Yamaguchi Takuya 山口拓也

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YAMAGUCHI Takuya 山口拓也

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Researcher Number	00748527
Other IDs	https://orcid.org/0000-0002-7533-430X
Affiliation (Current)	2025: 富山県立大学, 工学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 富山県立大学, 工学部, 助教 2017 – 2020: 筑波大学, 生命環境系, 助教
Review Section/Research Field	Principal Investigator Basic Section 38030:Applied biochemistry-related / Basic Section 38040:Bioorganic chemistry-related Except Principal Investigator Medium-sized Section 38:Agricultural chemistry and related fields / Medium-sized Section 39:Agricultural and environmental biology and related fields / Applied biochemistry
Keywords	Principal Investigator 脂肪酸水酸化酵素 / ビワ / ニトロ化合物 / シトクロムP450 / 2次代謝 / プロミスキュイティ / ウメ / 植物特化代謝物 / CYP94A / ニトロ基合成酵素 … More / 青酸配糖体 / 含窒素香気成分 / 二次代謝経路 / 生合成 / ニトリル化合物 / RNA-seq / 花香成分 … More Except Principal Investigator 酵素 / 可溶性変異 / 医薬品合成 / 人工知能 / デジタル技術 / 除草剤 / セーフナー / 酵素工学 / 機械学習 / 遺伝子発現 / 節足動物 / 可溶性発現 / アルドキシム-ニトリル経路 / アルドキシム脱水酵素 / ヤンバルトサカヤスデ / アルドキシムーニトリル経路 / ヒドロキシニトリルリアーゼ Less

ヤスデのゲノム情報を活用した超性能酵素の創出ー新たな産業用酵素としての利用展開ーPrincipal Investigator
- Principal Investigator
  
  山口拓也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Toyama Prefectural University
Unraveling the mechanism behind enhanced herbicide selectivity by safeners through molecular cross-species analyzes of crop and weed.
- Principal Investigator
  
  岩上哲史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 39:Agricultural and environmental biology and related fields
- Research Institution
  Kyoto University
Bio- and digital technologies for the enzyme development and application for pharmaceutical synthesis
- Principal Investigator
  
  浅野泰久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Toyama Prefectural University
Distribution of novel nitro group-forming enzymes in plants and structures involved in substrate recognitionPrincipal Investigator
- Principal Investigator
  
  Takuya Yamaguchi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Toyama Prefectural University
  University of Tsukuba
Fuctional characterization and molecular evolution of aldoxime-derived N-containing compounds biosynthetic enzymesPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Takuya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  University of Tsukuba
Development of soluble expression technology and utilization of enzymes from plants and animals
- Principal Investigator
  
  Asano Yasuhisa
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyama Prefectural University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book Patent

[Book] Plant Secondary Metabolism Engineering: Methods and Protocols2022
- Author(s)
  T. Yamaguchi, and Y. Asano
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-17H06169
[Journal Article] Structure-Based Site-Directed Mutagenesis of Hydroxynitrile Lyase from Cyanogenic Millipede, Oxidus gracilis for hydrocyanation and Henry reactions2024
- Author(s)
  S. Chaikaew、Y. Watanabe、D. J. Zheng、F. Motojima、T. Yamaguchi、Y. Asano
- Journal Title
  
  ChemBioChem
  
  Volume: - Issue: 11
- DOI
  10.1002/cbic.202400118
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00361
[Journal Article] Nitrile-synthesizing enzymes and biocatalytic synthesis of volatile nitrile compounds: A review2024
- Author(s)
  T. Yamaguchi、Y. Asano
- Journal Title
  
  J. Biotechnol.
  
  Volume: 384 Pages: 20-28
- DOI
  10.1016/j.jbiotec.2024.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00361
[Journal Article] Construction of the UDP-Glucose Biosynthetic Enzyme Gene Coexpression Plasmid for Prunasin Production in Escherichia coli2022
- Author(s)
  Yamaguchi Takuya、Asano Yasuhisa
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2022 Pages: 19-28
- DOI
  10.1007/978-1-0716-2185-1_2
- ISBN
  9781071621844, 9781071621851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00361
[Journal Article] A promiscuous fatty acid ω‐hydroxylase CYP94A90 is likely involved in biosynthesis of a floral nitro compound in loquat (Eriobotrya japonica)2022
- Author(s)
  Yamaguchi Takuya、Matsui Yumi、Kitaoka Naoki、Kuwahara Yasumasa、Asano Yasuhisa、Matsuura Hideyuki、Sunohara Yukari、Matsumoto Hiroshi
- Journal Title
  
  New Phytologist
  
  Volume: 3 Issue: 3 Pages: 1157-1170
- DOI
  10.1111/nph.17441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05861, KAKENHI-PROJECT-17H06169
[Journal Article] R-Hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis -A new entry to the carrier protein family Lipocalines -2020
- Author(s)
  F. Motojima, A. Izumi, A. Nuylert, Z.-Y. Zhai, M. Dadashipour, S. Shichida, T. Yamaguchi, S.　Nakano, and Y. Asano
- Journal Title
  
