Nakazawa Tsutomu 中澤務

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Nakzawa Tsutomu 中澤務

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Researcher Number	00772500
Other IDs	https://orcid.org/0000-0003-4286-9356
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2016 – 2023: 奈良県立医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related / Neurosurgery Except Principal Investigator Basic Section 56010:Neurosurgery-related / Neurosurgery
Keywords	Principal Investigator CRISPR/Cas9 / 膠芽腫 / CAR / HIF1α / 低酸素 / HIF-1α / NK細胞 / Glioma / CAR-T / EGFRｖIII … More / EGFRvIII / CRISPR/Cas / PD-1 / T細胞 / iPS細胞 / 遺伝子免疫細胞治療 … More Except Principal Investigator NK細胞 / 膠芽腫 / glioblastoma / natural killer cell / immunotherapy / Natural killer cell / ナチュラルキラー細胞 / キメラ抗原受容体 / 臍帯血 / chimeric antigen / cord blood cell / 悪性髄膜腫 / がん免疫 / 髄膜腫 / ICI / NK cells / 糖化PEG修飾型抗PD-L1抗体 / マウス膠芽腫細胞株 / Ischemic stroke / Mesenchymal stem cells / ischemic stroke / exosome / mesencymal stem cells / チェックポイント阻害 / チェックポインント阻害 / KIR / immune checkpoint / 細胞免疫療法 / iPS由来NK細胞 / EGFRvIII特異的CAR / iPS cell / EGFRvIII-CAR / natural killer 細胞 / EGFRvIII / CAR 遺伝子 / iPS / 免疫チェックポインント阻害剤 / 脳腫瘍 / 脳神経疾患 / PD-1 / NOGマウス / 化学療法 / チェックポイント阻害剤 / 抗PD-1抗体 / γδT細胞 / anti PD-1 antibody Less

Development of multidisciplinary immunotherapy utilizing NK cells in combination with PEG-conjugated immune checkpoint antibodies
- Principal Investigator
  
  前岡良輔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nara Medical University
悪性髄膜腫に対する末梢血および臍帯血由来NK細胞を用いた免疫細胞療法の開発
- Principal Investigator
  
  松田良介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nara Medical University
臍帯血由来CAR-NK細胞による膠芽腫治療法の開発
- Principal Investigator
  
  西村文彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nara Medical University
チェックポイント分子HIF1αをゲノム編集したNK細胞による膠芽腫治療法の開発Principal Investigator
- Principal Investigator
  
  中澤務
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nara Medical University
Adipose tissue-derived mesenchymal stem cells and mesenchymal stem cells-derived exosome for treatment of rat ischemic stroke.
- Principal Investigator
  
  中瀬裕之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nara Medical University
Combination Therapy of NK Cells and Novel Immune Checkpoint Inhibition for Glioblastoma
- Principal Investigator
  
  Matsuda Ryosuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nara Medical University
Development of PD-1 gene-disrupted EGFRvIII-specific CAR-T cell-based immunotherapy against glioblastomaPrincipal Investigator
- Principal Investigator
  
  Nakazawa Tsutomu
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nara Medical University
Basic study of CAR-NK cell therapy derived from iPS cells.
- Principal Investigator
  
  Nakase Hiroyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nara Medical University
Combined therapy with natural killer cell and anti PD-1 antibody for glioblastoma
- Principal Investigator
  
  Ryosuke Matsuda
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Nara Medical University
Novel therapeutic approach for glioblastoma with iPS cells-derived CAR-T cellsPrincipal Investigator
- Principal Investigator
  
