Flechsig Holger ＦＬＥＣＨＳＩＧＨＯＬＧＥＲ

… Alternative Names

FLECHSIG HOLGER フレクシグホルガー

FLECHSIG Holger

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Researcher Number	00758964
Other IDs
Affiliation (Current)	2025: 金沢大学, ナノ生命科学研究所, 特任准教授
Affiliation (based on the past Project Information) *help	2023: 金沢大学, ナノ生命科学研究所, 特任助教 2021: 金沢大学, ナノ生命科学研究所, 特任助教 2018 – 2019: 金沢大学, ナノ生命科学研究所, 特任助教 2017: 広島大学, 理学研究科, 研究員 2016: 広島大学, 理学研究科, 助教 2015: 広島大学, 大学院理学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 13040:Biophysics, chemical physics and soft matter physics-related Except Principal Investigator Biological physics/Chemical physics/Soft matter physics / Biological Sciences
Keywords	Principal Investigator energetics / modelling / molecular dynamics / high-speed AFM / myosin V / molecular motors Except Principal Investigator 生体高分子 / 酵素 / 分子機械 / 蛋白質 … More / 生体生命情報学 / 生物物理 / 計算生物物理学 / 進化的最適化 / 粗視化分子動力学 / タンパク質 / 構造機能相関 / 分子内情報伝達 / アロステリック制御 / 1分子時系列解析 / Dynamic Disorder / 細胞個性 / 情報幾何学 / 少数性生物学 / 数理モデル化 / １分子時系列解析 / 分子個性・細胞個性 / 複雑ネットワーク / 反応拡散系 / 生物物理学 Less

Modelling of myosin V motor dynamics to understand its ATP-less walking along actin filaments under interactive high-speed AFMPrincipal Investigator
- Principal Investigator
  
  Flechsig Holger
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
- Research Institution
  Kanazawa University
Design principles of protein structures underlying allosteric regulation
- Principal Investigator
  
  Togashi Yuichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological physics/Chemical physics/Soft matter physics
- Research Institution
  Hiroshima University
Constructing a theoretical framework to study reaction networks involving a small number of molecules: modeling with consideration of minority and hierarchy
- Principal Investigator
  
  TOGASHI Yuichi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
  Kobe University

All 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Allosteric communication in molecular machines via information exchange: what can be learned from dynamical modeling2020
- Author(s)
  Dimitri Loutchko, Holger Flechsig
- Journal Title
  
  Biophysical Reviews
  
  Volume: － Issue: 2 Pages: 443-452
- DOI
  10.1007/s12551-020-00667-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Analyzing Fluctuation Properties in Protein Elastic Networks with Sequence-Specific and Distance-Dependent Interactions2019
- Author(s)
  Romain Amyot, Yuichi Togashi, Holger Flechsig
- Journal Title
  
  Biomolecules
  
  Volume: 9 Issue: 10 Pages: 549-549
- DOI
  10.3390/biom9100549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Simple mechanics of protein machines2019
- Author(s)
  Flechsig Holger、Mikhailov Alexander S.
- Journal Title
  
  Journal of The Royal Society Interface
  
  Volume: 16 Issue: 155 Pages: 20190244-20190244
- DOI
  10.1098/rsif.2019.0244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K03765, KAKENHI-PROJECT-16K05518
[Journal Article] Designed Elastic Networks: Models of Complex Protein Machinery2018
- Author(s)
  Holger FLECHSIG, Yuichi TOGASHI
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 10 Pages: 3152-3152
- DOI
  10.3390/ijms19103152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Coarse-Grained Protein Dynamics Studies Using Elastic Network Models2018
- Author(s)
  Yuichi TOGASHI, Holger FLECHSIG
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 12 Pages: 3899-3899
- DOI
  10.3390/ijms19123899
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Design of Elastic Networks with Evolutionary Optimized Long-Range Communication as Mechanical Models of Allosteric Proteins2017
- Author(s)
  Holger Flechsig
- Journal Title
  
