AMACHI Ryota 天知良太

Researcher Number	00733891
Affiliation (based on the past Project Information) *help	2016 – 2017: 徳島大学, 病院, 医員 2015: 徳島大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Pathobiological dentistry/Dental radiology
Keywords	Principal Investigator 腫瘍排他的ニッチ / ミトコンドリア / 骨芽細胞 / 多発性骨髄腫 / 細胞微小環境

Research Projects
(2 results)
Research Products
(11 results)

骨芽細胞による癌抑制性ニッチ形成の実態解明とその誘導による新規治療法の開発Principal Investigator
- Principal Investigator
  
  天知良太
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The University of Tokushima
The elucidation of molecular mechanism of the formation of tumor-promoting or suppressing microenvironment by bone cellsPrincipal Investigator
- Principal Investigator
  
  AMACHI Ryota
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The University of Tokushima

All 2017 2016 2015

All Journal Article Presentation

[Journal Article] Expansion of Th1-like Vγ9Vδ2T　cells by new generation IMiDs, lenalidomide and pomalidomide, in combination with zoledronic acid2017
- Author(s)
  Takeshi Harada, Hirokazu Miki, Qu Cui, Asuka Oda, Ryota Amachi, Jumpei Teramachi, AriunzayaBat-Erdene, Kimiko Sogabe, Masami Iwasa, Shiro Fujii, Shingen Nakamura,Kumiko Kagawa,　Sumiko Yoshida, Itsuro Endo, Kenichi Aihara, Shuji Ozaki, Toshio Matsumoto, and Masahiro Abe
- Journal Title
  
  Leukemia
  
  Volume: 31(1) Pages: 258-262
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20385
[Journal Article] Pim-2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma2016
- Author(s)
  Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Takeshi Harada, Shingen Nakamura,　Ryota Amachi, Hirofumi Tenshin, Masami Iwasa, Shiro Fujii, Kumiko Kagawa, Hirokazu Miki,　Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Tatsuji Haneji, Toshio Matsumoto and Masahiro Abe
- Journal Title
  
  British Journal of Haematology
  
  Volume: 印刷中
- NAID
  120006549655
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20385
[Journal Article] Synergistic targeting of transcription factor specificity protein 1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors2016
- Author(s)
  Ariunzaya Bat-Erdene, Hirokazu Miki, Asuka Oda, Shingen Nakamura, Jumpei Teramachi, Ryota Amachi, Hirofumi Tenshin, Masahiro Hiasa,　Masami Iwasa, Takeshi Harada, Shiro Fujii,　Kimiko Sogabe, Kumiko Kagawa,　Sumiko Yoshida, Itsuro Endo, Ken-ichi Aihara, and Masahiro Abe.
- Journal Title
  
  Oncotarget
  
  Volume: 7(48) Pages: 79064-79075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20385
[Journal Article] A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration.2016
- Author(s)
  Amachi R, Hiasa M, Teramachi J, Harada T, Oda A, Nakamura S, Hanson D, Watanabe K, Fujii S, Miki H, Kagawa K, Iwasa M, Endo I, Kondo T, Yoshida S, Aihara K, Kurahashi K, Kuroda Y, Horikawa H, Tanaka E, Matsumoto T, Abe M.
- Journal Title
  
