Flechsig Holger ＦＬＥＣＨＳＩＧＨＯＬＧＥＲ

… Alternative Names

FLECHSIG HOLGER フレクシグホルガー

FLECHSIG Holger

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Researcher Number	00758964
Other IDs
Affiliation (Current)	2025: 金沢大学, ナノ生命科学研究所, 特任准教授
Affiliation (based on the past Project Information) *help	2025: 金沢大学, ナノ生命科学研究所, 特任准教授 2021 – 2023: 金沢大学, ナノ生命科学研究所, 特任助教 2018 – 2019: 金沢大学, ナノ生命科学研究所, 特任助教 2017: 広島大学, 理学研究科, 研究員 2016: 広島大学, 理学研究科, 助教 2015: 広島大学, 大学院理学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 13040:Biophysics, chemical physics and soft matter physics-related Except Principal Investigator Basic Section 28040:Nanobioscience-related / Biological physics/Chemical physics/Soft matter physics / Biological Sciences
Keywords	Principal Investigator molecular simulations / energetics / modelling / molecular dynamics / high-speed AFM / myosin V / molecular motors Except Principal Investigator 構造機能相関 / 生体高分子 / シミュレーション … More / 高速原子間力顕微鏡 / 天然変性タンパク質 / 酵素 / 分子機械 / 蛋白質 / 生体生命情報学 / 生物物理 / 計算生物物理学 / 進化的最適化 / 粗視化分子動力学 / タンパク質 / 分子内情報伝達 / アロステリック制御 / 1分子時系列解析 / Dynamic Disorder / 細胞個性 / 情報幾何学 / 少数性生物学 / 数理モデル化 / １分子時系列解析 / 分子個性・細胞個性 / 複雑ネットワーク / 反応拡散系 / 生物物理学 Less

高速AFMを中心とした統合解析による天然変性タンパク質の動的ナノ構造-機能相関解明
- Principal Investigator
  
  紺野宏記
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Kanazawa University
Modelling of myosin V motor dynamics to understand its ATP-less walking along actin filaments under interactive high-speed AFMPrincipal Investigator
- Principal Investigator
  
  Flechsig Holger
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
- Research Institution
  Kanazawa University
Design principles of protein structures underlying allosteric regulation
- Principal Investigator
  
  Togashi Yuichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological physics/Chemical physics/Soft matter physics
- Research Institution
  Hiroshima University
Constructing a theoretical framework to study reaction networks involving a small number of molecules: modeling with consideration of minority and hierarchy
- Principal Investigator
  
  TOGASHI Yuichi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
  Kobe University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Structural heterogeneity of the ion and lipid channel TMEM16F2024
- Author(s)
  Ye Zhongjie, Galvanetto Nicola, Puppulin Leonardo, Pifferi Simone, Flechsig Holger, Arndt Melanie, Trivino Cesar Adolfo Sanchez, Di Palma Michael, Guo Shifeng, Vogel Horst, Menini Anna, Franz Clemens Martin, Torre Vincento, Marchesi Arin
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 110-110
- DOI
  10.1038/s41467-023-44377-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03483
[Journal Article] Atom Filtering Algorithm and GPU-Accelerated Calculation of Simulation Atomic Force Microscopy Images2024
- Author(s)
  Amyot Romain、Kodera Noriyuki、Flechsig Holger
- Journal Title
  
  Algorithms
  
  Volume: 17 Issue: 1 Pages: 38-38
- DOI
  10.3390/a17010038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-21K03483, KAKENHI-PROJECT-22KF0153
[Journal Article] Dynamics of Target DNA Binding and Cleavage by Staphylococcus aureus Cas9 as Revealed by High-Speed Atomic Force Microscopy2023
- Author(s)
  Puppulin Leonardo、Ishikawa Junichiro、Sumino Ayumi、Marchesi Arin、Flechsig Holger、Umeda Kenichi、Kodera Noriyuki、Nishimasu Hiroshi、Shibata Mikihiro
- Journal Title
  
