Shimizu Takashi 清水峻志

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SHIMIZU TAKASHI 清水峻志

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Researcher Number	00792061
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 大学共同利用機関等の部局等, 講師
Affiliation (based on the past Project Information) *help	2025: 昭和医科大学, 大学共同利用機関等の部局等, 講師 2023 – 2024: 昭和大学, 大学共同利用機関等の部局等, 講師 2021: 東京大学, アイソトープ総合センター, 客員研究員 2020: 東京大学, アイソトープ総合センター, 特任助教 2018 – 2019: 東京大学, 医学部附属病院, 登録研究員
Review Section/Research Field	Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 53030:Respiratory medicine-related / Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 非小細胞肺がん / トラゾドン / 遺伝性肺動脈性肺高血圧症 / 肺動脈性肺高血圧症 / micro RNA / バイオマーカー / 周産期心筋症 Except Principal Investigator TMEM176A/B / CLEC12A / ICI（免疫チェックポイント阻害薬） / 非古典的単球 / 単球

非古典的単球及び非古典的単球由来細胞における新規同定単球遺伝子の機能解明
- Principal Investigator
  
  鈴木梨沙子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Showa Medical University
ICI耐性NSCLCにおけるSiglec-9の役割Principal Investigator
- Principal Investigator
  
  清水峻志
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Showa University
Development of New Therapeutic Drugs for Hereditary Pulmonary Arterial HypertensionPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKASHI
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Showa University
  The University of Tokyo
Analysis for biomarkers derived from placenta in postpartum cardiomyopathy with preeclampsiaPrincipal Investigator
- Principal Investigator
  
  Shimizu Takashi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  The University of Tokyo

All 2023 2021 2020 2018

All Journal Article Presentation

[Journal Article] Soluble PD-L1 changes in advanced non-small cell lung cancer patients treated with PD-1 inhibitors: an individual patient data meta-analysis.2023
- Author(s)
  Shimizu T, Inoue E, Ohkuma R, Kobayashi S, Tsunoda T, Wada S.
- Journal Title
  
  Front Immunol.
  
  Volume: 14 Pages: 1308381-1308381
- DOI
  10.3389/fimmu.2023.1308381
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15085, KAKENHI-PROJECT-21K07866, KAKENHI-PROJECT-23K09700, KAKENHI-PROJECT-20K17210
[Journal Article] Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD‐L1) expression in colorectal carcinoma2023
- Author(s)
  Ugai T, Shimizu T, Kawamura H, Ugai S, Takashima Y, Usui G, Vayrynen JP, Okadome K, Haruki K, Akimoto N, Masugi Y, da Silva A, Mima K, Zhang X, Chan AT, Wang M, Garrett WS, Freeman GJ, Meyerhardt JA, Nowak JA, Song M, Giannakis M, Ogino S
- Journal Title
  
  Clinical & Translational Immunology
  
  Volume: 12 Issue: 8 Pages: 1453-1453
- DOI
  10.1002/cti2.1453
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15980, KAKENHI-PROJECT-23K15435, KAKENHI-PROJECT-21K08805, KAKENHI-PROJECT-20K17210
[Journal Article] Non-classical Monocytes Enhance the Efficacy of Immune Checkpoint Inhibitors on Colon Cancer in a Syngeneic Mouse Model2023
- Author(s)
  GOSHIMA TSUBASA、IEGUCHI KATSUAKI、ONISHI NOBUYUKI、SHIMIZU TAKASHI、…、　HOFFMAN ROBERT M.、TSUNODA TAKUYA、WADA SATOSHI
- Journal Title
  
  Anticancer Research
  
  Volume: 44 Issue: 1 Pages: 23-29
- DOI
  10.21873/anticanres.16784
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17210
[Journal Article] Novel quantitative immunohistochemical analysis for evaluating PD-L1 expression with phosphor-integrated dots for predicting the efficacy of patients with cancer treated with immune checkpoint inhibitors2023
- Author(s)
  Ohkuma Ryotaro、Miura Sakiko、Muto Satoshi、Toyomasu Yoshitaka、Fujimoto Yuki、Ieguchi Katsuaki、Onishi Nobuyuki、Shimizu Takashi、Watanabe Makoto、Takayanagi Daisuke、Goshima Tsubasa、…、Wada Satoshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1260492-1260492
- DOI
  10.3389/fimmu.2023.1260492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17210
[Journal Article] PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation2021
- Author(s)
  Shimizu Takashi、Higashijima Yoshiki、Kanki Yasuharu、Nakaki Ryo、Kawamura Takeshi、Urade Yoshihiro、Wada Youichiro
- Journal Title
  
  Science Signaling
  
  Volume: 14 Issue: 667
- DOI
  10.1126/scisignal.abb3616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17210, KAKENHI-PROJECT-19K22679, KAKENHI-PROJECT-20H03432
[Journal Article] 2 Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma.2021
- Author(s)
  Ugai T, et al. Among authors: Nosho k.
- Journal Title
  
  OncoImmunology.
  
