Mihara Nozomi 美原希美

… Alternative Names

TOMIYAMA Nozomi 冨山希美

美原希美

MIHARA Nozomi 美原希美

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Researcher Number	00803264
Other IDs	https://orcid.org/0009-0002-8079-5837
Affiliation (Current)	2025: 日本歯科大学, 生命歯学部, 講師
Affiliation (based on the past Project Information) *help	2025: 日本歯科大学, 生命歯学部, 講師 2021 – 2023: 日本歯科大学, 生命歯学部, 講師 2017 – 2020: 日本歯科大学, 生命歯学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Functional basic dentistry Except Principal Investigator Basic Section 57020:Oral pathobiological science-related / Pathobiological dentistry/Dental radiology
Keywords	Principal Investigator KLF5 / 細胞分化 / 発現制御 / 口腔癌 / CREB1 / 癌 / 遺伝子 / ケラチノサイト / 上皮 / 分化 / 遺伝子抑制機構 / 上皮恒常性 … More Except Principal Investigator … More プロモーター / 口腔癌 / 浸潤 / ドメイン / MALT1 / Sp1 / 転写因子 / Sp3 / サイレンサー / 口腔癌細胞 / KLF5 / KLF Less

Exploring the expression control of KLF5 by CREB1 and cell differentiationPrincipal Investigator
- Principal Investigator
  
  美原希美
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  The Nippon Dental University
CREB複合体によるKLF5遺伝子発現抑制機構の解明：癌細胞分化の新たな分子的背景の探究Principal Investigator
- Principal Investigator
  
  美原希美
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  The Nippon Dental University
The mechanism of KLF5 gene suppression and the relationship exploration between the suppression and cell differentiationPrincipal Investigator
- Principal Investigator
  
  Mihara Nozomi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  The Nippon Dental University
Nuclear translocation mechanism of MALT1 and oral carcinoma cell invasion
- Principal Investigator
  
  Kazushi IMAI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  The Nippon Dental University
Analysis of KLF5 expression and regulatory mechanisms: elucidation of the new molecular background involved in epithelium homeostasisPrincipal Investigator
- Principal Investigator
  
  TOMIYAMA Nozomi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional basic dentistry
- Research Institution
  The Nippon Dental University
KLF-dependent cell differentiation- and EMT-inducing factor and suppression of oral carcinoma progression
- Principal Investigator
  
  Imai Kazushi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The Nippon Dental University

All 2024 2023 2021 2020 2019 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Suppression of KLF5 basal expression in oral carcinoma-derived cells through three intact CREB1-binding sites in the silencer region2024
- Author(s)
  Katsuumi Reiichi、Negishi Tsubasa、Imai Kazushi、Mihara Nozomi
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 66 Issue: 1 Pages: 217-224
- DOI
  10.1016/j.job.2023.12.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15988, KAKENHI-PROJECT-21K16957
[Journal Article] Suppression of Krüppel-like factor 5 basal expression by CREB1 binding to far distal element2023
- Author(s)
  Nozomi Mihara, Kazushi Imai
- Journal Title
  
  Tumor Biology
  
  Volume: 45 Issue: 1 Pages: 81-94
- DOI
  10.3233/tub-230017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16957
[Journal Article] NF-kB subunit RELA suppression of mucosa-associated lymphoi tissue lymphoma tranlocation protein 1 expression in oral carcinoma cells2021
- Author(s)
  Takaomi Nozawa, Nozomi Mihara-Tomiyama, Tadashige Chiba, Kazushi Imai
- Journal Title
  
  Biochemistry and Biophysical Research Communications
  
  Volume: 542 Pages: 24-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09542
[Journal Article] Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear translocation in oral carcinoma cells and the proliferation inhibition2020
- Author(s)
  H Hayashi, T Chiba, N Mihara-Tomiyama, T Negishi, Y Kodama, H Sakashita, K Imai
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 522 Issue: 3 Pages: 799-804
- DOI
  10.1016/j.bbrc.2019.11.171
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09542
[Journal Article] MALT1 Inhibition of Oral Carcinoma Cell Invasion and ERK/MAPK Activation.2016
- Author(s)
  Chiba T, Soeno Y, Shirako Y, Sudo H, Yagishita H, Taya Y, Kawashiri S, Okada Y, Imai K.
- Journal Title
  
  Journal of Dental Research
  
  Volume: 95 Issue: 4 Pages: 446-452
- DOI
  10.1177/0022034515621740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670861, KAKENHI-PROJECT-15H05042, KAKENHI-PROJECT-26462859
[Journal Article] Kruppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas.2015
- Author(s)
  Shibata M, Chiba T, Matsuoka T, Mihara N, Kawashiri S, Imai K.
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462859
[Journal Article] Krüppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas2015
- Author(s)
  Shibata M, Chiba T, Matsuoka T, Mihara N, Kawashiri S, Imai K
- Journal Title
  
  Int. J. Clin. Exp. Pathol.
  
