Noguchi Yoshihiko 野口吉彦

Researcher Number	00758170
Other IDs	https://orcid.org/0000-0002-7027-5822
Affiliation (based on the past Project Information) *help	2023: 北里大学, 感染制御科学府, 特任助教 2019 – 2020: 北里大学, 感染制御科学府, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator ポリセリン構造 / N末伸長 / 抗真菌 / 疎水性タグ / N-置換疎水性タグ / ポリセリン / 環状デプシペプチド / 抗真菌活性 / III型分泌装置 / 非抗菌的感染症治療薬 … More / カスケード反応 / 感染防御薬 / ピリドン / cis-テトラヒドロフラン / ポリエン / 収束的全合成 / III型分泌機構 / 非抗菌的坑感染症薬 Less

N-担持型疎水性タグの開発とポリセリン含有抗真菌性環状デプシペプチドの全合成研究Principal Investigator
- Principal Investigator
  
  野口吉彦
- Project Period (FY)
  2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University
Synthetic study of naturally occurring type III secretion system inhibitors towards the creation of non-microbial anti-infective agentPrincipal Investigator
- Principal Investigator
  
  Noguchi Yoshihiko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University

All 2024 2023 2021 2020 2019 Other

All Journal Article Presentation Other

[Journal Article] Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-80582024
- Author(s)
  Kimura So-ichiro、Watanabe Yoshihiro、Mikasa Yudai、Miyano Rei、Tokiwa Toshiyuki、Nonaka Kenichi、Nakashima Takuji、Noguchi Yoshihiko、Hirose Tomoyasu、Sunazuka Toshiaki、Hokari Rei、Ishiyama Aki、Iwatsuki Masato
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 77 Issue: 4 Pages: 206-213
- DOI
  10.1038/s41429-023-00699-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-23K06053
[Journal Article] Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-04992024
- Author(s)
  Azami Haruki、Watanabe Yoshihiro、Sakai Kazunari、Nakahara Hiroki、Kojima Hiroki、Tokiwa Toshiyuki、Nonaka Kenichi、Noguchi Yoshihiko、Nagano Yuriko、Hirose Tomoyasu、Sunazuka Toshiaki、Matsui Hidehito、Arima Naoaki、Abe Kazutoyo、Hanaki Hideaki、Iwatsuki Masato
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 77 Issue: 3 Pages: 156-162
- DOI
  10.1038/s41429-023-00696-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05293, KAKENHI-PROJECT-21K06328, KAKENHI-PROJECT-23K06053
[Journal Article] Development of a nitrogen-bound hydrophobic auxiliary: application to solid/hydrophobic-tag relay synthesis of calpinactam2023
- Author(s)
  Nakahara Hiroki、Sennari Goh、Noguchi Yoshihiko、Hirose Tomoyasu、Sunazuka Toshiaki
- Journal Title
  
  Chemical Science
  
  Volume: 14 Issue: 25 Pages: 6882-6889
- DOI
  10.1039/d3sc01432k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-23K06053
[Journal Article] Hakuhybotrol, a polyketide produced by <i>Hypomyces pseudocorticiicola</i>, characterized with the assistance of 3D ED/MicroED2023
- Author(s)
  Watanabe Yoshihiro、Takahashi Shuhei、Ito Sho、Tokiwa Toshiyuki、Noguchi Yoshihiko、Azami Haruki、Kojima Hiroki、Higo Mayuka、Ban Sayaka、Nagai Kenichiro、Hirose Tomoyasu、Sunazuka Toshiaki、Yaguchi Takashi、Nonaka Kenichi、Iwatsuki Masato
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 21 Issue: 11 Pages: 2320-2330
- DOI
  10.1039/d2ob02286a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05293, KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-23K06053
[Journal Article] Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ2023
- Author(s)
  Choi Jun Yong、Noguchi Yoshihiko、Alburger James M.、Bayle Simon、Chung Eugene、Grant Wayne、Chaikuad Apirat、Knapp Stefan、Duckett Derek R.、Roush William R.
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 66 Issue: 11 Pages: 7162-7178
- DOI
  10.1021/acs.jmedchem.2c01180
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06053
[Journal Article] Towards the total synthesis of aurodox: preparation of the key hemiacetal-lactone2021
- Author(s)
  Motoyoshi Ohara, Akari Ikeda, Asuka Nakajuma, Takanori Ono, Yoshihiko Noguchi,Akito Watanabe, Tomoyasu Hirose, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 66 Pages: 152799-152799
- DOI
  10.1016/j.tetlet.2020.152799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-21K05059
[Journal Article] Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C2021
- Author(s)
  Shu Takahashi, Aoi Kimishima, Tomoyasu Hirose, Takeshi Yamada, Akihiro Sugawara, Tatsuya Shirahata, Yoshihiko Noguchi, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Yoshinori Kobayashi, Toshiaki Sunazuka
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 67 Pages: 152895-152895
- DOI
  10.1016/j.tetlet.2021.152895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-20K05502, KAKENHI-PROJECT-21K05059
[Journal Article] Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-73822020
- Author(s)
  Matsuo Hirotaka、Noguchi Yoshihiko、Miyano Rei、Higo Mayuka、Nonaka Kenichi、Sunazuka Toshiaki、Takahashi Yoko、Omura Satoshi、Nakashima Takuji
- Journal Title
  
