    • Journal Title

      Nat. Commun

      Volume: 4巻 Issue: 1 Pages: 1654-1654

    • DOI

      10.1038/ncomms2668

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689017, KAKENHI-PROJECT-23590272, KAKENHI-PROJECT-23590955, KAKENHI-PROJECT-24380072, KAKENHI-PROJECT-24658129, KAKENHI-PROJECT-24700455, KAKENHI-PUBLICLY-24117524, KAKENHI-PUBLICLY-24117723
  • [Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis2013

    • Author(s)
      Otsubo T, Kawamura YI, Dohi T
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2013-12-11
    • Data Source
      KAKENHI-PROJECT-23590955
  • [Presentation] バレット食道および食道腺癌におけるDNAメチル化異常2013

    • Author(s)
      萩原 輝記、秋山 純一、三宅 大、大坪 武史、櫻井俊之、清水利夫、土肥多惠子、河村由紀
    • Organizer
      第86回日本生化学会大会
    • Year and Date
      2013-09-13
    • Data Source
      KAKENHI-PROJECT-23590955
  • [Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis2013

    • Author(s)
      大坪武史
    • Organizer
      第42回日本免疫学会学術総会
    • Place of Presentation
      幕張,千葉,日本
    • Year and Date
      2013-12-11
    • Data Source
      KAKENHI-PROJECT-24790729
  • [Presentation] Genome-Wide Epigenomic Analysis of Lamina Propria Mononuclear Cellsof Inflammatory Bowel Disease2012

    • Author(s)
      大坪武史
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      SanDiego, CA,USA
    • Year and Date
      2012-05-22
    • Data Source
      KAKENHI-PROJECT-24790729
  • [Presentation] 潰瘍性大腸炎粘膜固有層における少数のT細胞及びマクロファージ/樹状細胞を用いたエピゲノム解析2012

    • Author(s)
      大坪武史
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡,日本
    • Year and Date
      2012-12-16
    • Data Source
      KAKENHI-PROJECT-24790729
  • [Presentation] バレット食道および食道腺癌におけるDNAメチル化異常

    • Author(s)
      萩原 輝記、秋山 純一、三宅 大、大坪 武史、櫻井 俊之、清水 利夫、土肥 多惠子、河村 由紀
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590955
  • [Presentation] 潰瘍性大腸炎粘膜固有層における少数のT細胞及びマクロファージ/樹状細胞を用いたエピゲノム解析

    • Author(s)
      大坪武史
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡、日本
    • Data Source
      KAKENHI-PROJECT-24790729
  • [Presentation] Genome-Wide Epigenomic Analysis of Lamina Propria Mononuclear Cells of Inflammatory Bowel Disease.

    • Author(s)
      大坪武史
    • Organizer
      2012 Digestive Disease Week
    • Place of Presentation
      San Diego, CA, USA
    • Data Source
      KAKENHI-PROJECT-24790729
  • [Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis.

    • Author(s)
      Otsubo T, Kawamura YI, Dohi T.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-23590955
  • [Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis

    • Author(s)
      大坪武史
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張、千葉、日本
    • Data Source
      KAKENHI-PROJECT-24790729
  • [Presentation] Involvement of L1 retrotransposition in murine experimental colitis-cancer model.

    • Author(s)
      大坪武史
    • Organizer
      2013 Digestive Disease Week
    • Place of Presentation
      Orlando, FL, USA
    • Data Source
      KAKENHI-PROJECT-24790729
  • 1.  DOHI Taeko (60250221)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  KAWAMURA I Yuki (10392391)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 3.  ISHIZAKA Yukihito (30281687)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KAWASHIMA Rei (70392389)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  BURKLY Linda C.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  土肥 多恵子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 7.  箕越 靖彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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