OTSUBO Takeshi 大坪武史

Researcher Number	00623034
Other IDs
Affiliation (based on the past Project Information) *help	2013: 国立国際医療研究センター研究所肝炎・免疫研究センター, 消化器疾患研究部, 特任研究員 2012 – 2013: 独立行政法人国立国際医療研究センター, 消化器疾患研究部, 特任研究員
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 上部消化管学（食道、胃、十二指腸） / エピゲノム / 上部消化管学（食道、胃、十二指腸） Except Principal Investigator TNFSP / レトロトランスポジション / TNFSF / 消化管炎症 / 炎症 / DNA傷害 / Fn14 / TWEAK / 消化管上皮細胞

Epigenomic analysis for Barrette's esophagus and carcinomasPrincipal Investigator
- Principal Investigator
  
  OTSUBO Takeshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  独立行政法人国立国際医療研究センター
TWEAK is involved in DNA damage in intestinal epithelial cells
- Principal Investigator
  
  DOHI Taeko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Research Institute, International Medical Center of Japan

All 2014 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.2014
- Author(s)
  Obata, Y., Furusawa, Y., Endo, T. A., Sharif, J., Takahashi, D., Atarasho, K., Nakayama, M., Onawa, S., Fujimura, Y., Takahashi, M., Ikawa, T., Otsubo, T., Kawamura, Y. I., Dohi, T., Tajima, S., Masumoto, H., Ohara, O., Honda, K., Hori, S., Ohno, H., Koseki, H., Hase, K
- Journal Title
  
  Nat Immunol
  
  Volume: 15(6) Pages: 571-579
- Data Source
  KAKENHI-PROJECT-24790729
[Journal Article] A. Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice2014
- Author(s)
  Inagaki-Ohara, K., Mayuzumi, H., Kato, S., Minokoshi, Y., Otsubo, T., Kawamura, Y. I., Dohi, T., Matsuzaki, G., Yoshimura
- Journal Title
  
  Oncogene
  
  Volume: 33(1) Pages: 74-84
- Data Source
  KAKENHI-PROJECT-24790729
[Journal Article] Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.2014
- Author(s)
  Inagaki-Ohara K, Mayuzumi H, Kato S, Minokoshi Y, Otsubo T, Kawamura YI, Dohi T, Matsuzaki G, Yoshimura A.
- Journal Title
  
  Oncogene
  
  Volume: 33 Issue: 1 Pages: 74-84
- DOI
  10.1038/onc.2012.540
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22126005, KAKENHI-PROJECT-23590272, KAKENHI-PROJECT-23590955, KAKENHI-PROJECT-24390058
[Journal Article] Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice2013
- Author(s)
  Okada T
- Journal Title
  
  Nat. Commun
  
  Volume: 4巻 Issue: 1 Pages: 1654-1654
- DOI
  10.1038/ncomms2668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689017, KAKENHI-PROJECT-23590272, KAKENHI-PROJECT-23590955, KAKENHI-PROJECT-24380072, KAKENHI-PROJECT-24658129, KAKENHI-PROJECT-24700455, KAKENHI-PUBLICLY-24117524, KAKENHI-PUBLICLY-24117723
[Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis2013
- Author(s)
  Otsubo T, Kawamura YI, Dohi T
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2013-12-11
- Data Source
  KAKENHI-PROJECT-23590955
[Presentation] バレット食道および食道腺癌におけるDNAメチル化異常2013
- Author(s)
  萩原輝記、秋山純一、三宅大、大坪武史、櫻井俊之、清水利夫、土肥多惠子、河村由紀
- Organizer
  第86回日本生化学会大会
- Year and Date
  2013-09-13
- Data Source
  KAKENHI-PROJECT-23590955
[Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis2013
- Author(s)
  大坪武史
- Organizer
  第42回日本免疫学会学術総会
- Place of Presentation
  幕張,千葉,日本
- Year and Date
  2013-12-11
- Data Source
  KAKENHI-PROJECT-24790729
[Presentation] Genome-Wide Epigenomic Analysis of Lamina Propria Mononuclear Cellsof Inflammatory Bowel Disease2012
- Author(s)
  大坪武史
- Organizer
  Digestive Disease Week
- Place of Presentation
  SanDiego, CA,USA
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PROJECT-24790729
[Presentation] 潰瘍性大腸炎粘膜固有層における少数のT細胞及びマクロファージ/樹状細胞を用いたエピゲノム解析2012
- Author(s)
  大坪武史
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡,日本
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-24790729
[Presentation] バレット食道および食道腺癌におけるDNAメチル化異常
- Author(s)
  萩原　輝記、秋山　純一、三宅　大、大坪　武史、櫻井　俊之、清水　利夫、土肥　多惠子、河村　由紀
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590955
[Presentation] 潰瘍性大腸炎粘膜固有層における少数のT細胞及びマクロファージ/樹状細胞を用いたエピゲノム解析
- Author(s)
  大坪武史
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡、日本
- Data Source
  KAKENHI-PROJECT-24790729
[Presentation] Genome-Wide Epigenomic Analysis of Lamina Propria Mononuclear Cells of Inflammatory Bowel Disease.
- Author(s)
  大坪武史
- Organizer
  2012 Digestive Disease Week
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24790729
[Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis.
- Author(s)
  Otsubo T, Kawamura YI, Dohi T.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590955
[Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis
- Author(s)
  大坪武史
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張、千葉、日本
- Data Source
  KAKENHI-PROJECT-24790729
[Presentation] Involvement of L1 retrotransposition in murine experimental colitis-cancer model.
- Author(s)
  大坪武史
- Organizer
  2013 Digestive Disease Week
- Place of Presentation
  Orlando, FL, USA
- Data Source
  KAKENHI-PROJECT-24790729
[]

1. DOHI Taeko (60250221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. KAWAMURA I Yuki (10392391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. ISHIZAKA Yukihito (30281687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAWASHIMA Rei (70392389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. BURKLY Linda C.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 土肥多恵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. 箕越靖彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OTSUBO Takeshi 大坪 武史

Research Projects

Research Products

Co-Researchers

Epigenomic analysis for Barrette's esophagus and carcinomasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TWEAK is involved in DNA damage in intestinal epithelial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.2014

Author(s)

Journal Title

Data Source

[Journal Article] A. Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice2014

Author(s)

Journal Title

Data Source

[Journal Article] Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] バレット食道および食道腺癌におけるDNAメチル化異常2013

Author(s)

Organizer

Year and Date

Data Source

[Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Genome-Wide Epigenomic Analysis of Lamina Propria Mononuclear Cellsof Inflammatory Bowel Disease2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 潰瘍性大腸炎粘膜固有層における少数のT細胞及びマクロファージ/樹状細胞を用いたエピゲノム解析2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] バレット食道および食道腺癌におけるDNAメチル化異常

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 潰瘍性大腸炎粘膜固有層における少数のT細胞及びマクロファージ/樹状細胞を用いたエピゲノム解析

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Genome-Wide Epigenomic Analysis of Lamina Propria Mononuclear Cells of Inflammatory Bowel Disease.

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Cell type-specific, genome-wide epigenetic analysis for lamina propria cells isolated from the colon with ulcerative colitis.

Author(s)

OTSUBO Takeshi 大坪武史