KAJIHARA RYUTARO 梶原隆太郎

… Alternative Names

Kajihara Ryutaro 梶原隆太郎

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Researcher Number	00738221
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(保) , 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 熊本大学, 大学院生命科学研究部(保), 助教
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Pediatrics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 46010:Neuroscience-general-related
Keywords	Principal Investigator 免疫療法 / GM1ガングリオシド / アルツハイマー病 / 遺伝・先天異常学 / GM1ガングリオシドーシス Except Principal Investigator iPS細胞 / 脳神経疾患 / 疾患ヒトニューロン / 神経細胞死 / ライソゾーム病 … More / 神経細胞 / グロボトリアオシルスフィンゴシン / ろ紙血 / α-Gal A / 新生児スクリーニング / LC/MS/MS / Lyso-Gb3 / ファブリー病 / グルコシルスフィンゴシン / ライソソーム / ゴーシェ病 / 酸化ストレス / ミトコンドリア機能 / オートファジー / ポストシナプス機能 / プレシナプス機能 / 神経型ゴーシェ病 Less

ライソゾーム病の神経障害における細胞内カルシウム亢進と興奮毒性の役割
- Principal Investigator
  
  沼川忠広
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Kumamoto University
血漿Lyso-Gb3と血管内皮細胞解析を駆使した新しいファブリー病診断システムの構築
- Principal Investigator
  
  城戸淳
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kumamoto University
iPS細胞を用いたメラノーマに対する新規がん免疫療法の開発Principal Investigator
- Principal Investigator
  
  梶原隆太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kumamoto University
Development of a new treatment for Alzheimer's disease targeting GM1 gangliosidePrincipal Investigator
- Principal Investigator
  
  Kajihara Ryutaro
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kumamoto University
Development of novel pathological analysis and medicine in neuropathic Gaucher disease.
- Principal Investigator
  
  Kido Jun
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kumamoto University
Drug Development for GM1 Gangliosidosis using the patients-derived iPS cellsPrincipal Investigator
- Principal Investigator
  
  Kajihara Ryutaro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kumamoto University

All 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psychiatric Disorders2025
- Author(s)
  Numakawa Tadahiro、Kajihara Ryutaro
- Journal Title
  
  Molecules
  
  Volume: 30 Issue: 4 Pages: 848-848
- DOI
  10.3390/molecules30040848
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07772, KAKENHI-PROJECT-24K09645
[Journal Article] Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy2025
- Author(s)
  Kajihara Ryutaro、Long Mark D、Hoki Toshifumi、Chen Hongbin、Yamauchi Takayoshi、Kanemaru Hisashi、Segal Brahm H、Dy Grace K、Ito Fumito
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 13 Issue: 1 Pages: e010092-e010092
- DOI
  10.1136/jitc-2024-010092
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07772
[Journal Article] An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer’s Disease2024
- Author(s)
  Numakawa Tadahiro、Kajihara Ryutaro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 3 Pages: 1596-1596
- DOI
  10.3390/ijms25031596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07772
[Journal Article] Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer's Disease.2023
- Author(s)
  Numakawa T, Kajihara R.
- Journal Title
  
  Life (Basel).
  
  Volume: 13 Issue: 3 Pages: 647-647
- DOI
  10.3390/life13030647
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06857, KAKENHI-PROJECT-18K15369
[Journal Article] Unraveling Tumorigenicity in iPSC-Derived Immune Cells: The Impact of Chromosomal Abnormalities and Proliferative Intermediates2023
- Author(s)
  Begur Manali、Yamauchi Takayoshi、Saito Hidehito、Oba Takaaki、Kajihara Ryutaro、Stein Leighton、Hoenerhoff Mark、Ito Fumito
- Journal Title
  
  Blood
  
  Volume: 142 Issue: Supplement 1 Pages: 2081-2081
- DOI
  10.1182/blood-2023-186852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07772
[Journal Article] Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases2023
- Author(s)
  Numakawa Tadahiro、Kajihara Ryutaro
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 16 Pages: 1247422-1247422
- DOI
  10.3389/fnmol.2023.1247422
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07772
[Journal Article] Analysis of GM1 gangliosidosis iPS cells provides new phenotype of neural dysfunction and drug candidates2022
- Author(s)
  Era Takumi、Numakawa Tadahiro、Kajihara Ryutaro
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: 135 Issue: 2 Pages: S41-S42
- DOI
  10.1016/j.ymgme.2021.11.095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15369
[Journal Article] Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling2022
- Author(s)
  Makino Kenichi、Long Mark D、Kajihara Ryutaro、Matsueda Satoko、Oba Takaaki、Kanehira Kazunori、Liu Song、Ito Fumito
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 10 Issue: 1 Pages: e003827-e003827
- DOI
  10.1136/jitc-2021-003827
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15369
[Journal Article] Notch signaling is required for generation of conventional type 1 dendritic cells from human induced pluripotent stem cells2022
- Author(s)
  Ito Fumito、Long Mark D、Kajihara Ryutaro、Matsueda Satoko、Oba Takaaki、Kanehira Kazunori、Liu Song、Makino Kenichi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 208 Issue: Supplement_1 Pages: 47.07-47.07
- DOI
  10.4049/jimmunol.208.supp.47.07
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15369
[Journal Article] An iPSC-based neural model of sialidosis uncovers glycolytic impairment-causing presynaptic dysfunction and deregulation of Ca2+ dynamics.2021
- Author(s)
  Odaka H, Numakawa T, Soga M, Kido J, Matsumoto S, Kajihara R, Okumiya T, Tani N, Tanoue Y, Fukuda T, Furuya H, Inoue T, Era T.
- Journal Title
  
  Neurobiol Dis.
  
