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Tokuda Eiichi  徳田 栄一

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TOKUDA Eiichi  徳田 栄一

Eiichi Tokuda  徳田 栄一

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Researcher Number 00757510
Other IDs
Affiliation (Current) 2025: 日本大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help 2025: 日本大学, 薬学部, 講師
2021 – 2022: 日本大学, 薬学部, 講師
2018: 徳島文理大学, 薬学部, 講師
2016 – 2017: 慶應義塾大学, 理工学部(矢上), 助教
2015: 慶應義塾大学, 理工学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Medium-sized Section 52:General internal medicine and related fields / Structural biochemistry / Functional biochemistry
Keywords
Principal Investigator
筋萎縮性側索硬化症 / 神経変性疾患 / シーディング / タンパク質凝集体 / ホフマイスターイオン / 異常型タンパク質 / 早期発見 / 血液診断 / プリオン様特性 / マウスモデル … More / ミスフォールドタンパク質 / クロスシーディング / タンパク質線維 / スーパーオキサイド ディスムターゼ / 線虫 Less
  • Research Projects

    (4 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (4 People)
  •  ALS病変部位の拡大阻止に向けたTDP-43の構造多様性に基づく伝播特性の層別化Principal Investigator

    • Principal Investigator
      徳田 栄一
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Nihon University
  •  Development of a hemodiagnosis for ALS based on the seeding reaction induced by misfolded proteinsPrincipal Investigator

    • Principal Investigator
      TOKUDA Eiichi
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Nihon University
  •  Role of cross-seeding in the pathogenesis of neurodegenerative disordersPrincipal Investigator

    • Principal Investigator
      Eiichi Tokuda
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Tokushima Bunri University
      Keio University
  •  Molecular mechanism underlying propagation of pathogenic protein aggregates in neurodegenerative disordersPrincipal Investigator

    • Principal Investigator
      Eiichi Tokuda
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Functional biochemistry
    • Research Institution
      Keio University

All 2023 2022 2021 2019 2018 2017 2016

All Journal Article Presentation Book

  • [Book] Aggregation of FET proteins as a pathological change in amyotrophic lateral sclerosis.2017

    • Author(s)
      Furukawa Y and Tokuda E.
    • Total Pages
      161
    • Publisher
      Springer US
    • Data Source
      KAKENHI-PROJECT-15H06588
  • [Book] Protein Reviews2016

    • Author(s)
      Yoshiaki Furukawa and Eiichi Tokuda
    • Publisher
      Springer Link
    • Data Source
      KAKENHI-PROJECT-15H06588
  • [Journal Article] FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD2023

    • Author(s)
      Fujino Yuzo、Ueyama Morio、Ishiguro Taro、Ozawa Daisaku、Sugiki Toshihiko、Ito Hayato、Murata Asako、Ishiguro Akira、Gendron Tania F.、Mori Kohji、Tokuda Eiichi、Taminato Tomoya、Konno Takuya、Koyama Akihide、Kawabe Yuya et al.
    • Journal Title

      eLife

      Volume: 12

    • DOI

      10.7554/elife.84338.1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19456
  • [Journal Article] A Metal-Free, Disulfide Oxidized Form of Superoxide Dismutase 1 as a Primary Misfolded Species with Prion-Like Properties in the Extracellular Environments Surrounding Motor Neuron-Like Cells2021

    • Author(s)
      Takashima Chika、Kosuge Yasuhiro、Inoue Masahisa、Ono Shin-Ichi、Tokuda Eiichi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 8 Pages: 4155-4155

    • DOI

      10.3390/ijms22084155

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19456
  • [Journal Article] Apoptotic Effects of a Thioether Analog of Vitamin K3 in a Human Leukemia Cell Line2021

