Shiba Naoko 柴直子

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SHIBA Naoko 柴直子

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Researcher Number	00639289
Other IDs	https://orcid.org/0000-0003-0675-1721
Affiliation (Current)	2024: 信州大学, 学術研究院医学系, 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 信州大学, 学術研究院医学系, 助教 2020: 信州大学, 医学部, 助教 2017 – 2019: 信州大学, 医学部, 助教(特定雇用) 2018: 信州大学, 再生医科学教室, 助教(特定雇用) 2017: 信州大学, 医学部附属病院, 医員 2015 – 2016: 信州大学, 医学部附属病院, 特任研究員 2014: 信州大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 49030:Experimental pathology-related / Medical engineering assessment
Keywords	Principal Investigator 筋ジストロフィー / オステオポンチン / MMP-9 / 心不全 / iPS-CMs / DMD / ナトリウム利尿ペプチド / 骨格筋 / 心筋 / iPS細胞 … More / STIM1 / ミオパチー / Osteopontin / Fibrosis / dystrophin / MIP-2 / MCP-1 / ジストロフィン … More Except Principal Investigator Duchenne型筋ジストロフィー / iPS細胞 / デュシェンヌ型筋ジストロフィー / エクソンスキップ治療 / アンチセンス核酸 / ゲノム編集 / アンチセンス薬 / エクソン・スキップ治療 / DMD遺伝子 / ベッカー型筋ジストロフィー / ジストロフィン / 心筋細胞 / IGF2 / 心不全 / 臨床研究 / 臨床的に意義のある最少変化量 / 6分間歩行試験 / 運動機能評価 / 活動量 / DMD / ６分間歩行 / 再現性 / 6分間歩行 / 神経筋疾患 Less

筋ジストロフィー心筋症に対するナトリウム利尿ペプチドによる新規治療法の開発Principal Investigator
- Principal Investigator
  
  柴直子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shinshu University
Elucidation of the Pathology of STIM1 Myopathy in Skeletal and Cardiac Muscles and Development of Therapeutic Approaches Using iPSCsPrincipal Investigator
- Principal Investigator
  
  Shiba Naoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shinshu University
Research on pathogenesis and development of therapies for cardiac failure using dystrophin-deficient-cardiomyocytes derived from DMD patients
- Principal Investigator
  
  Miyazaki Daigo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Shinshu University
Development of DMD exon 3-9 skipping therapy using iPSc
- Principal Investigator
  
  Nakamura Akinori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Shinshu University
Evaluation of reliability and sensitivity of a new 6-minute walk test and pitch-up method for neuromuscular dystrophy
- Principal Investigator
  
  Nishizawa Hitomi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical engineering assessment
- Research Institution
  Shinshu University
Development of molecular targeted therapeutics for Duchenne muscular dystrophyPrincipal Investigator
- Principal Investigator
  
  Shiba Naoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Development of the therapy for Duchenne muscular dystrophy targeting MMP-9Principal Investigator
- Principal Investigator
  
  SHIBA Naoko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University

All 2022 2021 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] STIM1遺伝子異常によるtubular aggregate myopathyの1例2021
- Author(s)
  柴直子，高野亨，稲葉雄二，嶋田祥子，藤森充帆，夏目岳典，新美妙美，福山哲広
- Journal Title
  
  脳と発達
  
  Volume: 53S
- Data Source
  KAKENHI-PROJECT-20K08253
[Journal Article] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.2019
- Author(s)
  Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 520 Issue: 1 Pages: 179-185
- DOI
  10.1016/j.bbrc.2019.09.095
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02577, KAKENHI-PROJECT-18H02887, KAKENHI-PROJECT-18K15026, KAKENHI-PROJECT-18K14595
[Journal Article] フクチン遺伝子の非挿入型変異の複合ヘテロ接合による重度心不全を呈した拡張型心筋症（DCM1X）の1 例.2018
- Author(s)
  柴直子, 中村昭則, 小澤哲夫, 木村和広, 元木博彦, 桑原宏一郎, 那須野将, 竹内史穂子, 夏目岳典, 柳沢俊光, 本林光雄, 福山哲広, 稲葉雄二
- Journal Title
  
  脳と発達
  
  Volume: 50(Suppl.)
- Data Source
  KAKENHI-PROJECT-16K19636
[Journal Article] Importance of long-term motor function evaluation after prednisolone treatment for Duchenne muscular dystrophy2018
- Author(s)
  Nishizawa Hitomi、Shiba Naoko、Nakamura Akinori
- Journal Title
  