  Oncotarget
  
  Volume: 7(43) Pages: 70447-70461
- NAID
  120006576954
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20385
[Presentation] Restoration of bone formation induces an energy crisis in myeloma cells2017
- Author(s)
  Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Asuka Oda, Ariunzaya Bat-Erdene, Hirofumi Tenshin, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shiro Fujii, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe
- Organizer
  2017 IADR/AADR/CADR General Session & Exhibition
- Place of Presentation
  サンフランシスコ（アメリカ）
- Year and Date
  2017-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20385
[Presentation] Creation of a non-permissive niche for myeloma by bone formation2016
- Author(s)
  Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Asuka Oda, Ariunzaya Bat-Erdene, Hirofumi Tenshin, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shiro Fujii, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K20385
[Presentation] Up-regulation of the pH sensor TRPV1 in myeloma cells and their adaption to an acidic microenvironment2015
- Author(s)
  Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Asuka Oda , Hirofumi Tenshin, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shiro Fujii, Eiji Tanaka , Toshio Matsumoto , Masahiro Abe
- Organizer
  ASBMR 2015 Annual Meeting
- Place of Presentation
  Washington State Convention Center (Seattle, Washington, USA)
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K20385
[Presentation] Mechanism of the TRPV1 up-regulation in myeloma cells and adaption to an acidic microenvironment2015
- Author(s)
  Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Asuka Oda , Hirofumi Tenshin, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shiro Fujii, Eiji Tanaka , Toshio Matsumoto , Masahiro Abe
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂 (石川県金沢市)
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K20385
[Presentation] 酸環境での骨髄腫細胞のDR4発現抑制：酸によるエピジェネティックな遺伝子発現制御2015
- Author(s)
  天知良太、日浅雅博、寺町順平、小田明日香、天真寛文、渡邉佳一郎、中村信元、賀川久美子、三木浩和、藤井志朗、遠藤逸朗、田中栄二、松本俊夫、安倍正博
- Organizer
  第1回日本骨免疫学会
- Place of Presentation
  ホテルブリーズベイマリーナ (沖縄県宮古島市)
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-15K20385
[Presentation] 酸性環境での骨髄腫細胞のTRPV1の発現亢進と酸環境への適応2015
- Author(s)
  天知良太、日浅雅博、寺町順平、小田明日香、天真寛文、渡邉佳一郎、中村信元、遠藤逸朗、田中栄二、松本俊夫、安倍正博
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15K20385
[Presentation] Mechanism of the TRPV1 up-regulation in myeloma cells and adaption to an acidic microenvironment2015
- Author(s)
  Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Asuka Oda , Hirofumi Tenshin, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shiro Fujii, Eiji Tanaka , Toshio Matsumoto , Masahiro Abe
- Organizer
  Joint ANZBMS, MEPSA and MBSANZ Annual Scientific Meeting　2015
- Place of Presentation
  Hotel Grand Chancellor (Hobart,Tasmania)
- Year and Date
  2015-11-01
- Data Source
  KAKENHI-PROJECT-15K20385

AMACHI Ryota 天知 良太

Research Projects

Research Products

骨芽細胞による癌抑制性ニッチ形成の実態解明とその誘導による新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation of molecular mechanism of the formation of tumor-promoting or suppressing microenvironment by bone cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Expansion of Th1-like Vγ9Vδ2T cells by new generation IMiDs, lenalidomide and pomalidomide, in combination with zoledronic acid2017

Author(s)

Journal Title

Data Source

[Journal Article] Pim-2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synergistic targeting of transcription factor specificity protein 1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors2016

Author(s)

Journal Title

Data Source

[Journal Article] A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration.2016

Author(s)

Journal Title

NAID

Data Source

[Presentation] Restoration of bone formation induces an energy crisis in myeloma cells2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Creation of a non-permissive niche for myeloma by bone formation2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Up-regulation of the pH sensor TRPV1 in myeloma cells and their adaption to an acidic microenvironment2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Mechanism of the TRPV1 up-regulation in myeloma cells and adaption to an acidic microenvironment2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 酸環境での骨髄腫細胞のDR4発現抑制：酸によるエピジェネティックな遺伝子発現制御2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 酸性環境での骨髄腫細胞のTRPV1の発現亢進と酸環境への適応2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Mechanism of the TRPV1 up-regulation in myeloma cells and adaption to an acidic microenvironment2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

AMACHI Ryota 天知良太

[Journal Article] Expansion of Th1-like Vγ9Vδ2T　cells by new generation IMiDs, lenalidomide and pomalidomide, in combination with zoledronic acid2017