    • Author(s)
      Asami Satoru、Suzuki Mikana、Nakayama Toshimitsu、Shimoda Yasuyo、Miura Motofumi、Kato Koichi、Tokuda Eiichi、Ono Shinichi、Kawakubo Takashi、Nishizawa Kenji、Yamanaka Kenzo、Suzuki Takashi
    • Journal Title

      International Journal of Toxicology

      Volume: 40 Issue: 6 Pages: 517-529

    • DOI

      10.1177/10915818211047992

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19456
  • [Journal Article] Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS2021

    • Author(s)
      Hirose Mikako、Asano Mito、Watanabe-Matsumoto Saori、Yamanaka Koji、Abe Yoichiro、Yasui Masato、Tokuda Eiichi、Furukawa Yoshiaki、Misawa Hidemi
    • Journal Title

      Neuroscience Research

      Volume: 171 Pages: 74-82

    • DOI

      10.1016/j.neures.2020.10.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07128, KAKENHI-PROJECT-21K19456
  • [Journal Article] Cu/Zn-superoxide dismutase forms fibrillar hydrogels in a pH-dependent manner via a water-rich extended intermediate state2018

    • Author(s)
      Fujiwara Noriko、Wagatsuma Michiru、Oba Naoto、Yoshihara Daisaku、Tokuda Eiichi、Sakiyama Haruhiko、Eguchi Hironobu、Ichihashi Motoko、Furukawa Yoshiaki、Inoue Tadashi、Suzuki Keiichiro
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 10 Pages: e0205090-e0205090

    • DOI

      10.1371/journal.pone.0205090

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K13060, KAKENHI-PROJECT-17K15077
  • [Journal Article] A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis2018

    • Author(s)
      Tokuda Eiichi、Nomura Takao、Ohara Shinji、Watanabe Seiji、Yamanaka Koji、Morisaki Yuta、Misawa Hidemi、Furukawa Yoshiaki
    • Journal Title

      Biochimica et Biophysica Acta - Molecular Basis of Disease

      Volume: 印刷中 Issue: 6 Pages: 2119-2130

    • DOI

      10.1016/j.bbadis.2018.03.015

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K16634, KAKENHI-PROJECT-18K05329, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K15077
  • [Journal Article] An essential role of N-terminal domain of copper chaperone in the enzymatic activation of Cu/Zn-superoxide dismutase2017

    • Author(s)
      Fukuoka Mami、Tokuda Eiichi、Nakagome Kenta、Wu Zhiliang、Nagano Isao、Furukawa Yoshiaki
    • Journal Title

      Journal of Inorganic Biochemistry

      Volume: 175 Pages: 208-216

    • DOI

      10.1016/j.jinorgbio.2017.07.036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15077, KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768
  • [Journal Article] Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA312017

    • Author(s)
      Taro Ishiguro, Nozomu Sato, Morio Ueyama, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Eiichi Tokuda, Bita Zamiri, Terence Gall-Duncan, Mila Mirceta, Yoshiaki Furukawa, 他8名
    • Journal Title

      Neuron

      Volume: 94 Issue: 1 Pages: 108-124

    • DOI

      10.1016/j.neuron.2017.02.046

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-15H06181, KAKENHI-PROJECT-15H06588, KAKENHI-PROJECT-17K15077, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K09331
  • [Journal Article] A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis2017

    • Author(s)
      Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama, Fumito Endo, Koji Yamanaka, Hidemi Misawa, and Yoshiaki Furukawa
    • Journal Title

      Protein Science

      Volume: 26 Issue: 3 Pages: 484-496

    • DOI

      10.1002/pro.3094

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-15H06588, KAKENHI-PROJECT-15K14480, KAKENHI-PROJECT-16K09671
  • [Journal Article] Abnormal protein oligomers for neurodegeneration2017

    • Author(s)
      Tokuda Eiichi、Furukawa Yoshiaki
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 25 Pages: 39943-39944

    • DOI

      10.18632/oncotarget.18030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15077, KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768
  • [Journal Article] Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis2017