  Biophysical Journal
  
  Volume: 113 Issue: 3 Pages: 558-571
- DOI
  10.1016/j.bpj.2017.06.043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Deciphering Intrinsic Inter-subunit Couplings that Lead to Sequential Hydrolysis of F1-ATPase Ring2017
- Author(s)
  Liqiang Dai, Holger Flechsig, Jin Yu
- Journal Title
  
  Biophysical Journal
  
  Volume: 113 Issue: 7 Pages: 1440-1453
- DOI
  10.1016/j.bpj.2017.08.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Towards synthetic molecular motors: a model elastic-network study2016
- Author(s)
  Amartya Sarkar, Holger Flechsig, Alexander S. Mikhailov
- Journal Title
  
  New Journal of Physics
  
  Volume: 18 Issue: 4 Pages: 043006-043006
- DOI
  10.1088/1367-2630/18/4/043006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Journal Article] Nucleotide-induced conformational dynamics in ABC transporters from structure-based coarse grained modeling2016
- Author(s)
  Holger Flechsig
- Journal Title
  
  Frontiers in Physics
  
  Volume: 4 Pages: 3-3
- DOI
  10.3389/fphy.2016.00003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23115007
[Journal Article] TALEs from a Spring ― Superelasticity of Tal Effector Protein Structures2014
- Author(s)
  Holger Flechsig
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 10 Pages: e109919-e109919
- DOI
  10.1371/journal.pone.0109919
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Understanding of measurement results: Nanoscale modeling and simulations of biomolecular systems2020
- Author(s)
  Holger Flechsig
- Organizer
  1st WPI NanoLSI-iCeMS Joint Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Modeling of myosin V motor dynamics to understand high-speed AFM observations2019
- Author(s)
  Holger Flechsig
- Organizer
  第57回日本生物物理学会年会シンポジウム「生体分子機械の非平衡エナジェティクス」
- Invited
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Modeling of myosin V motor dynamics to understand high-speed AFM observations2019
- Author(s)
  Holger Flechsig
- Organizer
  Joint UBI-NanoLSI workshop - Trends in molecular biophysics of living cells
- Invited
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Understanding of measurement results: Nanoscale modeling and simulations of biomolecular systems2019
- Author(s)
  Holger Flechsig
- Organizer
  8th Bio-AFM Summer School
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Simulation of AFM imaging2018
- Author(s)
  Holger FLECHSIG
- Organizer
  The 7th Bio-AFM Summer School
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Towards synthetic molecular motors - computational model studies of mechanical networks2018
- Author(s)
  Holger FLECHSIG
- Organizer
  The 79th Okazaki Conference: Synthetic, Biological, and Hybrid Molecular Engines
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Modeling of myosin V motor dynamics to understand observations from high-speed AFM experiments2018
- Author(s)
  Holger FLECHSIG
- Organizer
  Workshop "Trends in Computational Molecular Biophysics"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] クロマチン動態プローブ開発2017
- Author(s)
  栃尾尚哉, 川嵜亮祐, 青木大将, 梅原康平, 吉村優一, 上脇隼一, Holger Flechsig, 冨樫祐一, 楯真一
- Organizer
  生命動態システム科学四拠点・CREST・PRESTO・QBiC合同シンポジウム2017“生命動態の分子メカニズムと数理”
- Place of Presentation
  理化学研究所生命システム研究センター（大阪府吹田市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] A generalised structural and dynamical model of allosteric proteins2017
- Author(s)
  Holger Flechsig
- Organizer
  Berlin Center for Studies of Complex Chemical Systems Seminar “Complex Nonlinear Processes in Chemistry and Biology”
- Place of Presentation
  ベルリン工科大学（ドイツ・ベルリン）
- Year and Date
  2017-01-06
- Invited
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Evolutionary designed soft matter systems - model studies to reveal signatures of biological function in protein machines2017
- Author(s)
  Holger Flechsig
- Organizer
  IGER International Symposium on Science of Molecular Assembly and Biomolecular Systems 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Nonlinear relaxation in protein elastic networks and in silico design of synthetic polymer network structures using evolutionary optimization2016
- Author(s)
  Holger Flechsig
- Organizer
  Symposium on “Spatio-temporal Pattern Formation under Nonequilibirum Conditions”
- Place of Presentation
  広島大学理学部（広島県東広島市）
- Year and Date
  2016-02-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] In Silico Design of Simple Polymer Networks: Models of Synthetic Protein Machines2016
- Author(s)
  Holger Flechsig
- Organizer
  The 2nd Hiroshima International Symposium on Future Science
- Place of Presentation
  広島大学理学部（広島県東広島市）
- Year and Date
  2016-03-17
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  生命動態システム科学四拠点・CREST・PRESTO・QBiC合同シンポジウム「生命動態の分子メカニズムと数理」
- Place of Presentation
  シェラトンホテル広島（広島県広島市）
- Year and Date
  2016-03-25
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] A generalized structural and dynamical model of allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  研究会「理論と実験」2016