  Nakzawa Tsutomu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Nara Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Antitumor Effects of Intravenous Natural Killer Cell Infusion in an Orthotopic Glioblastoma Xenograft Murine Model and Gene Expression Profile Analysis2024
- Author(s)
  Morimoto Takayuki、Nakazawa Tsutomu、Matsuda Ryosuke、Maeoka Ryosuke、Nishimura Fumihiko、Nakamura Mitsutoshi、Yamada Shuichi、Park Young-Soo、Tsujimura Takahiro、Nakagawa Ichiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 4 Pages: 2435-2435
- DOI
  10.3390/ijms25042435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16667, KAKENHI-PROJECT-22K09213
[Journal Article] Bulk RNA sequencing reveals the comprehensive genetic characteristics of human cord blood-derived natural killer cells2024
- Author(s)
  Morimoto Takayuki、Nakazawa Tsutomu、Maeoka Ryosuke、Matsuda Ryosuke、Nakamura Mitsutoshi、Nishimura Fumihiko、Yamada Shuichi、Nakagawa Ichiro、Park Young-Soo、Tsujimura Takahiro
- Journal Title
  
  Regenerative Therapy
  
  Volume: 25 Pages: 367-376
- DOI
  10.1016/j.reth.2024.02.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16667, KAKENHI-PROJECT-22K09213, KAKENHI-PROJECT-23K08550
[Journal Article] An efficient feeder-free and chemically-defined expansion strategy for highly purified natural killer cells derived from human cord blood2023
- Author(s)
  Nakazawa Tsutomu、Maeoka Ryosuke、Morimoto Takayuki、Matsuda Ryosuke、Nakamura Mitsutoshi、Nishimura Fumihiko、Yamada Shuichi、Nakagawa Ichiro、Park Young-Soo、Ito Toshihiro、Nakase Hiroyuki、Tsujimura Takahiro
- Journal Title
  
  Regenerative Therapy
  
  Volume: 24 Pages: 32-42
- DOI
  10.1016/j.reth.2023.05.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09213
[Journal Article] CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma2023
- Author(s)
  Nakazawa Tsutomu、Morimoto Takayuki、Maeoka Ryosuke、Matsuda Ryosuke、Nakamura Mitsutoshi、Nishimura Fumihiko、Ouji Noriko、Yamada Shuichi、Nakagawa Ichiro、Park Young Soo、Ito Toshihiro、Nakase Hiroyuki、Tsujimura Takahiro
- Journal Title
  
  Journal of Experimental & Clinical Cancer Research
  
  Volume: 42 Issue: 1 Pages: 205-205
- DOI
  10.1186/s13046-023-02770-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09213
[Journal Article] Intraoperative Ventricular Opening has No Effect on Complication Development Following BCNU Wafer Implantation for Malignant Glioma2023
- Author(s)
  Matsuda Ryosuke、Maeoka Ryosuke、Tokuda Noriaki、Nakazawa Tsutomu、Morimoto Takayuki、Kotsugi Masashi、Takeshima Yasuhiro、Tamura Kentaro、Yamada Shuichi、Nishimura Fumihiko、Nakagawa Ichiro、Park Young-Soo、Nakase Hiroyuki
- Journal Title
  
  World Neurosurgery
  
  Volume: 171 Pages: e707-e713
- DOI
  10.1016/j.wneu.2022.12.090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09213
[Journal Article] Therapeutic Anti-KIR Antibody of 1?7F9 Attenuates the Antitumor Effects of Expanded and Activated Human Primary Natural Killer Cells on In Vitro Glioblastoma-like Cells and Orthotopic Tumors Derived Therefrom2023
- Author(s)
  Maeoka Ryosuke、Nakazawa Tsutomu、Matsuda Ryosuke、Morimoto Takayuki、Shida Yoichi、Yamada Shuichi、Nishimura Fumihiko、Nakamura Mitsutoshi、Nakagawa Ichiro、Park Young-Soo、Tsujimura Takahiro、Nakase Hiroyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 18 Pages: 14183-14183
- DOI
  10.3390/ijms241814183
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09213
[Journal Article] Natural Killer Cell-Based Immunotherapy against Glioblastoma2023
- Author(s)
  Morimoto Takayuki、Nakazawa Tsutomu、Maeoka Ryosuke、Nakagawa Ichiro、Tsujimura Takahiro、Matsuda Ryosuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 3 Pages: 2111-2111
- DOI
  10.3390/ijms24032111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09213, KAKENHI-PROJECT-20K09353, KAKENHI-PROJECT-22K16667
[Journal Article] Establishment of an efficient ex?vivo expansion strategy for human natural killer cells stimulated by defined cytokine cocktail and antibodies against natural killer cell activating receptors2022
- Author(s)
  Nakazawa Tsutomu、Morimoto Takayuki、Maeoka Ryosuke、Matsuda Ryosuke、Nakamura Mitsutoshi、Nishimura Fumihiko、Yamada Shuichi、Nakagawa Ichiro、Park Young-Soo、Nakase Hiroyuki、Tsujimura Takahiro
- Journal Title
  