  FEBS Journal
  
  Volume: 288（5） Issue: 5 Pages: 1679-1695
- DOI
  10.1111/febs.15490
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06169
[Journal Article] Discovery and structural analysis to improve the enantioselectivity of hydroxynitrile lyase from Parafontaria laminata millipedes for (R)-2-chloromandelonitrile synthesis2020
- Author(s)
  A. Nuylert, M. Nakabayashi, T. Yamaguchi, and Y. Asano
- Journal Title
  
  ACS Omega
  
  Volume: 5 (43) Issue: 43 Pages: 27896-27908
- DOI
  10.1021/acsomega.0c03070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06169
[Journal Article] Development of a rapid and simple glycine analysis method using a stable glycine oxidase mutant2019
- Author(s)
  M. Tatsumi, W. Hoshino, Y. Kodama, T. Ueatrongchit, K. Takahashi, U. Tagami, H. Yamaguchi, H. Miyano, Y. Asano, T. Mizukoshi
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 587 Pages: 113447-113447
- DOI
  10.1016/j.ab.2019.113447
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06169
[Journal Article] Prunasin production using engineered Escherichia coli expressing UGT85A47 from Japanese apricot and UDP-glucose biosynthetic enzyme genes2018
- Author(s)
  Yamaguchi Takuya、Asano Yasuhisa
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 82 Issue: 11 Pages: 2021-2029
- DOI
  10.1080/09168451.2018.1497942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14385, KAKENHI-PROJECT-17H06169
[Journal Article] Protein engineering for improving the thermostability of tryptophan oxidase and insights from structural analysis2018
- Author(s)
  H. Yamaguchi, K. Takahashi, M. Tatsumi, U. Tagami, M. Sugiki, T. Kashiwagi, M. Kameya, S. Okazaki, T. Mizukoshi and Y. Asano
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 164(5) Issue: 5 Pages: 359-367
- DOI
  10.1093/jb/mvy065
- NAID
  40021724812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06169
[Journal Article] Characterization of a novel hydroxynitrile lyase from Nandina domestica Thunb2018
- Author(s)
  Isobe Kimiyasu、Kitagawa Asuka、Kanamori Kazuma、Kashiwagi Nozomi、Matsui Daisuke、Yamaguchi Takuya、Fuhshuku Ken-ichi、Semba Hisashi、Asano Yasuhisa
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 82 Issue: 10 Pages: 1760-1769
- DOI
  10.1080/09168451.2018.1490171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14385, KAKENHI-PROJECT-17H06169
[Journal Article] Hydroxynitrile lyases from cyanogenic millipedes: molecular cloning, heterologous expression, and whole-cell biocatalysis for the production of (R)-mandelonitrile2018
- Author(s)
  Yamaguchi, T., Nuylert A., Ina A., Tanabe T., and Asano Y.
- Journal Title
  