  Volume: 10 Issue: 1 Pages: 110-110
- DOI
  10.1080/2162402x.2021.1956173
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07646, KAKENHI-PROJECT-20K17210
[Journal Article] PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation2020
- Author(s)
  Shimizu Takashi、Maruyama Kazuaki、Kawamura Takeshi、Urade Yoshihiro、Wada Youichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20094-20094
- DOI
  10.1038/s41598-020-77199-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17072, KAKENHI-PROJECT-20K17210, KAKENHI-PROJECT-19K22679
[Journal Article] PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure2020
- Author(s)
  Shimizu Takashi、Taguchi Akashi、Higashijima Yoshiki、Takubo Naoko、Kanki Yasuharu、Urade Yoshihiro、Wada Youichiro
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 8 Pages: 101410-101410
- DOI
  10.1016/j.isci.2020.101410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17210, KAKENHI-PROJECT-19K22679, KAKENHI-PROJECT-20H03432
[Presentation] 免疫チェックポイント阻害薬の効果予測バイオマーカーの探索及びICI併用療法の検討2023
- Author(s)
  五嶋　翼、清水　峻志、…、和田　聡
- Organizer
  免疫チェックポイント阻害薬の効果予測バイオマーカーの探索及びICI併用療法の検討
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17210
[Presentation] 免疫チェックポイント阻害療法におけるSiglec-9の役割2023
- Author(s)
  伊藤優那, 清水峻志, … 和田聡
- Organizer
  第149回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K17210
[Presentation] 免疫チェックポイント阻害薬耐性非小細胞肺がんにおけるSiglec-9の役割2023
- Author(s)
  清水峻志, 五嶋翼, … 和田聡
- Organizer
  第36回日本バイオセラピィ学会学術集会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17210
[Presentation] Perk Inhibition Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension With Bmpr2 Mutation2020
- Author(s)
  Shimizu Takashi、Higashijima Yoshiki、Kanki Yasuharu、Nakaki Ryo、Kawamura Takeshi、Urade Yoshihiro、Wada Youichiro
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17210
[Presentation] miR-224-5p is a New Biomarker and Therapeutic Target for Peripartum Cardiomyopathy With Preeclampsia, Irrespective of 16 kDa Prolactin2018
- Author(s)
  Takashi Shimizu, Eiki Takimoto, Chizuko A. Kamiya, Jun Yoshimatsu, Atsunori Kamiya, Tomoaki Ikeda, Issei Komuro
- Organizer
  米国心臓病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16756

1. 和田聡 (30420102)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 神吉康晴 (00534869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 高柳大輔 (40595633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 川村猛 (70306835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鈴木梨沙子 (70928035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 角田卓也 (30275359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NOSHO Katsuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 大熊遼太朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 秋元直彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 丸山和晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Takashi 清水 峻志

SHIMIZU TAKASHI 清水 峻志

Research Projects

Research Products

Co-Researchers

非古典的単球及び非古典的単球由来細胞における新規同定単球遺伝子の機能解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ICI耐性NSCLCにおけるSiglec-9の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of New Therapeutic Drugs for Hereditary Pulmonary Arterial HypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis for biomarkers derived from placenta in postpartum cardiomyopathy with preeclampsiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Soluble PD-L1 changes in advanced non-small cell lung cancer patients treated with PD-1 inhibitors: an individual patient data meta-analysis.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD‐L1) expression in colorectal carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-classical Monocytes Enhance the Efficacy of Immune Checkpoint Inhibitors on Colon Cancer in a Syngeneic Mouse Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel quantitative immunohistochemical analysis for evaluating PD-L1 expression with phosphor-integrated dots for predicting the efficacy of patients with cancer treated with immune checkpoint inhibitors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2 Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 免疫チェックポイント阻害薬の効果予測バイオマーカーの探索及びICI併用療法の検討2023

Author(s)

Organizer

Data Source

[Presentation] 免疫チェックポイント阻害療法におけるSiglec-9の役割2023

Author(s)

Organizer

Data Source

[Presentation] 免疫チェックポイント阻害薬耐性非小細胞肺がんにおけるSiglec-9の役割2023

Author(s)

Organizer

Shimizu Takashi 清水峻志

SHIMIZU TAKASHI 清水峻志