Tanaka Atsushi 田中淳

Researcher Number	00724105
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2024: 京都大学, 医生物学研究所, 特定研究員 2022 – 2023: 大阪大学, 大学院医学系研究科, 特任准教授(常勤) 2016 – 2018: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) 2017: 大阪大学, 免疫学フロンティア研究センター, 特任助教 2014 – 2015: 大阪大学, 免疫学フロンティア研究センター, 特任助教
Review Section/Research Field	Principal Investigator Immunology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Immunology
Keywords	Principal Investigator 制御性T細胞 / 自己免疫 / 免疫自己寛容 / がん免疫 / 免疫寛容 / 自己免疫病 / TCRシグナル / ZAP-70 / 自己免疫疾患 Except Principal Investigator Autoimmunity … More / Self tolerance / Etiology of autoimmunity / Epigenetic regulation / Treg development / autoimmune diseases / immune tolerance / epigenetics / Regulatory T cells / エピジェネティクス / 自己免疫疾患 / 免疫寛容 Less

Targeting Treg cells in cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  田中淳
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyoto University
  Osaka University
Molecular basis of Treg-specific TCR signaling regulationPrincipal Investigator
- Principal Investigator
  
  Tanaka Atsushi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Identification of Genes Controlling Treg Development by Combining the CRISPR-Cas9 System and Bone Marrow Chimeric Mouse Model
- Principal Investigator
  
  Huang Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Elucidating the mechanism of autoimmune induction by self-reactive T and regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  Tanaka Atsushi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University

All 2024 2023 2022 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book

[Book] Chronic Inflammation: Mechanisms and Regulation2016
- Author(s)
  Wing, J., Tanaka, A., Sakaguchi, S.
- Total Pages
  695
- Publisher
  Springer, Japan
- Data Source
  KAKENHI-PROJECT-26860331
[Journal Article] Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy2023
- Author(s)
  Tay Christopher、Tanaka Atsushi、Sakaguchi Shimon
- Journal Title
  
  Cancer Cell
  
  Volume: 41 Issue: 3 Pages: 450-465
- DOI
  10.1016/j.ccell.2023.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24181
[Journal Article] Melanocyte-specific CD49a+CD8+ T cells in vitiligo lesion potentiate to maintain activity during systemic steroid therapy.2023
- Author(s)
  Yokoi K, Watanabe R, Kume M, Yamane S, Tanaka A, Fujimoto M, Tanemura A
- Journal Title
  
  Journal of Dermatology
  
  Volume: 50 Issue: 5 Pages: 710-714
- DOI
  10.1111/1346-8138.16680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08670, KAKENHI-PROJECT-23K24181
[Journal Article] Characterization of human epithelial resident memory regulatory T cells.2022
- Author(s)
  Sato T, Ogawa Y, Yokoi K, Nagasaka Y, Ishikawa A, Shiokawa I, Kinoshita M, Watanabe R, Shimada S, Tanaka A, Momosawa A, Kawamura T.
- Journal Title
  
  Front Immunol.
  
  Volume: 13 Pages: 962167-962167
- DOI
  10.3389/fimmu.2022.962167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08687, KAKENHI-PROJECT-23K24181
[Journal Article] PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment.2022
- Author(s)
  Thumkeo D, Punyawatthananukool S, Prasongtanakij S, Matsuura R, Arima K, Nie H, Yamamoto R, Aoyama N, Hamaguchi H, Sugahara S, Takeda S, Charoensawan V, Tanaka A, Sakaguchi S, Narumiya S.
- Journal Title
  
  Cell Reports
  
  Volume: 39(10) Issue: 10 Pages: 110914-110914
- DOI
  10.1016/j.celrep.2022.110914
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00498, KAKENHI-PROJECT-20K07287, KAKENHI-PROJECT-23K24181
[Journal Article] Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease2022
- Author(s)
  Tanaka Atsushi、Maeda Shinji、Nomura Takashi、Llamas-Covarrubias Mara Anais、Tanaka Satoshi、Jin Lin、Lim Ee Lyn、Morikawa Hiromasa、Kitagawa Yohko、Akizuki Shuji、Ito Yoshinaga、Fujimori Chihiro、Hirota Keiji、et al、Sakaguchi Shimon
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 220 Issue: 2 Pages: 1-5
- DOI
  10.1084/jem.20220386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-20K16286, KAKENHI-PROJECT-23K24181, KAKENHI-PROJECT-22K20758
[Journal Article] PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer2019
- Author(s)
  Takahiro Kamada, Yosuke Togashi, Danbee Ha, Akinori Sasaki, Yoshiaki Nakamura, Eiichi Sato, Shota Fukuoka, Yasuko Tada, Atsushi Tanaka, Akihito Kawazoe, Takahiro Kinoshita, Kohei Shitara, Shimon Sakaguchi, Hiroyoshi Nishikawa
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15723
[Journal Article] Treg分化と機能におけるTCRシグナルの役割2019
- Author(s)
  田中淳
- Journal Title
  