  Regenerative Therapy
  
  Volume: 21 Pages: 185-191
- DOI
  10.1016/j.reth.2022.07.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09213
[Journal Article] Capability of Human Dendritic Cells Pulsed with Autologous Induced Pluripotent Stem Cell Lysate to Induce Cytotoxic T Lymphocytes against HLA-A33-Matched Cancer Cells2022
- Author(s)
  Nakazawa Tsutomu、Maeoka Ryosuke、Morimoto Takayuki、Matsuda Ryosuke、Nakamura Mitsutoshi、Nishimura Fumihiko、Yamada Shuichi、Nakagawa Ichiro、Park Young-Soo、Nakase Hiroyuki、Tsujimura Takahiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 21 Pages: 12992-12992
- DOI
  10.3390/ijms232112992
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09213
[Journal Article] Combined Treatment With Radiotherapy and Immunotherapy for Isocitrate Dehydrogenase Mutant Brainstem Glioma in Adult: A Case Report2022
- Author(s)
  Morimoto Takayuki、Matsuda Ryosuke、Nakazawa Tsutomu、Nishimura Fumihiko、Nakagawa Ichiro
- Journal Title
  
  Brain Tumor Research and Treatment
  
  Volume: 10 Issue: 2 Pages: 129-129
- DOI
  10.14791/btrt.2022.0009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09213
[Journal Article] CRISPR-Cas9?Mediated TIM3 Knockout in Human Natural Killer Cells Enhances Growth Inhibitory Effects on Human Glioma Cells2021
- Author(s)
  Morimoto Takayuki、Nakazawa Tsutomu、Matsuda Ryosuke、Nishimura Fumihiko、Nakamura Mitsutoshi、Yamada Shuichi、Nakagawa Ichiro、Park Young-Soo、Tsujimura Takahiro、Nakase Hiroyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 7 Pages: 3489-3489
- DOI
  10.3390/ijms22073489
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02915
[Journal Article] Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on in vitro Human Glioblastoma Cell Growth2020
- Author(s)
  Nakazawa T, Nishimura F, Matsuda R, Nakamura M, Nakase H et al.
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 4 Pages: 998-1017
- DOI
  10.3390/cells9040998
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02915, KAKENHI-PROJECT-18K16567
[Journal Article] KHYG-1 Cells With EGFRvIII-specific CAR Induced a Pseudoprogression-like Feature in Subcutaneous Tumours Derived from Glioblastoma-like Cells2020
- Author(s)
  NAKAZAWA TSUTOMU、MURAKAMI TOSHIHARU、NATSUME ATSUSHI、NISHIMURA FUMIHIKO、MORIMOTO TAKAYUKI、MATSUDA RYOSUKE、NAKAMURA MITSUTOSHI、YAMADA SHUICHI、NAKAGAWA ICHIRO、PARK YOUNG-SOO、MOTOYAMA YASUSHI、TSUJIMURA TAKAHIRO、WAKABAYASHI TOSHIHIKO、NAKASE HIROYUKI
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 6 Pages: 3231-3237
- DOI
  10.21873/anticanres.14304
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02915
[Journal Article] Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer.2019
- Author(s)
  Omoto K, Matsuda R, Nakai Y, Tatsumi Y, Nakazawa T, Tanaka Y, Shida Y, Murakami T, Nishimura F, Nakagawa I, Motoyama Y, Nakamura M, Fujimoto K, Hiroyuki N.
- Journal Title
  