  ACS Nano
  
  Volume: 17 Issue: 5 Pages: 4629-4641
- DOI
  10.1021/acsnano.2c10709
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K04849, KAKENHI-PROJECT-22K19290, KAKENHI-PROJECT-21H01771, KAKENHI-PUBLICLY-21H00247, KAKENHI-PROJECT-23K23187, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-21K03483
[Journal Article] Structural Dynamics of E6AP E3 Ligase HECT Domain and Involvement of a Flexible Hinge Loop in the Ubiquitin Chain Synthesis Mechanism2023
- Author(s)
  Takeda Kazusa、Flechsig Holger、Muro Ikumi、Amyot Romain、Kobayashi Fuminori、Kodera Noriyuki、Ando Toshio、Konno Hiroki
- Journal Title
  
  Nano Letters
  
  Volume: 23 Issue: 24 Pages: 11940-11948
- DOI
  10.1021/acs.nanolett.3c04150
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KF0153, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-22H00405, KAKENHI-PROJECT-21K03483
[Journal Article] BioAFMviewer software for simulation atomic force microscopy of molecular structures and conformational dynamics2023
- Author(s)
  Amyot Romain、Kodera Noriyuki、Flechsig Holger
- Journal Title
  
  Journal of Structural Biology: X
  
  Volume: 7 Pages: 100086-100086
- DOI
  10.1016/j.yjsbx.2023.100086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KF0153, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-21K03483
[Journal Article] Biophysical Reviews Issue Focus call: Computational biophysics of atomic force microscopy2023
- Author(s)
  Sumikama Takashi、Hall Damien、Flechsig Holger
- Journal Title
  
  Biophysical Reviews
  
  Volume: 15 Issue: 1 Pages: 17-18
- DOI
  10.1007/s12551-023-01048-7
- Data Source
  KAKENHI-PROJECT-21K03483
[Journal Article] Computational biophysics of atomic force microscopy - an IUPAB-sponsored workshop (1st Computational Biophysics of Atomic Force Microscopy Workshop, Kanazawa)2023
- Author(s)
  Hall Damien, Flechsig Holger, Sumikama Takashi
- Journal Title
  
  Biophysical Reviews
  
  Volume: 15 Issue: 6 Pages: 17-18
- DOI
  10.1007/s12551-023-01170-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03483
[Journal Article] Predicting the placement of biomolecular structures on AFM substrates based on electrostatic interactions2023
- Author(s)
  Amyot Romain、Nakamoto Kaho、Kodera Noriyuki、Flechsig Holger
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 10 Pages: 1264161-1264161
- DOI
  10.3389/fmolb.2023.1264161
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KF0153, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-21K03483
[Journal Article] High-speed atomic force microscopy for filming protein molecules in dynamic action2023
- Author(s)
  Ando Toshio, Fukuda Shingo, Ngo Kien Xua, Flechsig Holger
- Journal Title
  
  Annual Review of Biophysics
  
  Volume: 53 Issue: 1 Pages: 1-1
- DOI
  10.1146/annurev-biophys-030722-113353
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03483, KAKENHI-PROJECT-22H00405, KAKENHI-PROJECT-23K27145, KAKENHI-PROJECT-23K05713
[Journal Article] Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy2023
- Author(s)
  Tsujioka Shotaro、Sumino Ayumi、Nagasawa Yutaro、Sumikama Takashi、Flechsig Holger、Puppulin Leonardo、Tomita Takuya、Baba Yudai、Kakuta Takahiro、Ogoshi Tomoki、Umeda Kenichi、Kodera Noriyuki、Murakoshi Hideji、Shibata Mikihiro
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 26
- DOI
  10.1126/sciadv.adh1069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K04849, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-21H01771, KAKENHI-PROJECT-21K03483
[Journal Article] Protein dynamics by the combination of high-speed AFM and computational modeling2023
- Author(s)
  Flechsig Holger、Ando Toshio
- Journal Title
  