  医学のあゆみ
  
  Volume: 268 Pages: 1086-1090
- Data Source
  KAKENHI-PROJECT-17K15723
[Journal Article] Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer2019
- Author(s)
  Wing James B.、Tanaka Atsushi、Sakaguchi Shimon
- Journal Title
  
  Immunity
  
  Volume: 50 Issue: 2 Pages: 302-316
- DOI
  10.1016/j.immuni.2019.01.020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-17K15723, KAKENHI-PROJECT-16H06295
[Journal Article] Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody2018
- Author(s)
  Ha Danbee、Tanaka Atsushi、Kibayashi Tatsuya、Tanemura Atsushi、Sugiyama Daisuke、Wing James Badger、Lim Ee Lyn、Teng Karen Wei Weng、Adeegbe Dennis、Newell Evan W.、Katayama Ichiro、Nishikawa Hiroyoshi、Sakaguchi Shimon
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 2 Pages: 609-618
- DOI
  10.1073/pnas.1812186116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-18K08267, KAKENHI-PROJECT-17K15723, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-17H06162
[Journal Article] Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis2018
- Author(s)
  Hirota Keiji、Hashimoto Motomu、Ito Yoshinaga、Matsuura Mayumi、Ito Hiromu、Tanaka Masao、Watanabe Hitomi、Kondoh Gen、Tanaka Atsushi、Yasuda Keiko、Kopf Manfred、Potocnik Alexandre J.、Stockinger Brigitta、Sakaguchi Noriko、Sakaguchi Shimon
- Journal Title
  
  Immunity
  
  Volume: 48 Issue: 6 Pages: 1220-1232
- DOI
  10.1016/j.immuni.2018.04.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-16H06233, KAKENHI-PROJECT-17K15723
[Journal Article] Tregは本当にがん免疫療法に役立つのか？2017
- Author(s)
  田中淳、坂口志文
- Journal Title
  
  腫瘍内科
  
  Volume: １９ Pages: 41-46
- Data Source
  KAKENHI-PROJECT-26860331
[Journal Article] Regulatory T cells in cancer immunotherapy2017
- Author(s)
  Tanaka, A., and Sakaguchi, S.
- Journal Title
  
  Cell Research
  
  Volume: 27 Issue: 1 Pages: 109-118
- DOI
  10.1038/cr.2016.151
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860331, KAKENHI-PROJECT-17K15723, KAKENHI-PROJECT-16H06295
[Journal Article] Identification of novel and noninvasive biomarkers of acute cellular rejection after liver transplantation by protein microarray2016
- Author(s)
  Okubo, K., Wada, H., Tanaka, A., Eguchi, E., Hamaguchi, M., Tomokuni, A., Tomimaru, Y., Asaoka, T., Hama, N., Kawamoto, K., Kobayashi, S., Marubashi, S., Nagano, H., Sakaguchi, N., Nishikawa, H., Doki, Y., Mori, M., Sakaguchi, S.
- Journal Title
  
  Transplant Direct
  
  Volume: 2 Issue: 12 Pages: e118-e118
- DOI
  10.1097/txd.0000000000000630
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860331, KAKENHI-PROJECT-16H06295
[Journal Article] Immunology. Early life Aire.2015
- Author(s)
  Tanaka A, Sakaguchi S.
- Journal Title
  
  Science
  
  Volume: 348(6234) Issue: 6234 Pages: 506-507
- DOI
  10.1126/science.aab2998
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860331
[Journal Article] Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)2015
- Author(s)
  Leverson JD, Zhang H, Chen J, Tahir SK, Phillips DC, Xue J, Nimmer P, Jin S, Smith M, Xiao Y, Kovar P, Tanaka A et al.
- Journal Title
  
  Cell Death and Disease
  
  Volume: 6 Issue: 1 Pages: e1590-e1590
- DOI
  10.1038/cddis.2014.561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860331
[Journal Article] 制御性T細胞の同定とその役割2015
- Author(s)
  田中淳、坂口志文
- Journal Title
  
