Kawagoe Fumihiro 川越文裕

Researcher Number	00756520
Other IDs
Affiliation (Current)	2025: 東京理科大学, 理学部第二部化学科, 助教
Affiliation (based on the past Project Information) *help	2024: 東京理科大学, 理学部第二部化学科, 助教 2022 – 2023: 帝京大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 33020:Synthetic organic chemistry-related Except Principal Investigator Basic Section 38050:Food sciences-related
Keywords	Principal Investigator 医薬品 / 合成 / ライブラリー / CYP24A1 / IL19 / 乾癬 / フッ素化 / ビタミンD Except Principal Investigator 炎症性腸疾患 / ビタミンD

ビタミンDによる抗炎症機構の解明および炎症性腸疾患との関連
- Principal Investigator
  
  岡田只士
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Okayama Gakuin University
フッ素化ビタミンD3の効率的合成法の開発とライブラリー構築、生物活性Principal Investigator
- Principal Investigator
  
  川越文裕
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 33020:Synthetic organic chemistry-related
- Research Institution
  Teikyo University

All 2024 2023 2022

All Journal Article Presentation Patent

[Journal Article] An Improved and Scalable Synthesis of the Potent SREBP Inhibitor KK-052 via [3+2] Cycloaddition2023
- Author(s)
  Kittaka Atsushi、Kawagoe Fumihiro、Mototani Sayuri、Takemoto Yasushi、Uesugi Motonari
- Journal Title
  
  Synthesis
  
  Volume: 56 Issue: 09 Pages: 1460-1464
- DOI
  10.1055/a-2236-0413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-22K05354, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556
[Journal Article] Synthesis of New 26,27-Difluoro- and 26,26,27,27-Tetrafluoro-25-hydroxyvitamin D3: Effects of Terminal Fluorine Atoms on Biological Activity and Half-life2023
- Author(s)
 Kawagoe Fumihiro、Mototani Sayuri、Yasuda Kaori、Mano Hiroki、Takeuchi Akiko、Saitoh Hiroshi、Sakaki Toshiyuki、Kittaka Atsushi
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 71 Issue: 9 Pages: 717-723
- DOI
 10.1248/cpb.c23-00395
- ISSN
 0009-2363, 1347-5223
- Year and Date
 2023-09-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-23K23530
[Journal Article] Synthesis of (22R)-, (22S)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D3 and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism2023
- Author(s)
 Kawagoe Fumihiro、Mototani Sayuri、Yasuda Kaori、Takeuchi Akiko、Mano Hiroki、Kakuda Shinji、Saitoh Hiroshi、Sakaki Toshiyuki、Kittaka Atsushi
- Journal Title
 
 The Journal of Organic Chemistry
 
 Volume: 88 Issue: 17 Pages: 12394-12408
- DOI
 10.1021/acs.joc.3c01134
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-23K23530
[Journal Article] Efficient Stereo-Selective Fluorination on Vitamin D3 Side-Chain Using Electrophilic Fluorination2023
- Author(s)
  Kawagoe Fumihiro、Mototani Sayuri、Kittaka Atsushi
- Journal Title
  
  Biomolecules
  
  Volume: 14 Issue: 1 Pages: 37-37
- DOI
  10.3390/biom14010037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556
[Journal Article] Structure?activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-0522023
- Author(s)
  Kawagoe Fumihiro、Mototani Sayuri、Mendoza Aileen、Takemoto Yasushi、Uesugi Motonari、Kittaka Atsushi
- Journal Title
  
