PARAJULI Bijay ＰＡＲＡＪＵＬＩＢｉｊａｙ

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Parajuli Bijay PARAJULI Bijay

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Researcher Number	00748783
Other IDs
Affiliation (Current)	2026: 山梨大学, 大学院総合研究部, 特任助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 山梨大学, 大学院総合研究部, 研究助教 2021 – 2022: 山梨大学, 大学院総合研究部, 研究員 2020: 山梨大学, 大学院総合研究部, 特任助教 2018 – 2019: 山梨大学, 大学院総合研究部, 助教 2017: 愛知医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator ミクログリア移植 / ミクログリア / ヒト化マウス / 移植 / ヒトミクログリア / 経鼻移植 / ミクログリア置換 / 細胞移植 / ミクログリアヒト化マウス

ミクログリア置換による新しい脳疾患治療の確立Principal Investigator
- Principal Investigator
  
  PARAJULI Bijay
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Yamanashi
Elucidation of in-vivo characteristic of human microglia using microglia humanized mouse.Principal Investigator
- Principal Investigator
  
  Bijay Parajuli
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Yamanashi
Transplantation of human human induced pluripotent stem cell-derived microglia to the brain of micePrincipal Investigator
- Principal Investigator
  
  Parajuli Bijay
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Yamanashi
  Aichi Medical University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Establishment and Use of Primary Cultured Astrocytes from Alexander Disease Model Mice2024
- Author(s)
  Kubota Yuto、Shigetomi Eiji、Saito Kozo、Shinozaki Youichi、Kobayashi Kenji、Tanaka Masayoshi、Parajuli Bijay、Tanaka Kenji F.、Koizumi Schuichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 22 Pages: 12100-12100
- DOI
  10.3390/ijms252212100
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05896, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-24H00583, KAKENHI-PROJECT-22K07368, KAKENHI-PROJECT-23K18162, KAKENHI-PROJECT-20KK0366, KAKENHI-PROJECT-23K05976
[Journal Article] Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia2024
- Author(s)
  Parajuli Bijay、Koizumi Schuichi
- Journal Title
  
  Purinergic Signalling
  
  Volume: 20 Issue: 6 Pages: 573-575
- DOI
  10.1007/s11302-024-10014-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-24H00583, KAKENHI-PROJECT-23K18162, KAKENHI-PROJECT-23K05976
[Journal Article] Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model2023
- Author(s)
  Saito Kozo、Shigetomi Eiji、Shinozaki Youichi、Kobayashi Kenji、Parajuli Bijay、Kubota Yuto、Sakai Kent、Miyakawa Miho、Horiuchi Hiroshi、Nabekura Junichi、Koizumi Schuichi
- Journal Title
  
  Brain
  
  Volume: 147 Issue: 2 Pages: 698-716
- DOI
  10.1093/brain/awad358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19411, KAKENHI-PROJECT-22K15704, KAKENHI-PROJECT-22K06445, KAKENHI-PROJECT-23K05976, KAKENHI-PROJECT-19K17042, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H04786, KAKENHI-PROJECT-20H00500, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22K07368, KAKENHI-PROJECT-20KK0366
[Journal Article] Severity of Peripheral Infection Differentially Affects Brain Functions in Mice via Microglia-Dependent and -Independent Mechanisms2023
- Author(s)
  Le Yen-Phung、Saito Kozo、Parajuli Bijay、Sakai Kent、Kubota Yuto、Miyakawa Miho、Shinozaki Youichi、Shigetomi Eiji、Koizumi Schuichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 24 Pages: 17597-17597
- DOI
  10.3390/ijms242417597
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18162, KAKENHI-PROJECT-20KK0366, KAKENHI-PROJECT-22K06445, KAKENHI-PROJECT-22K07368, KAKENHI-PROJECT-23K05976, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786
[Journal Article] Strategies for Manipulating Microglia to Determine Their Role in the Healthy and Diseased Brain2022
- Author(s)
  Parajuli Bijay、Koizumi Schuichi
- Journal Title
  
