Koma Takaaki 駒貴明

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KOMA Takaaki 駒貴明

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Researcher Number	00803496
Other IDs	https://orcid.org/0000-0001-9767-990X
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(医学域), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 徳島大学, 大学院医歯薬学研究部(医学域), 准教授 2018: 徳島大学, 大学院医歯薬学研究部(医学域), 助教 2017: 徳島大学, 大学院医歯薬学研究部(医学系), 助教
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Basic Section 49060:Virology-related / Virology Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 47060:Clinical pharmacy-related / Basic Section 54030:Infectious disease medicine-related / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator HIV-1 / Env取込み / Transmitted/Founder / Env / 液-液相分離 / 粒子形成 / Gag / 集合 / 多量体形成 / Gag集合 … More / ウイルス / ワクチン / N型糖鎖修飾 / 広域中和抗体 … More Except Principal Investigator siRNA / 超保存残基 / エンベロープ / HIV-1 / 代謝拮抗剤 / 抗ウイルス剤 / 4'-チオ核酸 / 新型コロナウイルス / mRNAワクチン / 予防薬 / ヌクレオシド / 治療薬 / RNAウイルス感染症 Less

核酸医薬の毒性を回避するドラッグリポジショニング研究の新展開
- Principal Investigator
  
  田良島典子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokushima
Transmitted/Founder HIV-1における粒子へのエンベロープタンパク質取込み機構の解明Principal Investigator
- Principal Investigator
  
  駒貴明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  The University of Tokushima
Establishment of next-generation drug discovery platform for viral infections
- Principal Investigator
  
  南川典昭
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  The University of Tokushima
超保存脆弱部位を基盤とする抗エンベロープウイルスプラットフォーム技術の構築
- Principal Investigator
  
  野間口雅子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  The University of Tokushima
HIV-1粒子形成に至るGag複合体の実体解明Principal Investigator
- Principal Investigator
  
  駒貴明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  The University of Tokushima
Treatment and prevention of RNA virus infections based on 4'-thionucleic acid technology
- Principal Investigator
  
  MINAKAWA Noriaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  The University of Tokushima
Establishment of broadly neutralizing antibody induction technology by modification of N-glycosylationPrincipal Investigator
- Principal Investigator
  
  KOMA Takaaki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Virology
- Research Institution
  The University of Tokushima

All 2024 2023 2022 2019 2018 2017

All Journal Article Presentation

[Journal Article] Concomitant enhancement of HIV-1 replication potential and neutralization-resistance in concert with three adaptive mutations in Env V1/C2/C4 domains.2019
- Author(s)
  Doi N, Yokoyama M, Koma T, Kotani O, Sato H, Adachi A, Nomaguchi M.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 10 Pages: 2510-2510
- DOI
  10.3389/fmicb.2019.00002
- NAID
  120006937678
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08860, KAKENHI-PROJECT-17H06907, KAKENHI-PROJECT-16K08824
[Journal Article] Virological characterization of HIV‐1 CA‐NTD mutants constructed in a virus‐lineage reflected manner2018
- Author(s)
  Nakanishi Shouko、Watanabe sakimi、Doi Naoya、Koma Takaaki、Adachi Akio、Nomaguchi Masako
- Journal Title
  
  J. Med. Invest.
  
  Volume: 65 Issue: 1.2 Pages: 110-115
- DOI
  10.2152/jmi.65.110
- NAID
  130006575575
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08860, KAKENHI-PROJECT-17H06907
[Journal Article] CXCR4- and CCR5-tropic HIV-1 clones are both tractable to grow in rhesus macaques.2018
- Author(s)
  Doi N, Miura T, Mori H, Sakawaki H, Koma T, Adachi A, and Nomaguchi M.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 9 Pages: 2510-2510
- DOI
  10.3389/fmicb.2018.02510
- NAID
  120006937677
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08860, KAKENHI-PROJECT-16H04682, KAKENHI-PROJECT-17H06907
[Journal Article] Complete genome sequences of human immunodeficiency type 1 viruses genetically engineered to be tropic for rhesus macaques2017
- Author(s)
  Nomaguchi Masako、Doi Naoya、Koma Takaaki、Adachi Akio
- Journal Title
  