  Photodiagnosis Photodyn Ther
  
  Volume: 25 Pages: 309-316
- DOI
  10.1016/j.pdpdt.2019.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16567, KAKENHI-PROJECT-18H02915
[Journal Article] Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro2019
- Author(s)
  Tanaka Y, Nakazawa T, Nakamura M, Nishimura F, Matsuda R, Omoto K, Shida Y, Murakami T, Nakagawa I, Motoyama Y, Morita H, Tsujimura T, Nakase H
- Journal Title
  
  PLoS One
  
  Volume: 6 Pages: 1-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10768
[Journal Article] Risk of brain herniation after craniotomy with lumbar spinal drainage: a propensity score analysis.2019
- Author(s)
  Yasushi Motoyama
- Journal Title
  
  Journal of Neurosurgery
  
  Volume: 130 Issue: 5 Pages: 1710-1720
- DOI
  10.3171/2017.12.jns172215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10904, KAKENHI-PROJECT-18K16567
[Journal Article] Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.2019
- Author(s)
  Tanaka Y, Nakazawa T(corresponding author), Nakamura M, Nishimura F, Matsuda R, Omoto K, Shida Y, Murakami T, Nakagawa I, Motoyama Y, Morita H, Tsujimura T, Nakase H.
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 3 Pages: e0212455-e0212455
- DOI
  10.1371/journal.pone.0212455
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16567, KAKENHI-PROJECT-18H02915
[Journal Article] Novel Human NK Cell Line Carrying CAR Targeting EGFRvIII Induces Antitumor Effects in Glioblastoma Cells.2018
- Author(s)
  Murakami T, Nakazawa T(equally contribution), Natsume A, Nishimura F, Nakamura M, Matsuda R, Omoto K, Tanaka Y, Shida Y, Park YS, Motoyama Y, Nakagawa I, Yamada S, Tamura K, Takeshima Y, Takamura Y,
- Journal Title
  
  Anticancer Res
  
  Volume: 38 Issue: 9 Pages: 5049-5056
- DOI
  10.21873/anticanres.12824
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16567, KAKENHI-PLANNED-17H06356, KAKENHI-PROJECT-18H02915, KAKENHI-PROJECT-16K10767, KAKENHI-PROJECT-16K10768
[Journal Article] Antitumor effects of minodronate, a third-generation nitrogen-containing bisphosphonate, in synergy with γδT cells in human glioblastoma in vitro and in vivo.2016
- Author(s)
  Nakazawa T, Nakamura M, Matsuda R, Nishimura F, Park YS, Motoyama Y, Hironaka Y, Nakagawa I, Yokota H, Yamada S, Tamura K, Takeshima Y, Omoto K, Tanaka Y, Ouji Y, Yoshikawa M, Tsujimura T, Nakase H.
- Journal Title
  
  J Neurooncol
  
  Volume: 129 Issue: 2 Pages: 231-241
- DOI
  10.1007/s11060-016-2186-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05482, KAKENHI-PROJECT-26462188, KAKENHI-PROJECT-16K10133, KAKENHI-PROJECT-16K10768, KAKENHI-PROJECT-16K20022
[Journal Article] Minodronic Acid in Combination with γδT Cells Induces Apoptosis of Non-small Cell Lung Carcinoma Cell Lines.2016
- Author(s)
  Yasukawa M, Nakazawa T, Kawaguchi T, Kawai N, Tsujimura T, Tojo T, Taniguchi S.
- Journal Title
  
  Anticancer Research
  
  Volume: 36 Pages: 5883-5886
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K20022
[Journal Article] Tumor-Inhibition Effect of Levetiracetam in Combination with Temozolomide in Glioblastoma Cells2016
- Author(s)
  Marutani A., Nakamura M., Nishimura F., Nakazawa T., Matsuda R., Hironaka Y., Nakagawa I., Tamura K., Takeshima Y., Motoyama Y., Park Y-S, Ouji Y., Yoshikawa M., Nakase H.
- Journal Title
  