  Neurochemical Research
  
  Volume: 48（4） Issue: 4 Pages: 1066-1076
- DOI
  10.1007/s11064-022-03742-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786, KAKENHI-PROJECT-21K19309, KAKENHI-PROJECT-20K15899
[Journal Article] Transplantation of Human Induced Pluripotent Stem Cell-Derived Microglia in Immunocompetent Mice Brain via Non-Invasive Transnasal Route2022
- Author(s)
  Parajuli Bijay、Shinozaki Youichi、Shigetomi Eiji、Koizumi Schuichi
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 183 Issue: 183
- DOI
  10.3791/63574
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07368, KAKENHI-PROJECT-20KK0366, KAKENHI-ORGANIZER-20H05894, KAKENHI-PROJECT-20K15899, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786
[Journal Article] Transnasal transplantation of human induced pluripotent stem cell‐derived microglia to the brain of immunocompetent mice2021
- Author(s)
  Parajuli Bijay、Saito Hiroki、Shinozaki Youichi、Shigetomi Eiji、Miwa Hiroto、Yoneda Sosuke、Tanimura Miki、Omachi Shigeki、Asaki Toshiyuki、Takahashi Koji、Fujita Masahide、Nakashima Kinichi、Koizumi Schuichi
- Journal Title
  
  Glia
  
  Volume: 69 Issue: 10 Pages: 2332-2348
- DOI
  10.1002/glia.23985
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06481, KAKENHI-PROJECT-21K19309, KAKENHI-PROJECT-20K15899, KAKENHI-PROJECT-20KK0366, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786
[Presentation] Development of localized microglia replacement strategy and its utilization to decipher microglial biology2025
- Author(s)
  Parajuli B, Shigetomi E, Koizumi S.
- Organizer
  APPW2025
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K05976
[Presentation] Critical role of microglia in the functional development and maturation of prefrontal cortex.2024
- Author(s)
  Parajuli B, Shigetomi E, Koizumi S.
- Organizer
  The 4th International Symposium on Frontend Brain Science-Yamanashi GLIA center
- Data Source
  KAKENHI-PROJECT-23K05976
[Presentation] Development of localized microglia replacement strategy and its utilization to decipher microglial biology2024
- Author(s)
  Parajuli B, Shigetomi E, Koizumi S.
- Organizer
  日本薬理学会関東部会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K05976
[Presentation] Critical role of microglia in the functional development and maturation of prefrontal cortex.2024
- Author(s)
  Parajuli B, Shigetomi E, Koizumi S
- Organizer
  NEURO2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K05976
[Presentation] 脈絡叢エピプレクサスマクロファージはミクログリア由来である2023
- Author(s)
  Parajuli B, Shigetomi E, Koizumi S.
- Organizer
  日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K05976

1. SHINOZAKI Youichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 堀内浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小泉修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 田中謙二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

PARAJULI Bijay ＰＡＲＡＪＵＬＩ Ｂｉｊａｙ

Parajuli Bijay PARAJULI Bijay

Research Projects

Research Products

Co-Researchers

ミクログリア置換による新しい脳疾患治療の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of in-vivo characteristic of human microglia using microglia humanized mouse.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transplantation of human human induced pluripotent stem cell-derived microglia to the brain of micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Establishment and Use of Primary Cultured Astrocytes from Alexander Disease Model Mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severity of Peripheral Infection Differentially Affects Brain Functions in Mice via Microglia-Dependent and -Independent Mechanisms2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Strategies for Manipulating Microglia to Determine Their Role in the Healthy and Diseased Brain2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transplantation of Human Induced Pluripotent Stem Cell-Derived Microglia in Immunocompetent Mice Brain via Non-Invasive Transnasal Route2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transnasal transplantation of human induced pluripotent stem cell‐derived microglia to the brain of immunocompetent mice2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Development of localized microglia replacement strategy and its utilization to decipher microglial biology2025

Author(s)

Organizer

Data Source

[Presentation] Critical role of microglia in the functional development and maturation of prefrontal cortex.2024

Author(s)

Organizer

Data Source

[Presentation] Development of localized microglia replacement strategy and its utilization to decipher microglial biology2024

Author(s)

Organizer

Data Source

[Presentation] Critical role of microglia in the functional development and maturation of prefrontal cortex.2024

Author(s)

Organizer

Data Source

[Presentation] 脈絡叢エピプレクサスマクロファージはミクログリア由来である2023

Author(s)

Organizer

Data Source

PARAJULI Bijay ＰＡＲＡＪＵＬＩＢｉｊａｙ