• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Shiba Naoko  柴 直子

… Alternative Names

SHIBA Naoko  柴 直子

Less
Researcher Number 00639289
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-0675-1721
Affiliation (Current) 2025: 信州大学, 学術研究院医学系, 助教
Affiliation (based on the past Project Information) *help 2020 – 2023: 信州大学, 学術研究院医学系, 助教
2020: 信州大学, 医学部, 助教
2017 – 2019: 信州大学, 医学部, 助教(特定雇用)
2018: 信州大学, 再生医科学教室, 助教(特定雇用)
2017: 信州大学, 医学部附属病院, 医員
2015 – 2016: 信州大学, 医学部附属病院, 特任研究員
2014: 信州大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Except Principal Investigator
Basic Section 47040:Pharmacology-related / Basic Section 49030:Experimental pathology-related / Medical engineering assessment
Keywords
Principal Investigator
iPS細胞 / 筋ジストロフィー / オステオポンチン / MMP-9 / 心不全 / iPS-CMs / 拡張型心筋症 / DMD / ナトリウム利尿ペプチド / 骨格筋 … More / 心筋 / STIM1 / ミオパチー / Osteopontin / Fibrosis / dystrophin / MIP-2 / MCP-1 / ジストロフィン … More
Except Principal Investigator
Duchenne型筋ジストロフィー / iPS細胞 / デュシェンヌ型筋ジストロフィー / エクソンスキップ治療 / アンチセンス核酸 / ゲノム編集 / アンチセンス薬 / エクソン・スキップ治療 / DMD遺伝子 / ベッカー型筋ジストロフィー / ジストロフィン / 心筋細胞 / IGF2 / 心不全 / 臨床研究 / 臨床的に意義のある最少変化量 / 6分間歩行試験 / 運動機能評価 / 活動量 / DMD / 6分間歩行 / 再現性 / 6分間歩行 / 神経筋疾患 Less
  • Research Projects

    (7 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (10 People)
  •  筋ジストロフィー心筋症に対するナトリウム利尿ペプチドによる新規治療法の開発Principal Investigator

    • Principal Investigator
      柴 直子
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Shinshu University
  •  Elucidation of the Pathology of STIM1 Myopathy in Skeletal and Cardiac Muscles and Development of Therapeutic Approaches Using iPSCsPrincipal Investigator

    • Principal Investigator
      Shiba Naoko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Shinshu University
  •  Research on pathogenesis and development of therapies for cardiac failure using dystrophin-deficient-cardiomyocytes derived from DMD patients

    • Principal Investigator
      Miyazaki Daigo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Shinshu University
  •  Development of DMD exon 3-9 skipping therapy using iPSc

    • Principal Investigator
      Nakamura Akinori
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Shinshu University
  •  Evaluation of reliability and sensitivity of a new 6-minute walk test and pitch-up method for neuromuscular dystrophy

    • Principal Investigator
      Nishizawa Hitomi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical engineering assessment
    • Research Institution
      Shinshu University
  •  Development of molecular targeted therapeutics for Duchenne muscular dystrophyPrincipal Investigator

    • Principal Investigator
      Shiba Naoko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Shinshu University
  •  Development of the therapy for Duchenne muscular dystrophy targeting MMP-9Principal Investigator

    • Principal Investigator
      SHIBA Naoko
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Shinshu University

All 2024 2023 2022 2021 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids2024

    • Author(s)
      Kobayashi H, Tohyama S, Ichimura H, Ohashi N, Chino S, Soma Y, Tani H, Tanaka Y, Yang X, Shiba N, Kadota S, Haga K, Moriwaki T, Morita-Umei Y, Umei T, Sekine O, Kishino Y, Kanazawa H, Kawagishi H, Yamada M, Naritah K, Naito T, Seto T, Kuwahara K, Shiba Y, and Fukuda K
    • Journal Title

      Circulation

      Volume: 123 Issue: 8 Pages: 611-621

    • DOI

      10.1161/circulationaha.123.064876

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07328, KAKENHI-PROJECT-21K06780, KAKENHI-PROJECT-21K16084, KAKENHI-PROJECT-23K21433
  • [Journal Article] Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin2023

    • Author(s)
      Tanaka Yuki、Kadota Shin、Zhao Jian、Kobayashi Hideki、Okano Satomi、Izumi Masaki、Honda Yusuke、Ichimura Hajime、Shiba Naoko、Uemura Takeshi、Wada Yuko、Chuma Shinichiro、Nakada Tsutomu、Tohyama Shugo、Fukuda Keiichi、Yamada Mitsuhiko、Seto Tatsuichiro、Kuwahara Koichiro、Shiba Yuji
    • Journal Title

      Stem Cell Research and Therapy

      Volume: 14 Issue: 1 Pages: 240-240

    • DOI

      10.1186/s13287-023-03468-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06828, KAKENHI-PROJECT-23K06332, KAKENHI-PROJECT-23K07328, KAKENHI-PROJECT-21K08100, KAKENHI-PROJECT-22K19521, KAKENHI-PROJECT-23K21433
  • [Journal Article] Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 12023

