NAGASHIMA Hiroaki 長嶋宏明

Researcher Number	00794950
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 神戸大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related Except Principal Investigator Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator PAR / Temozolomide / DNA damage / Glioma / DNA複製異常 / 悪性神経膠腫 / WEE1 / グリオーマ / PARG Except Principal Investigator グリオーマ … More / 低酸素 / 膜脂質代謝 / microbiota / ketogenic diet / glioma / マクロファージ / 髄芽腫 / medulloblastoma / D47 / sCD163 / macrophage / SIRPa Less

予後不良なCDKN2A共欠失グリオーマの病態解明とWee1を標的とした新規治療法の開発Principal Investigator
- Principal Investigator
  
  長嶋宏明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Microbiota of ketogenic diet in glioblastoma patients and enhancement effect of synbiotics
- Principal Investigator
  
  篠山隆司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Molecular mechanism of membrane lipid remodeling in hypoxic glioma cells
- Principal Investigator
  
  田中一寛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Development of new treatments for medulloblastoma targeting macrophage
- Principal Investigator
  
  西原賢在
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Targeting PARG in malignant glioma therapyPrincipal Investigator
- Principal Investigator
  
  長嶋宏明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma2024
- Author(s)
  Spitzer Avishay、Gritsch Simon、Nomura Masashi、LeeLee Christine K.、Nagashima Hiroaki、Miller Julie J.、Arrillaga-Romany Isabel、Louis David N.、Wakimoto Hiroaki、Pisano Will、Wen Patrick Y.、Mak Tak W.、Sanson Marc、Touat Mehdi、Landau Dan A.、Ligon Keith L.、Cahill Daniel P.、Suv? Mario L.、Tirosh Itay
- Journal Title
  
  Cancer Cell
  
  Volume: 13(4) Issue: 5 Pages: 904-914.e9
- DOI
  10.1016/j.ccell.2024.03.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16630
[Journal Article] Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells.2023
- Author(s)
  Ishikawa T, Ogura Y, Tanaka K, Nagashima H, Sasayama T, Endo M, Minami Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 114 Issue: 2 Pages: 561-561
- DOI
  10.1111/cas.15630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09284, KAKENHI-PROJECT-23K08542
[Journal Article] 2-Hydroxyglutarate magnetic resonance spectroscopy in adult brainstem glioma.2023
- Author(s)
  Iwahashi H, Nagashima H, Tanaka K, Uno T, Hashiguchi M, Maeyama M, Somiya Y, Komatsu M, Hirose T, Itoh T, Sasaki R, Sasayama T.
- Journal Title
  
  J Neurosurg
  
  Volume: 1 Issue: 2 Pages: 1-1
- DOI
  10.3171/2022.12.jns221954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09284, KAKENHI-PROJECT-20K09369, KAKENHI-PROJECT-21K16630, KAKENHI-PROJECT-20KK0192, KAKENHI-PROJECT-20K06430, KAKENHI-PROJECT-21K07594, KAKENHI-PROJECT-21K07642, KAKENHI-PROJECT-23K08542, KAKENHI-PROJECT-20K08108, KAKENHI-PROJECT-20K21576, KAKENHI-PROJECT-23K24287
[Journal Article] Glutamic Acid and Total Creatine as Predictive Markers for Epilepsy in Glioblastoma by Using Magnetic Resonance Spectroscopy Before Surgery2022
- Author(s)
  Hashiguchi Mitsuru、Tanaka Kazuhiro、Nagashima Hiroaki、Fujita Yuichi、Tanaka Hirotomo、Kohta Masaaki、Nakai Tomoaki、Uozumi Yoichi、Maeyama Masahiro、Somiya Yuichiro、Kohmura Eiji、Sasayama Takashi
- Journal Title
  
  World Neurosurgery
  
  Volume: 160 Pages: 501-501
- DOI
  10.1016/j.wneu.2022.01.056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09369, KAKENHI-PROJECT-22K09284, KAKENHI-PROJECT-20K09389
[Presentation] 3テスラMRSによるグリオーマ術前てんかん予測因子2023
- Author(s)
  長嶋宏明、田中一寛、篠山隆司
- Organizer
  第82回日本脳神経外科学会学学術総会
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] 成人diffuse midline gliomaにおけるH3K27M変異と生命予後2023
- Author(s)
  田中一寛、長嶋宏明、山西俊介、伊藤智雄、篠山隆司
- Organizer
  第82回日本脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08542
[Presentation] 一次運動野近傍にある悪性脳腫瘍に対する術中画像支援と摘出術2023
- Author(s)
  田中一寛、長嶋宏明、山西俊介、藤本陽介、篠山隆司
- Organizer
  第41回日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-23K08542
[Presentation] 成人diffuse midline gliomaにおけるH3K27M変異と生命予後2023
- Author(s)
  田中一寛、長嶋宏明、篠山隆司
- Organizer
  第82回日本脳神経外科学会学学術総会
- Data Source
  KAKENHI-PROJECT-22K09284

1. 篠山隆司 (10379399)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. 田中一寛 (70467661)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. 藤田祐一 (40895132)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 西原賢在 (20452493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高橋政友 (30844419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 田中宏知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGASHIMA Hiroaki 長嶋 宏明

Research Projects

Research Products

Co-Researchers

予後不良なCDKN2A共欠失グリオーマの病態解明とWee1を標的とした新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Microbiota of ketogenic diet in glioblastoma patients and enhancement effect of synbiotics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of membrane lipid remodeling in hypoxic glioma cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new treatments for medulloblastoma targeting macrophage

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting PARG in malignant glioma therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2-Hydroxyglutarate magnetic resonance spectroscopy in adult brainstem glioma.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glutamic Acid and Total Creatine as Predictive Markers for Epilepsy in Glioblastoma by Using Magnetic Resonance Spectroscopy Before Surgery2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] 3テスラMRSによるグリオーマ術前てんかん予測因子2023

Author(s)

Organizer

Data Source

[Presentation] 成人diffuse midline gliomaにおけるH3K27M変異と生命予後2023

Author(s)

Organizer

Data Source

[Presentation] 一次運動野近傍にある悪性脳腫瘍に対する術中画像支援と摘出術2023

Author(s)

Organizer

Data Source

[Presentation] 成人diffuse midline gliomaにおけるH3K27M変異と生命予後2023

Author(s)

Organizer

Data Source

NAGASHIMA Hiroaki 長嶋宏明