Kinoshita Takashi 木下崇

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KINOSHITA Takashi 木下崇

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Researcher Number	00648462
Other IDs
Affiliation (Current)	2025: 千葉県がんセンター(研究所), 頭頸科, 部長
Affiliation (based on the past Project Information) *help	2022 – 2023: 千葉県がんセンター(研究所), 頭頸科, 部長 2020 – 2021: 千葉大学, 医学部附属病院, 助教 2019: 千葉大学, 医学部附属病院, 医員 2013 – 2014: 千葉大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology
Keywords	Principal Investigator マイクロRNA / microRNA / 細胞外小胞 / 血清 / エクソソーム / 口腔癌 / 癌関連線維芽細胞 / シークエンス / シークセンス / プロファイリング … More / small RNA sequence / バイオマーカー / マイクロアレイ / microrna / 唾液腺導管癌 / 頭頸部癌 Less

細胞外小胞を介した口腔扁平上皮癌細胞の悪性化能獲得機構の解明Principal Investigator
- Principal Investigator
  
  木下崇
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Serum exosomal biomaker analysis in oral cacerPrincipal Investigator
- Principal Investigator
  
  Kinoshita Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Chiba University
Identification of microRNA-mediated networks in salivary duct carcinomaPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Takashi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University

All 2022 2021 2019 2015 2014 2013 Other

All Journal Article Presentation Other

[Journal Article] Impact of miR-1/miR-133 Clustered miRNAs: PFN2 Facilitates Malignant Phenotypes in Head and Neck Squamous Cell Carcinoma2022
- Author(s)
  Asai Shunichi、Koma Ayaka、Nohata Nijiro、Kinoshita Takashi、Kikkawa Naoko、Kato Mayuko、Minemura Chikashi、Uzawa Katsuhiro、Hanazawa Toyoyuki、Seki Naohiko
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 3 Pages: 663-663
- DOI
  10.3390/biomedicines10030663
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09863, KAKENHI-PROJECT-19K18759, KAKENHI-PROJECT-21K09577
[Journal Article] Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma2021
- Author(s)
  Tanaka Nozomi、Minemura Chikashi、Asai Shunichi、Kikkawa Naoko、Kinoshita Takashi、Oshima Sachi、Koma Ayaka、Kasamatsu Atsushi、Hanazawa Toyoyuki、Uzawa Katsuhiro、Seki Naohiko
- Journal Title
  
  Genes
  
  Volume: 12 Issue: 12 Pages: 1910-1910
- DOI
  10.3390/genes12121910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09863, KAKENHI-PROJECT-19K18759, KAKENHI-PROJECT-21K09577
[Journal Article] Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma2021
- Author(s)
  Koma Ayaka、Asai Shunichi、Minemura Chikashi、Oshima Sachi、Kinoshita Takashi、Kikkawa Naoko、Koshizuka Keiichi、Moriya Shogo、Kasamatsu Atsushi、Hanazawa Toyoyuki、Uzawa Katsuhiro、Seki Naohiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 18 Pages: 9947-9947
- DOI
  10.3390/ijms22189947
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09863, KAKENHI-PROJECT-19K18759, KAKENHI-PROJECT-21K09577
[Journal Article] Regulation of Oncogenic Targets by miR-99a-3p (Passenger Strand of miR-99a-Duplex) in Head and Neck Squamous Cell Carcinoma2019
- Author(s)
  Okada Reona、Koshizuka Keiichi、Yamada Yasutaka、Moriya Shogo、Kikkawa Naoko、Kinoshita Takashi、Hanazawa Toyoyuki、Seki Naohiko
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 12 Pages: 1535-1535
- DOI
  10.3390/cells8121535
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09338, KAKENHI-PROJECT-19K18759, KAKENHI-PROJECT-19K18795, KAKENHI-PROJECT-17K11375
[Journal Article] MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.2015
- Author(s)
  Fukumoto I, Hanazawa T, Kinoshita T, Kikkawa N, Koshizuka K, Goto Y, Nishikawa R, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Br J Cancer
  
  Volume: 112 Issue: 5 Pages: 891-900
- DOI
  10.1038/bjc.2015.19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462676, KAKENHI-PROJECT-25861528, KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-26462596
[Journal Article] microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.2014
- Author(s)
  Kikkawa N, Kinoshita T, Nohata N, Hanazawa T, Yamamoto N, Fukumoto I, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Int J Oncol.
  