  Volume: 152 Pages: 105279-105279
- DOI
  10.1016/j.nbd.2021.105279
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08207, KAKENHI-PROJECT-20K06857, KAKENHI-PROJECT-19K16263
[Journal Article] Novel Drug Candidates Improve Ganglioside Accumulation and Neural Dysfunction in GM1 Gangliosidosis Models with Autophagy Activation2020
- Author(s)
  Ryutaro Kajihara, Tadahiro Numakawa, Haruki Odaka, Yuji Yaginuma, Noemi Fusaki, Toshika Okumiya, Hirokazu Furuya, Seiji Inui, and Takumi Era
- Journal Title
  
  Stem Cell Reports
  
  Volume: 14 Issue: 5 Pages: 1-15
- DOI
  10.1016/j.stemcr.2020.03.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15369, KAKENHI-PROJECT-20K06857, KAKENHI-PROJECT-19K16263, KAKENHI-PROJECT-18K06264
[Journal Article] Presynaptic Dysfunction in Neurons Derived from Tay-Sachs iPSCs.2019
- Author(s)
  Matsushita K, Numakawa T, Odaka H, Kajihara R, Soga M, Ozasa S, Nakamura K, Mizuta H and Era T.
- Journal Title
  
  Neuroscience
  
  Volume: 414 Pages: 128-140
- DOI
  10.1016/j.neuroscience.2019.06.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06264, KAKENHI-PROJECT-18K15369
[Patent] GM1ガングリオシドーシス予防剤又は治療剤、及びGM1ガングリオシドーシス予防用又は治療用組成物2018
- Inventor(s)
  江良択実、梶原隆太郎
- Industrial Property Rights Holder
  江良択実、梶原隆太郎
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18K15369
[Patent] PROPHYLACTIC OR THERAPEUTIC FOR GM1 GANGLIOSIDOSIS, AND COMPOSITION FOR PREVENTING OR TREATING GM1 GANGLIOSIDOSIS2018
- Inventor(s)
  ERA Takumi, KAJIHARA Ryutaro
- Industrial Property Rights Holder
  ERA Takumi, KAJIHARA Ryutaro
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K15369
[Patent] PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE, SCREENING METHOD THEREFOR, AND COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE2018
- Inventor(s)
  ERA Takumi, KAJIHARA Ryutaro
- Industrial Property Rights Holder
  ERA Takumi, KAJIHARA Ryutaro
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K15369
[Patent] アルツハイマー病予防剤又は治療剤、そのスクリーニング方法、及びアルツハイマー病予防用又は治療用組成物2018
- Inventor(s)
  江良択実、梶原隆太郎
- Industrial Property Rights Holder
  江良択実、梶原隆太郎
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18K15369
[Patent] アルツハイマー病予防剤又は治療剤、そのスクリーニング方法、アルツハイマー予防用又は治療用組成物、及びアルツハイマー病モデル動物2017
- Inventor(s)
  梶原隆太郎，江良択実
- Industrial Property Rights Holder
  梶原隆太郎，江良択実
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-254887
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-16K19654
[Patent] ＧＭ１ガングリオシドーシス予防剤又は治療剤、及びＧＭ１ガングリオシドーシス予防用又は治療用組成物2017
- Inventor(s)
  梶原隆太郎，江良択実
- Industrial Property Rights Holder
  梶原隆太郎，江良択実
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-254888
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-16K19654
[Patent] 先天代謝異常症由来iPS細胞を使った神経変性疾患の新規薬剤スクリーニング法2016
- Inventor(s)
  梶原隆太郎江良択実
- Industrial Property Rights Holder
  梶原隆太郎江良択実
- Industrial Property Rights Type
  特許
- Filing Date
  2016-08-29
- Data Source
  KAKENHI-PROJECT-16K19654
[Presentation] Calcium dysregulation in Tay-Sachs disease neurons2024
- Author(s)
  張雨萌、沼川忠広、梶原隆太郎、Kiseok Lee、Jing Pu、堀田知里、城戸淳、松尾宗明、江良択実.
- Organizer
  第65回日本先天代謝異常学会学術集会・第20回アジア先天代謝異常症シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K09645
[Presentation] HETEROGENEITY AND FUNCTION OF CONVENTIONAL DENDRITIC CELLS DIFFERENTIATED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS2022
- Author(s)
  Fumito Ito, Mark D Long, Ryutaro Kajihara, Satoko Matsueda, Takaaki Oba, Kazunori Kanehira, Song Liu, Kenichi Makino
- Organizer
  ISSCR 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15369
[Presentation] Drug development for GM1 gangliosidosis using the patient-derived iPS cells2019
- Author(s)
  Ryutaro Kajihara, Tadahiro Numakawa, Haruki Odaka, Takumi Era
- Organizer
  The 18th Congress of the Japanese Society for Regenerative Medicine
- Invited
- Data Source
  KAKENHI-PROJECT-18K15369
