Hayashi Hironori 林宏典

Researcher Number	00752916
Other IDs
Affiliation (Current)	2025: 東北大学, 災害科学国際研究所, 助教 2025: 国立健康危機管理研究機構, 国立国際医療研究所, 客員研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 災害科学国際研究所, 助教 2020 – 2021: 東北大学, 災害科学国際研究所, 助教 2018 – 2019: 東北大学, 医学系研究科, 助教 2017: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Virology Except Principal Investigator Broad Section E / Medium-sized Section 35:Polymers, organic materials, and related fields / Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator 創薬 / 感染症災害 / レジリエンス / 薬剤耐性 / 抗菌薬開発 / ウイルス横断的な創薬研究 / ウイルス学 / ウイルス横断的創薬 / 感染症 / 新型コロナウイルス … More / ノロウイルス / プロテアーゼ / 薬剤開発 / ウイルス横断的研究 / 結晶構造解析 / ＨＩＶ－１ / HIV-1 / 薬剤耐性化 / EFdA / 逆転写酵素 / HIV … More Except Principal Investigator 触媒的RNA切断 / 治療基盤 / RNA / 構造解析 / 基盤技術 / 切断機構解明 / オフターゲット効果低減 / 薬効向上 / RNase H / 触媒的切断 / 核酸医薬 / ウイルス / 化学合成 / 天然物 / 感染症 / 薬学 / ウイルス学 Less

高活性触媒的標的RNA切断機能付与型人工核酸の構築と新興感染症等治療基盤の創製
- Principal Investigator
  
  和田健彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 35:Polymers, organic materials, and related fields
- Research Institution
  Tohoku University
Construction of Artificial Nucleic Acids with Highly Active Catalytic Target RNA Cleavage Ability and Development as a Therapeutic Platform
- Principal Investigator
  
  和田健彦
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section E
- Research Institution
  Tohoku University
Development of novel antibacterial agents using crystal structure-based drug screeningPrincipal Investigator
- Principal Investigator
  
  林宏典
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Tohoku University
Development of cross-virus drugs using norovirus as a modelPrincipal Investigator
- Principal Investigator
  
  hayashi hironori
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Tohoku University
Development of therapeutics for intractable infections using diverse natural products combined with stress-inductive biosynthesis and chemical modification
- Principal Investigator
  
  Kodama Eiichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Tohoku University
The study for elucidating the mechanisms of HIV-1's EFdA resistance.Principal Investigator
- Principal Investigator
  
  Hayashi Hironori
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Tohoku University
  National Center for Global Health and Medicine

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] HIV感染症とAIDSの治療2017
- Author(s)
  林　宏典, 満屋　裕明
- Total Pages
  8
- Publisher
  株式会社メディカルレビュー社
- ISBN
  9784779219023
- Data Source
  KAKENHI-PROJECT-17K15710
[Journal Article] Helix-based screening with structure prediction using artificial intelligence has potential for the rapid development of peptide inhibitors targeting class I viral fusion2024
- Author(s)
  Suzuki Satoshi、Kuroda Mio、Aoki Keisuke、Kawaji Kumi、Hiramatsu Yoshiki、Sasano Mina、Nishiyama Akie、Murayama Kazutaka、Kodama Eiichi N.、Oishi Shinya、Hayashi Hironori
- Journal Title
  
  RSC Chemical Biology
  
  Volume: 5 Issue: 2 Pages: 131-140
- DOI
  10.1039/d3cb00166k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07918, KAKENHI-PROJECT-21K19366
[Journal Article] Helical peptides with disordered regions for measles viruses provide new generalized insights into fusion inhibitors2024
- Author(s)
  Hirata Kazushige、Takahara Aoi、Suzuki Satoshi、Murakami Shumei、Kawaji Kumi、Nishiyama Akie、Sasano Mina、Shoji-Ueno Mariko、Usui Emiko、Murayama Kazutaka、Hayashi Hironori、Oishi Shinya、Kodama Eiichi N.
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 2 Pages: 108961-108961
- DOI
  10.1016/j.isci.2024.108961
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07918, KAKENHI-PROJECT-21K19366
[Journal Article] Establishing an Accurate and Sensitive In Vitro Drug Screening System for Human Adenovirus Infection with Human Corneal Cells2023
- Author(s)
  Mina Sasano, Hironori Hayashi, Kumi Kawaji, Emiko Usui, Eiich N Kodama.
- Journal Title
  