- Place of Presentation
  広島大学（広島県東広島市）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  NIG International Symposium 2016 “Force, Information and Dynamics: X factors shaping living systems”
- Place of Presentation
  東京大学生産技術研究所（東京都目黒区）
- Year and Date
  2016-01-09
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] A generalized structural and dynamical model of allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  Interdisciplinary Applications of Nonlinear Science
- Place of Presentation
  鹿児島大学（鹿児島県鹿児島市）
- Year and Date
  2016-11-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Evolutionary optimisation of elastic network structures: Models of allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] 少数分子反応系の理論～化学・力学複合ネットワークの理論へ2016
- Author(s)
  中川正基, Holger Flechsig, 新海創也, 冨樫祐一
- Organizer
  新学術領域「少数性生物学」研究成果報告会
- Place of Presentation
  東京大学伊藤謝恩ホール（東京都文京区）
- Year and Date
  2016-03-15
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  International Workshop “New Frontiers in Nonlinear Sciences”
- Place of Presentation
  ホテル甘露の森（北海道虻田郡ニセコ町）
- Year and Date
  2016-03-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  新学術領域「少数性生物学」研究成果報告会
- Place of Presentation
  東京大学伊藤謝恩ホール（東京都文京区）
- Year and Date
  2016-03-15
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Designed Elastic Networks as Models of Allosteric Enzymes2015
- Author(s)
  Holger Flechsig
- Organizer
  新学術領域「少数性生物学」第9回領域会議
- Place of Presentation
  万国津梁館（沖縄県名護市）
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Mechanical properties of transcription activator-like effector proteins2015
- Author(s)
  Holger Flechsig
- Organizer
  4th International Symposium of the Mathematics on Chromatin Live Dynamics
- Place of Presentation
  JMSアステールプラザ（広島県広島市）
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2015
- Author(s)
  Holger Flechsig
- Organizer
  数学協働プログラムワークショップ「生命ダイナミクスの数理とその応用：理論からのさらなる深化」
- Place of Presentation
  東京大学大学院数理科学研究科（東京都目黒区）
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines and motors from coarse-grained modeling2015
- Author(s)
  Holger Flechsig
- Organizer
  The 2015 International Chemical Congress of Pacific Basin Societies, Symposium #137 Life at Small Copy Numbers
- Place of Presentation
  Sheraton Waikiki (Honolulu, HI, USA)
- Year and Date
  2015-12-20
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] 少数分子反応ネットワーク理論の構築 (7)2015
- Author(s)
  冨樫祐一, 小松崎民樹, 李振風, 寺本央, 新海創也, Holger Flechsig, James Nick Taylor, 中川正基
- Organizer
  新学術領域「少数性生物学」第9回領域会議
- Place of Presentation
  万国津梁館（沖縄県名護市）
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational dynamics of molecular machines and motors from coarse-grained elastic network modeling2015
- Author(s)
  Holger Flechsig
- Organizer
  研究会「理論と実験」2015
- Place of Presentation
  広島大学理学部（広島県東広島市）
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines: elastic-network computational studies2014
- Author(s)
  Holger Flechsig
- Organizer
  第52回日本生物物理学会年会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Mechanochemical conformational dynamics of kinesin-like NCD motors from modelling studies2014
- Author(s)
  Holger Flechsig, Yuichi Togashi
- Organizer
  新学術領域「少数性生物学」第7回領域会議
- Place of Presentation
  びわこクラブ（滋賀県）
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational dynamics of molecular machines and motors from coarse-grained elastic network modeling2014
- Author(s)
  Holger Flechsig
- Organizer
  Tutorial talk, Beijing Computational Science Research Center (CSRC)
- Place of Presentation
  Beijing Computational Science Research Center (CSRC) (China)
- Year and Date
  2014-11-19
- Invited
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines: elastic-network computational studies2014
- Author(s)
  Holger Flechsig
- Organizer
  2nd International Symposium of the Mathematics on Chromatin Live Dynamics
- Place of Presentation
  広島大学広仁会館
- Year and Date
  2014-03-11
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] 少数分子反応ネットワーク理論の構築 (6)
- Author(s)
  冨樫祐一, 小松崎民樹, 李振風, 寺本央, 新海創也, James Nick Taylor, Holger Flechsig
- Organizer
  新学術領域「少数性生物学」第8回領域会議・さきがけ「細胞機能の構成的な理解と制御」第6回領域会議・合同シンポジウム
- Place of Presentation
  ルスツリゾート（北海道）
- Year and Date
  2015-01-30 – 2015-02-02
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] 少数分子反応ネットワーク理論の構築 (5)
- Author(s)
  冨樫祐一, 小松崎民樹, 李振風, 寺本央, 新海創也, James Nick Taylor, Holger Flechsig
- Organizer
  新学術領域「少数性生物学」第7回領域会議
- Place of Presentation
  びわこクラブ（滋賀県）
- Year and Date
  2014-06-21 – 2014-06-22
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines: elastic-network computational studies
- Author(s)
  Holger Flechsig
- Organizer
  新学術領域研究「少数性生物学」第6回領域会議
- Place of Presentation
  ヒルトンニセコビレッジ
- Year and Date
  2014-02-21 – 2014-02-22
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines: elastic-network computational studies
- Author(s)
  Holger Flechsig
- Organizer
  研究会「理論と実験」2014
- Place of Presentation
  広島大学理学部（広島県）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PLANNED-23115007

