TOMITA Hiroya 冨田宏矢

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Tomita Hiroya 冨田宏矢

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Researcher Number	00814229
Other IDs	https://orcid.org/0000-0001-7967-921X
Affiliation (Current)	2025: 大阪大学, 生物工学国際交流センター, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 生物工学国際交流センター, 准教授 2021 – 2022: 北海道大学, 工学研究院, 助教 2018 – 2019: 東京大学, 大学院農学生命科学研究科(農学部), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 38030:Applied biochemistry-related / Basic Section 38020:Applied microbiology-related Except Principal Investigator Basic Section 64030:Environmental materials and recycle technology-related
Keywords	Principal Investigator 生合成 / ポリ乳酸 / 指向性進化 / ポリヒドロキシアルカン酸 / 酵素改変 / 生分解性プラスチック / ぽリヒドロキシアルカン酸 / ニトロ基 / 二次代謝 / Streptomyces … More / 天然物 / シトクロムP450 / ニトロ化 / 放線菌 … More Except Principal Investigator 自己組織化 / バイオベースポリマー / 生分解性材料 / 生分解性プラスチック / 酵素重合 / バイオベースプラスチック / 微生物産生プラスチック / 酵素分子進化 / バイオプラスチック / バイオポリマー Less

Biosynthesis of sequence-regulated biodegradable polyesters and analysis of the mechanism of synthesis
- Principal Investigator
  
  Matsumoto Ken'ichiro
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 64030:Environmental materials and recycle technology-related
- Research Institution
  Hokkaido University
Directed evolution of sequence-regulationg polyhydroxyalkanoatae synthase for novel biopolyester biosynthesisPrincipal Investigator
- Principal Investigator
  
  Tomita Hiroya
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Osaka University
Identification of novel nitrating cytochrome P450s from ActinomycetesPrincipal Investigator
- Principal Investigator
  
  Tomita Hiroya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2022 2021 2019

All Journal Article Presentation

[Journal Article] Creation of sequence-regulating polyhydroxyalkanoate (PHA) synthases with improved thermostability using a full consensus design for the biosynthesis of 2-hydroxyalkanoate-based PHA block copolymers2025
- Author(s)
  Furukawa Shoko、Nakagawa Naoya、Hachisuka Shin-ichi、Nakano Shogo、Tomita Hiroya、Kikukawa Hiroshi、Matsumoto Ken'ichiro
- Journal Title
  
  Polymer Degradation and Stability
  
  Volume: 236 Pages: 111295-111295
- DOI
  10.1016/j.polymdegradstab.2025.111295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20394, KAKENHI-PROJECT-22K05422
[Journal Article] Biosynthesis of High Toughness Poly(3-Hydroxypropionate)-Based Block Copolymers With Poly(D-2-Hydroxybutyrate) and Poly(D-Lactate) Segments Using Evolved Monomer Sequence-Regulating Polyester Synthase2024
- Author(s)
  Kawakami Tomoya、Tomita Hiroya、Hien Phan Thi、Matsumoto Ken'ichiro
- Journal Title
  
  Biopolymers
  
  Volume: 115 Issue: 6 Pages: 1-11
- DOI
  10.1002/bip.23618
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20394, KAKENHI-PROJECT-22K05422
[Journal Article] Engineering of the long-main-chain monomer-incorporating polyhydroxyalkanoate synthase PhaCAR for the biosynthesis of poly[(R)-3-hydroxybutyrate-co-6-hydroxyalkanoate]2024
- Author(s)
  Yuka Hozumi, Shin-ichi Hachisuka, Hiroya Tomita, Hiroshi Kikukawa, Ken'ichiro Matsumoto
- Journal Title
  
  iomacromolecules
  
  Volume: in press Issue: 5 Pages: 2973-2979
- DOI
  10.1021/acs.biomac.4c00116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20394, KAKENHI-PROJECT-22K05422
[Journal Article] Real-time NMR analysis of polyhydroxyalkanoate synthase reaction that synthesizes block copolymer comprising glycolate and 3-hydroxybutyrate2023
- Author(s)
  Yanagawa Kengo、Kajikawa Ayaka、Sakakibara Sayaka、Kumeta Hiroyuki、Tomita Hiroya、Matsumoto Ken'ichiro
- Journal Title
  
  Biophysical Chemistry
  
  Volume: 296 Pages: 107001-107001
- DOI
  10.1016/j.bpc.2023.107001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20394
[Journal Article] Biosynthesis of High-Molecular-Weight Poly(d-lactate)-Containing Block Copolyesters Using Evolved Sequence-Regulating Polyhydroxyalkanoate Synthase PhaCAR2023
- Author(s)
  Phan Hien Thi、Furukawa Shoko、Imai Koto、Tomita Hiroya、Isono Takuya、Satoh Toshifumi、Matsumoto Ken’ichiro
- Journal Title
  
