NAKAMURA TOMOFUMI 中村朋文

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Nakamura Tomofumi 中村朋文

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Researcher Number	00772526
Other IDs	https://orcid.org/0000-0001-7589-9514
Affiliation (Current)	2024: 熊本大学, 病院, 診療助手
Affiliation (based on the past Project Information) *help	2021 – 2024: 熊本大学, 病院, 診療助手 2016 – 2020: 熊本大学, 大学院生命科学研究部(医), 研究員
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine Except Principal Investigator Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator HIV-1 / CRISPA-Cas9 / HIV-1感染症 / 相分離現象 / HIV-1形態 / NCINIs / HIV-1　タンパク質 / HIV-1 形態 / HIV-1 タンパク質 / HIV-1 nucleocapsid … More / HIV-1 integrase / HIV-1 RNA / NCINI耐性変異 / 潜伏感染 / GesicleCRISPR/Cas9 / SaCas9 / AAV / HIV-1ゲノム編集 / 新規HIV-1治療法 / アデノウイルス随伴ベクター / ゲノム編集 / エイズ / 逆転写酵素阻害剤によるNHEJ促進効果 / Cas9による遺伝子編集 / NHEJ経路 / 逆転写酵素阻害剤 / 蛍光蛋白質 / CRISPR-Cas9 / 遺伝子編集 … More Except Principal Investigator 創薬 / 脱核 / 蛋白自壊 / キャプシド蛋白 / 薬剤開発 / 脱殻 / 蛋白自己崩壊 / CA蛋白 / HIV-1 Less

Development of novel HIV-1 capsid (CA) inhibitors, and determination regarding novel mechanism of CA uncoating
- Principal Investigator
  
  天野将之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Mechanism of viral particle formation based on HIV-1 proteins and RNAPrincipal Investigator
- Principal Investigator
  
  Nakamura Tomofumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Development of a HIV-1 genome editing system and genome inducing agent for HIV-1 treatmentPrincipal Investigator
- Principal Investigator
  
  Nakamura Tomofumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Development and applications of allosteric reverse transcriptase inhibitors for Genome engineeringPrincipal Investigator
- Principal Investigator
  
  Nakamura Tomofumi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University

All 2024 2023 2022 2020

All Journal Article Presentation Patent

[Journal Article] Partial Splenic Embolization in a Patient with Hemophilia A and Severe Thrombocytopenia: A Case Report2024
- Author(s)
  Nakamura Tomofumi、Uchiba Mitsuhiro、Nakata Hirotomo、Mizumoto Takao、Beppu Toru、Matsushita Shuzo
- Journal Title
  
  Hematology Reports
  
  Volume: 16 Issue: 2 Pages: 185-192
- DOI
  10.3390/hematolrep16020019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16324
[Journal Article] Conversion of raltegravir carrying a 1,3,4-oxadiazole ring to a hydrolysis product upon pH changes decreases its antiviral activity2023
- Author(s)
  Nakamura Tomofumi、Okumura Mayu、Takamune Nobutoki、Hirotsu Tatsunori、Sugiura Masaharu、Yasunaga Junichiro、Nakata Hirotomo
- Journal Title
  
  PNAS Nexus
  
  Volume: 3 Issue: 1
- DOI
  10.1093/pnasnexus/pgad446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16324, KAKENHI-PROJECT-20H03514
[Journal Article] A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor2020
- Author(s)
  Nakamura Tomofumi、Nakamura Teruya、Amano Masayuki、Miyakawa Toshikazu、Yamagata Yuriko、Matsuoka Masao、Nakata Hirotomo
- Journal Title
  
  Journal of Virology
  
  Volume: 94 Issue: 19 Pages: 1-20
- DOI
  10.1128/jvi.00486-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06600, KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-18K08436, KAKENHI-PROJECT-18K16180
[Patent] 抗HIV 医薬組成物2023
- Inventor(s)
  天野将之；中村朋文; 杉浦正晴
- Industrial Property Rights Holder
  天野将之；中村朋文; 杉浦正晴
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-23K24379
[Presentation] 1,3,4-oxadiazole 環を有するRaltegravirは強酸性下で加水分解され、抗HIV活性が低下する2023
- Author(s)
  中村朋文, 奥村真由, 高宗暢暁, 弘津辰徳, 杉浦正晴, 安永純一朗, 中田浩智
- Organizer
  第37回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21K16324
[Presentation] ドラッグデリバリーシステム(DDS)による薬剤の安定性および局在変化による抗HIV-1効果への影響2022
- Author(s)
  中村朋文, 奥村真由, 高宗暢暁, 弘津辰徳, 松岡雅雄, 中田浩智
- Organizer
  エイズ学会
- Data Source
  KAKENHI-PROJECT-21K16324
[Presentation] 感染効率を上昇させるHIV-1ヌクレオカプシド内に認められた薬剤耐性変異2020
- Author(s)
  中村朋文天野将之 Travis Chia 松岡雅雄中田浩智
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K16180

1. 天野将之 (30575080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 杉浦正晴 (00376592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岡田誠治 (50282455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高宗暢暁 (60322749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 刈谷龍昇 (40757663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Otsu Sachiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAMURA Teruya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAMURA TOMOFUMI 中村 朋文

Nakamura Tomofumi 中村 朋文

Research Projects

Research Products

Co-Researchers

Development of novel HIV-1 capsid (CA) inhibitors, and determination regarding novel mechanism of CA uncoating

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of viral particle formation based on HIV-1 proteins and RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a HIV-1 genome editing system and genome inducing agent for HIV-1 treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and applications of allosteric reverse transcriptase inhibitors for Genome engineeringPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Partial Splenic Embolization in a Patient with Hemophilia A and Severe Thrombocytopenia: A Case Report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conversion of raltegravir carrying a 1,3,4-oxadiazole ring to a hydrolysis product upon pH changes decreases its antiviral activity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor2020

Author(s)

Journal Title

DOI

Data Source

[Patent] 抗HIV 医薬組成物2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Data Source

[Presentation] 1,3,4-oxadiazole 環を有するRaltegravirは強酸性下で加水分解され、抗HIV活性が低下する2023

Author(s)

Organizer

Data Source

[Presentation] ドラッグデリバリーシステム(DDS)による薬剤の安定性および局在変化による抗HIV-1効果への影響2022

Author(s)

Organizer

Data Source

[Presentation] 感染効率を上昇させるHIV-1ヌクレオカプシド内に認められた薬剤耐性変異2020

Author(s)

Organizer

Data Source

NAKAMURA TOMOFUMI 中村朋文

Nakamura Tomofumi 中村朋文