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Shibata Takehiko  柴田 岳彦

ORCIDConnect your ORCID iD *help
Researcher Number 00739196
Other IDs
Affiliation (Current) 2025: 東京医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 東京医科大学, 医学部, 准教授
2018 – 2019: 国立感染症研究所, 免疫部, 主任研究官
2016 – 2017: 国立感染症研究所, 免疫部, 研究員
2014 – 2015: 国立感染症研究所, その他部局等, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine / Immunology
Except Principal Investigator
Basic Section 53030:Respiratory medicine-related
Keywords
Principal Investigator
アレルギー / 感染症 / Gas6 / Axl / RSV / ワクチン / RSウイルス / Gas6/Axl / 免疫制御 / 糖尿病 … More / 老化 / 細胞老化 / 加齢 / 重症化 / マクロファージ / 気管支喘息 / 好中球 / M2様マクロファージ / MMP-12 / 増悪 / 喘息 / アレルギー・ぜんそく / ウィルス / 免疫学 / タイプ2免疫 / Th1/Th2 / 衛生仮説 Less
  • Research Projects

    (6 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (3 People)
  •  RSウイルス感染に伴うMMP-12産生とCOPD増悪機構の解明

    • Principal Investigator
      中野 千裕
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Toho University
  •  Regulation of immune response by aging-induced Gas6/Axl axis.Principal Investigator

    • Principal Investigator
      Shibata Takehiko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Tokyo Medical University
  •  The mechanism of RSV-induced exacerbation of asthmaPrincipal Investigator

    • Principal Investigator
      Shibata Takehiko
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Tokyo Medical University
      National Institute of Infectious Diseases
  •  The role of Gas6/Axl signal in the immune response associated with RSV infectionPrincipal Investigator

    • Principal Investigator
      Shibata Takehiko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      National Institute of Infectious Diseases
  •  The effect of RSV infection in infancy on hygiene hypothesisPrincipal Investigator

    • Principal Investigator
      Shibata Takehiko
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      National Institute of Infectious Diseases
  •  RSV感染におけるGas6/TAMシグナリングによる免疫応答の制御機構の解明Principal Investigator

    • Principal Investigator
      柴田 岳彦
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Immunology
    • Research Institution
      National Institute of Infectious Diseases

All 2024 2023 2021 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

  • [Journal Article] A critical role of Gas6/Axl signal in allergic airway responses during RSV vaccine-enhanced disease2017

    • Author(s)
      Shibata Takehiko、Ato Manabu
    • Journal Title

      Immunology & Cell Biology

      Volume: 95 Issue: 10 Pages: 906-915

    • DOI

      10.1038/icb.2017.61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H06246
  • [Journal Article] Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.2014

    • Author(s)
      Shibata T, Habiel DM, Coelho AL, Kunkel SL, Lukacs NW, Hogaboam CM.
    • Journal Title

      Journal of Immunology

      Volume: 192 Issue: 8 Pages: 3569-3581

    • DOI

      10.4049/jimmunol.1302766

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26893333
  • [Journal Article] Role of growth arrest-specific gene 6 in the development of fungal allergic airway disease in mice.2014

    • Author(s)
      Shibata T, Ismailoglu UB, Kittan NA, Moreira AP, Coelho AL, Chupp GL, Kunkel SL, Lukacs NW, Hogaboam CM.
    • Journal Title

      American Journal of Respiratory Cell and Molecular Biology

      Volume: 5 Issue: 5 Pages: 615-625

    • DOI

      10.1165/rcmb.2014-0049oc

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26893333
  • [Journal Article] Axl receptor blockade protects from invasive pulmonary aspergillosis in mice.2014

    • Author(s)
      Shibata T, Habiel DM, Coelho AL, Hogaboam CM.
    • Journal Title

      Journal of Immunology

      Volume: 193 Issue: 7 Pages: 3559-3565

    • DOI

      10.4049/jimmunol.1401258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26893333
  • [Journal Article] Gas6'ing the innate immune response during experimental asthma.2014

    • Author(s)
      Shibata T, Hogaboam CM.
    • Journal Title

      Annals of the American Thoracic Society

      Volume: Suppl 5 Issue: Supplement 5 Pages: S303-S305

    • DOI

      10.1513/annalsats.201401-013aw

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26893333
  • [Presentation] High levels of Gas6 induced by cellular senescence in aged mice cause severe infections2024

    • Author(s)
      呉優貴恵、柴田岳彦
    • Organizer
      第52回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-21H02929
  • [Presentation] 呼吸器感染症の重症化とその回避2023

    • Author(s)
      柴田岳彦
    • Organizer
      大阪大学微生物病研究所 Advanced Seminar
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02929
  • [Presentation] RSウイルス感染に伴うMMP-12産生と好中球浸潤の促進は アレルギー性気道炎症を増悪させる2021

    • Author(s)
      柴田岳彦
    • Organizer
      第95回日本感染症学会学術講演会
    • Data Source
      KAKENHI-PROJECT-19K08618
  • [Presentation] RSウイルス感染が誘導するMMP-12はアレルギー性気道炎症を増悪させる2021

    • Author(s)
      柴田岳彦
    • Organizer
      第61回日本呼吸器学会学術講演会
    • Data Source
      KAKENHI-PROJECT-19K08618
  • [Presentation] Increased matrix metalloproteinase-12 by respiratory syncytial virus infection leads to the exacerbation of asthma2019

    • Author(s)
      Airi Makino, Kisaburo Nagata, Toshihiro Ito, Yoshimasa Takahashi, Takehiko Shibata
    • Organizer
      日本免疫学会
    • Data Source
      KAKENHI-PROJECT-19K08618
  • [Presentation] RSV induces suppressive Gas6/Axl signaling in macrophages increasing susceptibility to secondary S. pneumoniae infection.2018

    • Author(s)
      Takehiko Shibata, Toshihiro Ito, Yoshimasa Takahashi, Manabu Ato
    • Organizer
      The 47th Annual Meeting of The Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-16H06246
  • [Presentation] The role of RSV-induced Gas6/Axl signaling in secondary bacterial infection.2017

    • Author(s)
      Takehiko Shibata
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H06246
  • [Presentation] RSV-induced Gas6/Axl signal ultimately leads to severer bacterial pneumonia2017

    • Author(s)
      Takehiko Shibata
    • Organizer
      the 5th Annual Meeting of the International Cytokine and Interferon Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06246
  • [Presentation] Gas6/Axl signal causes the failure of RSV vaccine development in mice.2016

    • Author(s)
      Takehiko Shibata, Manabu Ato
    • Organizer
      The 24th International Symposium on Molecular Cell Biology of Macrophages
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06246
  • [Presentation] Gas6/Axl signal plays critical roles in allergic responses and insufficient protection by formalin-inactivated RSV vaccine in mice2016

    • Author(s)
      Takehiko Shibata, Manabu Ato
    • Organizer
      第45回日本免疫学会学術集会46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H06246
  • [Presentation] Gas6/TAMシグナリングによる免疫応答の制御2015

    • Author(s)
      柴田岳彦
    • Organizer
      第24回東京免疫フォーラム
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2015-02-25
    • Data Source
      KAKENHI-PROJECT-26893333
  • [Presentation] A Role of Gas6/TAM signaling in the development and exacerbation of fungal allergic airway disease in mice

    • Author(s)
      Takehiko Shibata
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26893333
  • 1.  中野 千裕 (60769933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  小高 倫生 (30385710)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  松瀬 厚人 (60336154)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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