  ACS Sustainable Chemistry & Engineering
  
  Volume: 11 Issue: 30 Pages: 11123-11129
- DOI
  10.1021/acssuschemeng.3c01696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05422, KAKENHI-PROJECT-23K20394
[Journal Article] Versatile aliphatic polyester biosynthesis system for producing random and block copolymers composed of 2-, 3-, 4-, 5-, and 6-hydroxyalkanoates using the sequence-regulating polyhydroxyalkanoate synthase PhaCAR2022
- Author(s)
  Satoh Keigo、Kawakami Tomoya、Isobe Nagi、Pasquier Loic、Tomita Hiroya、Zinn Manfred、Matsumoto Ken’ichiro
- Journal Title
  
  Microbial Cell Factories
  
  Volume: 21 Issue: 1 Pages: 84-84
- DOI
  10.1186/s12934-022-01811-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K20394
[Journal Article] Directed Evolution of Sequence-Regulating Polyhydroxyalkanoate Synthase to Synthesize a Medium-Chain-Length-Short-Chain-Length (MCL-SCL) Block Copolymer2022
- Author(s)
  Phan Hien Thi、Hosoe Yumi、Guex Maureen、Tomoi Masayoshi、Tomita Hiroya、Zinn Manfred、Matsumoto Ken’ichiro
- Journal Title
  
  Biomacromolecules
  
  Volume: 23 Issue: 3 Pages: 1221-1231
- DOI
  10.1021/acs.biomac.1c01480
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05422, KAKENHI-PROJECT-23K20394
[Journal Article] Artificial polyhydroxyalkanoate poly[2-hydroxybutyrate-block-3-hydroxybutyrate] elastomer-like material2021
- Author(s)
  Kageyama Yuki、Tomita Hiroya、Isono Takuya、Satoh Toshifumi、Matsumoto Ken’ichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 22446-22446
- DOI
  10.1038/s41598-021-01828-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20394
[Journal Article] Biosynthesis of poly(glycolate-co-3-hydroxybutyrate-co-3-hydroxyhexanoate) in Escherichia coli expressing sequence-regulating polyhydroxyalkanoate synthase and medium-chain-length 3-hydroxyalkanoic acid coenzyme A ligase2021
- Author(s)
  Tomita Hiroya、Satoh Keigo、Nomura Christopher T、Matsumoto Ken'ichiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 86 Issue: 2 Pages: 217-223
- DOI
  10.1093/bbb/zbab198
- NAID
  120007187734
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K20394
[Presentation] In vitro analysis of enzymatic synthesis of polyhydroxyalkanoates block copolymer2025
- Author(s)
  柳川謙吾 , 冨田宏矢 , 蜂須賀真一 , 菊川寛史 , 松本謙一郎
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] 顕微鏡観察法によるポリヒドロキシアルカン酸生産過程におけるエネルギー代謝動態解析2024
- Author(s)
  富士航至、梶川彩香、蜂須賀真一、冨田宏矢、菊川寛史、松本謙一郎
- Organizer
  2024生物工学若手の会夏のセミナー
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] ポリヒドロキシアルカン酸ブロック共重合反応の酵素メカニズム解析2024
- Author(s)
  柳川謙吾、冨田宏矢、蜂須賀真一、菊川寛史、松本謙一郎
- Organizer
  日本生物工学会2024年度北日本支部シンポジウム
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] Substrate switching during block copolymerization catalyzed by polyhydroxyalkanoate synthase PhaCAR2024
- Author(s)
  Kengo Yanagawa, Hiroya Tomita, Shin-ichi Hachisuka, Hiroshi Kikukawa, Ken’ichiro Matsumoto
- Organizer
  International Symposium on Bipolymers 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] 顕微鏡観察法によるポリヒドロキシアルカン酸生産過程におけるエネルギー代謝動態解析2024
- Author(s)
  富士航至、梶川彩香、蜂須賀真一、冨田宏矢、菊川寛史、松本謙一郎
- Organizer
  2024年度第6回脂質駆動学術産業創生研究部会講演会
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] ポリヒドロキシアルカン酸ブロック共重合体の酵素合成メカニズム解析2024
- Author(s)
  柳川謙吾 , 冨田宏矢 , 蜂須賀真一 , 菊川寛史 , 松本謙一郎
- Organizer
  日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] 配列制御型ポリヒドロキシアルカン酸重合酵素のブロック共重合メカニズム in vitro 解析2024
- Author(s)
  柳川謙吾、冨田宏矢、蜂須賀真一、菊川寛史、松本謙一郎
- Organizer
  2024生物工学若手の会夏のセミナー
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] 微生物生産ポリエステルの生合成における連鎖移動剤の新規作用機序の解析2024
- Author(s)
  田中聖也、蜂須賀真一、菊川寛史、冨田宏矢、松本謙一郎
- Organizer
  日本生物工学会2024年度北日本支部シンポジウム
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] ポリ乳酸セグメントを含む新規ブロック共重合体の微生物合成と物性制御2023
- Author(s)
  今井昂渡、蜂須賀真一、菊川寛史、冨田宏矢、松本謙一郎
- Organizer
  2023年度　日本農芸化学会北海道支部／第53回日本栄養・食糧学会北海道支部　合同学術講演会
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] 機能改変型ポリヒドロキシアルカン酸合成酵素のモノマー配列制御の特性解析2022
- Author(s)
  富士航至、Phan Thi Hien、細江有美、 Guex Maureen、友居昌慶、冨田宏矢、Zinn Manfred、松本謙一郎
- Organizer
  日本農芸化学会北海道・東北支部合同支部会
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] Engineering of polyhydroxyalkanoate synthase for biosynthesis of medium-chain-length (MCL)-short-chain-length (SCL) block copolymer2022
- Author(s)
  Hien Thi Phan, Yumi Hosoe, Maureen Guex, Masayoshi Tomoi , Hiroya Tomita, Manfred Zinn, and Ken’ichiro Matsumoto
- Organizer
  ISBP2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] 中鎖モノマー認識に向けたポリヒドロキシアルカン酸合成酵素の基質特異性の改変2022
- Author(s)
  向井太一、Phan Thi Hien、冨田宏矢、松本謙一郎
- Organizer
  日本農芸化学会北海道・東北支部合同支部会
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] ポリエステル合成酵素の機能改変による新規ブロック共重合体の生合成2022
- Author(s)
  冨田宏矢
- Organizer
  ノボザイムズジャパンバイオテクノロジーフォーラム 2022
- Invited
- Data Source
  KAKENHI-PROJECT-22K05422
[Presentation] ラホヤマイシン生合成に関与する脂肪族ニトロ化酵素に関する研究2019
- Author(s)
  冨田宏矢、勝山陽平、大西康夫
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K14370
[Presentation] Genome mining for novel nitrating cytochrome P450s provides insights into lajollamycin biosynthesis2019
- Author(s)
  Hiroya Tomita, Yohei Katsuyama, Yasuo Ohnishi
- Organizer
  The 4th A3 Forsight Symposium on Chemical and Synthetic Biology of Natural Products
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14370