  Genome Announcements
  
  Volume: 5 Issue: 39
- DOI
  10.1128/genomea.01063-17
- NAID
  120007001411
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08860, KAKENHI-PROJECT-17H06907
[Journal Article] Production of HIV-1 vif mRNA Is Modulated by Natural Nucleotide Variations and SLSA1 RNA Structure in SA1D2prox Genomic Region2017
- Author(s)
  Nomaguchi Masako、Doi Naoya、Yoshida Tomoya、Koma Takaaki、Adachi Shun、Ode Hirotaka、Iwatani Yasumasa、Yokoyama Masaru、Sato Hironori、Adachi Akio
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 8 Pages: 2542-2542
- DOI
  10.3389/fmicb.2017.02542
- NAID
  120006937675
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-17K08860, KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-15H04740, KAKENHI-PROJECT-17H06907
[Journal Article] HIV-1 mutates to adapt in fluxing environments2017
- Author(s)
  Nomaguchi Masako、Doi Naoya、Koma Takaaki、Adachi Akio
- Journal Title
  
  Microbes and Infection
  
  Volume: S1286-4579(17)30118-1 Issue: 9-10 Pages: 610-614
- DOI
  10.1016/j.micinf.2017.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08860, KAKENHI-PROJECT-17H06907
[Presentation] SARS-CoV-2活性を発揮する3-デアザグアノシンの発見と作用メカニズム解明2024
- Author(s)
  吉田圭吾、日野谷直人、小笠萌香、田良島典子、駒貴明、野間口雅子、南川典昭
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 3-Deazaguanosine exhibits anti-SARS-CoV-2 activity and blocks the development of COVID-19 pneumonis in hamsters.2024
- Author(s)
  Minakawa N., Saito-Tarashima N., Koma T., Hinotani N., Yoshida K., Ogasa M., Murai A., Inoue S., Kondo T., Doi N., Tsuneyama K., Nomaguchi M.
- Organizer
  Supra FIBER International Summit for Nucleic Acids (S-FISNA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 抗SARS-CoV-2活性を指標とした4’-チオ修飾siRNAの最適化2024
- Author(s)
  野木悠平、田良島典子、駒貴明、月本準、野間口雅子、南川典昭
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] HIV-1 Gag-MA S9残基の集合における役割解明2023
- Author(s)
  駒貴明
- Organizer
  熊本大学ヒトレトロウイルス学共同研究センター第18回ウイルス研究交流会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07102
[Presentation] Development of the 4’-thiomodified siRNAs against SARS-CoV-22023
- Author(s)
  Nogi Y., Saito-Tarashima N., Koma T., Nomaguchi M., Minakawa N.
- Organizer
  14th AFMC International Medicinal Chemistry Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 4’-チオ核酸修飾siRNAの開発(1)2023
- Author(s)
  野木悠平、田良島典子、駒貴明、野間口雅子、南川典昭
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 抗SARS-CoV-2の活性獲得を目指した3-デアザプリンヌクレオシド類の合成2023
- Author(s)
  小笠萌香、日野谷直人、田良島典子、駒貴明、野間口雅子、南川典昭
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] 4’-チオ核酸修飾siRNAの開発(2)2023
- Author(s)
  尾崎里奈、野木悠平、田良島典子、駒貴明、月本準、野間口雅子、南川典昭
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] SARS-CoV-2を標的とした4’-チオ修飾siRNAの創製2023
- Author(s)
  野木悠平、田良島典子、駒貴明、野間口雅子、南川典昭
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-21H02606
[Presentation] HIV-1集合における Gag-NCとgRNAの相互作用の意義2023
- Author(s)
  駒貴明、Bao Quoc Le、土肥直哉、薦田奈々子、一ノ宮匠海、近藤智之、足立昭夫、野間口雅子
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07102
[Presentation] HIV-1 Gag-MAにおけるGag前駆体二量体化部位のウイルス学的解析2022
- Author(s)
  駒　貴明、小谷治、土肥　直哉、近藤　智之、横山勝、足立　昭夫、佐藤裕徳、野間口　雅子
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07102
[Presentation] HIV-1 Gag MAのGag二量体化における役割の解明2022
- Author(s)
  駒　貴明、小谷治、土肥　直哉、近藤　智之、横山勝、足立　昭夫、佐藤裕徳、野間口　雅子
- Organizer
  第36回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-22K07102
[Presentation] HIV-1複製後期過程におけるGag-CAリンカードメインの役割2018
- Author(s)
  駒貴明、小谷治、土肥直哉、宮川敬、梁明秀、横山勝、佐藤裕徳、足立昭夫、野間口雅子
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06907
[Presentation] SA1D2proxに関するHIV-1 Vif低発現変異体NL-gatは、Vif発現量適応変異あるいはenv変異の獲得により増殖能を向上させる2018
- Author(s)
  野間口雅子、土肥直哉、駒貴明、吉田和子、足立昭夫
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06907
[Presentation] 馴化型R5-tropic HIV-1rmtで同定されたEnvによる増殖促進の解析2018
- Author(s)
  土肥直哉、駒貴明、中西仁奈、足立昭夫、野間口雅子
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06907
[Presentation] SA1D2prox領域に関するHIV-1 Vif超低発現変異体 NL-tacのAPOBEC3G高発現下における適応過程の解析2018
- Author(s)
  足立昭夫、土肥直哉、駒貴明、大久保隼人、吉田和子、野間口雅子
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06907
[Presentation] Env domain swappingにより増殖効率が向上した馴化型R5-tropic HIV-1rmtの構築2017
- Author(s)
  土肥直哉, 駒貴明, 中西祥子, 渡邊咲仁, 野間口雅子, 足立昭夫
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06907
[Presentation] HIV-1 SA1D2prox Vif低発現変異体は複製抑制下で適応しVif発現を回復する2017
- Author(s)
  渡邊咲仁, 中西祥子, 駒貴明, 土肥直哉, 足立昭夫, 野間口雅子
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06907
[Presentation] HIV-1 Env V1/C4 domain内の1アミノ酸変異は協調的にCD4親和性を増加させ、ウイルス増殖を促進する2017
- Author(s)
  中西祥子, 渡邊咲仁, 土肥直哉, 駒貴明, 足立昭夫, 野間口雅子
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06907
[Presentation] HIV-1複製後期過程におけるGag-CAリンカー領域内アミノ酸残基S149及びI150の役割2017
- Author(s)
  駒貴明, 土肥直哉, 宮川敬, 梁明秀, 足立昭夫, 野間口雅子
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06907
[Presentation] HIV-1 vif産生量とSLSA1の構造・エネルギー安定性の連関解析2017
- Author(s)
  足立昭夫, 土肥直哉, 駒貴明, 中西祥子, 渡邊咲仁, 野間口雅子
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06907

