Lu Yonggang ＬｕＹｏｎｇｇａｎｇ

Researcher Number	00817033
Other IDs	https://orcid.org/0000-0003-0198-8906
Affiliation (Current)	2025: 大阪大学, ヒューマン・メタバース疾患研究拠点, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2023 – 2024: 大阪大学, ヒューマン・メタバース疾患研究拠点, 特任准教授(常勤) 2021 – 2022: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) 2020: 大阪大学, 微生物病研究所, 特任助教(常勤) 2018 – 2019: 大阪大学, 微生物病研究所, 特任研究員(常勤)
Review Section/Research Field	Principal Investigator Basic Section 44020:Developmental biology-related / Basic Section 44010:Cell biology-related / Basic Section 56030:Urology-related
Keywords	Principal Investigator Fertilization / Sperm-egg fusion / Fusogen / Male infertility / Genome editing / Sperm / Spermatology / Male reproduction / Membrane fusion / Interactome … More / Cell biology / piRNA biogenesis / Spermiogenesis / Protein interaction / Gene knockout / Reproductive biology / Male fertility / Testis / Spermatogenesis / sperm-oocyte fusion / sperm function / sperm-egg fusion / sperm / male contraception / male reproduction / Male contraception / Mouse model / Knockout / CRISPR/Cas9 Less

Deciphering the molecular networks underpinning mammalian sperm-egg fusionPrincipal Investigator
- Principal Investigator
  
  Lu Yonggang
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Osaka University
Deciphering the cellular and molecular mechanisms underlying mammalian sperm-egg fusionPrincipal Investigator
- Principal Investigator
  
  Lu Yonggang
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Osaka University
Discovery of genes essential for male fertility using CRISPR/Cas9-based genome editing technologyPrincipal Investigator
- Principal Investigator
  
  Lu Yonggang
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility2024
- Author(s)
  Shimada Keisuke、Lu Yonggang、Ikawa Masahito
- Journal Title
  
  Exp. Anim.
  
  Volume: 73 Issue: 1 Pages: 1-10
- DOI
  10.1538/expanim.23-0055
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15103, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033
[Journal Article] ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat2024
- Author(s)
  Nishio S、Emori C、Wiseman B、Fahrenkamp D、Dioguardi E、Zamora-Caballero S、Bokhove M、Han L、Stsiapanava A、Algarra B、Lu Y、Kodani M、Bainbridge RE、Komondor KM、CA、Landreh M、de Sanctis D、Yasumasu S、Ikawa M、Jovine L
- Journal Title
  
  Cell
  
  Volume: 187 Issue: 6 Pages: 1440-1459
- DOI
  10.1016/j.cell.2024.02.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K20043, KAKENHI-PROJECT-23K05879, KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-21H05033
[Journal Article] ADAD2 functions in spermiogenesis and piRNA biogenesis in mice2023
- Author(s)
  Lu Yonggang、Nagamori Ippei、Kobayashi Hisato、Kojima‐Kita Kanako、Shirane Kenjiro、Chang Hsin‐Yi、Nishimura Toru、Koyano Takayuki、Yu Zhifeng、Castaneda Julio M.、Matsuyama Makoto、Kuramochi‐Miyagawa Satomi、Matzuk Martin M.、Ikawa Masahito
- Journal Title
  
  Andrology
  
  Volume: 11 Issue: 4 Pages: 698-709
- DOI
  10.1111/andr.13400
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05033, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-22K15125, KAKENHI-PROJECT-23K21282
[Journal Article] CRISPR/Cas9‐mediated genome editing reveals seven testis‐enriched transmembrane glycoproteins dispensable for male fertility in mice2023
- Author(s)
  Ogawa Yo、Lu Yonggang、Kiyozumi Daiji、Chang Hsin‐Yi、Ikawa Masahito
- Journal Title
  