1. TOGASHI Yuichi (50456919)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. KOMATSUZAKI Tamiki (30270549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. LI Chun-Biu (90397795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. TERAMOTO Hiroshi (90463728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. SHINKAI Soya (60547058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. TSUGAWA Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAGAWA Masaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. TAYLOR James N.

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. Mikhailov Alex.S

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Flechsig Holger ＦＬＥＣＨＳＩＧ ＨＯＬＧＥＲ

FLECHSIG HOLGER フレクシグ ホルガー

FLECHSIG Holger

Research Projects

Research Products

Co-Researchers

Modelling of myosin V motor dynamics to understand its ATP-less walking along actin filaments under interactive high-speed AFMPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Design principles of protein structures underlying allosteric regulation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Constructing a theoretical framework to study reaction networks involving a small number of molecules: modeling with consideration of minority and hierarchy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Allosteric communication in molecular machines via information exchange: what can be learned from dynamical modeling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analyzing Fluctuation Properties in Protein Elastic Networks with Sequence-Specific and Distance-Dependent Interactions2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simple mechanics of protein machines2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Designed Elastic Networks: Models of Complex Protein Machinery2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Coarse-Grained Protein Dynamics Studies Using Elastic Network Models2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design of Elastic Networks with Evolutionary Optimized Long-Range Communication as Mechanical Models of Allosteric Proteins2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deciphering Intrinsic Inter-subunit Couplings that Lead to Sequential Hydrolysis of F1-ATPase Ring2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Towards synthetic molecular motors: a model elastic-network study2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleotide-induced conformational dynamics in ABC transporters from structure-based coarse grained modeling2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TALEs from a Spring ― Superelasticity of Tal Effector Protein Structures2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] Understanding of measurement results: Nanoscale modeling and simulations of biomolecular systems2020

Author(s)

Organizer

Data Source

[Presentation] Modeling of myosin V motor dynamics to understand high-speed AFM observations2019

Author(s)

Flechsig Holger ＦＬＥＣＨＳＩＧＨＯＬＧＥＲ

FLECHSIG HOLGER フレクシグホルガー