Tamaki Yukihiro 玉城志博

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TAMAKI Yukihiro 玉城志博

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Researcher Number	00720822
Other IDs
Affiliation (Current)	2025: 琉球大学, 熱帯生物圏研究センター, 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 琉球大学, 熱帯生物圏研究センター, 助教 2015: 琉球大学, 熱帯生物圏研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 40030:Aquatic bioproduction science-related / Bacteriology (including mycology) Except Principal Investigator Basic Section 42020:Veterinary medical science-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Experimental pathology
Keywords	Principal Investigator ウイルス様粒子（VLP） / 大腸菌発現 / 組換えワクチン / モザイク / 発現タンパク質の比率制御 / 分子足場（scaffold） / ウイルス様粒子（VLPs） / 足場（scaffold） / 分子設計 / 魚病ウイルス … More / 魚病ワクチン / EHEC / 志賀毒素 / 分子デザイン / 融合タンパク質 / B鎖標的型 / トキソイドワクチン / AB5型毒素 / 志賀毒素（Stx） / 志賀毒素産生性大腸菌（STEC） … More Except Principal Investigator 志賀毒素 / 易熱性腸管毒素（LT） / 腸管毒素原性大腸菌 / ワクチン / 分子不安定性要因解明 / ２型志賀毒素 / B鎖５量体 / 志賀毒素産生性大腸菌 / 豚の浮腫病 / 変異体 / 分子安定性 / 5量体 / 動物実験 / 2型志賀毒素ワクチン開発 / 生存率 / 毒素攻撃 / アミノ酸置換 / 5量体分子安定化 / 2型志賀毒素ワクチン / T=3 正二十面体ウイルス / Protrusion domain / Shell domain / 分子足場（molecular scaffold） / 神経壊死性ウイルス / ノンエンベロープウイルス / 正二十面体ウイルス / 人工知能対分子デザイン能力 / B鎖５量体形成維持 / 分子安定化技術 / トキソイドワクチン / ワクチン抗原 / 多価ワクチン / ワクチン開発 / B鎖５量体(LTB) / 融合タンパク質 / 可溶性発現 / 蛋白質リフォールディング法 / タンパク質巻き戻し / 封入体発現 / B鎖５量体（LTB） / 毒素原性大腸菌 / ５量体 / 交叉反応性 / コレラ毒素（CT） / サブユニットワクチン / 耐熱性腸管毒素（STa） / 腸管毒素原性大腸菌（ETEC） / 天然型タンパク質立体構造 / ジスルフィド結合 / コレラ毒素 / 耐熱性腸管毒素 / 易熱性腸管毒素 / 食中毒 / 大腸菌 / 腸管毒素 / タンパク質リフォールディング / 組換えタンパク質発現 / 感染症 Less

Construction of a technological platform for controlling the ratio of VLP component proteins and its application to the development of recombinant vaccinesPrincipal Investigator
- Principal Investigator
  
  玉城志博
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 40030:Aquatic bioproduction science-related
- Research Institution
  University of the Ryukyus
T=3正二十面体ウイルス粒子構造を模した分子構築法の開発と感染症ワクチンへの応用
- Principal Investigator
  
  新川武
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  University of the Ryukyus
VLP vaccine development against a fish disease virus and the scaffold techniques and designs for vaccine developmentPrincipal Investigator
- Principal Investigator
  
  Tamaki Yukihiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 40030:Aquatic bioproduction science-related
- Research Institution
  University of the Ryukyus
２型志賀毒素B鎖５量体不安定性要因の分子機構解明と第２世代志賀毒素ワクチン開発
- Principal Investigator
  
  新川武
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  University of the Ryukyus
Recombinant toxoid vaccine development against Shiga toxin type 2
- Principal Investigator
  
  Arakawa Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  University of the Ryukyus
Development of recombinant toxoid vaccines targeting B-subunit against Shiga toxinsPrincipal Investigator
- Principal Investigator
  
  TAMAKI Yukihiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  University of the Ryukyus
Recombinant toxoid vaccine development against Enterotoxigenic Escherichia coli (ETEC)
- Principal Investigator
  