    • Author(s)
      Shiba Naoko、Yang Xiao、Sato Mitsuto、Kadota Shin、Suzuki Yota、Agata Masahiro、Nagamine Kohei、Izumi Masaki、Honda Yusuke、Koganehira Tomoya、Kobayashi Hideki、Ichimura Hajime、Chuma Shinichiro、Nakai Junichi、Tohyama Shugo、Fukuda Keiichi、Miyazaki Daigo、Nakamura Akinori、Shiba Yuji
    • Journal Title

      Molecular Therapy - Nucleic Acids

      Volume: 34 Pages: 102060-102060

    • DOI

      10.1016/j.omtn.2023.102060

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07328, KAKENHI-PROJECT-22K19521, KAKENHI-PROJECT-20H03850
  • [Journal Article] STIM1遺伝子異常によるtubular aggregate myopathyの1例2021

    • Author(s)
      柴直子,高野亨,稲葉雄二,嶋田祥子,藤森充帆,夏目岳典,新美妙美,福山哲広
    • Journal Title

      脳と発達

      Volume: 53S

    • Data Source
      KAKENHI-PROJECT-20K08253
  • [Journal Article] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.2019

    • Author(s)
      Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 520 Issue: 1 Pages: 179-185

    • DOI

      10.1016/j.bbrc.2019.09.095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02577, KAKENHI-PROJECT-18H02887, KAKENHI-PROJECT-18K15026, KAKENHI-PROJECT-18K14595
  • [Journal Article] フクチン遺伝子の非挿入型変異の複合ヘテロ接合による重度心不全を呈した拡張型心筋症(DCM1X)の1 例.2018

    • Author(s)
      柴 直子, 中村 昭則, 小澤 哲夫, 木村 和広, 元木 博彦, 桑原 宏一郎, 那須野 将, 竹内 史穂子, 夏目 岳典, 柳沢 俊光, 本林 光雄, 福山 哲広, 稲葉 雄二
    • Journal Title

      脳と発達

      Volume: 50(Suppl.)

    • Data Source
      KAKENHI-PROJECT-16K19636
  • [Journal Article] Importance of long-term motor function evaluation after prednisolone treatment for Duchenne muscular dystrophy2018

    • Author(s)
      Nishizawa Hitomi、Shiba Naoko、Nakamura Akinori
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 30 Issue: 9 Pages: 1211-1214

    • DOI

      10.1589/jpts.30.1211

    • NAID

      130007481320

    • ISSN
      0915-5287, 2187-5626
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K19636
  • [Journal Article] A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis2018

    • Author(s)
      Naoko Shiba, Yuji Inaba, Mitsuo Motobayashi, et al.
    • Journal Title

      Case reports in pediatrics

      Volume: 2018 Pages: 1-4

    • DOI

      10.1155/2018/6931206

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K19636
  • [Journal Article] The effect of wearing night splints for one year on the standing motor function of patients with Duchenne muscular dystrophy2018

    • Author(s)
      Nishizawa H, Matsukiyo A, Shiba N, Koinuma M, Nakamura A.
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 30 Issue: 4 Pages: 576-579

    • DOI

      10.1589/jpts.30.576

    • NAID

      130006712204

    • ISSN
      0915-5287, 2187-5626
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K19636
  • [Journal Article] West症候群を合併したXp21.1微細欠失によるDuchenne型筋ジストロフィーの1例2018

    • Author(s)
      夏目 岳典, 柴 直子, 那須野 将, 柳沢 俊光, 本林 光雄, 高野 亨子, 涌井 敬子, 稲葉 雄二
    • Journal Title

      脳と発達

      Volume: 50(Suppl.)

    • Data Source
      KAKENHI-PROJECT-16K19636
  • [Journal Article] DMD患者iPS細胞由来の心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害の発症機序に関する研究2018

    • Author(s)
      宮崎 大吾, 佐藤 充人, 柴 直子, 柴 祐司, 青木 吉嗣, 武田 伸一, 中村 昭則
    • Journal Title

      日本筋学会学術集会プログラム・抄録集

      Volume: 4 Pages: 158-158

    • Data Source
      KAKENHI-PROJECT-16K19636
  • [Journal Article] Comparison of the phenotypes of patients harboring in-frame deletions starting at exon 45 in the Duchenne muscular dystrophy gene indicates potential for the development of exon skipping therapy2017

    • Author(s)
      Akinori Nakamura, Naoko Shiba, Daigo Miyazaki, Hitomi Nishizawa, Yuji Inaba, Noboru Fueki, Rika Maruyama, Yusuke Echigoya & Toshifumi Yokota
    • Journal Title

      Journal of human genetics

      Volume: 62 Issue: 4 Pages: 459-463

    • DOI

      10.1038/jhg.2016.152

    • NAID

      40021158222

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19636
  • [Journal Article] Cardiac Sodium Channel Disease Modeling Using Patient-Derived Induced Pluripotent Stem Cells2017

