Nagano Masanobu 長野正展

… Alternative Names

長野正展ナガノマサノブ

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Researcher Number	00771619
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院総合文化研究科, 特任助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 東京大学, 大学院総合文化研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Transformative Research Areas, Section (II)
Keywords	Principal Investigator 化合物ライブラリー / 低分子 / 植物タンパク質 / 抗体 / キャピラリー電気泳動 / DEL Except Principal Investigator 核酸アプタマー / 精密合成高分子 / 核酸医薬 / 低分子薬 … More / トロンビン / 高感度分析 / 血液凝固 / アプタマー / 血液凝固疾患 / 創薬 / 合成高分子 / 分子進化工学 / 核酸 Less

Precision macromolecular evolution system combined use of nucleic acid and high-precision separation methods
- Principal Investigator
  
  吉本敬太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
Selection of small molecules modulating endogenous antibodiesPrincipal Investigator
- Principal Investigator
  
  長野正展
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  The University of Tokyo

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice2023
- Author(s)
  Masanobu Nagano , Kazuki Kubota , Asuka Sakata , Rei Nakamura , Toru Yoshitomi , Koji Wakui , Keitaro Yoshimoto
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: - Pages: 762-772
- DOI
  10.1016/j.omtn.2023.07.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06450, KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05049
[Journal Article] Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide2023
- Author(s)
  Troisi Romualdo、Napolitano Valeria、Rossitto Emanuele、Osman Waleed、Nagano Masanobu、Wakui Koji、Popowicz Grzegorz?M、Yoshimoto Keitaro、Sica Filomena
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 16 Pages: 8880-8890
- DOI
  10.1093/nar/gkad634
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05049
[Journal Article] Discovery of a Highly Specific Anti-methotrexate (MTX) DNA Aptamer for Antibody-Independent MTX Detection2022
- Author(s)
  Nagano Masanobu、Toda Takumi、Makino Kurumi、Miki Hiroko、Sugizaki Yoshiaki、Tomizawa Hideyuki、Isobayashi Atsunobu、Yoshimoto Keitaro
- Journal Title
  
  Analytical Chemistry
  
  Volume: 94 Issue: 49 Pages: 17255-17262
- DOI
  10.1021/acs.analchem.2c04182
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05049
[Journal Article] Evaluation of G-quartet-forming deoxyguanines in antiparallel G-quadruplexes using optical spectroscopy and deoxyguanine-to-deoxythymidine scanning2022
- Author(s)
  Nagano Masanobu、Nakano Sosuke、Yoshimoto Keitaro
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 658 Pages: 114903-114903
- DOI
  10.1016/j.ab.2022.114903
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05049
[Presentation] 微粒子支援型キャピラリー電気泳動を用いたタンパク質-低分子相互作用の分離能評価2021
- Author(s)
  大河内遼, 長野正展, 吉本敬太郎
- Organizer
  第9回Chem-Bio Joint Seminar
- Data Source
  KAKENHI-PROJECT-21K06450
[Presentation] 核酸タグ付き低分子ライブラリーのヒット化合物探索への微粒子支援型キャピラリー電気泳動の応用2021
- Author(s)
  大河内遼, 長野正展, 吉本敬太郎
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K06450
[Presentation] 微粒子支援型キャピラリー電気泳動を用いたタンパク質-低分子相互作用の分離能評価2021
- Author(s)
  大河内遼, 長野正展, 吉本敬太郎
- Organizer
  第70回日本分析化学会
- Data Source
  KAKENHI-PROJECT-21K06450

1. 吉本敬太郎 (60392172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 坂田飛鳥 (90528457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松尾宗征 (90869025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nagano Masanobu 長野 正展

長野 正展 ナガノ マサノブ

Research Projects

Research Products

Co-Researchers

Precision macromolecular evolution system combined use of nucleic acid and high-precision separation methods

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Selection of small molecules modulating endogenous antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of a Highly Specific Anti-methotrexate (MTX) DNA Aptamer for Antibody-Independent MTX Detection2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of G-quartet-forming deoxyguanines in antiparallel G-quadruplexes using optical spectroscopy and deoxyguanine-to-deoxythymidine scanning2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] 微粒子支援型キャピラリー電気泳動を用いたタンパク質-低分子相互作用の分離能評価2021

Author(s)

Organizer

Data Source

[Presentation] 核酸タグ付き低分子ライブラリーのヒット化合物探索への微粒子支援型キャピラリー電気泳動の応用2021

Author(s)

Organizer

Data Source

[Presentation] 微粒子支援型キャピラリー電気泳動を用いたタンパク質-低分子相互作用の分離能評価2021

Author(s)

Organizer

Data Source

Nagano Masanobu 長野正展

長野正展ナガノマサノブ