  Current Opinion in Structural Biology
  
  Volume: 80 Pages: 102591-102591
- DOI
  10.1016/j.sbi.2023.102591
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00405, KAKENHI-PROJECT-21K03483
[Journal Article] Importance of annexin V N-terminus for 2D crystal formation and quick purification protocol of recombinant annexin V2022
- Author(s)
  Yamada Ryusei、Trang Tran Ngoc、Flechsig Holger、Takeda Toshiki、Kodera Noriyuki、Konno Hiroki
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 12 Pages: e0278553-e0278553
- DOI
  10.1371/journal.pone.0278553
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-21K03483
[Journal Article] Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells2022
- Author(s)
  Biyani Madhu、Yasuda Kaori、Isogai Yasuhiro、Okamoto Yuki、Weilin Wei、Kodera Noriyuki、Flechsig Holger、Sakaki Toshiyuki、Nakajima Miki、Biyani Manish
- Journal Title
  
  ACS Applied Materials, and Interfaces
  
  Volume: 14 Issue: 16 Pages: 18064-18078
- DOI
  10.1021/acsami.1c22965
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05829, KAKENHI-PROJECT-19H02889, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-21H04127, KAKENHI-PROJECT-18K04905, KAKENHI-PROJECT-21K15239, KAKENHI-PROJECT-23K23530, KAKENHI-PROJECT-21K03483
[Journal Article] Simulation atomic force microscopy for atomic reconstruction of biomolecular structures from resolution-limited experimental images2022
- Author(s)
  Romain Amyot, Arin Marchesi, Clemens M Franz, Igancio Casuso, Holger Flechsig
- Journal Title
  
  PLoS Computational Biology
  
  Volume: 18 Issue: 3 Pages: e1009970-e1009970
- DOI
  10.1371/journal.pcbi.1009970
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03483
[Journal Article] Allosteric communication in molecular machines via information exchange: what can be learned from dynamical modeling2020
- Author(s)
  Dimitri Loutchko, Holger Flechsig
- Journal Title
  
  Biophysical Reviews
  
  Volume: － Issue: 2 Pages: 443-452
- DOI
  10.1007/s12551-020-00667-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Analyzing Fluctuation Properties in Protein Elastic Networks with Sequence-Specific and Distance-Dependent Interactions2019
- Author(s)
  Romain Amyot, Yuichi Togashi, Holger Flechsig
- Journal Title
  
  Biomolecules
  
  Volume: 9 Issue: 10 Pages: 549-549
- DOI
  10.3390/biom9100549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Simple mechanics of protein machines2019
- Author(s)
  Flechsig Holger、Mikhailov Alexander S.
- Journal Title
  
  Journal of The Royal Society Interface
  
  Volume: 16 Issue: 155 Pages: 20190244-20190244
- DOI
  10.1098/rsif.2019.0244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K03765, KAKENHI-PROJECT-16K05518
[Journal Article] Designed Elastic Networks: Models of Complex Protein Machinery2018
- Author(s)
  Holger FLECHSIG, Yuichi TOGASHI
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 10 Pages: 3152-3152
- DOI
  10.3390/ijms19103152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Coarse-Grained Protein Dynamics Studies Using Elastic Network Models2018
- Author(s)
  Yuichi TOGASHI, Holger FLECHSIG
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 12 Pages: 3899-3899
- DOI
  10.3390/ijms19123899
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Design of Elastic Networks with Evolutionary Optimized Long-Range Communication as Mechanical Models of Allosteric Proteins2017
- Author(s)
  Holger Flechsig
- Journal Title
  
  Biophysical Journal
  
  Volume: 113 Issue: 3 Pages: 558-571
- DOI
  10.1016/j.bpj.2017.06.043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Deciphering Intrinsic Inter-subunit Couplings that Lead to Sequential Hydrolysis of F1-ATPase Ring2017
- Author(s)
  Liqiang Dai, Holger Flechsig, Jin Yu
- Journal Title
  