  Neurochemical Journal
  
  Volume: Volume10, No4 Issue: 1 Pages: 333-339
- DOI
  10.1134/s1819712416040073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462188, KAKENHI-PROJECT-16K20022, KAKENHI-PROJECT-16K10768
[Presentation] Efficient feeder-free expansion system for highly purified NK cells derived from human cord blood2024
- Author(s)
  中澤務 , 森本尭之, 前岡良輔, 松田良介, 西村文彦, 中村光利 , 山田修一, 中川一郎, 辻村貴弘
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K08550
[Presentation] 膠芽腫モデルに対する NK 細胞の抗腫瘍効果の検証と抗 KIR2DL1 抗体の影響2023
- Author(s)
  前岡良輔、中澤務、森本尭之、松田良介、西村文彦、中村光利、山田修一、中川一郎、辻村貴弘、中瀬裕之
- Organizer
  第41回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] CISノックアウトヒト同種NK細胞の膠芽腫に対する抗腫瘍効果2023
- Author(s)
  中澤務、前岡良輔、森本尭之、松田良介、中村光利、辻村貴弘
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] valuation of Comprehensive Gene Expression and NK Cell-Mediated Killing in Glioblastoma Cell Line-Derive spheroids.2023
- Author(s)
  森本尭之、中澤務、松田良介、西村文彦、中村光利、山田修一、中川一郎、朴永銖、辻村貴弘、中瀬裕之
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] CIS deletion with CRISPR/Cas9 enhances primary human NK cell functions against allogeneic GBM cells2023
- Author(s)
  中澤務、前岡良輔、森本尭之、松田良介、中村光利、西村文彦、山田修一、中川一郎、中瀬裕之、辻村貴弘
- Organizer
  第22回日本再生医療学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] Targeting a checkpoint molecule enhances human NK cell functions against allogeneic glioblastoma.2023
- Author(s)
  中澤務、前岡良輔、森本尭之、松田良介、中村光利、西村文彦、山田修一、中川一郎、辻村貴弘
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] 膠芽腫に対するNK細胞療法の研究開発　- オールドルーキーの帰還 -2023
- Author(s)
  膠芽腫に対するNK細胞療法の研究開発　- オールドルーキーの帰還 - 前岡良輔、中澤務、松田良介、中村光利、山田修一、辻村貴弘、中川
- Organizer
  日本脳神経外科学会第82回学術総会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] Natural killer 細胞を用いた膠芽腫に対する細胞移植治療の基礎的研究2022
- Author(s)
  松田良介、中澤務、森本尭之、至田洋一、前岡良輔、西村文彦、中川一郎、辻村貴弘、中瀬裕之
- Organizer
  第22回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] 膠芽腫スフェロイドモデルにおける遺伝子発現解析とNK細胞の傷害活性についての検討2022
- Author(s)
  森本尭之, 中澤務, 松田良介, 西村文彦, 中村光利, 山田修一, 中川一郎, 朴永銖, 辻村貴弘, 中瀬裕之
- Organizer
  第40回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] Ablation of the intracellular immune checkpoint molecule CIS potentiates antitumor effects against glioblastoma by unleashing the functions of NK cells derived from human peripheral blood.2022
- Author(s)
  Nakazawa T, Morimoto T, Maeoka R, Matsuda R, Nishimura F, Nakamura M, Yamada S, Nakagawa I, Park YS, Tsujimura T, Nakase H.
- Organizer
  The 51st Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] Anti-tumor effect of genuine induced natural killer cells for glioblastoma in vitro and vivo study2022
- Author(s)
  松田良介　中澤務　前岡良輔　森本尭之　至田洋一　西村文彦　中川一郎　辻村貴弘　中瀬裕之
- Organizer
  第26回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-20K09353
[Presentation] Anti-tumor effect of genuine induced natural killer cells for glioblastoma in vitro and vivo study2022
- Author(s)
  松田良介、中澤務、森本尭之、前岡良輔、西村文彦、中川一郎、辻村貴弘、中瀬裕之
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] CIS deletion by CRISPR/Cas9 enhances human NK cell-mediated antitumor effects in glioblastoma2022
- Author(s)
  前岡良輔、中澤務、森本尭之、松田良介、西村文彦、中村光利、山田修一、中川一郎、辻村貴弘、中瀬裕之
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] CRISPR/Cas9を用いたCIS欠損NK細胞の膠芽腫に対する抗腫瘍効果の検討2022
- Author(s)
  前岡良輔, 中澤務, 森本尭之, 松田良介, 西村文彦, 中川一郎, 辻村貴弘, 中瀬裕之
- Organizer
  第40回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09213
[Presentation] Effect of CRISPR/Cas9-mediated PD-1-disrupted primary human third-generation CAR-T cells targeting EGFRvIII on human glioblastoma cell growth2020
- Author(s)
  Nakazawa T, Natsume A, Nishimura F, Matsuda R, Murakami T, Nakagawa I, Motoyama Y, Park YS, Tsujimura T, Wakabayashi T, Nakase H