  Scientific Reports
  
  Volume: オンラインジャーナル Issue: 1 Pages: 3051-3051
- DOI
  10.1038/s41598-018-20190-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07482, KAKENHI-PROJECT-17H06169
[Patent] ヒドロキシニトリルリアーゼ2022
- Inventor(s)
  浅野泰久、山口拓也
- Industrial Property Rights Holder
  浅野泰久、山口拓也
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-22H00361
[Patent] ヒドロキシニトリルリアーゼ2018
- Inventor(s)
  浅野泰久、山口拓也
- Industrial Property Rights Holder
  浅野泰久、山口拓也
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-17H06169
[Presentation] UDP-グルコース供給系とUDP-グルコース転移酵素を用いた配糖体の微生物生産2023
- Author(s)
  伊澤悠、山口拓也、浅野泰久
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-22H00361
[Presentation] ヤンバルトサカヤスデのゲノム解析とヒドロキシニトリルリアーゼの分子進化2023
- Author(s)
  山口拓也、浅野泰久
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-22H00361
[Presentation] 動植物のアルドキシムを介したニトリルやニトロ化合物の代謝に関する研究2023
- Author(s)
  山口拓也
- Organizer
  日本農芸化学会2023年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K05861
[Presentation] ビワの花におけるフェニルアセトニトリル生合成に関わるCYP77Aの同定と性状解析2023
- Author(s)
  野村拓矢, 山口拓也, 浅野泰久
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-20K05861
[Presentation] ビワの花香成分フェニルアセトニトリルの生合成に関わるCYP77Aの同定と性状解析2023
- Author(s)
  野村拓矢、山口拓也、浅野泰久
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-22H00361
[Presentation] ビワのニトロ化合物生合成に関わるpromiscuousな脂肪酸水酸化酵素CYP94A90の発見2022
- Author(s)
  山口拓也
- Organizer
  日本農芸化学会中部支部第194回例会
- Invited
- Data Source
  KAKENHI-PROJECT-20K05861
[Presentation] ビワの花香成分フェニルアセトニトリルの生合成に関わるCYP77Aの同定と性状解析2022
- Author(s)
  野村拓矢、山口拓也、浅野泰久
- Organizer
  内外環境応答・代謝酵素研究会（ポスター発表）
- Data Source
  KAKENHI-PROJECT-22H00361
[Presentation] ビワの花香成分(2-ニトロエチル)ベンゼンの生合成に関わるCYP94A90の同定と性状解析2022
- Author(s)
  山口拓也、浅野泰久
- Organizer
  内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-22H00361
[Presentation] ビワの花におけるフェニルアセトニトリル生合成に関わるCYP77Aの同定と性状解析2022
- Author(s)
  野村拓矢, 山口拓也, 浅野泰久
- Organizer
  令和4年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-20K05861
[Presentation] ビワの花香成分(2-ニトロエチル)ベンゼンの生合成に関わるCYP94A90の同定と性状解析2022
- Author(s)
  山口拓也, 浅野泰久
- Organizer
  令和4年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-20K05861
[Presentation] Discovery and structural analysis to improve the enantioselectivity of hydroxynitrile lyase from Parafontaria laminata millipede2021
- Author(s)
  A. Nuylert, M. Nakabayashi, T. Yamaguchi, Y. Asano
- Organizer
  2nd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06169
[Presentation] Molecular Characterization of Rhodanese Enzyme in Cyanogenic Millipede (Chamberlinius hualinesis)2021
- Author(s)
  K. Palasin、山口拓也、浅野泰久
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H06169
[Presentation] ビワの(2-ニトロエチル)ベンゼン生合成酵素の同定と機能解析2019
- Author(s)
  山口拓也, 桑原保正, 浅野泰久, 春原由香里, 松本宏
- Organizer
  日本農芸化学会関東支部 2019年度大会
- Data Source
  KAKENHI-PROJECT-18K14385
[Presentation] ヤンバルトサカヤスデの全ゲノム解析とシアン発生酵素遺伝子の分子進化2019
- Author(s)
  山口拓也・浅野泰久
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17H06169
[Presentation] ビワの(2-ニトロエチル)ベンゼン生合成経路の解明2019
- Author(s)
  山口拓也, 桑原保正, 浅野泰久, 春原由香里, 松本宏
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-18K14385
[Presentation] Hydrogen peroxide as a new defensive compound among “benzoyl cyanide” producing Polydesmida2017
- Author(s)
  Y. Kuwahara, T. Yamaguchi, Y. Ichiki, T. Tanabe, Y. Asano
- Organizer
  The joint meeting of the 33rd annual meeting of the ISCE and the 9th meeting of the APACE
- Data Source
  KAKENHI-PROJECT-17H06169

1. Asano Yasuhisa (00222589)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. 日比慎 (30432347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松井大亮 (40748513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 中野祥吾 (80748541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 岩上哲史 (00761107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 白澤健太 (60527026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 榊原一紀 (30388110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中村正樹 (40345658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TANABE Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Takuya 山口 拓也

YAMAGUCHI Takuya 山口 拓也

Research Projects

Research Products

Co-Researchers

ヤスデのゲノム情報を活用した超性能酵素の創出ー新たな産業用酵素としての利用展開ーPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling the mechanism behind enhanced herbicide selectivity by safeners through molecular cross-species analyzes of crop and weed.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Bio- and digital technologies for the enzyme development and application for pharmaceutical synthesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Distribution of novel nitro group-forming enzymes in plants and structures involved in substrate recognitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fuctional characterization and molecular evolution of aldoxime-derived N-containing compounds biosynthetic enzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of soluble expression technology and utilization of enzymes from plants and animals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Plant Secondary Metabolism Engineering: Methods and Protocols2022

Author(s)

Publisher

Data Source

[Journal Article] Structure-Based Site-Directed Mutagenesis of Hydroxynitrile Lyase from Cyanogenic Millipede, Oxidus gracilis for hydrocyanation and Henry reactions2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nitrile-synthesizing enzymes and biocatalytic synthesis of volatile nitrile compounds: A review2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Construction of the UDP-Glucose Biosynthetic Enzyme Gene Coexpression Plasmid for Prunasin Production in Escherichia coli2022

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] A promiscuous fatty acid ω‐hydroxylase CYP94A90 is likely involved in biosynthesis of a floral nitro compound in loquat (Eriobotrya japonica)2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] R-Hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis -A new entry to the carrier protein family Lipocalines -2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery and structural analysis to improve the enantioselectivity of hydroxynitrile lyase from Parafontaria laminata millipedes for (R)-2-chloromandelonitrile synthesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a rapid and simple glycine analysis method using a stable glycine oxidase mutant2019

Author(s)

Journal Title

DOI

Yamaguchi Takuya 山口拓也

YAMAGUCHI Takuya 山口拓也