  Journal of Physical Therapy Science
  
  Volume: 30 Issue: 9 Pages: 1211-1214
- DOI
  10.1589/jpts.30.1211
- NAID
  130007481320
- ISSN
  0915-5287, 2187-5626
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19636
[Journal Article] A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis2018
- Author(s)
  Naoko Shiba, Yuji Inaba, Mitsuo Motobayashi, et al.
- Journal Title
  
  Case reports in pediatrics
  
  Volume: 2018 Pages: 1-4
- DOI
  10.1155/2018/6931206
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19636
[Journal Article] The effect of wearing night splints for one year on the standing motor function of patients with Duchenne muscular dystrophy2018
- Author(s)
  Nishizawa H, Matsukiyo A, Shiba N, Koinuma M, Nakamura A.
- Journal Title
  
  Journal of Physical Therapy Science
  
  Volume: 30 Issue: 4 Pages: 576-579
- DOI
  10.1589/jpts.30.576
- NAID
  130006712204
- ISSN
  0915-5287, 2187-5626
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19636
[Journal Article] West症候群を合併したXp21.1微細欠失によるDuchenne型筋ジストロフィーの1例2018
- Author(s)
  夏目岳典, 柴直子, 那須野将, 柳沢俊光, 本林光雄, 高野亨子, 涌井敬子, 稲葉雄二
- Journal Title
  
  脳と発達
  
  Volume: 50(Suppl.)
- Data Source
  KAKENHI-PROJECT-16K19636
[Journal Article] DMD患者iPS細胞由来の心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害の発症機序に関する研究2018
- Author(s)
  宮崎大吾, 佐藤充人, 柴直子, 柴祐司, 青木吉嗣, 武田伸一, 中村昭則
- Journal Title
  
  日本筋学会学術集会プログラム・抄録集
  
  Volume: 4 Pages: 158-158
- Data Source
  KAKENHI-PROJECT-16K19636
[Journal Article] Comparison of the phenotypes of patients harboring in-frame deletions starting at exon 45 in the Duchenne muscular dystrophy gene indicates potential for the development of exon skipping therapy2017
- Author(s)
  Akinori Nakamura, Naoko Shiba, Daigo Miyazaki, Hitomi Nishizawa, Yuji Inaba, Noboru Fueki, Rika Maruyama, Yusuke Echigoya & Toshifumi Yokota
- Journal Title
  
  Journal of human genetics
  
  Volume: 62 Issue: 4 Pages: 459-463
- DOI
  10.1038/jhg.2016.152
- NAID
  40021158222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19636
[Journal Article] Cardiac Sodium Channel Disease Modeling Using Patient-Derived Induced Pluripotent Stem Cells2017
- Author(s)
  Shin Kadota, Naoko Shiba, Yuji Shiba
- Journal Title
  
  Circ J
  
  Volume: 81 Issue: 12 Pages: 1764-1765
- DOI
  10.1253/circj.CJ-17-1134
- NAID
  130006219240
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19636, KAKENHI-PROJECT-17H06724
[Journal Article] Usefulness of continual actigraph for assessing the effect of corticosteroid treatment to Duchenne muscular dystrophy: A case report2016
- Author(s)
  Hitomi Nishizawa, Naoko Shiba, Akinori Nakamura
- Journal Title
  