- Organizer
  American Association of Immunology (AAI) 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16567
[Presentation] Characterization of a novel type NK cell line KHYG-1 carrying EGFRvIII-specific CAR in glioblastoma cells2020
- Author(s)
  Morimoto T, Nakazawa T, Natsume A, Nishimura F, Matsuda R, Murakami T, Nakagawa I, Motoyama Y, Park YS, Tsujimura T, Wakabayashi T, Nakase H
- Organizer
  American Association of Immunology (AAI) 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16567
[Presentation] Novel human NK cell line carrying CAR Targeting EGFRvIII Induces antitumor effects in glioblastoma cells2019
- Author(s)
  Murakami T, Nakazawa T, Nishimira F, Natsume A, Wakabayashi T, Nakase H
- Organizer
  European Association for Cancer Research: Defence is the Best Attack: Immuno-Oncology Breakthroughs
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16567
[Presentation] Capability of dendritic cells loaded with induced-pluripotent stem cells to induce cancer-responsive T cells from a donor with HLA class I-A33 alleles in vitro.2019
- Author(s)
  Nakazawa T, Nishimura F, Matsuda R, Yamashita Y, Nakamura M, Nakagawa I, Motoyama Y, Tsujimura T, Nakase H.
- Organizer
  European Association for Cancer Research: Defence is the Best Attack: Immuno-Oncology Breakthroughs
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16567
[Presentation] Capability of dendritic cells loaded with induced-pluripotent stem cells to induce cancer-responsive T cells from a donor with HLA class I-A33 alleles in vitro2019
- Author(s)
  Nakazawa T, Nishimura F, Matsuda R, Nakamura M, Nakase H et al.
- Organizer
  European Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02915
[Presentation] Novel Human NK Cell Line Carrying CAR Targeting EGFRvIII Induces Antitumor Effects in Glioblastoma Cells2019
- Author(s)
  Murakami T, Nakazawa T, Nishimura F, Natsume A, Wakabayashi T, Nakase H
- Organizer
  European Association for Cancer Research: Defence is the Best Attack: Immuno-Oncology Breakthroughs
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10768
[Presentation] Establishment of an efficient ex-vivo expansion method for highly purified human natural killer cells and evaluation of their antitumor activity on glioblastoma2019
- Author(s)
  Nakazawa T, Nakamura M, Nishimura F, Matsuda R, Nakase H et al.
- Organizer
  Keystone Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02915
[Presentation] Establishment of an efficient ex-vivo expansion method for highly purified human natural killer cells and evaluation of their antitumor activity on glioblastoma2019
- Author(s)
  Tsutomu Nakazawa, Yoshitaka Tanaka, Yoichi Shida ,Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Takahiro Tsujimura, Hiroyuki Nakase
- Organizer
  Keystone symposia Innate and Non-Classical Immune Cell in Cancer Immunotherapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10768
[Presentation] Establishment of an efficient ex-vivo expansion method for highly purified human natural killer cells and evaluation of their antitumor activity on glioblastoma.2019
- Author(s)
  Nakazawa T, Tanaka Y, Shida Y, Nakamura M, Nishimura F, Matsuda R, Murakami T, Nakagawa I, Motoyama Y, Tsujimura T, Nakase H.
- Organizer
  Keystone Symposia: Innate and Non-Classical Immune Cells in Cancer Immunotherapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16567
[Presentation] 膠芽腫に対する高純度NK細胞と免疫チェックポイント阻害薬併用による抗腫瘍効果の検討2019
- Author(s)
  至田洋一、中澤務、中村光利、辻村貴弘、森本尭之、田中祥貴、村上敏春、尾本幸治、松田良介、中川一郎、西村文彦、本山靖、朴永銖、中瀬裕之