  Virology
  
  Volume: 581 Pages: 34-38
- DOI
  10.1016/j.virol.2023.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19366, KAKENHI-PROJECT-23H05465
[Journal Article] GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants2023
- Author(s)
  Aoki M, Aoki-Ogata H, Bulut H, Hayashi H, Takamune N, Kishimoto N, Tanaka H, Higashi-Kuwata N, Hattori S, Das D, Rao KV, Iwama K, Davis DA, Hasegawa K, Murayama K, Yarchoan R, Ghosh AK, Pau AK, Machida S, Misumi S, and Hiroaki Mitsuya H.
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 28 Pages: 1-15
- DOI
  10.1126/sciadv.adg2955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07918, KAKENHI-PROJECT-23K07956
[Journal Article] Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-22023
- Author(s)
  Higashi-Kuwata Nobuyo、Tsuji Kohei、Hayashi Hironori、Bulut Haydar、Kiso Maki、Imai Masaki、Ogata-Aoki Hiromi、Ishii Takahiro、Kobayakawa Takuya、Nakano Kenta、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1076-1076
- DOI
  10.1038/s41467-023-36729-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-20K07134, KAKENHI-PROJECT-23H05465
[Journal Article] Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-01576022022
- Author(s)
  Ohata Yoshitsugu、Tomonaga Mitsunori、Watanabe Yasuo、Tomura Keiko、Kimura Koji、Akaki Tatsuo、Adachi Kaoru、Kodama Eiichi N.、Matsuzaki Yuji、Hayashi Hironori
- Journal Title
  
  Journal of Virology
  
  Volume: 96 Issue: 6
- DOI
  10.1128/jvi.01843-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-21K19366
[Journal Article] Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan2022
- Author(s)
  Oshima Kengo、Nakajima Chie、Hirata Kazushige、Hayashi Hironori、Kodama Eiichi N.、Fukushima Yukari、Suzuki Yasuhiko、Kanamori Hajime、Baba Hiroaki、Aoyagi Tetsuji、Tokuda Koichi、Kaku Mitsuo
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: S1341-321X Issue: 7 Pages: 00048-4
- DOI
  10.1016/j.jiac.2022.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-21K19366
[Journal Article] Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors <i>In Vitro</i>2022
- Author(s)
  Amano Masayuki、Yedidi Ravikiran S.、Salcedo-Gomez Pedro Miguel、Hayashi Hironori、Hasegawa Kazuya、Martyr Cuthbert D.、Ghosh Arun K.、Mitsuya Hiroaki
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 66 Issue: 2
- DOI
  10.1128/aac.01715-21
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03701
[Journal Article] A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication2021
- Author(s)
  Hattori Shin-ichiro、Hayashi Hironori、Kodama Eiichi N.、et.al.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 668-668
- DOI
  10.1038/s41467-021-20900-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-19K17921
[Journal Article] Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity2020
- Author(s)
  Bulut Haydar、Hattori Shin-ichiro、Aoki-Ogata Hiromi、Hayashi Hironori、Das Debananda、Aoki Manabu、Davis David A.、Rao Kalapala Venkateswara、Nyalapatla Prasanth R.、Ghosh Arun K.、Mitsuya Hiroaki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 10664-10675
- DOI
  10.1038/s41598-020-65993-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-19K17921
[Journal Article] Synthetic biology based construction of biological activity-related library focused on fungal decalin-containing diterpenoid pyrones2020
- Author(s)
  1.Tsukada K, Shinki S, Kaneko A, Murakami K, Irie K, Murai M, Miyoshi H, Dan S, Kawaji K, Hayashi H, Kodama E, Hori A, Salim E, Kuraishi T, Hirata N, Kanda Y, Asai T.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1830-1830
- DOI
  10.1038/s41467-020-15664-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16349, KAKENHI-PROJECT-17H04107, KAKENHI-PROJECT-20K20463, KAKENHI-PROJECT-16H06194, KAKENHI-PUBLICLY-19H04642, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-17H05055, KAKENHI-PROJECT-18K19388, KAKENHI-PROJECT-19K17921
[Journal Article] Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir2020
- Author(s)
  Kohsuke Nakagawara, Hironori Hayashi, Kumi Kawaji, Mina Sasano, Eiichi N Kodama
- Journal Title
  
  Antiviral Chemistry and Chemotherapy
  
  Volume: 28 Pages: 1-5
- DOI
  10.1177/2040206620921319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20463, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-19K17921
[Journal Article] Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-52020
- Author(s)
  Oikawa Yoshitsugu、Izumi Rumiko、Koide Masashi、、、Aoki Masashi、Kure Shigeo、Abe Takaaki
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 12 Pages: e0231064-e0231064
- DOI
  10.1371/journal.pone.0231064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21563, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-18K08199, KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-19K23933, KAKENHI-PROJECT-20H04118
[Journal Article] Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications2019
- Author(s)
  Masayuki Amano, Pedro Miguel Salcedo-Gomez, Ravikiran S. Yedidi, Rui Zhao, Hironori Hayashi, Kazuya Hasegawa, Tomofumi Nakamura, Cuthbert D. Martyr, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy.
  