    • Author(s)
      Tokuda E, Anzai I, Nomura T, Toichi K, Watanabe M, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, and Furukawa Y.
    • Journal Title

      Molecular Neurodegeneration

      Volume: 12 Pages: 2-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06588
  • [Journal Article] Screening of Drugs Inhibiting In vitro Oligomerization of Cu/Zn-Superoxide Dismutase with a Mutation Causing Amyotrophic Lateral Sclerosis2016

    • Author(s)
      Itsuki Anzai, Keisuke Toichi, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama, and Yoshiaki Furukawa
    • Journal Title

      Frontiers in Molecular Biosciences

      Volume: 3 Pages: 40-40

    • DOI

      10.3389/fmolb.2016.00040

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-15H06588, KAKENHI-PROJECT-15K14480
  • [Journal Article] Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase2016

    • Author(s)
      Eiichi Tokuda, Thomas Brannstrom, Peter M. Andersen, and Stefan L. Marklund
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 4 Issue: 1 Pages: 6-6

    • DOI

      10.1186/s40478-016-0274-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06588
  • [Presentation] Zn未結合型SOD1を認識する市販ミスフォールドSOD1抗体MS7852023

    • Author(s)
      徳田 栄一、阪下 優芽、山老 直哉
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-21K19456
  • [Presentation] ALS病因タンパク質の凝集化を抑制するZn結合型メタロチオネイン2022

    • Author(s)
      徳田 栄一、桂馬 茉衣子、池田知亜子、小菅 康弘、小野 真一
    • Organizer
      日本薬学会 第142年会
    • Data Source
      KAKENHI-PROJECT-21K19456
  • [Presentation] Zinc-binding metallothionein inhibits the SOD1 aggregation via binding of core regions for aggregate growth2022

    • Author(s)
      Eiichi Tokuda、Maiko Keima、Chiako Ikeda、Yasuhiro Kosuge、Shin-ichi Ono
    • Organizer
      Neuro2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19456
  • [Presentation] 神経難病ALSの創薬標的としてのメタロチオネイン: ALS関連タンパク質の凝集抑制作用2022

    • Author(s)
      徳田栄一
    • Organizer
      千葉エリア産官学公金共創イノベーションネットワーク 第1回産官学公金マッチングシンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19456
  • [Presentation] A conformational feature of extracellular misfolded SOD1 with prion-like properties in the extracellular environment surrounding motor neuron-like cells2021

    • Author(s)
      Eiichi Tokuda, Chika Takashima, Yasuhiro Kosuge, Masahisa Inoue, and Shin-ichi Ono
    • Organizer
      第44回 日本神経科学大会 CJK第1回国際会議
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19456
  • [Presentation] 神経変性疾患ALSに対するメタロチオネインの防御作用: SOD1タンパク質の凝集化抑制2021

    • Author(s)
      徳田栄一, 桂馬茉衣子, 池田知亜子, 小野真一
    • Organizer
      第47回 日本毒性学会学術年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19456
  • [Presentation] Neuroprotection of metallothionein in ALS-SOD1 is mediated via an endocytic receptor Megalin2019

    • Author(s)
      Tokuda Eiichi
    • Organizer
      1st International Mini Symposium on Metal in ALS
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] Conformational dependent toxicity of Cu/Zn-superoxide dismutase in Caenortabditis elegans2018

    • Author(s)
      Toba Ayano, Tokuda Eiichi, Furukawa Yoshiaki
    • Organizer
      9th Asian Biological Inorganic Chemistry Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] Wild-type SOD1 is misfolded in cerebrospinal fluid of sporadic ALS2018

    • Author(s)
      Furukawa Yoshiaki, Tokuda Eiichi, Ohara Shinji, Fujiwara Noriko
    • Organizer
      29th International Symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] 筋萎縮性側索硬化症 (Amyotrophic Lateral Sclerosis; ALS) と Cu、Zn、そして misfolding2018