- Organizer
  第20回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-18K16567
[Presentation] Establishment of highly purified human natural killer cells and evaluation of their antitumor activity on glioblastoma2019
- Author(s)
  松田良介、中澤務、田中祥貴、至田洋一、中村光利、西村文彦、村上敏春、中川一郎、本山靖、辻村貴弘、中瀬裕之
- Organizer
  第23回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K16567
[Presentation] Capability of dendritic cells loaded with inducedpluripotent stem cells to induce cancer-responsive T cells from a donor with HLA class I-A33 in vitro2019
- Author(s)
  Tsutomu Nakazawa, Fumihiko Nishimura, Ryosuke Matsuda, Mitsutoshi Nakamura, Yaeko Yamashita, Ichiro Nakagawa, Yasushi Motoyama, Takahiro Tsujimura, Hiroyuki Nakase
- Organizer
  European Association for Cancer Research: Defence is the Best Attack: Immuno-Oncology Breakthroughs
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10768
[Presentation] Anti-tumor effect of minodronate, a third-generation nitrogen-containing bisphosphonate, in synergy with γδT cells, in human glioblastoma invitro and in vivo2018
- Author(s)
  Nakazawa T, Nakamura M, Matsuda R, Nishimura F, Park YS, Motoyama Y, Nakagawa I, Yokota H, Yamada S, Tamura K, Takeshima Y, Omoto K, Tanaka Y, Shida Y, Murakami T Takanabe R, Tsujimura T, Nakase H
- Organizer
  The AACR Special Conference on Immunobiology of Primary and Metastatic CNS Cancer
- Data Source
  KAKENHI-PROJECT-16K10768
[Presentation] Antitumor effects of minodronate, a third-generation nitrogen-containing bisphosphonate, in synergy with γδT cells in human glioblastoma in vitro and in vivo.2018
- Author(s)
  Nakazawa T, Nakamura M, Matsuda R, Nishimura F, Nakase H et al.
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02915
[Presentation] Antitumor effects of minodronate, a third-generation nitrogen-containing bisphosphonate, in synergy with γδT cells, in human glioblastoma in vitro and in vivo2018
- Author(s)
  Tsutomu Nakazawa, Mitsutoshi Nakamura, Ryosuke Matsuda, Fumihiko Nishimura, Young Soo Park, Yasushi Motoyama, Ichiro Nakagawa, Hiroshi Yokota, Shuichi Yamada, Kentaro Tamura, Yasuhiro Takeshima, Kouji Omoto, Yoshitaka Tanaka, Youichi Shida, Toshiharu Murakami, Rieko Takanabe, Takahiro Tsujimura, Hiroyuki Nakase
- Organizer
  The AACR Special Conference on Immunobiology of Primary and Metastatic CNS Cancer
- Data Source
  KAKENHI-PROJECT-16K20022
[Presentation] Novel human NK cell line carrying CAR targeting EGFRvIII induces antitumor effects in glioblastoma cells in vitro2018
- Author(s)
  村上敏春、中澤　務、夏目敦至、西村文彦、中村光利、松田良介、至田洋一、朴　永銖、本山　靖、中川一郎、山田修一、田村健太郎、竹島靖浩、高村慶旭、若林俊彦、中瀬裕之
- Organizer
  第19回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-16K10768
[Presentation] Novel human NK cell line carrying CAR targeting EGFRvIII induces antitumor effects in glioblastoma cells in vitro2018
- Author(s)
  村上敏春、中澤務、夏目敦至、西村文彦、中村光利、松田良介、至田洋一、朴永銖、本山靖、中川一郎、山田修一、田村健太郎、竹島靖浩、高村慶旭、若林俊彦、中瀬裕之
- Organizer
  第19回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-18K16567
[Presentation] 高純度NK細胞を用いた膠芽腫細胞に対する抗腫瘍効果とTMZを用いた併用効果の基礎的検討2017
- Author(s)
  田中祥貴族、中澤務、中村光利、辻村貴弘、竹島靖浩、松田良介、田村健太郎、山田修一、中川一郎、西村文彦、横田浩、本山靖、朴永銖、中瀬裕之
- Organizer
  第14回日本免疫治療学研究会学術集会
- Place of Presentation
  東京大学伊藤国際学術研究センター
- Year and Date
  2017-02-11
- Data Source
  KAKENHI-PROJECT-16K10768
[Presentation] 高純度NK細胞を用いた膠芽腫細胞に対する抗腫瘍効果とTMZを用いた併用効果の基礎的検討2017
- Author(s)
  田中祥貴, 中澤務, 中村光利, 辻村貴弘, 竹島靖浩, 松田良介, 田村健太郎, 山田修一, 中川一郎, 西村文彦, 横田浩, 本山靖, 朴永銖, 中瀬裕之
- Organizer
  第14回日本免疫治療学研究会学術集会
- Place of Presentation
  東京大学伊藤国際学術研究センター
- Year and Date
  2017-02-11
- Data Source
  KAKENHI-PROJECT-16K20022

