Yamada Kaoru 山田薫

… Alternative Names

KAORU Yamada 山田薫

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Researcher Number	00735152
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院医学系研究科(医学部), 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 東京大学, 大学院医学系研究科(医学部), 助教 2014 – 2015: 東京大学, 医学(系)研究科(研究院), 助教 1988: 東京大学, 医学部, 医員 1987 – 1988: 東京大学, 医学部(病), 医員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Biological Sciences / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology Except Principal Investigator Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields / Neurology / Circulatory organs internal medicine
Keywords	Principal Investigator 神経科学 / アルツハイマー病 / タウ / 伝播 / 神経活動 / グリア細胞 / グリアリンパ系 / aquaporin-4 / glymphatic system / α-synuclein / アルファシヌクレイン … More Except Principal Investigator … More アルツハイマー病 / タウ / グリアリンパ系 / 液・液相分離 / 神経変性疾患 / 運動ニューロン疾患 / タウ蓄積症 / パーキンソン病 / 神経変性 / 細胞ストレス / 脳神経疾患 / tau / amyloid beta peptide / Aβ / essential hypertension / Salt and hypertension / Na^+-K^+-ATPase inhibitor Renal tubular epithelial cells / Vascular smooth muscle cells / Ouabain / Endogenous digitalis-like factor / Na^+, K^+-ATPase抑制因子 / 本態性高血圧症 / Na利尿ホルモン / Na^+、K^+-ATPase抑制因子 / 本能性高血圧症 / 食塩と高血圧 / 腎尿細管細胞 / 血管平滑車筋細胞 / ウアバイン / 内因性ジギタリス様物質 Less

細胞外タウプロテオスタシス異常が導く神経変性機序の解明Principal Investigator
- Principal Investigator
  
  山田薫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokyo
アルツハイマー血液バイオマーカー：経頭蓋リンパ系放出機構と病態生理学的意義の確立
- Principal Investigator
  
  岩坪威
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  The University of Tokyo
Stress dependent production and release of aggregated proteins in neurodegenerative disorders
- Principal Investigator
  
  Iwatsubo Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokyo
Elucidation of the mechanisms involved in extracellular tau dynamics in brainPrincipal Investigator
- Principal Investigator
  
  Yamada Kaoru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokyo
細胞間伝播を導くタウの細胞外量調節機構の解明Principal Investigator
- Principal Investigator
  
  山田薫
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of the molecular mechanisms of Abeta economy in the brain of Alzheimer's disease
- Principal Investigator
  
  Iwatsubo Takeshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
Activity depepdent regulation of alpha-synuclein release from neuronsPrincipal Investigator
- Principal Investigator
  
  Yamada Kaoru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
細胞間伝播を導くタウの細胞外放出の分子機構の解明Principal Investigator
- Principal Investigator
  
  山田薫
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
αシヌクレインの細胞外放出と細胞間伝播に関する研究Principal Investigator
- Principal Investigator
  
  山田薫
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
Study on the role of hypothalamic Na^+-K^+-ATPase inhibitor in essential hypertension
- Principal Investigator
  