  Volume: ８ Pages: 3701-3709
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462859
[Presentation] カルシウム誘導性ケラチノサイト分化におけるKLF5の発現2023
- Author(s)
  美原希美、今井一志
- Organizer
  第65回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-23K15988
[Presentation] KLF5遺伝子のサイレンサー領域とCREB結合サイトの解析2023
- Author(s)
  勝海怜一、美原希美、根岸翼、今井一志
- Organizer
  第65回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-23K15988
[Presentation] KLF5遺伝子におけるサイレンサー領域とCREBの関与2021
- Author(s)
  美原希美、今井一志
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K16957
[Presentation] 口腔癌細胞におけるMALT1核移行ドメインの解析2019
- Author(s)
  林宏泰、千葉忠成、冨山希美、今井一志、坂下英明
- Organizer
  第73回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09542
[Presentation] Kruppel-like factor 5遺伝子発現の必要最小領域とSp3の関与2016
- Author(s)
  美原希美
- Organizer
  第58回日本歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌市）
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-26462859
[Presentation] 口腔癌細胞におけるKruppel-like factor 4発現とプロモーターのメチル化2015
- Author(s)
  山口光祐，千葉忠成，美原希美，須藤遥，今井一志
- Organizer
  第57回日本歯科基礎医学会学術大会・総会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26462859
[Presentation] Kruppel-like factor 5遺伝子のプロモーター解析2014
- Author(s)
  美原希美、千葉忠成、須藤遥、今井一志
- Organizer
  歯科基礎医学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26462859
[Presentation] Promoter analysis of Kruppel-like factor 5 gene.
- Author(s)
  Mihara N, Chiba T, Sudo H, Imai K
- Organizer
  General Session and Exhibition of the IADR
- Place of Presentation
  ボストン（米国）
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-26462859

1. Imai Kazushi (10328859)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. 千葉忠成 (60350138)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. 須藤遙 (20372980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 川尻秀一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mihara Nozomi 美原 希美

TOMIYAMA Nozomi 冨山 希美

美原希美

MIHARA Nozomi 美原 希美

Research Projects

Research Products

Co-Researchers

Exploring the expression control of KLF5 by CREB1 and cell differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CREB複合体によるKLF5遺伝子発現抑制機構の解明：癌細胞分化の新たな分子的背景の探究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of KLF5 gene suppression and the relationship exploration between the suppression and cell differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Nuclear translocation mechanism of MALT1 and oral carcinoma cell invasion

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of KLF5 expression and regulatory mechanisms: elucidation of the new molecular background involved in epithelium homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

KLF-dependent cell differentiation- and EMT-inducing factor and suppression of oral carcinoma progression

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Suppression of KLF5 basal expression in oral carcinoma-derived cells through three intact CREB1-binding sites in the silencer region2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppression of Krüppel-like factor 5 basal expression by CREB1 binding to far distal element2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NF-kB subunit RELA suppression of mucosa-associated lymphoi tissue lymphoma tranlocation protein 1 expression in oral carcinoma cells2021

Author(s)

Journal Title

Data Source

[Journal Article] Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear translocation in oral carcinoma cells and the proliferation inhibition2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MALT1 Inhibition of Oral Carcinoma Cell Invasion and ERK/MAPK Activation.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kruppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas.2015

Author(s)

Journal Title

Data Source

[Journal Article] Kr&#252;ppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas2015

Author(s)

Journal Title

Data Source

[Presentation] カルシウム誘導性ケラチノサイト分化におけるKLF5の発現2023

Author(s)

Organizer

Data Source

[Presentation] KLF5遺伝子のサイレンサー領域とCREB結合サイトの解析2023

Mihara Nozomi 美原希美

TOMIYAMA Nozomi 冨山希美

MIHARA Nozomi 美原希美

[Journal Article] Krüppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas2015