1. Matsumoto Ken'ichiro (80360642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 大井俊彦 (40223713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOMITA Hiroya 冨田 宏矢

Tomita Hiroya 冨田 宏矢

Research Projects

Research Products

Co-Researchers

Biosynthesis of sequence-regulated biodegradable polyesters and analysis of the mechanism of synthesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Directed evolution of sequence-regulationg polyhydroxyalkanoatae synthase for novel biopolyester biosynthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel nitrating cytochrome P450s from ActinomycetesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Creation of sequence-regulating polyhydroxyalkanoate (PHA) synthases with improved thermostability using a full consensus design for the biosynthesis of 2-hydroxyalkanoate-based PHA block copolymers2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biosynthesis of High Toughness Poly(3-Hydroxypropionate)-Based Block Copolymers With Poly(D-2-Hydroxybutyrate) and Poly(D-Lactate) Segments Using Evolved Monomer Sequence-Regulating Polyester Synthase2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Engineering of the long-main-chain monomer-incorporating polyhydroxyalkanoate synthase PhaCAR for the biosynthesis of poly[(R)-3-hydroxybutyrate-co-6-hydroxyalkanoate]2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Real-time NMR analysis of polyhydroxyalkanoate synthase reaction that synthesizes block copolymer comprising glycolate and 3-hydroxybutyrate2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biosynthesis of High-Molecular-Weight Poly(d-lactate)-Containing Block Copolyesters Using Evolved Sequence-Regulating Polyhydroxyalkanoate Synthase PhaCAR2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Versatile aliphatic polyester biosynthesis system for producing random and block copolymers composed of 2-, 3-, 4-, 5-, and 6-hydroxyalkanoates using the sequence-regulating polyhydroxyalkanoate synthase PhaCAR2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Directed Evolution of Sequence-Regulating Polyhydroxyalkanoate Synthase to Synthesize a Medium-Chain-Length-Short-Chain-Length (MCL-SCL) Block Copolymer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Artificial polyhydroxyalkanoate poly[2-hydroxybutyrate-block-3-hydroxybutyrate] elastomer-like material2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biosynthesis of poly(glycolate-co-3-hydroxybutyrate-co-3-hydroxyhexanoate) in Escherichia coli expressing sequence-regulating polyhydroxyalkanoate synthase and medium-chain-length 3-hydroxyalkanoic acid coenzyme A ligase2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] In vitro analysis of enzymatic synthesis of polyhydroxyalkanoates block copolymer2025

Author(s)

Organizer

Data Source

[Presentation] 顕微鏡観察法によるポリヒドロキシアルカン酸生産過程におけるエネルギー代謝動態解析2024

Author(s)

Organizer

Data Source

[Presentation] ポリヒドロキシアルカン酸ブロック共重合反応の酵素メカニズム解析2024

Author(s)

Organizer

TOMITA Hiroya 冨田宏矢

Tomita Hiroya 冨田宏矢