  Biophysical Journal
  
  Volume: 113 Issue: 7 Pages: 1440-1453
- DOI
  10.1016/j.bpj.2017.08.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Journal Article] Towards synthetic molecular motors: a model elastic-network study2016
- Author(s)
  Amartya Sarkar, Holger Flechsig, Alexander S. Mikhailov
- Journal Title
  
  New Journal of Physics
  
  Volume: 18 Issue: 4 Pages: 043006-043006
- DOI
  10.1088/1367-2630/18/4/043006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Journal Article] Nucleotide-induced conformational dynamics in ABC transporters from structure-based coarse grained modeling2016
- Author(s)
  Holger Flechsig
- Journal Title
  
  Frontiers in Physics
  
  Volume: 4 Pages: 3-3
- DOI
  10.3389/fphy.2016.00003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23115007
[Journal Article] TALEs from a Spring ― Superelasticity of Tal Effector Protein Structures2014
- Author(s)
  Holger Flechsig
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 10 Pages: e109919-e109919
- DOI
  10.1371/journal.pone.0109919
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Protein dynamics by the combination of high-speed atomic force microscopy and computational modeling2023
- Author(s)
  Flechsig Holger
- Organizer
  61st Annual Meeting of the Biophysical Society Japan, Nagoya
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03483
[Presentation] Protein dynamics by the combination of high-speed atomic force microscopy and computational modeling2023
- Author(s)
  Flechsig Holger
- Organizer
  1st NanoBioCom Conference, Quy Nhon, Vietnam
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03483
[Presentation] Molecular modeling of protein machinery and simulation atomic force microscopy for interpretation of limited-resolution Bio-AFM imaging2022
- Author(s)
  Holger Flechsig
- Organizer
  1st Workshop on Computational Biophysics of Atomic Force Microscopy
- Invited
- Data Source
  KAKENHI-PROJECT-21K03483
[Presentation] Simulation atomic force microscopy2022
- Author(s)
  Holger Flechsig
- Organizer
  5th NanoLSI Symposium - Understanding nanoscale biological processes in the cells
- Invited
- Data Source
  KAKENHI-PROJECT-21K03483
[Presentation] Simulation atomic force microscopy for interpretation and quantitative validation of resolution-limited Bio-AFM imaging2022
- Author(s)
  Holger Flechsig
- Organizer
  AFM BioMed 2022 Nagoya/Okazaki
- Invited
- Data Source
  KAKENHI-PROJECT-21K03483
[Presentation] HFSP progress report2022
- Author(s)
  Holger Flechsig
- Organizer
  HFSP Meeting: Self-organization and biomechanical properties of the endosomal membrane
- Invited
- Data Source
  KAKENHI-PROJECT-21K03483
[Presentation] Simulation atomic force microscopy for analysis of imaging2022
- Author(s)
  Holger Flechsig
- Organizer
  Bio-SPM Summer School 2022, Kanazawa University
- Invited
- Data Source
  KAKENHI-PROJECT-21K03483
[Presentation] Computational microscope towards understanding complex protein machinery in biological cells2021
- Author(s)
  Holger Flechsig
- Organizer
  The 16th Anniversary India-Japan Fest BICON 2021
- Invited
- Data Source
  KAKENHI-PROJECT-21K03483
[Presentation] Simulation atomic force microscopy - a journey below the surface2021
- Author(s)
  Holger Flechsig
- Organizer
  WPI Nano Life Science Institute Open Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-21K03483
[Presentation] Understanding of measurement results: Nanoscale modeling and simulations of biomolecular systems2020
- Author(s)
  Holger Flechsig
- Organizer
  1st WPI NanoLSI-iCeMS Joint Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Modeling of myosin V motor dynamics to understand high-speed AFM observations2019
- Author(s)
  Holger Flechsig
- Organizer
  第57回日本生物物理学会年会シンポジウム「生体分子機械の非平衡エナジェティクス」
- Invited
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Modeling of myosin V motor dynamics to understand high-speed AFM observations2019
- Author(s)
  Holger Flechsig
- Organizer
  Joint UBI-NanoLSI workshop - Trends in molecular biophysics of living cells
- Invited
