Goto Yusuke 五島悠介

… Alternative Names

GOTO YUSUKE 五島悠介

GOTO Yusuke 五島悠介

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Researcher Number	00710576
Other IDs
Affiliation (Current)	2025: 帝京大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 帝京大学, 医学部, 講師 2021 – 2023: 千葉大学, 大学院医学研究院, 助教 2020 – 2021: 千葉大学, 大学院医学研究院, 特任助教 2015 – 2016: 千葉大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / 0906:Surgery related to the biological and sensory functions and related fields / Urology Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 57060:Surgical dentistry-related / Basic Section 56030:Urology-related
Keywords	Principal Investigator 去勢抵抗性前立腺癌 / 前立腺癌 / 機能性RNA / ムスカリン受容体 / YAP / FAK / Gタンパク共役型受容体 / G蛋白共役型受容体 / 去勢抵抗性増殖 / 神経支配 / 神経依存的増殖 / マイクロRNA … More Except Principal Investigator … More 肺癌 / がん微小環境 / 免疫回避 / 口腔扁平上皮癌 / YAP/TAZ / Hippo経路 / miRNA / スーパーエンハンサー / マイクロRNA / ATAC sequence / シスプラチン / 治療抵抗性 / 尿路上皮癌 Less

Deciphering the regulatory mechanism of cancer microenvironment induced by disruption of the Hippo pathway and novel therapeutic approach
- Principal Investigator
  
  安藤俊範
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hiroshima University
合成致死性に基づいたKRAS変異陽性肺癌におけるソトラシブ併用新規治療法の開発
- Principal Investigator
  
  萩原陽子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kagoshima University
アンドロゲン受容体標的薬と合成致死性をもつシグナル伝達分子の網羅的探索Principal Investigator
- Principal Investigator
  
  五島悠介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Teikyo University
Identification of super-enhancer and master genes involved in treatment resistance of urothelial cancer
- Principal Investigator
  
  KATO MAYUKO
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Chiba University
Identification of GPCR which activates FAK-YAP signaling and promotes castration-resistant growth of prostate cancerPrincipal Investigator
- Principal Investigator
  
  Goto Yusuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Chiba University
Identification of mechanism of castration resistant growth of prostate cancer cells by innervationPrincipal Investigator
- Principal Investigator
  
  GOTO YUSUKE
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0906:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Chiba University
Identification of novel CRPC therapeutics by inhibition of activated functional RNA signalingPrincipal Investigator
- Principal Investigator
  
  GOTO Yusuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Chiba University

All 2023 2021 2017 2016 2015 Other

All Journal Article Presentation Other

[Journal Article] MiR-15b-5p inhibits castration-resistant growth of prostate cancer cells by targeting the muscarinic cholinergic receptor CHRM32023
- Author(s)
  Shunichi Asai, Yusuke Goto, Kengo Tanigawa, Yuya Tomioka, Mayuko Kato, Keiko Mizuno, Shinichi Sakamoto, Naohiko Seki
- Journal Title
  
  FEBS Letter
  
  Volume: - Issue: 8 Pages: 1164-1175
- DOI
  10.1002/1873-3468.14598
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09367, KAKENHI-PROJECT-20K09555, KAKENHI-PROJECT-21K09577, KAKENHI-PROJECT-21K16753
[Journal Article] EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB12021
- Author(s)
  Ando Toshinori、Arang Nadia、Wang Zhiyong、Costea Daniela Elena、Feng Xiaodong、Goto Yusuke、Izumi Hiroki、Gilardi Mara、Ando Kazuyo、Gutkind J. Silvio
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1
- DOI
  10.1038/s42003-021-02744-4
- Data Source
  KAKENHI-PROJECT-20K22970
[Journal Article] The roles of microRNAs in the progression of castration-resistant prostate cancer.2017
- Author(s)
  Kojima, S. Goto, Y. Naya, Y.
- Journal Title
  
  J Hum Genet
  
  Volume: 62（１） Issue: 1 Pages: 25-31
- DOI
  10.1038/jhg.2016.69
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462430, KAKENHI-PROJECT-15K20071, KAKENHI-PROJECT-17K11160
[Journal Article] Regulation of E3 ubiquitin ligase-1 (WWP1) by microRNA-452 inhibits cancer cell migration and invasion in prostate cancer.2016
- Author(s)
  Goto Y, Kojima S, Kurozumi A, Kato M, Okato A, Matsushita R, Ichikawa T, Seki N.
- Journal Title
  
  Br J Cancer
  
  Volume: 114 Issue: 10 Pages: 1135-1144
- DOI
  10.1038/bjc.2016.95
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-26462430, KAKENHI-PROJECT-15K20071
[Journal Article] Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer.2016
- Author(s)
  Okato A, Goto Y, Kurozumi A, Kato M, Kojima S, Matsushita R, Yonemori M, Miyamoto K, Ichikawa T, Seki N.
- Journal Title
  
  Int J Oncol
  
  Volume: 49 Issue: 1 Pages: 111-122
- DOI
  10.3892/ijo.2016.3522
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-26462430, KAKENHI-PROJECT-15K20071
[Journal Article] MicroRNA expression signature of castration-resistant prostate cancer: the microRNA-221/222 cluster functions as a tumour suppressor and disease progression marker.2015
- Author(s)
  Goto Y, Kojima S, Nishikawa R, Kurozumi A, Kato M, Enokida H, Matsushita R, Yamazaki K, Ishida Y, Nakagawa M, Naya Y, Ichikawa T, Seki N
- Journal Title
  