[Presentation] プロテインホスファターゼはIgEクラススイッチを促進する2019
- Author(s)
  田邊香野, 梶原隆太郎, 乾誠治
- Organizer
  第９回日本プロテインホスファターゼ研究会学術集会
- Data Source
  KAKENHI-PROJECT-18K15369
[Presentation] iPS細胞技術を用いたGM1ガングリオシドーシスの解析・薬剤開発2019
- Author(s)
  梶原隆太郎, 沼川忠広, 小高陽樹, 奥宮敏可, 古谷博和, 江良択実
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18K15369
[Presentation] iPS細胞技術をいたGM1ガングリオシドーシスの解析・薬剤開発2019
- Author(s)
  梶原隆太郎, 沼川忠広, 小高陽樹, 奥宮敏可, 古谷　博和, 江良択実
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18K15369
[Presentation] Drug development for GM1 gangliosidosis using the patient-derived iPS cells2019
- Author(s)
  Ryutaro Kajihara
- Organizer
  The 18th Congress of the Japanese Society for Regenerative Medicine
- Invited
- Data Source
  KAKENHI-PROJECT-18K15369
[Presentation] Tay-Sachs病患者由来の人工多能性幹細胞から誘導した神経細胞における、神経機能異常2018
- Author(s)
  松下紘三, 沼川忠広, 曽我美南, 梶原隆太郎, 小高陽樹, 江藤真哉, 中村英一, 江良択実
- Organizer
  第 41 回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15369
[Presentation] GM1 ガングリオシドーシス患者由来iPS 細胞をいた神経障害の機能的解析2018
- Author(s)
  梶原隆太郎, 沼川忠広, 小高陽樹, 奥宮敏可, 乾誠治, 江良択実
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K15369
[Presentation] GM1ガングリオシドーシス患者iPS細胞を用いた疾患モデルおよび薬剤スクリーニング2017
- Author(s)
  梶原隆太郎江良択実
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-16K19654
[Presentation] Drug screening for GM1 gangliosidosis using the patient-derived iPS cells2017
- Author(s)
  Ryutaro Kajihara, Takumi Era
- Organizer
  第15回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-16K19654
[Presentation] GM1 ガングリオシドーシス患者由来iPS 細胞を用いた薬剤開発2017
- Author(s)
  梶原隆太郎，江良択実
- Organizer
  第59回日本先天代謝異常学会総会・併催：第15回アジア先天代謝異常症シンポジウム
- Data Source
  KAKENHI-PROJECT-16K19654
[Presentation] ガングリオシドーシス患者由来iPS細胞を用いたハイスループット薬剤スクリーニング系の構築2016
- Author(s)
  梶原隆太郎江良択実
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19654

1. NUMAKAWA Tadahiro (40425690)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. Kido Jun (70721215)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. MASTUMOTO Shirou (70467992)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. ERA Takumi (00273706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. ENDO Fumio (00176801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小高陽樹 (40831243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 曽我美南 (80768002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 澤田貴彰 (40839065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KAJIHARA RYUTARO 梶原 隆太郎

Kajihara Ryutaro 梶原 隆太郎

Research Projects

Research Products

Co-Researchers

ライソゾーム病の神経障害における細胞内カルシウム亢進と興奮毒性の役割

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血漿Lyso-Gb3と血管内皮細胞解析を駆使した新しいファブリー病診断システムの構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

iPS細胞を用いたメラノーマに対する新規がん免疫療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new treatment for Alzheimer's disease targeting GM1 gangliosidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel pathological analysis and medicine in neuropathic Gaucher disease.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug Development for GM1 Gangliosidosis using the patients-derived iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psychiatric Disorders2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer’s Disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer's Disease.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unraveling Tumorigenicity in iPSC-Derived Immune Cells: The Impact of Chromosomal Abnormalities and Proliferative Intermediates2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of GM1 gangliosidosis iPS cells provides new phenotype of neural dysfunction and drug candidates2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling2022

Author(s)

Journal Title

DOI

KAJIHARA RYUTARO 梶原隆太郎

Kajihara Ryutaro 梶原隆太郎

[Patent] GM1ガングリオシドーシス予防剤又は治療剤、及びGM1ガングリオシドーシス予防用又は治療用組成物2018

[Patent] アルツハイマー病予防剤又は治療剤、そのスクリーニング方法、及びアルツハイマー病予防用又は治療用組成物2018