  Andrology
  
  Volume: -
- DOI
  10.1111/andr.13564
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19263, KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-21H05033
[Journal Article] 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction2023
- Author(s)
  Lu Yonggang、Shimada Kentaro、Tang Shaogeng、Zhang Jingjing、Ogawa Yo、Noda Taichi、Shibuya Hiroki、Ikawa Masahito
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 8 Pages: 1-11
- DOI
  10.1073/pnas.2207263120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-20H03172, KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05750
[Journal Article] Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish2022
- Author(s)
  Noda Taichi、Blaha Andreas、Fujihara Yoshitaka、Gert Krista R.、Emori Chihiro、Deneke Victoria E.、Oura Seiya、Panser Karin、Lu Yonggang、Berent Sara、Kodani Mayo、Cabrera-Quio Luis Enrique、Pauli Andrea、Ikawa Masahito
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-022-03289-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-20KK0155, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-20H03172, KAKENHI-PROJECT-21H02397, KAKENHI-PROJECT-21K19198, KAKENHI-PLANNED-19H05750
[Journal Article] Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats2022
- Author(s)
  Matsumura Takafumi、Noda Taichi、Satouh Yuhkoh、Morohoshi Akane、Yuri Shunsuke、Ogawa Masaki、Lu Yonggang、Isotani Ayako、Ikawa Masahito
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9 Pages: 1-10
- DOI
  10.3389/fcell.2021.810118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06686, KAKENHI-PROJECT-18K16735, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-20H03172
[Journal Article] C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane2022
- Author(s)
  Hwang Jae Yeon、Wang Huafeng、Lu Yonggang、Ikawa Masahito、Chung Jean-Ju
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 3 Pages: 110226-110226
- DOI
  10.1016/j.celrep.2021.110226
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033
[Journal Article] Eukaryotic fertilization and gamete fusion at a glance2022
- Author(s)
  Lu Yonggang、Ikawa Masahito
- Journal Title
  
  Journal of Cell Science
  
  Volume: 135 Issue: 22
- DOI
  10.1242/jcs.260296
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-21H05033, KAKENHI-PLANNED-19H05750
[Journal Article] Human sperm TMEM95 binds eggs and facilitates membrane fusion2022
- Author(s)
  Tang Shaogeng、Lu Yonggang、Skinner Will M.、Sanyal Mrinmoy、Lishko Polina V.、Ikawa Masahito、Kim Peter S.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 40
- DOI
  10.1073/pnas.2207805119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15103, KAKENHI-PROJECT-21H05033, KAKENHI-PLANNED-19H05750
[Journal Article] LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice2021
- Author(s)
  Zhang Xin、Sun Jiang、Lu Yonggang、Zhang Jintao、Shimada Keisuke、Noda Taichi、Zhao Shuqin、Koyano Takayuki、Matsuyama Makoto、Zhou Shushu、Wu Jiayan、Ikawa Masahito、Liu Mingxi
- Journal Title
  
  Journal of Cell Science
  
  Volume: 134 Issue: 20 Pages: 1-14
- DOI
  10.1242/jcs.259381
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-PROJECT-20H03172, KAKENHI-PROJECT-20K16107
[Journal Article] Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization2021
- Author(s)
  Qu Yongcun、Chen Qi、Guo Shanshan、Ma Chiyuan、Lu Yonggang、Shi Junchao、Liu Shichao、Zhou Tong、Noda Taichi、Qian Jingjing、Zhang Liwen、Zhu Xili、Lei Xiaohua、Cao Yujing、Li Wei、Li Wei、Plachta Nicolas、Matzuk Martin M.、Ikawa Masahito、Duan Enkui、Zhang Ying、Wang Hongmei
- Journal Title
  
  Protein & Cell
  
  Volume: 12 Issue: 10 Pages: 810-817
- DOI
  10.1007/s13238-021-00825-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735
[Journal Article] Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice2020
- Author(s)
  Fujihara Yoshitaka、Lu Yonggang、Noda Taichi、Oji Asami、Larasati Tamara、Kojima-Kita Kanako、Yu Zhifeng、Matzuk Ryan M.、Matzuk Martin M.、Ikawa Masahito
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 17 Pages: 9393-9400
- DOI
  10.1073/pnas.1917060117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-16KK0180, KAKENHI-PROJECT-18K16735, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394
[Journal Article] Prss55 but not Prss51 is required for male fertility in mice†2020
- Author(s)
  Kobayashi Kiyonori、Endo Tsutomu、Matsumura Takafumi、Lu Yonggang、Yu Zhifeng、Matzuk Martin M、Ikawa Masahito
- Journal Title
  