  ARAKAWA Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of the Ryukyus

All 2024 2022 2018 2016

All Journal Article Presentation

[Journal Article] Shiga toxin type 2 B subunit protects mice against toxin challenge when leashed and bundled by a stable pentameric coiled-coil molecule2024
- Author(s)
  Tamaki Yukihiro、Harakuni Tetsuya、Arakawa Takeshi
- Journal Title
  
  Vaccine
  
  Volume: 42 Issue: 7 Pages: 1757-1767
- DOI
  10.1016/j.vaccine.2024.01.102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05728
[Journal Article] Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25, by silkworm and its biochemical analysis.2022
- Author(s)
  Miyata T, Minamihata K, Kurihara K, Kamizuru Y, Gotanda M, Obayashi M, Kitagawa T, Sato K, Kimura M, Oyama K, Ikeda Y, Tamaki Y, Lee JM, Sakao K, Hamanaka D, Kusakabe T, Tachibana M, Ibrahim HR
- Journal Title
  
  Protein Expression and Purification
  
  Volume: 195-196 Pages: 106096-106096
- DOI
  10.1016/j.pep.2022.106096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05728
[Journal Article] Cholera toxin B subunit pentamer reassembled from Escherichia coli inclusion bodies for use in vaccination.2016
- Author(s)
  Tamaki Y, Harakuni T, Yamaguchi R, Miyata T, Arakawa T
- Journal Title
  
  Vaccine
  
  Volume: 34(10) Issue: 10 Pages: 1268-1274
- DOI
  10.1016/j.vaccine.2016.01.034
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08428, KAKENHI-PROJECT-26460511, KAKENHI-PROJECT-15K19096
[Presentation] 豚浮腫病ワクチンの野外における有効性および安全性評価2018
- Author(s)
  脇貴志、長田友世、本田容子、紺屋勝美、山崎憲一、新川武、玉城志博
- Organizer
  第１６１回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15687
[Presentation] 志賀毒素B鎖５量体安定化とそのワクチン機能2018
- Author(s)
  玉城志博、原國哲也、新川武
- Organizer
  第２２回日本ワクチン学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15687
[Presentation] 志賀毒素（Stx）に対するB鎖標的型組換えワクチンの分子構築2016
- Author(s)
  玉城志博、原國哲也、新川武
- Organizer
  第20回日本ワクチン学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-15K08428

1. ARAKAWA Takeshi (50305190)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
2. 原國哲也 (60593598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Tamaki Yukihiro 玉城 志博

TAMAKI Yukihiro 玉城 志博

Research Projects

Research Products

Co-Researchers

Construction of a technological platform for controlling the ratio of VLP component proteins and its application to the development of recombinant vaccinesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

T=3正二十面体ウイルス粒子構造を模した分子構築法の開発と感染症ワクチンへの応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

VLP vaccine development against a fish disease virus and the scaffold techniques and designs for vaccine developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

２型志賀毒素B鎖５量体不安定性要因の分子機構解明と第２世代志賀毒素ワクチン開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Recombinant toxoid vaccine development against Shiga toxin type 2

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of recombinant toxoid vaccines targeting B-subunit against Shiga toxinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Recombinant toxoid vaccine development against Enterotoxigenic Escherichia coli (ETEC)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Shiga toxin type 2 B subunit protects mice against toxin challenge when leashed and bundled by a stable pentameric coiled-coil molecule2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25, by silkworm and its biochemical analysis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cholera toxin B subunit pentamer reassembled from Escherichia coli inclusion bodies for use in vaccination.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 豚浮腫病ワクチンの野外における有効性および安全性評価2018

Author(s)

Organizer

Data Source

[Presentation] 志賀毒素B鎖５量体安定化とそのワクチン機能2018

Author(s)

Organizer

Data Source

[Presentation] 志賀毒素（Stx）に対するB鎖標的型組換えワクチンの分子構築2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Tamaki Yukihiro 玉城志博

TAMAKI Yukihiro 玉城志博