  RSC Medicinal Chemistry
  
  Volume: 14 Issue: 10 Pages: 2030-2034
- DOI
  10.1039/d3md00352c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-22K05354, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556
[Journal Article] 23,25-Dihydroxyvitamin D3 is liberated as a major vitamin D3 metabolite in human urine after treatment with β-glucuronidase: Quantitative comparison with 24,25-dihydroxyvitamin D3 by LC/MS/MS2022
- Author(s)
  Takada Kazunari、Hagiwara Yukino、Togashi Moeka、Kittaka Atsushi、Kawagoe Fumihiro、Uesugi Motonari、Nishimoto-Kusunose Shoichi、Higashi Tatsuya
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 223 Pages: 106133-106133
- DOI
  10.1016/j.jsbmb.2022.106133
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-23K23530
[Journal Article] The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities2022
- Author(s)
  Mototani Sayuri、Kawagoe Fumihiro、Yasuda Kaori、Mano Hiroki、Sakaki Toshiyuki、Kittaka Atsushi
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 16 Pages: 5352-5352
- DOI
  10.3390/molecules27165352
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-23K23530
[Patent] 脂質生合成を選択的に阻害するビタミンD誘導体2023
- Inventor(s)
  上杉志成　竹本靖　長澤和夫　橘髙敦史　川越文裕など
- Industrial Property Rights Holder
  上杉志成　竹本靖　長澤和夫　橘髙敦史　川越文裕など
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-517858
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K14688
[Patent] ＣＤ環側鎖置換ビタミンＤ誘導体含有ＩＬ－１９分泌抑制剤2023
- Inventor(s)
  川越文裕 , 橘髙敦史
- Industrial Property Rights Holder
  川越文裕 , 橘髙敦史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-068498
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K14688
[Patent] ＣＤ環側鎖置換ビタミンＤ誘導体含有ＩＬ－１９分泌抑制剤2023
- Inventor(s)
  橘髙敦史　川越文裕
- Industrial Property Rights Holder
  橘髙敦史　川越文裕
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-068498
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K14688
[Patent] 脂質生合成を選択的に阻害するビタミンD誘導体2023
- Inventor(s)
  上杉志成、竹本靖、長澤和夫, 橘高敦史 , 川越文裕,など
- Industrial Property Rights Holder
  上杉志成、竹本靖、長澤和夫, 橘高敦史 , 川越文裕,など
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-517858
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 未定2024
- Author(s)
  川越文裕
- Organizer
  第十三回フッ素若手の会
- Invited
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 22位がフッ素化された25-ヒドロキシビタミンD3誘導体の合成2023
- Author(s)
  川越文裕本谷小佑里安田佳織榊利之橘高敦史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] Comprehensive synthesis of side-chain fluorinated vitamin D3 derivatives and their stability to hCYP24A1-dependent catabolism2023
- Author(s)
  川越文裕
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] Synthesis of 22,22-difluoro-25-hydroxyvitamin D3 and effects of side chain fluorination on vitamin D receptor binding affinity and CYP24A1-dependent metabolism2023
- Author(s)
  川越文裕
- Organizer
  AMEX2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] (22R)-および(22S)-フルオロ-25- ヒドロキシビタミンD3の立体選択的合成2022
- Author(s)
  川越文裕、本谷小佑里、安田佳織、榊　利之、橘高敦史
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 24位がヒドロキシ化された23,23- ジフルオロビタミンD3誘導体の合成2022
- Author(s)
  川越文裕本谷小佑里安田佳織榊利之橘高敦史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] Comprehensive synthesis of side-chain fluorinated vitamin D3 analogues： Construction of chemical library and exploration of drug candidates2022
- Author(s)
  川越文裕、本谷小佑里、安田佳織、榊　利之、橘高敦史
- Organizer
  Asia Pacific Society for Materials Research 2022 Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] ビタミンD3側鎖22位への立体選択的フッ素導入法開発2022
- Author(s)
  川越文裕、本谷小佑里、安田佳織、榊　利之、橘高敦史
- Organizer
  日本ビタミン学会第74回大会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 22位フッ素化ビタミンD3誘導体の立体選択的合成2022
- Author(s)
  川越文裕、本谷小佑里、安田佳織、榊　利之、橘高敦史
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K14688

1. 岡田只士 (30623855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 安田佳織 (70707231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KITTAKA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kawagoe Fumihiro 川越 文裕

Research Projects

Research Products

Co-Researchers

ビタミンDによる抗炎症機構の解明および炎症性腸疾患との関連

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

フッ素化ビタミンD3の効率的合成法の開発とライブラリー構築、生物活性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] An Improved and Scalable Synthesis of the Potent SREBP Inhibitor KK-052 via [3+2] Cycloaddition2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of New 26,27-Difluoro- and 26,26,27,27-Tetrafluoro-25-hydroxyvitamin D<sub>3</sub>: Effects of Terminal Fluorine Atoms on Biological Activity and Half-life2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Synthesis of (22<i>R</i>)-, (22<i>S</i>)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D<sub>3</sub> and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient Stereo-Selective Fluorination on Vitamin D3 Side-Chain Using Electrophilic Fluorination2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure?activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-0522023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 23,25-Dihydroxyvitamin D3 is liberated as a major vitamin D3 metabolite in human urine after treatment with β-glucuronidase: Quantitative comparison with 24,25-dihydroxyvitamin D3 by LC/MS/MS2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities2022

Author(s)

Journal Title

DOI

Data Source

[Patent] 脂質生合成を選択的に阻害するビタミンD誘導体2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] ＣＤ環側鎖置換ビタミンＤ誘導体含有ＩＬ－１９分泌抑制剤2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] ＣＤ環側鎖置換ビタミンＤ誘導体含有ＩＬ－１９分泌抑制剤2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] 脂質生合成を選択的に阻害するビタミンD誘導体2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Kawagoe Fumihiro 川越文裕

[Presentation] 22位がフッ素化された25-ヒドロキシビタミンD3誘導体の合成2023

[Presentation] (22R)-および(22S)-フルオロ-25- ヒドロキシビタミンD3の立体選択的合成2022

[Presentation] 22位フッ素化ビタミンD3誘導体の立体選択的合成2022