    • Author(s)
      Shin Kadota, Naoko Shiba, Yuji Shiba
    • Journal Title

      Circ J

      Volume: 81 Issue: 12 Pages: 1764-1765

    • DOI

      10.1253/circj.CJ-17-1134

    • NAID

      130006219240

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K19636, KAKENHI-PROJECT-17H06724
  • [Journal Article] Usefulness of continual actigraph for assessing the effect of corticosteroid treatment to Duchenne muscular dystrophy: A case report2016

    • Author(s)
      Hitomi Nishizawa, Naoko Shiba, Akinori Nakamura
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 28 Pages: 3249-3251

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K01435
  • [Journal Article] Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy2015

    • Author(s)
      Naoko Shiba, Daigo Miyazaki, Takahiro Yoshizawa, Kazuhiro Fukushima, Yuji Shiba, Yuji Inaba, Michihiro Imamura, Shin'ichi Takeda, Kenichi Koike, Akinori Nakamura
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1852 Issue: 10 Pages: 2170-2182

    • DOI

      10.1016/j.bbadis.2015.07.008

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860792, KAKENHI-PROJECT-26293182
  • [Presentation] ABD1領域の変異による心筋症に対するエクソンスキッピング治療の検討2023

    • Author(s)
      柴直子
    • Organizer
      第23回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-23K07328
  • [Presentation] ABD1領域の変異によるDMD心筋症に対するエクソンスキッピング治療の検討2022

    • Author(s)
      柴直子
    • Organizer
      令和4年度 精神・神経疾患研究開発費2-6 青木班班会議
    • Data Source
      KAKENHI-PROJECT-20K08253
  • [Presentation] A case of tubular aggregate myopathy with miosis and hyposplenism caused by STIM1 mutation2021

    • Author(s)
      柴直子,高野亨,稲葉雄二,嶋田祥子,藤森充帆,夏目岳典,新美妙美,福山哲広
    • Organizer
      第63回日本小児神経学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08253
  • [Presentation] DMD患者由来心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害への影響に関する研究2019

    • Author(s)
      宮崎大吾、柴直子、佐藤充人、柴祐司、越後谷裕介、横田俊文、溝部吉高、青木吉嗣、武田伸一、中村昭則
    • Organizer
      第14回筋ジストロフィー治療研究会
    • Data Source
      KAKENHI-PROJECT-18H02577
  • [Presentation] DMD遺伝子exon46-55欠失変異を持つDMD患者iPSC由来心筋細胞に対するexon 45 skip治療に関する研究2019

    • Author(s)
      佐藤充人、宮崎大吾、柴直子、柴祐司、越後谷裕介、横田俊文、青木吉嗣、武田伸一、中村昭則
    • Organizer
      日本筋学会第5回学術集会
    • Data Source
      KAKENHI-PROJECT-18H02577
  • [Presentation] Gene expression in cardiomyocytes from DMD with exon 46-55 deletion after exon 45 skipping therapy.2019

    • Author(s)
      Miyazaki D., Sato M., Shiba N., Shiba Y., Echigoya Y., Yokota T., Aoki Y., Takeda S., Nakamura A.
    • Organizer
      60th Annual Meeting of The Japanese Society of Neurology
    • Data Source
      KAKENHI-PROJECT-18H02577
  • [Presentation] 筋障害モデルおよびジストロフィン欠損筋における MMP-9 の機能の解明2015

    • Author(s)
      中村昭則、柴直子、宮崎大吾、福島和広
    • Organizer
      第56回日本神経学会学術集会
    • Place of Presentation
      新潟県新潟市 新潟コンベンションセンター
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26860792
  • [Presentation] Ablation of MMP-9 ameliorates the dystrophic phenotype by modulating chemotaxis in early stage but exacerbates fibrosis in late stage in mdx mice2015

    • Author(s)
      Naoko Shiba, Daigo Miyazaki, Takahiro Yoshizawa, Kazuhiro Fukushima, Michihiro Imamura, Shin'ichi Takeda, Kenichi Koike, Akinori Nakamura
    • Organizer
      20th International Congress of the World Muscle Society
    • Place of Presentation
      Brighton, UK
    • Year and Date
      2015-10-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860792
  • [Presentation] ジストロフィン欠損骨格筋におけるMatrix Metalloproteinase (MMP)-9の役割について2014

    • Author(s)
      柴直子、宮崎大吾、福島和広、吉沢隆浩、中村昭則
    • Organizer
      第9回筋ジストロフィー治療研究合同発表会
    • Place of Presentation
      箱根湯元温泉吉池旅館
    • Year and Date
      2014-11-01
    • Data Source
      KAKENHI-PROJECT-26860792
  • 1.  NAKAMURA Akinori (10303471)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 12 results
  • 2.  MIYAZAKI Daigo (80596370)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 3.  柴 祐司 (70613503)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 4.  FUKUSHIMA Kazuhiro (10421835)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 5.  YOSHIZAWA Takahiro (40713392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Nishizawa Hitomi (90573379)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  青木 吉嗣 (80534172)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 8.  武田 伸一 (90171644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 9.  吉沢 隆浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 10.  中田 勉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi