KAKIZAKI Masatoshi 柿崎正敏

… Alternative Names

柿崎正敏カキザキマサトシ

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Researcher Number	00778954
Other IDs	https://orcid.org/0000-0002-9388-8402
Affiliation (Current)	2026: 国立健康危機管理研究機構, 国立感染症研究所呼吸器系ウイルス研究部, 主任研究員
Affiliation (based on the past Project Information) *help	2026: 国立健康危機管理研究機構, 国立感染症研究所呼吸器系ウイルス研究部, 主任研究員 2023 – 2024: 国立感染症研究所, ウイルス第三部, 主任研究官 2021: 国立感染症研究所, ウイルス第三部, 研究員 2019 – 2020: 東海大学, 医学部, 助教 2018: 東海大学, 医学部, 奨励研究員
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Basic Section 53010:Gastroenterology-related / Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator HBV / RSウイルス / 気相液相界面培養 / ヒトボカウイルス / ウイルス-ウイルス間相互作用 / 呼吸器感染症 / エピジェネティクス / non-coding RNA / cccDNA / 反復配列 … More / ノンコーディングRNA / エピジェネティック制御 / 骨髄 / 腸内細菌叢 / 腸管 / 肝臓 / 腸管免疫 / PD-L1 / ハイドロダイナミックインジェクション / 細胞外小胞 / B型肝炎ウイルス Less

ウイルス共感染はRSV感染症の重症化リスク因子となり得るかPrincipal Investigator
- Principal Investigator
  
  柿崎正敏
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Japan Institute for Health Security
呼吸器感染症におけるウイルス-ウイルス間相互作用の基盤研究Principal Investigator
- Principal Investigator
  
  柿崎正敏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Institute of Infectious Diseases
Epigenetic regulation based on non-coding RNA in HBV infectionPrincipal Investigator
- Principal Investigator
  
  Kakizaki Masatoshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Institute of Infectious Diseases
  Tokai University
Investigation of the role of extracellular vesicles from HBV infected cells in composition of intestinal microbiotaPrincipal Investigator
- Principal Investigator
  
  KAKIZAKI Masatoshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokai University

All 2025 2024 2023 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids2025
- Author(s)
  Kakizaki Masatoshi、Hashimoto Rina、Nagata Noriyo、Yamamoto Takuya、Okura Takashi、Katoh Hiroshi、Kitai Yuki、Akahori Yukiko、Shirato Kazuya、Ryo Akihide、Takayama Kazuo、Takeda Makoto
- Journal Title
  
  Journal of Virology
  
  Volume: 99 Issue: 1
- DOI
  10.1128/jvi.01853-24
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07935, KAKENHI-PROJECT-23K17416
[Journal Article] A Clinical Isolate of Human Parainfluenza Virus 3 (Fukushima/O695/2019) Contains a Mutation in the Serial Guanosines in the RNA Editing Site of the P Gene and Produces an Atypical Number of Nongenomic Guanosine Insertions During RNA Editing2025
- Author(s)
  Shirato Kazuya、Kawase Miyuki、Suwa Reiko、Kakizaki Masatoshi、Sugimoto Satoko、Kume Yohei、Chishiki Mina、Ono Takashi、Okabe Hisao、Norito Sakurako、Hosoya Mitsuaki、Ujike Makoto、Hashimoto Koichi
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 69 Issue: 4 Pages: 220-228
- DOI
  10.1111/1348-0421.13203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05542, KAKENHI-PROJECT-23K07935
[Journal Article] Evidence of the simultaneous replications of active viruses in specimens positive for multiple respiratory viruses2024
- Author(s)
  Kawase Miyuki、Suwa Reiko、Sugimoto Satoko、Kakizaki Masatoshi、Kume Yohei、Chishiki Mina、Ono Takashi、Okabe Hisao、Norito Sakurako、Ujike Makoto、Hosoya Mitsuaki、Hashimoto Koichi、Shirato Kazuya
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 12 Issue: 1
- DOI
  10.1128/spectrum.01920-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05542, KAKENHI-PROJECT-23K07935
[Journal Article] Replication Efficiency of SARS-CoV-2 Omicron Subvariants BA.2.75, BA.5, and XBB.1 in Human Mini-Gut Organoids2024
- Author(s)
  Miyakawa Kei、Machida Masakazu、Kawasaki Tomoyuki、Kakizaki Masatoshi、Kimura Yayoi、Sugiyama Masaya、Hasegawa Hideki、Umezawa Akihiro、Akutsu Hidenori、Ryo Akihide
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: - Issue: 6 Pages: 1066-1068
- DOI
  10.1016/j.jcmgh.2024.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07935, KAKENHI-PROJECT-23K27419
[Journal Article] MARCH8 Restricts RSV Replication by Promoting Cellular Apoptosis Through Ubiquitin-Mediated Proteolysis of Viral SH Protein2024
- Author(s)
  Okura Takashi、Takahashi Tatsuki、Kameya Taichi、Mizukoshi Fuminori、Nakai Yusuke、Kakizaki Masatoshi、Nishi Mayuko、Otsuki Noriyuki、Kimura Hirokazu、Miyakawa Kei、Shirato Kazuya、Kamitani Wataru、Ryo Akihide
- Journal Title
  