  がん分子標的治療
  
  Volume: 13(4) Pages: 66-70
- Data Source
  KAKENHI-PROJECT-26860331
[Journal Article] Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease.2014
- Author(s)
  Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali D, Kappler J, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.
- Journal Title
  
  Science
  
  Volume: 346 Issue: 6207 Pages: 363-8
- DOI
  10.1126/science.1259077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25713019, KAKENHI-PROJECT-26290054, KAKENHI-PROJECT-26670192, KAKENHI-PROJECT-26670477, KAKENHI-PROJECT-26670581, KAKENHI-PROJECT-26860331
[Presentation] Regulation of TCR signaling molecules in Treg cells2024
- Author(s)
  Atsushi Tanaka
- Organizer
  The 2nd Doherty Institute & partners Immunology Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24181
[Presentation] Treg-specific TCR signaling as a target of cancer immunotherapy2023
- Author(s)
  Atsushi Tanaka
- Organizer
  The Society for Immunotherapy of Cancer’s 38th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24181
[Presentation] Treg-specific control of TCR signaling molecules2019
- Author(s)
  Atsushi Tanaka
- Organizer
  Keystone Symposia: Uncovering Mechanisms of Immune-Based Therapy in Cancer and Autoimmunity (B3)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15723
[Presentation] 制御性T細胞と腫瘍免疫2018
- Author(s)
  田中淳
- Organizer
  Immuno-Checkpoint Blockade Seminar in Osaka 2018
- Invited
- Data Source
  KAKENHI-PROJECT-17K15723
[Presentation] Treg-specific control of TCR signaling molecules2017
- Author(s)
  Atsushi Tanaka
- Organizer
  第４６回日本免疫学会総会・学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15723
[Presentation] MBD3, A COMPONENT OF THE NURD COMPLEX, SHAPES THE T-CELL RECEPTOR REPERTOIRE OF REGULATORY T CELLS2016
- Author(s)
  Jun Huang, Yohko Kitagawa, Atsushi Tanaka, Naganari Ohkura,Shimon Sakaguchi
- Organizer
  3rd Cold Spring Harbor Laboratory meeting on Epigenetics & Chromatin
- Place of Presentation
  Cold Spring Harbor Laboratory, NY, USA
- Year and Date
  2016-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15154
[Presentation] 制御性T細胞の特異的なTCRシグナル制御とその応用2016
- Author(s)
  田中淳
- Organizer
  第１６回　LEGEND Seminar 2016
- Place of Presentation
  沖縄県那覇市ANAクラウンプラザホテル沖縄
- Invited
- Data Source
  KAKENHI-PROJECT-26860331
[Presentation] Selective control of regulatory T cells through TCR signaling molecule2016
- Author(s)
  Atsushi Tanaka
- Organizer
  16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860331
[Presentation] Selective control of regulatory T cells through TCR signaling molecule2016
- Author(s)
  田中淳
- Organizer
  第２６回 Kyoto T Cell Conference
- Place of Presentation
  滋賀県大津市延暦寺会館
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-26860331
[Presentation] “Autoimmune range of T cell receptor signaling”2015
- Author(s)
  Atsushi Tanaka, Shinji Maeda, Takashi Nomura, Satoshi Tanaka, Lin Jin, Shuji Akizuki, Rose Zamoyska, Daron M Standley, Noriko Sakaguchi, Shimon Sakaguchi
- Organizer
  Keystone symposia T Cells: Regulation and Effector Function
- Place of Presentation
  米国ユタ州　Snowbird
- Year and Date
  2015-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860331

1. Huang Jun (00751207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. Ohkura Naganari (20300949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Kitagawa Yohko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. OGAWA Youichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. TANEMURA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. ウィングジェイムス

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 廣田圭司

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 成宮周

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tanaka Atsushi 田中 淳

Research Projects

Research Products

Co-Researchers

Targeting Treg cells in cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of Treg-specific TCR signaling regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of Genes Controlling Treg Development by Combining the CRISPR-Cas9 System and Bone Marrow Chimeric Mouse Model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidating the mechanism of autoimmune induction by self-reactive T and regulatory T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Chronic Inflammation: Mechanisms and Regulation2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Melanocyte-specific CD49a+CD8+ T cells in vitiligo lesion potentiate to maintain activity during systemic steroid therapy.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of human epithelial resident memory regulatory T cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer2019

Author(s)

Journal Title

Data Source

[Journal Article] Treg分化と機能におけるTCRシグナルの役割2019

Author(s)

Journal Title

Data Source

[Journal Article] Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis2018

Author(s)

Journal Title

DOI

Tanaka Atsushi 田中淳