1. 野間口雅子 (80452647)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. 田良島典子 (90755183)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. MINAKAWA Noriaki (40209820)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 横山勝 (70296028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 合田光寛 (40585965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小暮健太朗 (70262540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Koma Takaaki 駒 貴明

KOMA Takaaki 駒 貴明

Research Projects

Research Products

Co-Researchers

核酸医薬の毒性を回避するドラッグリポジショニング研究の新展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transmitted/Founder HIV-1における粒子へのエンベロープタンパク質取込み機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of next-generation drug discovery platform for viral infections

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

超保存脆弱部位を基盤とする抗エンベロープウイルスプラットフォーム技術の構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HIV-1粒子形成に至るGag複合体の実体解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Treatment and prevention of RNA virus infections based on 4'-thionucleic acid technology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of broadly neutralizing antibody induction technology by modification of N-glycosylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Concomitant enhancement of HIV-1 replication potential and neutralization-resistance in concert with three adaptive mutations in Env V1/C2/C4 domains.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Virological characterization of HIV‐1 CA‐NTD mutants constructed in a virus‐lineage reflected manner2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] CXCR4- and CCR5-tropic HIV-1 clones are both tractable to grow in rhesus macaques.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Complete genome sequences of human immunodeficiency type 1 viruses genetically engineered to be tropic for rhesus macaques2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Production of HIV-1 vif mRNA Is Modulated by Natural Nucleotide Variations and SLSA1 RNA Structure in SA1D2prox Genomic Region2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] HIV-1 mutates to adapt in fluxing environments2017

Koma Takaaki 駒貴明

KOMA Takaaki 駒貴明