Hirata Yoshiyuki 平田佳之

… Alternative Names

平田佳之ヒラタヨシユキ

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Researcher Number	00745854
Other IDs
Affiliation (Current)	2025: 大阪医科薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 大阪医科薬科大学, 薬学部, 助教 2019 – 2020: 大阪薬科大学, 薬学部, 助教 2017: 大阪薬科大学, 薬学部, 助教 2016: 大阪薬科大学, 薬学部, 助手(移行)
Review Section/Research Field	Except Principal Investigator Basic Section 38020:Applied microbiology-related / Applied pharmacology
Keywords	Except Principal Investigator 酵素 / ケモエンザイマティック反応 / ケト酸 / アミド化合物合成 / アミド合成 / 可溶性発現 / 統計解析 / ロジスティック回帰分析 / 機械学習 / L-アミノ酸酸化酵素 … More / アミノ酸合成 / ペプチド合成 / アミド結合 / アミド化合物 / アミノ酸酸化酵素 / トランスレーショナルリサーチ / 創薬化学 / 蛋白蛋白相互作用 / 蛋白質 / 脳神経疾患 / パーキンソン病 / 脳虚血 / 低分子化合物 / 神経保護剤 / 蛋白相互作用阻害剤 / 血液脳関門 / 血管内皮細胞 / 血管内皮 / 神経細胞 / MDMX / MDM2 / p53 / PPI阻害剤 Less

新可溶性発現技術を用いたケモエンザイマティック反応によるアミド化合物合成法の開発
- Principal Investigator
  
  松井大亮
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Ritsumeikan University
Development of chemoenzymatic synthesis of amino acids and derivatives based on enzyme engineering
- Principal Investigator
  
  Matsui Daisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Ritsumeikan University
  Toyama Prefectural University
Novel therapy for neurological disorders by protein-protein interaction inhibitor
- Principal Investigator
  
  SASAKI Tsutomu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Osaka University

All 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Combination of Enzymatic Oxidation of Amino Acid and Native Chemical Ligation with Hydroxylamine for Amide Formation toward a One-pot Process2021
- Author(s)
  Matsui Daisuke、Hirata Yoshiyuki、Iwakawa Akihisa、Toyotake Yosuke、Wakayama Mamoru、Asano Yasuhisa
- Journal Title
  
  Chemistry Letters
  
  Volume: 50 Issue: 9 Pages: 1632-1634
- DOI
  10.1246/cl.210286
- NAID
  130008088183
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05775, KAKENHI-PROJECT-17H06169
[Journal Article] Enhanced solubility and permeability of quercetin by composite formation between α-glucosyl stevia and hydrophilic polymer2019
- Author(s)
  H. Uchiyama, Y. Wada, Y. Hatanaka, Y. Hirata, M. Taniguchi, A. Nakanishi, M. Tandia, K. Kadota, Y. Tozuka
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 108 Issue: 6 Pages: 2033-2040
- DOI
  10.1016/j.xphs.2019.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06614, KAKENHI-PROJECT-19K05775
[Journal Article] New 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death.2018
- Author(s)
  Hirata Y, Sasaki T, Kanki H, Choong CJ, Nishiyama K, Kubo G, Hotei A, Taniguchi M, Mochizuki H, Uesato S.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1400-1400
- DOI
  10.1038/s41598-018-19664-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05700, KAKENHI-PROJECT-17F17413, KAKENHI-PROJECT-16K15317
[Journal Article] Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities2016
- Author(s)
  Uesato, S.; Matsuura, Y.; Matsue, S.; Sumiyoshi, T.; Hirata, Y.; Takemoto, S.; Kawaratani, Y.; Yamai, Y.; Ishida, K.; Sasaki, T.; Enari, M.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 8 Pages: 1919-1926
- DOI
  10.1016/j.bmc.2016.03.021
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18903, KAKENHI-PROJECT-24390222, KAKENHI-PROJECT-16K15317
[Journal Article] Potential Application of 5-Aryl-Substituted 2-Amino- benzamide Type of HDAC1/2-Selective Inhibitors to Pharmaceuticals.2016
- Author(s)
  Uesato S, Hirata Y, Sasaki T.
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume: 22, Dec Issue: 40 Pages: 6149-6159
- DOI
  10.2174/1381612822666161208143417
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K15317
[Presentation] ケト酸を介したアミド化合物のケモエンザイマティック合成2021
- Author(s)
  松井大亮、平田佳之、岩川晃久、若林香菜子、久保梓、豊竹洋佑、若山守、浅野泰久
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19K05775
[Presentation] D-アミノ酸酸化酵素により調製したケト酸とヒドロキシルアミンとの縮合によるアミド化合物の合成2021
- Author(s)
  岩川晃久, 平田佳之, 豊竹洋佑, 若山守, 松井大亮
- Organizer
  日本農芸化学会 2021年度西日本・中四国・関西支部合同大会
- Data Source
  KAKENHI-PROJECT-19K05775
[Presentation] 芳香族アミド化合物のOne-pot chemoenzymatic 合成法を利用した簡便ヒストン脱アセチル化酵素1阻害剤スクリーニング法の開発2021
- Author(s)
  平田佳之, 上里新一, 松井大亮
- Organizer
  第73回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-19K05775
[Presentation] ニガキ由来アルカロイドpicrasidine L のヒト神経芽腫細胞株 SHSY5Y に対するオートファジー誘導効果2019
- Author(s)
  木村　耕介、平田　佳之、光高　蓉平、佐々木　勉、長岡　康夫、上里　新一、芝野　真喜雄、谷口　雅彦
- Organizer
  日本生薬学会第66回年会
- Data Source
  KAKENHI-PROJECT-19K05775
[Presentation] ビンロウジ (Areca catechu)アルカロイドのSIRT1阻害活性2019
- Author(s)
  平田　佳之、上山　浩世、平櫛　実穂、根上　朋子、礒野　悠也、佐々木　勉、上里　新一、芝野　真喜雄、谷口　雅彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-19K05775
[Presentation] ケミカルプルダウン法を用いたビンロウジアルカロイドの神経突起成長関連タンパク質の探索2019
- Author(s)
  平田　佳之、佐々木　勉、長岡　康夫、上里　新一、芝野　真喜雄、谷口　雅彦
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-19K05775
[Presentation] Screening for small-molecule inhibitors of protein-protein interaction (PPI) with neuroprotective effect in experimental PD2017
- Author(s)
  Choong CJ, Sasaki T, Baba K, Hirata Y, Uesato S and Mochizuki H
- Organizer
  The XXIII World Congress of Neurology (WCN 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15317
[Presentation] The mechanisms of neuroprotective effects of isoform selective HDAC inhibitors for brain ischemia.2017
- Author(s)
  Sasaki T, Kanki H, Choong CJ, Baba K, Hirata Y, Sakaguchi M, Uesato S and Mochizuki H
- Organizer
  The XXIII World Congress of Neurology (WCN 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15317
[Presentation] Small-molecule p53/negative regulator-interaction inhibitors confer neuroprotection against MPP+/MPTP-induced neurotoxicity in experimental PD2017
- Author(s)
  Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, and Hideki Mochizuki
- Organizer
  Suzhou Basic Scientists Summer School 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15317