  Volume: 63 Issue: 7 Pages: 1-1
- DOI
  10.1128/aac.00466-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-19H03701
[Journal Article] Novel p97 / VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib‐sensitive and ‐resistant multiple myeloma cells2019
- Author(s)
  Nishimura Nao、Radwan Mohamed O.、Amano Masayuki、Endo Shinya、Fujii Eri、Hayashi Hironori、Ueno Shikiko、Ueno Niina、Tatetsu Hiro、Hata Hiroyuki、Okamoto Yoshinari、Otsuka Masami、Mitsuya Hiroaki、Matsuoka Masao、Okuno Yutaka
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 10 Pages: 3275-3287
- DOI
  10.1111/cas.14154
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-17H03999
[Journal Article] Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants2019
- Author(s)
  Hattori Shin-ichiro、Hayashi Hironori、Bulut Haydar、Rao Kalapala Venkateswara、Nyalapatla Prasanth R.、Hasegawa Kazuya、Aoki Manabu、Ghosh Arun K.、Mitsuya Hiroaki
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 63 Issue: 6 Pages: 1-1
- DOI
  10.1128/aac.02635-18
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-19H03701
[Journal Article] Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance2019
- Author(s)
  Yuki Takamatsu, Manabu Aoki, Haydar Bulut, Debananda Das, Masayuki Amano, Venkata Reddy Sheri, Ladislau C. Kovari, Hironori Hayashi, Nicole S. Delino, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy.
  
  Volume: 63 Issue: 8 Pages: 1-1
- DOI
  10.1128/aac.00372-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-19H03701
[Journal Article] Pyrimidine Analogues as a New Class of Gram-Positive Antibiotics, Mainly Targeting Thymineless-Death Related Proteins2019
- Author(s)
  Oe Chihiro、Hayashi Hironori、Hirata Kazushige、Kawaji Kumi、Hashima Fusako、Sasano Mina、Furuichi Maaya、Usui Emiko、Katsumi Makoto、Suzuki Yasuhiko、Nakajima Chie、Kaku Mitsuo、Kodama Eiichi N.
- Journal Title
  
  ACS Infectious Diseases
  
  Volume: １ Issue: 6 Pages: 1-1
- DOI
  10.1021/acsinfecdis.9b00305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-20K20463
[Journal Article] Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.2018
- Author(s)
  Aoki M, Das D, Hayashi H, Aoki-Ogata H, Takamatsu Y, Ghosh AK, Mitsuya H.
- Journal Title
  
  MBio.
  
  Volume: 9(2) Issue: 2
- DOI
  10.1128/mbio.02425-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17K15710
[Journal Article] GRL-079, a novel P2-Tp-THF-C5-alkylamine- and P2' -Abt-containing HIV-1 protease inhibitor, is extremely potent against multi-drug-resistant HIV-1 variants including HIVDRVRp51 and has a high genetic barrier against the emergence of resistant variants.2018
- Author(s)
  Delino NS, Aoki M, Hayashi H, Hattori SI, Chang SB, Takamatsu Y, Martyr CD, Das D, Ghosh AK, Mitsuya H.
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 62(5) Issue: 5 Pages: 02060-17
- DOI
  10.1128/aac.02060-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-17K15710
[Journal Article] Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1 JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3 ?/? mice transplanted with human PBMCs2018
- Author(s)
  Ogata-Aoki Hiromi、Higashi-Kuwata Nobuyo、Hattori Shin-ichiro、Hayashi Hironori、Danish Matthew、Aoki Manabu、Shiotsu Chiemi、Hashiguchi Yumi、Hamada Akinobu、Kobayashi Hisataka、Ihn Hironobu、Okada Seiji、Mitsuya Hiroaki
- Journal Title
  
  Antiviral Research
  
  Volume: 149 Pages: 78-88
- DOI
  10.1016/j.antiviral.2017.09.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08742, KAKENHI-PROJECT-16K10165, KAKENHI-PROJECT-17K15710
[Journal Article] HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.2018
- Author(s)
  Yasutake Y, Hattori SI, Hayashi H, Matsuda K, Tamura N, Kohgo S, Maeda K, Mitsuya H.
- Journal Title
  
  Sci Rep.
  