  Volume: 44(6) Issue: 6 Pages: 2085-92
- DOI
  10.3892/ijo.2014.2349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24592590, KAKENHI-PROJECT-25861528
[Journal Article] Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature2014
- Author(s)
  Fukumoto I, Kinoshita T, Hanazawa T, Kikkawa N, Chiyomaru T, Enokida H, Yamamoto N, Goto Y, Nishikawa R, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  British Journal of Cancer
  
  Volume: 111 Issue: 2 Pages: 386-394
- DOI
  10.1038/bjc.2014.293
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592590, KAKENHI-PROJECT-25462676, KAKENHI-PROJECT-25861528
[Journal Article] Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.2013
- Author(s)
  Nohata N, Hanazawa T, Kinoshita T, Inamine A, Kikkawa N, Itesako T, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Br J Cancer
  
  Volume: 108 Issue: 8 Pages: 1648-1658
- DOI
  10.1038/bjc.2013.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592505, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24592575, KAKENHI-PROJECT-25861528
[Journal Article] Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma.2013
- Author(s)
  Kinoshita T, Nohata N, Hanazawa T, Kikkawa N, Yamamoto N, Yoshino H, Itesako T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Br J Cancer
  
  Volume: 109 Issue: 10 Pages: 2636-2645
- DOI
  10.1038/bjc.2013.607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592505, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24592590, KAKENHI-PROJECT-25670694, KAKENHI-PROJECT-25861528
[Presentation] Tumor suppressive microRNA-218 targeting focal adhesion pathway in head and neck squamous cell carcinoma2013
- Author(s)
  Takashi Kinoshita, Toyoyuki Hanazawa, Nijiro Nohata, Naoko Kikkawa, Hideki Enokida, Hirofumi Yoshino, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25861528
[Presentation] 頭頸部扁平上皮癌におけるmicroRNA-218の機能解析：ラミニン・インテグリン分子ネットワークの抑制機構の解明2013
- Author(s)
  木下崇、花澤豊行、野畑二次郎、吉川直子、茶薗英明、岡本美孝、関直彦
- Organizer
  第37回日本頭頸部癌学会
- Place of Presentation
  東京都　京王プラザホテル
- Data Source
  KAKENHI-PROJECT-25861528
[Presentation] Tumor suppressive microRNAs (miR-29s/miR-218) regulate laminin-integrin signaling in head and neck squamous cell carcinoma
- Author(s)
  Takashi Kinoshita, Nijiro Nohata, Toyoyuki Hanazawa, Naoko Kikkawa, Noriko Yamamoto, Hirofumi Yoshino, Toshihiko Itesako, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
- Organizer
  American Association of Cancer Research Annual Meeting 2014
- Place of Presentation
  San Diego Convention Center, San Diego, CA, USA
- Year and Date
  2014-04-06 – 2014-04-11
- Data Source
  KAKENHI-PROJECT-25861528
[Presentation] 頭頸部扁平上皮癌におけるmicroRNA-29sによるラミニン・インテグリンシグナル制御機構
- Author(s)
  木下崇、花澤豊行、野畑二次郎、吉川直子、岡本美孝
- Organizer
  第115回日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  福岡市　ヒルトン福岡シーホーク
- Year and Date
  2014-05-14 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25861528
[Presentation] 下咽頭癌マイクロRNA発現プロファイルに基づく、癌抑制型マイクロRNAの探索とマイクロRNAが制御する標的癌遺伝子の同定
- Author(s)
  木下崇、福本一郎、吉川直子、花澤豊行、岡本美孝、関直彦
- Organizer
  第38回日本頭頸部癌学会学術講演会
- Place of Presentation
  東京都江東区　東京ファッションタウンビル
- Year and Date
  2014-06-12 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25861528
[]

1. 関直彦 (50345013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. 花澤豊行 (90272327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. 吉川直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
4. 岡本美孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 福本一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kinoshita Takashi 木下 崇

KINOSHITA Takashi 木下 崇

Research Projects

Research Products

Co-Researchers

細胞外小胞を介した口腔扁平上皮癌細胞の悪性化能獲得機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Serum exosomal biomaker analysis in oral cacerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of microRNA-mediated networks in salivary duct carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Impact of miR-1/miR-133 Clustered miRNAs: PFN2 Facilitates Malignant Phenotypes in Head and Neck Squamous Cell Carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of Oncogenic Targets by miR-99a-3p (Passenger Strand of miR-99a-Duplex) in Head and Neck Squamous Cell Carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Tumor suppressive microRNA-218 targeting focal adhesion pathway in head and neck squamous cell carcinoma2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 頭頸部扁平上皮癌におけるmicroRNA-218の機能解析： ラミニン・インテグリン分子ネットワークの抑制機構の解明2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Tumor suppressive microRNAs (miR-29s/miR-218) regulate laminin-integrin signaling in head and neck squamous cell carcinoma

Author(s)

Kinoshita Takashi 木下崇

KINOSHITA Takashi 木下崇

[Presentation] 頭頸部扁平上皮癌におけるmicroRNA-218の機能解析：ラミニン・インテグリン分子ネットワークの抑制機構の解明2013