  ATSUO Goto
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Glymphatic system clears extracellular tau and protect from tau aggregation and neurodegeneration.2022
- Author(s)
  Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 219 Issue: 3
- DOI
  10.1084/jem.20211275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-19J21850, KAKENHI-PROJECT-21K07270
[Journal Article] Seeding Activity-Based Detection Uncovers the Different Release Mechanisms of Seed-Competent Tau Versus Inert Tau via Lysosomal Exocytosis2019
- Author(s)
  Yuki Tanaka, Kaoru Yamada, Kyoko Satake, Itaru Nishida, Matthias Heuberger, Tomoki Kuwahara, Takeshi Iwatsubo
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 13 Pages: 1258-1258
- DOI
  10.3389/fnins.2019.01258
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07816, KAKENHI-PROJECT-19J21850, KAKENHI-PROJECT-17H04193
[Journal Article] Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease2019
- Author(s)
  Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 14 Issue: 1 Pages: 15-15
- DOI
  10.1186/s13024-019-0315-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K08991, KAKENHI-PROJECT-19H01052, KAKENHI-PROJECT-26000012, KAKENHI-PROJECT-17H04193, KAKENHI-PROJECT-18H02860
[Journal Article] Extracellular α-synuclein levels are regulated by neuronal activity2018
- Author(s)
  Yamada Kaoru、Iwatsubo Takeshi
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 13 Issue: 1 Pages: 9-9
- DOI
  10.1186/s13024-018-0241-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20969
[Journal Article] In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes2018
- Author(s)
  Yamada Kaoru
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 139 Issue: 139
- DOI
  10.3791/57869
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05689
[Journal Article] Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology2017
- Author(s)
  Yamada Kaoru
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 11 Pages: 667-667
- DOI
  10.3389/fnins.2017.00667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05689
[Journal Article] In vivo microdialysis of brain interstitial fluid for the determination of extracellular Tau levels.2017
- Author(s)
  Kaoru Yamada
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1523 Pages: 285-296
- DOI
  10.1007/978-1-4939-6598-4_17
- ISBN
  9781493965960, 9781493965984
- Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01552
[Journal Article] In vivo microdialysis of brain interstitial fluid for the determination of extracellular Tau levels2016
- Author(s)
  Kaoru Yamada
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 印刷中
- Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01552
[Presentation] Aquaporin4 がタウ蓄積と神経変性に果たす役割2021
- Author(s)
  山田　薫、石田　和久、橋本　唯史、阿部　陽一郎、安井　正人、岩坪　威
- Organizer
  第40回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00525
[Presentation] Aquaporin-4 deficiency exacerbates tau accumulation and neurodegeneration in a mouse model of tauopathies.2020
- Author(s)
  Kaoru Yamada, Kazuhisa Ishida, Tadafumi Hashimoto, Yoichiro Abe, Masato Yasui, Takeshi Iwatsubo
- Organizer
  第43回日本神経科学大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07388
[Presentation] Aquaporin-4が細胞外タウのクリアランスとタウ蓄積に与える影響2020
- Author(s)
  石田　和久、山田　薫、橋本　唯史、阿部　陽一郎、安井　正人、岩坪　威
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07388
[Presentation] Aquaporin-4 deficiency exacerbates tau accumulation and neurodegeneration in a mouse model of tauopathies.2020
- Author(s)
  Yamada K, Ishida K, Hashimoto T, Abe Y, Yasui M, Iwatsubo T
- Organizer
  第 43回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00525
[Presentation] タウ蓄積と神経細胞死におけるaquaporin-4の役割2020
- Author(s)
  山田　薫、石田　和久、橋本　唯史、阿部　陽一郎、安井　正人、岩坪　威
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07388
[Presentation] Aquaporin-4の欠損はタウの蓄積と神経細胞死を増悪させる2019
- Author(s)
  石田和久、山田　薫、橋本　唯史、阿部　陽一郎、安井　正人、岩坪　威
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07388
[Presentation] Activity dependent pathway determines extracellular alpha-synuclein levels.2016
- Author(s)
  Kaoru Yamada, Takeshi Iwastubo
- Organizer
  Gordon research conference (Neurobiology of Brain Disorders)
- Place of Presentation
  Girona, Spain
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20969
[Presentation] In vivo microdialysis法を用いたアルファシヌクレイン分泌機構の解明2016
- Author(s)
  山田　薫、岩坪　威
- Organizer
  第35回　日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K20969
[Presentation] Characterization of synaptic activity dependent release of endogenous tau from neurons2016
- Author(s)
  Kaoru Yamada
- Organizer
  Brain Protein Ageing and Dementia Control International Workshop 2016
- Place of Presentation
  名古屋大学鶴友会館（名古屋)
- Year and Date
  2016-09-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01552

1. Iwatsubo Takeshi (50223409)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 若林朋子 (20530330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 橋本唯史 (30334337)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. ATSUO Goto (00150277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 桑原知樹 (10533903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 新美芳樹 (90521708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamada Kaoru 山田 薫

KAORU Yamada 山田 薫

Research Projects

Research Products

Co-Researchers

細胞外タウプロテオスタシス異常が導く神経変性機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルツハイマー血液バイオマーカー：経頭蓋リンパ系放出機構と病態生理学的意義の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Stress dependent production and release of aggregated proteins in neurodegenerative disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms involved in extracellular tau dynamics in brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞間伝播を導くタウの細胞外量調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanisms of Abeta economy in the brain of Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Activity depepdent regulation of alpha-synuclein release from neuronsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞間伝播を導くタウの細胞外放出の分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

αシヌクレインの細胞外放出と細胞間伝播に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the role of hypothalamic Na^+-K^+-ATPase inhibitor in essential hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glymphatic system clears extracellular tau and protect from tau aggregation and neurodegeneration.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Seeding Activity-Based Detection Uncovers the Different Release Mechanisms of Seed-Competent Tau Versus Inert Tau via Lysosomal Exocytosis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease2019

Author(s)

Journal Title

DOI

Data Source

Yamada Kaoru 山田薫

KAORU Yamada 山田薫