  Antibiotics
  
  Volume: 9 Issue: 5 Pages: 236-236
- DOI
  10.3390/antibiotics9050236
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-19K15758
[Journal Article] Nanaomycin K, a new epithelial?mesenchymal transition inhibitor produced by the actinomycete “Streptomyces rosa subsp. notoensis” OS-39662020
- Author(s)
  Matsuo Hirotaka、Nakanishi Jun、Noguchi Yoshihiko、Kitagawa Koichi、Shigemura Katsumi、Sunazuka Toshiaki、Takahashi Yoko、Omura Satoshi、Nakashima Takuji
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 129 Issue: 3 Pages: 291-295
- DOI
  10.1016/j.jbiosc.2019.09.007
- NAID
  40022194469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16318
[Journal Article] Trichothioneic acid, a new antioxidant compound produced by the fungal strain Trichoderma virens FKI-75732020
- Author(s)
  Miyano Rei、Matsuo Hirotaka、Mokudai Takayuki、Noguchi Yoshihiko、Higo Mayuka、Nonaka Kenichi、Niwano Yoshimi、Sunazuka Toshiaki、Shiomi Kazuro、Takahashi Yoko、Omura Satoshi、Nakashima Takuji
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 129 Issue: 4 Pages: 508-513
- DOI
  10.1016/j.jbiosc.2019.11.007
- NAID
  40022216167
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04629, KAKENHI-PROJECT-19K16318
[Journal Article] Efficient synthesis of a ryanodine binding inhibitor verticilide using two practical approache2020
- Author(s)
  Watanabe, A., Noguchi, Y., Hirose, T., Monma, S., Satake T., Arai, M., Masuda, K., Murashima, N., Shiomi, R., Omura, S., and Sunazuka, T.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 61 Issue: 13 Pages: 151699-151703
- DOI
  10.1016/j.tetlet.2020.151699
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04629, KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K16318
[Journal Article] The Nonantibiotic Macrolide EM900 Attenuates House Dust Mite-Induced Airway Inflammation in a Mouse Model of Obesity-Associated Asthma2020
- Author(s)
  Sadamatsu Hironori、Takahashi Koichiro、Tashiro Hiroki、Kurihara Yuki、Kato Go、Uchida Masaru、Noguchi Yoshihiko、Kurata Keigo、Omura Satoshi、Sunazuka Toshiaki、Kimura Shinya、Sueoka-Aragane Naoko
- Journal Title
  
  International Archives of Allergy and Immunology
  
  Volume: 181 Issue: 9 Pages: 665-674
- DOI
  10.1159/000508709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16318
[Journal Article] The non-antibiotic macrolide EM900 attenuates HDM and poly(I:C)-induced airway inflammation with inhibition of macrophages in a mouse model2019
- Author(s)
  Sadamatsu Hironori、Takahashi Koichiro、Tashiro Hiroki、Kato Go、Noguchi Yoshihiko、Kurata Keigo、Omura Satoshi、Kimura Shinya、Sunazuka Toshiaki、Sueoka-Aragane Naoko
- Journal Title
  
  Inflammation Research
  
  Volume: 69 Issue: 1 Pages: 139-151
- DOI
  10.1007/s00011-019-01302-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16318
[Journal Article] Jietacins, azoxy natural products, as novel NF-kB inhibitors: discovery, synthesis, biological activity, and mode of action2019
- Author(s)
  Mariko Watanabe, Akihiro Sugawara, Yoshihiko Noguchi, Tomoyasu Hirose, Satoshi Omura, Toshiaki Sunazuka, Ryouichi Horie
- Journal Title
  
  Eur. J. Med. Chem.
  