  Viruses
  
  Volume: 16 Issue: 12 Pages: 1935-1935
- DOI
  10.3390/v16121935
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08616, KAKENHI-PROJECT-23K27419, KAKENHI-PROJECT-23K27641, KAKENHI-PROJECT-23K07935
[Journal Article] Development of a duplex real-time RT-PCR assay for the detection and identification of two subgroups of human metapneumovirus in a single tube2023
- Author(s)
  Sugimoto Satoko、Kawase Miyuki、Suwa Reiko、Kakizaki Masatoshi、Kume Yohei、Chishiki Mina、Ono Takashi、Okabe Hisao、Norito Sakurako、Hosoya Mitsuaki、Hashimoto Koichi、Shirato Kazuya
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 322 Pages: 114812-114812
- DOI
  10.1016/j.jviromet.2023.114812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07935
[Journal Article] Human hepatocyte-derived extracellular vesicles attenuate the carbon tetrachloride-induced acute liver injury in mice2021
- Author(s)
  Kakizaki Masatoshi、Yamamoto Yuichiro、Nakayama Shunya、Kameda Kazuaki、Nagashima Etsuko、Ito Masatoshi、Suyama Takashi、Matsuzaki Yumi、Chiba Tetsuhiro、Sumiyoshi Hideaki、Inagaki Yutaka、Kotani Ai
- Journal Title
  
  Cell Death and Disease
  
  Volume: 12 Issue: 11 Pages: 1010-1010
- DOI
  10.1038/s41419-021-04204-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22627, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20K17064, KAKENHI-PROJECT-20H03716, KAKENHI-PROJECT-20J14747, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-21K15420, KAKENHI-PROJECT-21H02907
[Journal Article] Extracellular vesicles secreted by HBV-infected cells modulate HBV persistence in hydrodynamic HBV transfection mouse model2020
- Author(s)
  Kakizaki Masatoshi、Yamamoto Yuichiro、Otsuka Motoyuki、Kitamura Kouichi、Ito Masatoshi、Kawai Hideki Derek、Muramatsu Masamichi、Kagawa Tatehiro、Kotani Ai
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 35 Pages: 12449-12460
- DOI
  10.1074/jbc.ra120.014317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07583, KAKENHI-PROJECT-20K08380, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20K17064, KAKENHI-PROJECT-20H03716
[Journal Article] PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma2020
- Author(s)
  Kawashima M, Carreras J, Higuchi H, Kotaki R, Hoshina T, Okuyama K, Suzuki N, Kakizaki M, Miyatake Y, Ando K, Nakayama M, Umezu S, Horie R, Higuchi Y, Katagiri K, Goyama S, Kitamura T, Chamoto K, Yano S,Nakamura N, and A Kotani
- Journal Title
  
  Leukemia
  
  Volume: - Issue: 9 Pages: 2405-2417
- DOI
  10.1038/s41375-020-0737-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07612, KAKENHI-PROJECT-17H04212, KAKENHI-PROJECT-19H03880, KAKENHI-PROJECT-18K15100, KAKENHI-PROJECT-18K15131, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K07459, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20H03716
[Journal Article] PD-L1 is induced on hepatocyte surface via CKLF-like MARVEL transmembrane domain-containing protein 6 upregulation by the anti-HBV drug Entecavir2020
- Author(s)
  Yamamoto Yuichiro、Kakizaki Masatoshi、Shimizu Takayuki、Carreras Joaquim、Chiba Tetsuhiro、Chamoto Kenji、Kagawa Tatehiro、Aoki Taku、Nakamura Naoya、Ando Kiyoshi、Kotani Ai
- Journal Title
  