1. Matsui Daisuke (40748513)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. SASAKI Tsutomu (20534879)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 長岡康夫 (90243039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 榊原一紀 (30388110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 住吉孝明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 望月秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 戸塚裕一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirata Yoshiyuki 平田 佳之

平田 佳之 ヒラタ ヨシユキ

Research Projects

Research Products

Co-Researchers

新可溶性発現技術を用いたケモエンザイマティック反応によるアミド化合物合成法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of chemoenzymatic synthesis of amino acids and derivatives based on enzyme engineering

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapy for neurological disorders by protein-protein interaction inhibitor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Combination of Enzymatic Oxidation of Amino Acid and Native Chemical Ligation with Hydroxylamine for Amide Formation toward a One-pot Process2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Enhanced solubility and permeability of quercetin by composite formation between α-glucosyl stevia and hydrophilic polymer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential Application of 5-Aryl-Substituted 2-Amino- benzamide Type of HDAC1/2-Selective Inhibitors to Pharmaceuticals.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] ケト酸を介したアミド化合物のケモエンザイマティック合成2021

Author(s)

Organizer

Data Source

[Presentation] D-アミノ酸酸化酵素により調製したケト酸とヒドロキシルアミンとの 縮合によるアミド化合物の合成2021

Author(s)

Organizer

Data Source

[Presentation] 芳香族アミド化合物のOne-pot chemoenzymatic 合成法を利用した簡便ヒストン脱アセチル化酵素1阻害剤スクリーニング法の開発2021

Author(s)

Organizer

Data Source

[Presentation] ニガキ由来アルカロイドpicrasidine L のヒト神経芽腫細胞株 SHSY5Y に対するオートファジー誘導効果2019

Author(s)

Organizer

Data Source

[Presentation] ビンロウジ (Areca catechu)アルカロイドのSIRT1阻害活性2019

Author(s)

Organizer

Data Source

[Presentation] ケミカルプルダウン法を用いたビンロウジアルカロイドの神経突起成長関連タンパク質の探索2019

Author(s)

Organizer

Data Source

[Presentation] Screening for small-molecule inhibitors of protein-protein interaction (PPI) with neuroprotective effect in experimental PD2017

Author(s)

Organizer

Data Source

[Presentation] The mechanisms of neuroprotective effects of isoform selective HDAC inhibitors for brain ischemia.2017

Author(s)

Organizer

Hirata Yoshiyuki 平田佳之

平田佳之ヒラタヨシユキ

[Presentation] D-アミノ酸酸化酵素により調製したケト酸とヒドロキシルアミンとの縮合によるアミド化合物の合成2021