  Volume: 8(1) Issue: 1 Pages: 1624-1624
- DOI
  10.1038/s41598-018-19602-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-16K08826, KAKENHI-PROJECT-17K15710
[Journal Article] The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase2018
- Author(s)
  Takamatsu Yuki、Das Debananda、Kohgo Satoru、Hayashi Hironori、Delino Nicole S.、Sarafianos Stefan G.、Mitsuya Hiroaki、Maeda Kenji
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 25 Issue: 10 Pages: 1268-1278
- DOI
  10.1016/j.chembiol.2018.07.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08826, KAKENHI-PROJECT-17K15710
[Journal Article] Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure-Activity Studies and Biological and X-ray Structural Studies.2018
- Author(s)
  Ghosh AK, Williams JN, Ho RY, Simpson HM, Hattori SI, Hayashi H, Agniswamy J, Wang YF, Weber IT, Mitsuya H.
- Journal Title
  
  J Med Chem.
  
  Volume: 61(21) Issue: 21 Pages: 9722-9737
- DOI
  10.1021/acs.jmedchem.8b01227
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17K15710
[Journal Article] A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.2017
- Author(s)
  Aoki M, Hayashi H, Rao KV, Das D, Higashi-Kuwata N, Bulut H, Aoki-Ogata H, Takamatsu Y, Yedidi RS, Davis DA, Hattori SI, Nishida N, Hasegawa K, Takamune N, Nyalapatla PR, Osswald HL, Jono H, Saito H, Yarchoan R, Misumi S, Ghosh AK, Mitsuya H.
- Journal Title
  
  Elife
  
  Volume: 6
- DOI
  10.7554/elife.28020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17K15710, KAKENHI-PROJECT-17H04104, KAKENHI-PROJECT-17H04222
[Journal Article] Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.2017
- Author(s)
  Ghosh AK, Rao KV, Nyalapatla PR, Osswald HL, Martyr CD, Aoki M, Hayashi H, Agniswamy J, Wang YF, Bulut H, Das D, Weber IT, Mitsuya H.
- Journal Title
  
  J Med Chem.
  
  Volume: 60(10) Issue: 10 Pages: 4267-4278
- DOI
  10.1021/acs.jmedchem.7b00172
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17K15710, KAKENHI-PROJECT-17H04222
[Journal Article] Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3 -/- mice2017
- Author(s)
  Higashi-Kuwata Nobuyo、Ogata-Aoki Hiromi、Hattori Shin-ichiro、Hayashi Hironori、Danish Matthew、Aoki Manabu、Shiotsu Chiemi、Kawamura Tatsuyoshi、Ihn Hironobu、Kobayashi Hisataka、Okada Seiji、Mitsuya Hiroaki
- Journal Title
  