1. Ryosuke Matsuda (60453164)

# of Collaborated Projects: 8 results

# of Collaborated Products: 35 results
2. 中村光利 (00305715)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
3. 西村文彦 (70433331)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
4. Nakase Hiroyuki (10217739)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. 中川一郎 (20550825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 竹島靖浩 (60510203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 前岡良輔 (70812337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 持田祐希 (60739134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 森本尭之 (20865563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. TAMURA Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 王寺幸輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 吉川正英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 本山靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nakazawa Tsutomu 中澤 務

Nakzawa Tsutomu 中澤 務

Research Projects

Research Products

Co-Researchers

Development of multidisciplinary immunotherapy utilizing NK cells in combination with PEG-conjugated immune checkpoint antibodies

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悪性髄膜腫に対する末梢血および臍帯血由来NK細胞を用いた免疫細胞療法の開発

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臍帯血由来CAR-NK細胞による膠芽腫治療法の開発

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チェックポイント分子HIF1αをゲノム編集したNK細胞による膠芽腫治療法の開発Principal Investigator

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Adipose tissue-derived mesenchymal stem cells and mesenchymal stem cells-derived exosome for treatment of rat ischemic stroke.

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Combination Therapy of NK Cells and Novel Immune Checkpoint Inhibition for Glioblastoma

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Development of PD-1 gene-disrupted EGFRvIII-specific CAR-T cell-based immunotherapy against glioblastomaPrincipal Investigator

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Basic study of CAR-NK cell therapy derived from iPS cells.

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Combined therapy with natural killer cell and anti PD-1 antibody for glioblastoma

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Novel therapeutic approach for glioblastoma with iPS cells-derived CAR-T cellsPrincipal Investigator

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[Journal Article] Antitumor Effects of Intravenous Natural Killer Cell Infusion in an Orthotopic Glioblastoma Xenograft Murine Model and Gene Expression Profile Analysis2024

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[Journal Article] Bulk RNA sequencing reveals the comprehensive genetic characteristics of human cord blood-derived natural killer cells2024

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[Journal Article] An efficient feeder-free and chemically-defined expansion strategy for highly purified natural killer cells derived from human cord blood2023

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Nakazawa Tsutomu 中澤務

Nakzawa Tsutomu 中澤務