  Br J Cancer
  
  Volume: 113 Issue: 7 Pages: 1055-1065
- DOI
  10.1038/bjc.2015.300
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462430, KAKENHI-PROJECT-15K20071, KAKENHI-PROJECT-25293333
[Presentation] microRNA-15b-5p/ Muscarinic receptors/ YAP signaling Contributes to Castration-resistant Growth of Prostate Cancer2023
- Author(s)
  Yusuke Goto*, Shunichi Asai, Shinichi Sakamoto, Tomokazu Sazuka, Yusuke Imamura, Naohiko Seki, Tomohiko Ichikawa, Chiba, Japan
- Organizer
  2023年米国泌尿器科学会年次総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16753
[Presentation] Identification of dual tumor-suppressors (miR-222-5p/miR-222-3p) based on microRNA expression signature by deep sequencing of CRPC2016
- Author(s)
  Yusuke Goto, Satoko Kojima, Akira Kurozumi, Mayuko Kato, Atsushi Okato, Yukio Naya, Hideki Enokida, Ryosuke Matsushita, Masayuki Nakagawa, Tomohiko Ichikawa, Naohiko Seki
- Organizer
  American Urological Association
- Place of Presentation
  アメリカ合衆国サンディエゴ市　サンディエゴコンベンションセンター
- Year and Date
  2016-05-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20071
[Presentation] Identification of dual tumor-suppressors (miR-222-5p/miR-222-3p) based on microRNA expression signature by deep sequencing of CRPC2016
- Author(s)
  Goto Y, Kojima S, Kurozumi A, Kato M, Okato A, Naya Y, Enokida H, Matsushita R, Nakagawa M, Ichikawa T, Seki N
- Organizer
  AUA annual meeting 2016
- Place of Presentation
  アメリカ合衆国サンディエゴ市
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20071
[Presentation] Regulation of UHRF1-mediated pathways by tumor-suppressive microRNA-101 in molecular targeted therapy resistant renal cell carcinoma.2016
- Author(s)
  Goto Y, Kurozumi A, Kato M, Okato A, Kojima S, Matsushita R, Yoshino H, Enokida H, Nakagawa M, Naya Y, Ichikawa T, Seki N.
- Organizer
  AUA annual meeting 2016
- Place of Presentation
  アメリカ合衆国サンディエゴ市
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20071
[Presentation] 全ゲノムCRPC機能性RNA発現解析に基づくCRPC活性化分子経路の探索2016
- Author(s)
  五島悠介、小島聡子、松下良介、黒住顕、加藤繭子、西川里佳、坂本信一、榎田英樹、中川昌之、納谷幸男、市川智彦、関直彦
- Organizer
  第104回日本泌尿器科学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-15K20071
[Presentation] 去勢抵抗性前立腺癌克服に向けた全ゲノム機能性RNA解析2016
- Author(s)
  五島悠介
- Organizer
  第104回日本泌尿器科学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-15K20071
[Presentation] miR-221/222 cluster as a tumor suppressor based on microRNA expression signature of castration-resistant prostate cancer.2015
- Author(s)
  Yusuke Goto, Satoko Kojima, Rika Nishikawa, Ryosuke Matsushita, Ichiro Fukumoto, Shinichi Sakamoto, Hideki Enokida, Masayuki Nakagawa, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki.
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  愛知県名古屋市　名古屋国際会議場
- Year and Date
  2015-10-06
- Data Source
  KAKENHI-PROJECT-15K20071
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1. 関直彦 (50345013)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. KATO MAYUKO (80733857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 市川智彦 (20241953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 安藤俊範 (40754552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 加治屋幹人 (00633041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 柳本惣市 (10315260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 泉大樹 (80813485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 萩原陽子 (30992226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 水野圭子 (50531414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 末次隆行 (90862863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小島聡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Goto Yusuke 五島 悠介

GOTO YUSUKE 五島 悠介

GOTO Yusuke 五島 悠介

Research Projects

Research Products

Co-Researchers

Deciphering the regulatory mechanism of cancer microenvironment induced by disruption of the Hippo pathway and novel therapeutic approach

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

合成致死性に基づいたKRAS変異陽性肺癌におけるソトラシブ併用新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アンドロゲン受容体標的薬と合成致死性をもつシグナル伝達分子の網羅的探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of super-enhancer and master genes involved in treatment resistance of urothelial cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of GPCR which activates FAK-YAP signaling and promotes castration-resistant growth of prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of mechanism of castration resistant growth of prostate cancer cells by innervationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel CRPC therapeutics by inhibition of activated functional RNA signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] MiR-15b-5p inhibits castration-resistant growth of prostate cancer cells by targeting the muscarinic cholinergic receptor CHRM32023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB12021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The roles of microRNAs in the progression of castration-resistant prostate cancer.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of E3 ubiquitin ligase-1 (WWP1) by microRNA-452 inhibits cancer cell migration and invasion in prostate cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MicroRNA expression signature of castration-resistant prostate cancer: the microRNA-221/222 cluster functions as a tumour suppressor and disease progression marker.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] microRNA-15b-5p/ Muscarinic receptors/ YAP signaling Contributes to Castration-resistant Growth of Prostate Cancer2023

Author(s)

Goto Yusuke 五島悠介

GOTO YUSUKE 五島悠介

GOTO Yusuke 五島悠介