  Volume: 178 Pages: 636-647
- DOI
  10.1016/j.ejmech.2019.05.079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K07442, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-17K08728
[Journal Article] Nanaomycin I and J: New nanaomycins generated by mycothiol-mediated compounds from “Streptomyces rosa subsp. notoensis” OS-39662019
- Author(s)
  Matsuo Hirotaka、Noguchi Yoshihiko、Take Akira、Nakanishi Jun、Shigemura Katsumi、Sunazuka Toshiaki、Takahashi Yoko、Omura Satoshi、Nakashima Takuji
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 127 Issue: 5 Pages: 549-553
- DOI
  10.1016/j.jbiosc.2018.10.013
- NAID
  40021891586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16318
[Journal Article] Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity2019
- Author(s)
  Uchimura Tomoya、Nakamura Daisy S.、Link Eric M.、Noguchi Yoshihiko、Omura Satoshi、Sunazuka Toshiaki、Greenblatt David J.、Zeng Li
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 165 Pages: 79-90
- DOI
  10.1016/j.bcp.2019.03.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] ペプチド伸長戦略を拡張するN-担時型疎水性Tag"TCbz"の開発2023
- Author(s)
  中原大生、野口吉彦、千成恒、関怜子、長井賢一郎、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K06053
[Presentation] ポットエコノミーを指向した生物活性環状デプシペプチドの疎水性タグ合成2023
- Author(s)
  野口吉彦、関川章悟、野垣祐貴、佐竹雄大、村島徳史、桐沢貴志、Schiffer Guido、Koebberling Johannes、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K06053
[Presentation] 新規PPI阻害剤創製を指向した中分子天然物ジチロマイシンの全合成研究-22023
- Author(s)
  金井田將裕、鈴木大貴、野口吉彦、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K06053
[Presentation] 新規PPI阻害剤創製を指向した中分子天然物ジチロマイシンの全合成研究-12023
- Author(s)
  鈴木大貴、金井田將裕、野口吉彦、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K06053
[Presentation] 抗マラリア活性を有するDiatretolの不斉全合成と構造活性相関研究2021
- Author(s)
  高橋脩、君嶋葵、山田健、菅原章公、白畑辰弥、野口吉彦、岩月正人、穗苅玲、石山亜紀、小林義典、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] 環状デプシペプチド類の効率的合成を志向した疎水性タグのワンポット化2021
- Author(s)
  関川　章悟、野口　吉彦、廣瀬　友靖、砂塚　敏明
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] 抗トリパノソーマ活性を有するActinoallolide Aの全合成研究2021
- Author(s)
  大野孝典、野口吉彦、渡邊彰人、岩月正人、稲橋佑起、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] Ⅲ型分泌装置(T3SS)阻害活性を有するAurodoxの全合成研究2021
- Author(s)
  大原基義、池田朱里、中嶋明日香、大野孝典、野口吉彦、渡邊彰人、廣瀬友靖、砂塚敏明
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] 抗嫌気性菌活性を有するエフロトマイシンの全合成研究2020
- Author(s)
  大原基義、池田朱里、中嶋明日香、野口吉彦、渡邊彰人、廣瀬友靖、大村智、砂塚敏明
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-19K16318
[Presentation] 抗嫌気性菌活性を有するエフロトマイシンの全合成研究2019
- Author(s)
  大原基義、池田朱里、中嶋明日香、野口吉彦、渡邊彰人、廣瀬友靖、大村智、砂塚敏明
- Organizer
  第63回日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16318
[]

1. 廣瀬友靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
2. 渡邊善洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 砂塚敏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Noguchi Yoshihiko 野口 吉彦

Research Projects

Research Products

Co-Researchers

N-担持型疎水性タグの開発とポリセリン含有抗真菌性環状デプシペプチドの全合成研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthetic study of naturally occurring type III secretion system inhibitors towards the creation of non-microbial anti-infective agentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-80582024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-04992024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a nitrogen-bound hydrophobic auxiliary: application to solid/hydrophobic-tag relay synthesis of calpinactam2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hakuhybotrol, a polyketide produced by <i>Hypomyces pseudocorticiicola</i>, characterized with the assistance of 3D ED/MicroED2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Towards the total synthesis of aurodox: preparation of the key hemiacetal-lactone2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-73822020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nanaomycin K, a new epithelial?mesenchymal transition inhibitor produced by the actinomycete “Streptomyces rosa subsp. notoensis” OS-39662020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Trichothioneic acid, a new antioxidant compound produced by the fungal strain Trichoderma virens FKI-75732020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Efficient synthesis of a ryanodine binding inhibitor verticilide using two practical approache2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Nonantibiotic Macrolide EM900 Attenuates House Dust Mite-Induced Airway Inflammation in a Mouse Model of Obesity-Associated Asthma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The non-antibiotic macrolide EM900 attenuates HDM and poly(I:C)-induced airway inflammation with inhibition of macrophages in a mouse model2019

Author(s)

Noguchi Yoshihiko 野口吉彦