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Understanding of measurement results: Nanoscale modeling and simulations of biomolecular systems2019
- Author(s)
  Holger Flechsig
- Organizer
  8th Bio-AFM Summer School
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Simulation of AFM imaging2018
- Author(s)
  Holger FLECHSIG
- Organizer
  The 7th Bio-AFM Summer School
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Towards synthetic molecular motors - computational model studies of mechanical networks2018
- Author(s)
  Holger FLECHSIG
- Organizer
  The 79th Okazaki Conference: Synthetic, Biological, and Hybrid Molecular Engines
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Modeling of myosin V motor dynamics to understand observations from high-speed AFM experiments2018
- Author(s)
  Holger FLECHSIG
- Organizer
  Workshop "Trends in Computational Molecular Biophysics"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] クロマチン動態プローブ開発2017
- Author(s)
  栃尾尚哉, 川嵜亮祐, 青木大将, 梅原康平, 吉村優一, 上脇隼一, Holger Flechsig, 冨樫祐一, 楯真一
- Organizer
  生命動態システム科学四拠点・CREST・PRESTO・QBiC合同シンポジウム2017“生命動態の分子メカニズムと数理”
- Place of Presentation
  理化学研究所生命システム研究センター（大阪府吹田市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] A generalised structural and dynamical model of allosteric proteins2017
- Author(s)
  Holger Flechsig
- Organizer
  Berlin Center for Studies of Complex Chemical Systems Seminar “Complex Nonlinear Processes in Chemistry and Biology”
- Place of Presentation
  ベルリン工科大学（ドイツ・ベルリン）
- Year and Date
  2017-01-06
- Invited
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Evolutionary designed soft matter systems - model studies to reveal signatures of biological function in protein machines2017
- Author(s)
  Holger Flechsig
- Organizer
  IGER International Symposium on Science of Molecular Assembly and Biomolecular Systems 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Nonlinear relaxation in protein elastic networks and in silico design of synthetic polymer network structures using evolutionary optimization2016
- Author(s)
  Holger Flechsig
- Organizer
  Symposium on “Spatio-temporal Pattern Formation under Nonequilibirum Conditions”
- Place of Presentation
  広島大学理学部（広島県東広島市）
- Year and Date
  2016-02-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] In Silico Design of Simple Polymer Networks: Models of Synthetic Protein Machines2016
- Author(s)
  Holger Flechsig
- Organizer
  The 2nd Hiroshima International Symposium on Future Science
- Place of Presentation
  広島大学理学部（広島県東広島市）
- Year and Date
  2016-03-17
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  生命動態システム科学四拠点・CREST・PRESTO・QBiC合同シンポジウム「生命動態の分子メカニズムと数理」
- Place of Presentation
  シェラトンホテル広島（広島県広島市）
- Year and Date
  2016-03-25
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] A generalized structural and dynamical model of allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  研究会「理論と実験」2016
- Place of Presentation
  広島大学（広島県東広島市）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  NIG International Symposium 2016 “Force, Information and Dynamics: X factors shaping living systems”
- Place of Presentation
  東京大学生産技術研究所（東京都目黒区）
- Year and Date
  2016-01-09
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] A generalized structural and dynamical model of allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  Interdisciplinary Applications of Nonlinear Science
- Place of Presentation
  鹿児島大学（鹿児島県鹿児島市）
- Year and Date
  2016-11-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] Evolutionary optimisation of elastic network structures: Models of allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16K05518
[Presentation] 少数分子反応系の理論～化学・力学複合ネットワークの理論へ2016
- Author(s)
  中川正基, Holger Flechsig, 新海創也, 冨樫祐一
- Organizer
  新学術領域「少数性生物学」研究成果報告会
- Place of Presentation
  東京大学伊藤謝恩ホール（東京都文京区）
- Year and Date
  2016-03-15
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  International Workshop “New Frontiers in Nonlinear Sciences”
- Place of Presentation
  ホテル甘露の森（北海道虻田郡ニセコ町）
- Year and Date