  Journal of Physical Therapy Science
  
  Volume: 28 Pages: 3249-3251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01435
[Journal Article] Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy2015
- Author(s)
  Naoko Shiba, Daigo Miyazaki, Takahiro Yoshizawa, Kazuhiro Fukushima, Yuji Shiba, Yuji Inaba, Michihiro Imamura, Shin'ichi Takeda, Kenichi Koike, Akinori Nakamura
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1852 Issue: 10 Pages: 2170-2182
- DOI
  10.1016/j.bbadis.2015.07.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860792, KAKENHI-PROJECT-26293182
[Presentation] ABD1領域の変異によるDMD心筋症に対するエクソンスキッピング治療の検討2022
- Author(s)
  柴直子
- Organizer
  令和4年度　精神・神経疾患研究開発費2-6　青木班班会議
- Data Source
  KAKENHI-PROJECT-20K08253
[Presentation] A case of tubular aggregate myopathy with miosis and hyposplenism caused by STIM1 mutation2021
- Author(s)
  柴直子，高野亨，稲葉雄二，嶋田祥子，藤森充帆，夏目岳典，新美妙美，福山哲広
- Organizer
  第63回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08253
[Presentation] DMD患者由来心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害への影響に関する研究2019
- Author(s)
  宮崎大吾、柴直子、佐藤充人、柴祐司、越後谷裕介、横田俊文、溝部吉高、青木吉嗣、武田伸一、中村昭則
- Organizer
  第14回筋ジストロフィー治療研究会
- Data Source
  KAKENHI-PROJECT-18H02577
[Presentation] DMD遺伝子exon46-55欠失変異を持つDMD患者iPSC由来心筋細胞に対するexon 45 skip治療に関する研究2019
- Author(s)
  佐藤充人、宮崎大吾、柴直子、柴祐司、越後谷裕介、横田俊文、青木吉嗣、武田伸一、中村昭則
- Organizer
  日本筋学会第5回学術集会
- Data Source
  KAKENHI-PROJECT-18H02577
[Presentation] Gene expression in cardiomyocytes from DMD with exon 46-55 deletion after exon 45 skipping therapy.2019
- Author(s)
  Miyazaki D., Sato M., Shiba N., Shiba Y., Echigoya Y., Yokota T., Aoki Y., Takeda S., Nakamura A.
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-18H02577
[Presentation] 筋障害モデルおよびジストロフィン欠損筋における MMP-9 の機能の解明2015
- Author(s)
  中村昭則、柴直子、宮崎大吾、福島和広
- Organizer
  第56回日本神経学会学術集会
- Place of Presentation
  新潟県新潟市　新潟コンベンションセンター
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26860792
[Presentation] Ablation of MMP-9 ameliorates the dystrophic phenotype by modulating chemotaxis in early stage but exacerbates fibrosis in late stage in mdx mice2015
- Author(s)
  Naoko Shiba, Daigo Miyazaki, Takahiro Yoshizawa, Kazuhiro Fukushima, Michihiro Imamura, Shin'ichi Takeda, Kenichi Koike, Akinori Nakamura
- Organizer
  20th International Congress of the World Muscle Society
- Place of Presentation
  Brighton, UK
- Year and Date
  2015-10-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860792
[Presentation] ジストロフィン欠損骨格筋におけるMatrix Metalloproteinase (MMP)-9の役割について2014
- Author(s)
  柴直子、宮崎大吾、福島和広、吉沢隆浩、中村昭則
- Organizer
  第9回筋ジストロフィー治療研究合同発表会
- Place of Presentation
  箱根湯元温泉吉池旅館
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-26860792

1. NAKAMURA Akinori (10303471)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
2. MIYAZAKI Daigo (80596370)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
3. 柴祐司 (70613503)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. FUKUSHIMA Kazuhiro (10421835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. YOSHIZAWA Takahiro (40713392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Nishizawa Hitomi (90573379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 青木吉嗣 (80534172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 武田伸一 (90171644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 吉沢隆浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Shiba Naoko 柴 直子

SHIBA Naoko 柴 直子

Research Projects

Research Products

Co-Researchers

筋ジストロフィー心筋症に対するナトリウム利尿ペプチドによる新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Pathology of STIM1 Myopathy in Skeletal and Cardiac Muscles and Development of Therapeutic Approaches Using iPSCsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on pathogenesis and development of therapies for cardiac failure using dystrophin-deficient-cardiomyocytes derived from DMD patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of DMD exon 3-9 skipping therapy using iPSc

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of reliability and sensitivity of a new 6-minute walk test and pitch-up method for neuromuscular dystrophy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of molecular targeted therapeutics for Duchenne muscular dystrophyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the therapy for Duchenne muscular dystrophy targeting MMP-9Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] STIM1遺伝子異常によるtubular aggregate myopathyの1例2021

Author(s)

Journal Title

Data Source

[Journal Article] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] フクチン遺伝子の非挿入型変異の複合ヘテロ接合による重度心不全を呈した拡張型心筋症（DCM1X）の1 例.2018

Author(s)

Journal Title

Data Source

[Journal Article] Importance of long-term motor function evaluation after prednisolone treatment for Duchenne muscular dystrophy2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of wearing night splints for one year on the standing motor function of patients with Duchenne muscular dystrophy2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Shiba Naoko 柴直子

SHIBA Naoko 柴直子