  Antiviral Research
  
  Volume: 144 Pages: 83-92
- DOI
  10.1016/j.antiviral.2017.03.027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08742, KAKENHI-PROJECT-16K10165, KAKENHI-PROJECT-17K15710
[Presentation] 抗SARS-CoV-2メインプロテアーゼ阻害剤 TKB272の研究開発2023
- Author(s)
  青木宏美、鍬田伸好、辻耕平、林宏典、Haydar Bulut、今井正樹、服部真一朗、高松悠樹、助長義和、岡村匡史、三隅将吾、河岡義裕、玉村啓和、満屋裕明
- Organizer
  第31回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K07918
[Presentation] 抗SARS-CoV-2メインプロテアーゼ阻害剤の創薬研究開発2023
- Author(s)
  鍬田伸好、辻耕平、林宏典、石井貴大、小早川拓也、中野堅太、服部真一朗、岸本直樹、高宗暢暁、青木宏美、Haydar Bulut、Debananda Das、今井正樹、木曽真紀、助永義和、高松悠樹、岡村匡史、三隅将吾、河岡義裕、玉村啓和、満屋裕明
- Organizer
  第37回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K07918
[Presentation] 糸状菌ジテルペノイドピロン類のコンビナトリアル生合成と生物活性評価2019
- Author(s)
  塚田健人, 金子秋穂, 新木翔之, 河治久実, 林宏典, 児玉栄一, 倉石貴透, 村井正俊, 三芳秀人, 村上一馬, 入江一浩, 平田尚也, 諫田泰成, 浅井禎吾
- Organizer
  第61回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19H03701
[Presentation] 麻疹ウイルス膜融合阻害ペプチドの構造活性相関研究　―抗ウイルス活性に必要な最小配列の同定―2019
- Author(s)
  髙原葵、平田和成、林宏典、河治久実、井貫晋輔、大野浩章、児玉栄一、大石真也
- Organizer
  第69回日本薬学会関西支部総会
- Data Source
  KAKENHI-PROJECT-19H03701
[Presentation] P2-bis-THF基およびP2'-CpAbt基を有し、多剤耐性HIV変異株に対しても強力な抗ウイルス活性を発揮する新規プロテアーゼ阻害薬の同定2019
- Author(s)
  高松悠樹、青木学、 Haydar Bulut、Debananda Das、天野将之、 Venkata Reddy Sheri、 Ladislau C. Kovari、林宏典、 Nicole S. Delino、Arun K. Ghosh、満屋裕明
- Organizer
  第33回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03701
[Presentation] The resistant mechanism of measles virus against peptide based fusion inhibitors2019
- Author(s)
  Kazushige Hirata, Aoi Takahara, Kumi Kawaji, Hironori Hayashi, Shinya Oishi, and Eiichi N.Kodama.
- Organizer
  The29th KSCLM Annual Meeting,Korean Society for Clinical Laboratory Microbiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03701
[Presentation] P2-bis-THF基およびP2'-CpAbt基を有し、多剤耐性HIV変異株に対しても強力な抗ウイルス活性を発揮する新規プロテアーゼ阻害薬の同定2019
- Author(s)
  高松悠樹、青木　学、 Haydar Bulut、Debananda Das、天野将之、Venkata Reddy Sheri、 Ladislau C. Kovari、林　宏典、 Nicole S. Delino、Arun K. Ghosh、満屋裕明
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19K17921
[Presentation] HIVプロテアーゼ阻害剤GRL-142とその誘導体の強力な抗ウイルス活性発揮機序の解明2019
- Author(s)
  服部真一朗、Haydar Bulut、林　宏典、青木　学、青木宏美、長谷川和也、Arun K. Ghosh、満屋裕明
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19K17921
[Presentation] 麻疹ウイルス膜融合阻害ペプチドの最小活性配列の同定と相互作用解析2019
- Author(s)
  髙原葵、中津亨、平田和成、林宏典、河治久実、井貫晋輔、大野浩章、加藤博章、児玉栄一、大石真也
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03701
[Presentation] HIVプロテアーゼ阻害剤GRL-142とその誘導体の強力な抗ウイルス活性発揮機序の解明2019
- Author(s)
  服部真一朗、Haydar Bulut、林宏典、青木学、青木宏美、長谷川和也、Arun K. Ghosh、満屋裕明
- Organizer
  第33回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03701

1. Kodama Eiichi (50271151)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 和田健彦 (20220957)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 稲垣雅仁 (60881092)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 西嶋政樹 (70448017)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 荒木保幸 (80361179)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 浅井禎吾 (60572310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 菊地晴久 (90302166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 辻耕平 (50866639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 天野将之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 満屋裕明

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
11. 岡田誠治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 前田賢次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 堀亜紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 青木正志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Hironori 林 宏典

Research Projects

Research Products

Co-Researchers

高活性触媒的標的RNA切断機能付与型人工核酸の構築と新興感染症等治療基盤の創製

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of Artificial Nucleic Acids with Highly Active Catalytic Target RNA Cleavage Ability and Development as a Therapeutic Platform

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel antibacterial agents using crystal structure-based drug screeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cross-virus drugs using norovirus as a modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutics for intractable infections using diverse natural products combined with stress-inductive biosynthesis and chemical modification

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study for elucidating the mechanisms of HIV-1's EFdA resistance.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] HIV感染症とAIDSの治療2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Helix-based screening with structure prediction using artificial intelligence has potential for the rapid development of peptide inhibitors targeting class I viral fusion2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Helical peptides with disordered regions for measles viruses provide new generalized insights into fusion inhibitors2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishing an Accurate and Sensitive In Vitro Drug Screening System for Human Adenovirus Infection with Human Corneal Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-22023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-01576022022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan2022

Author(s)

Journal Title

DOI

Hayashi Hironori 林宏典