  2016-03-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2016
- Author(s)
  Holger Flechsig
- Organizer
  新学術領域「少数性生物学」研究成果報告会
- Place of Presentation
  東京大学伊藤謝恩ホール（東京都文京区）
- Year and Date
  2016-03-15
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Designed Elastic Networks as Models of Allosteric Enzymes2015
- Author(s)
  Holger Flechsig
- Organizer
  新学術領域「少数性生物学」第9回領域会議
- Place of Presentation
  万国津梁館（沖縄県名護市）
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Mechanical properties of transcription activator-like effector proteins2015
- Author(s)
  Holger Flechsig
- Organizer
  4th International Symposium of the Mathematics on Chromatin Live Dynamics
- Place of Presentation
  JMSアステールプラザ（広島県広島市）
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Evolutionary optimization of simple polymer networks: Models of synthetic allosteric proteins2015
- Author(s)
  Holger Flechsig
- Organizer
  数学協働プログラムワークショップ「生命ダイナミクスの数理とその応用：理論からのさらなる深化」
- Place of Presentation
  東京大学大学院数理科学研究科（東京都目黒区）
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines and motors from coarse-grained modeling2015
- Author(s)
  Holger Flechsig
- Organizer
  The 2015 International Chemical Congress of Pacific Basin Societies, Symposium #137 Life at Small Copy Numbers
- Place of Presentation
  Sheraton Waikiki (Honolulu, HI, USA)
- Year and Date
  2015-12-20
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] 少数分子反応ネットワーク理論の構築 (7)2015
- Author(s)
  冨樫祐一, 小松崎民樹, 李振風, 寺本央, 新海創也, Holger Flechsig, James Nick Taylor, 中川正基
- Organizer
  新学術領域「少数性生物学」第9回領域会議
- Place of Presentation
  万国津梁館（沖縄県名護市）
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational dynamics of molecular machines and motors from coarse-grained elastic network modeling2015
- Author(s)
  Holger Flechsig
- Organizer
  研究会「理論と実験」2015
- Place of Presentation
  広島大学理学部（広島県東広島市）
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines: elastic-network computational studies2014
- Author(s)
  Holger Flechsig
- Organizer
  第52回日本生物物理学会年会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Mechanochemical conformational dynamics of kinesin-like NCD motors from modelling studies2014
- Author(s)
  Holger Flechsig, Yuichi Togashi
- Organizer
  新学術領域「少数性生物学」第7回領域会議
- Place of Presentation
  びわこクラブ（滋賀県）
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational dynamics of molecular machines and motors from coarse-grained elastic network modeling2014
- Author(s)
  Holger Flechsig
- Organizer
  Tutorial talk, Beijing Computational Science Research Center (CSRC)
- Place of Presentation
  Beijing Computational Science Research Center (CSRC) (China)
- Year and Date
  2014-11-19
- Invited
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines: elastic-network computational studies2014
- Author(s)
  Holger Flechsig
- Organizer
  2nd International Symposium of the Mathematics on Chromatin Live Dynamics
- Place of Presentation
  広島大学広仁会館
- Year and Date
  2014-03-11
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] 少数分子反応ネットワーク理論の構築 (6)
- Author(s)
  冨樫祐一, 小松崎民樹, 李振風, 寺本央, 新海創也, James Nick Taylor, Holger Flechsig
- Organizer
  新学術領域「少数性生物学」第8回領域会議・さきがけ「細胞機能の構成的な理解と制御」第6回領域会議・合同シンポジウム
- Place of Presentation
  ルスツリゾート（北海道）
- Year and Date
  2015-01-30 – 2015-02-02
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] 少数分子反応ネットワーク理論の構築 (5)
- Author(s)
  冨樫祐一, 小松崎民樹, 李振風, 寺本央, 新海創也, James Nick Taylor, Holger Flechsig
- Organizer
  新学術領域「少数性生物学」第7回領域会議
- Place of Presentation
  びわこクラブ（滋賀県）
- Year and Date
  2014-06-21 – 2014-06-22
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines: elastic-network computational studies
- Author(s)
  Holger Flechsig
- Organizer
  新学術領域研究「少数性生物学」第6回領域会議
- Place of Presentation
  ヒルトンニセコビレッジ
- Year and Date
  2014-02-21 – 2014-02-22
- Data Source
  KAKENHI-PLANNED-23115007
[Presentation] Conformational motions in protein machines: elastic-network computational studies
- Author(s)
  Holger Flechsig
- Organizer
  研究会「理論と実験」2014
- Place of Presentation
  広島大学理学部（広島県）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PLANNED-23115007