  International Immunology
  
  Volume: - Issue: 8 Pages: 519-531
- DOI
  10.1093/intimm/dxaa018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15100, KAKENHI-PROJECT-18K15131, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20H03716
[Journal Article] The immunological function of extracellular vesicles in hepatitis B virus-infected hepatocytes2018
- Author(s)
  Kakizaki Masatoshi、Yamamoto Yuichiro、Yabuta Suemi、Kurosaki Natsumi、Kagawa Tatehiro、Kotani Ai
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 12 Pages: e0205886-e0205886
- DOI
  10.1371/journal.pone.0205886
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15131, KAKENHI-PROJECT-17H04212
[Presentation] 気液界面培養を用いたヒト気道上皮培養モデルにおいてヒトボカウイルス1の共感染はRSウイルスの増殖を促進する2024
- Author(s)
  柿崎正敏、白戸憲也、梁明秀
- Organizer
  第28回日本ワクチン学会・第65回日本臨床ウイルス学会合同学術集会
- Data Source
  KAKENHI-PROJECT-23K07935
[Presentation] ヒトボカウイルス1はRSウイルスとヒトライノウイルスと共感染するが増殖に影響を与えない2023
- Author(s)
  柿崎正敏、杉元聡子、諏訪麗子 , 川瀬みゆき , 白戸憲也 , 梁明秀
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07935
[Presentation] Multi organ association mediated by extracellular vesicles secreted from HBV positive hepatocyte2019
- Author(s)
  Ai Kotani, Masatoshi Kakizaki, Yuichiro Yamamoto, Motoyuki Otsuka, and Tatehiro Kagawa
- Organizer
  International society for extracellular vesicles 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15131
[Presentation] Extracellular vesicles secreted from HBV-infected cells inhibit the eradication of HBV-infected cells in the HBV-infection mouse model.2019
- Author(s)
  Masatoshi Kakizaki, Yuichiro Yamamoto, Ai Kotani
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15131

1. INAGAKI Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. CARRERAS Joaquim

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 村松正道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 氏家誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 片桐晃子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 大倉喬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAKIZAKI Masatoshi 柿崎 正敏

柿崎 正敏 カキザキ マサトシ

Research Projects

Research Products

Co-Researchers

ウイルス共感染はRSV感染症の重症化リスク因子となり得るかPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

呼吸器感染症におけるウイルス-ウイルス間相互作用の基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic regulation based on non-coding RNA in HBV infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the role of extracellular vesicles from HBV infected cells in composition of intestinal microbiotaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Clinical Isolate of Human Parainfluenza Virus 3 (Fukushima/O695/2019) Contains a Mutation in the Serial Guanosines in the RNA Editing Site of the P Gene and Produces an Atypical Number of Nongenomic Guanosine Insertions During RNA Editing2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evidence of the simultaneous replications of active viruses in specimens positive for multiple respiratory viruses2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Replication Efficiency of SARS-CoV-2 Omicron Subvariants BA.2.75, BA.5, and XBB.1 in Human Mini-Gut Organoids2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MARCH8 Restricts RSV Replication by Promoting Cellular Apoptosis Through Ubiquitin-Mediated Proteolysis of Viral SH Protein2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a duplex real-time RT-PCR assay for the detection and identification of two subgroups of human metapneumovirus in a single tube2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human hepatocyte-derived extracellular vesicles attenuate the carbon tetrachloride-induced acute liver injury in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular vesicles secreted by HBV-infected cells modulate HBV persistence in hydrodynamic HBV transfection mouse model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-L1 is induced on hepatocyte surface via CKLF-like MARVEL transmembrane domain-containing protein 6 upregulation by the anti-HBV drug Entecavir2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The immunological function of extracellular vesicles in hepatitis B virus-infected hepatocytes2018

KAKIZAKI Masatoshi 柿崎正敏

柿崎正敏カキザキマサトシ