    • Author(s)
      小野真一、徳田栄一
    • Organizer
      メタルバイオサイエンス研究会2018
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] 運動ニューロン疾患ALSにおけるミスフォールドタンパク質のプリオン様特性:現状と今後の展望2018

    • Author(s)
      徳田栄一, Marklund Stefan, 古川良明
    • Organizer
      日本薬学会138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] システイン残基の酸化が促進するSOD1タンパク質のミスフォールディング2018

    • Author(s)
      安齋樹, 徳田栄一, 古川良明
    • Organizer
      第18回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] 運動ニューロン疾患ALSにおけるミスフォールドタンパク質のプリオン様特性:現状と今後の展望2018

    • Author(s)
      徳田栄一、Stefan Marklund、 古川良明
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] SOD1タンパク質への銅イオン供給に金属シャペロンCCSが果たす役割2018

    • Author(s)
      羽飼友昭, 福岡真実, 徳田栄一, 古川良明
    • Organizer
      第18回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] A misfolding mechanism of Cu/Zn-superoxide dismutase under oxidative conditions of amyotrophic lateral sclerosis2018

    • Author(s)
      Anzai Itsuki, Tokuda Eiichi, Mukaiyama Atsushi, Akiyama Shuji, Furukawa Yoshiaki
    • Organizer
      9th Asian Biological Inorganic Chemistry Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] 筋萎縮性側索硬化症に見られるSOD1タンパク質の凝集を抑制するメカニズム2018

    • Author(s)
      松本響佳, 中村滉平, 徳田栄一, 古川良明
    • Organizer
      第18回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] Development of peptides that specifically recognize misfolded SOD1 proteins in amyotrophic lateral sclerosis2017

    • Author(s)
      Eiichi Tokuda、Kenichi Nagasawa、Takao Nomura、Hidemi Misawa、Shinji Ohara、Koji Yamanaka、Yoshiaki Furukawa
    • Organizer
      28th International Symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] 筋萎縮性側索硬化症における変異SOD1オリゴマーの免疫化学的な検出2017

    • Author(s)
      徳田栄一、森崎祐太、三澤日出巳、渡邊征爾、山中宏二、大原慎司、古川良明
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-15H06588
  • [Presentation] 神経変性疾患ALSの病初期に現れる銅イオン欠乏型SOD12017

    • Author(s)
      徳田栄一、大原慎司、山中宏二、三澤日出巳、 古川良明
    • Organizer
      メタルバイオサイエンス研究会2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] Development of peptides that specifically recognize misfolded SOD1 proteins in amyotrophic lateral sclerosis2017

    • Author(s)
      Eiichi Tokuda、Kenichi Nagasawa、Takao Nomura、Hidemi Misawa、Shinji Ohara、Koji Yamanaka、Yoshiaki Furukawa
    • Organizer
      第40回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] 筋萎縮性側索硬化症における変異SOD1オリゴマーの免疫化学的な検出2017

    • Author(s)
      徳田栄一、三澤日出巳、山中宏二、 大原慎司、古川良明
    • Organizer
      慶應ライフサイエンスシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K15077
  • [Presentation] 銅・亜鉛スーパーオキサイドディスムターゼの金属イオン結合状態を識別できる新規抗体の開発と筋萎縮性側索硬化症の病理解明への応用2016

    • Author(s)
      徳田栄一、森崎祐太、三澤日出巳、渡邊征爾、山中宏二、古川良明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15H06588
  • [Presentation] In vivo and in vitro characterization of SOD1 in early stages of ALS as a precursor to insoluble aggregates2016

    • Author(s)
      Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, and Yoshiaki Furukawa
    • Organizer
      27th International Symposium on ALS/MND
    • Place of Presentation
      Dublin (Ireland)
    • Year and Date
      2016-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06588
  • 1.  原 誠 (10817224)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  中嶋 秀人 (20330095)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  古川 良明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 4.  三澤 日出巳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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