1. TOGASHI Yuichi (50456919)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. KOMATSUZAKI Tamiki (30270549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. LI Chun-Biu (90397795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. TERAMOTO Hiroshi (90463728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. SHINKAI Soya (60547058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 紺野宏記 (80419267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大橋祐美子 (10422669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TSUGAWA Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKAGAWA Masaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. TAYLOR James N.

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. KODERA Noriyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
12. 梅田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 戸田佳織

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. AMYOT ROMAIN

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
15. 安藤敏夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. Mikhailov Alex.S

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Flechsig Holger ＦＬＥＣＨＳＩＧ ＨＯＬＧＥＲ

FLECHSIG HOLGER フレクシグ ホルガー

FLECHSIG Holger

Research Projects

Research Products

Co-Researchers

高速AFMを中心とした統合解析による天然変性タンパク質の動的ナノ構造-機能相関解明

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Modelling of myosin V motor dynamics to understand its ATP-less walking along actin filaments under interactive high-speed AFMPrincipal Investigator

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Design principles of protein structures underlying allosteric regulation

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Constructing a theoretical framework to study reaction networks involving a small number of molecules: modeling with consideration of minority and hierarchy

Principal Investigator

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Research Institution

[Journal Article] Structural heterogeneity of the ion and lipid channel TMEM16F2024

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[Journal Article] Atom Filtering Algorithm and GPU-Accelerated Calculation of Simulation Atomic Force Microscopy Images2024

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[Journal Article] Dynamics of Target DNA Binding and Cleavage by Staphylococcus aureus Cas9 as Revealed by High-Speed Atomic Force Microscopy2023

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[Journal Article] Structural Dynamics of E6AP E3 Ligase HECT Domain and Involvement of a Flexible Hinge Loop in the Ubiquitin Chain Synthesis Mechanism2023

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[Journal Article] BioAFMviewer software for simulation atomic force microscopy of molecular structures and conformational dynamics2023

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[Journal Article] Biophysical Reviews Issue Focus call: Computational biophysics of atomic force microscopy2023

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[Journal Article] Computational biophysics of atomic force microscopy - an IUPAB-sponsored workshop (1st Computational Biophysics of Atomic Force Microscopy Workshop, Kanazawa)2023

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[Journal Article] Predicting the placement of biomolecular structures on AFM substrates based on electrostatic interactions2023

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[Journal Article] High-speed atomic force microscopy for filming protein molecules in dynamic action2023

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[Journal Article] Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy2023

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Flechsig Holger ＦＬＥＣＨＳＩＧＨＯＬＧＥＲ

FLECHSIG HOLGER フレクシグホルガー