  Biology of Reproduction
  
  Volume: - Issue: 2 Pages: 223-234
- DOI
  10.1093/biolre/ioaa041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06439, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-18K16735, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394
[Journal Article] Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm－oocyte fusion in mice2020
- Author(s)
  Taichi Noda, Yonggang Lu, Yoshitaka Fujihara, View ORCID ProfileSeiya Oura, View ORCID ProfileTakayuki Koyano, Sumire Kobayashi, Martin M. Matzuk, and View ORCID ProfileMasahito Ikawa
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 21 Pages: 11493-11502
- DOI
  10.1073/pnas.1922650117
- NAID
  120006957465
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-16KK0180, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-19J21619
[Journal Article] CIB4 Is Essential for the Haploid Phase of Spermatogenesis in Mice2020
- Author(s)
  Zoulan Xu, Haruhiko Miyata, Yuki Kaneda, Julio M Castaneda, Yonggang Lu, Akane Morohoshi, Zhifeng Yu, Martin M Matzuk, Masahito Ikawa
- Journal Title
  
  Biology of Reproduction
  
  Volume: 102 Issue: 2 Pages: 1-9
- DOI
  10.1093/biolre/ioaa059
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14715, KAKENHI-PROJECT-18K16735, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-17H04987
[Journal Article] CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction2020
- Author(s)
  Sun Jiang、Lu Yonggang、Nozawa Kaori、Xu Zoulan、Morohoshi Akane、Castaneda Julio M、Noda Taichi、Miyata Haruhiko、Abbasi Ferheen、Shawki Hossam H、Takahashi Satoru、Devlin Darius J、Yu Zhifeng、Matzuk Ryan M、Garcia Thomas X、Matzuk Martin M、Ikawa Masahito
- Journal Title
  
  Biology of Reproduction
  
  Volume: N/A Issue: 2 Pages: 183-194
- DOI
  10.1093/biolre/ioaa083
- NAID
  120007190927
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-PROJECT-19K16027, KAKENHI-PROJECT-20K15804, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-20H03172, KAKENHI-PROJECT-17H04987
[Journal Article] CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†2019
- Author(s)
  Yonggang Lu, Oura Seiya, Matsumura Takafumi, et al.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 101 Issue: 2 Pages: 501-511
- DOI
  10.1093/biolre/ioz103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-PUBLICLY-18H04885, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-17H04987, KAKENHI-PROJECT-19J00865, KAKENHI-PROJECT-17K17852, KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-18K14715, KAKENHI-PROJECT-16KK0180
[Presentation] ERP2 is required for sperm motility and male fertility in male mice2023
- Author(s)
  Chang Hsin-Yi、Lu Yonggang、Ikawa Masahito
- Organizer
  The 1st Asian Congress for Reproductive Immunology (ACRI)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15103
[Presentation] 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm?egg interaction2023
- Author(s)
  Lu Yonggang、Shimada Kentaro、Tang Shaogeng、Zhang Jingjing、Ogawa Yo、Noda Taichi、Shibuya Hiroki、Ikawa Masahito
- Organizer
  Society for the Study of Reproduction (SSR) 56th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15103
[Presentation] ADAD2 functions in spermiogenesis and piRNA biogenesis in mice2023
- Author(s)
  Lu Yonggang
- Organizer
  The 1st Asian Congress for Reproductive Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15103
[Presentation] ADAD2 functions in spermiogenesis and piRNA biogenesis in mice2023
- Author(s)
  Lu Yonggang、Nagamori Ippei、Kobayashi Hisato、Kojima‐Kita Kanako、Shirane Kenjiro、Chang Hsin‐Yi、Nishimura Toru、Koyano Takayuki、Yu Zhifeng、Casta?eda Julio M.、Matsuyama Makoto、Kuramochi‐Miyagawa Satomi、Matzuk Martin M.、Ikawa Masahito
- Organizer
  The 1st Asian Congress for Reproductive Immunology (ACRI)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15103
[Presentation] Identification of a sperm trimeric complex essential for vertebrate fertilization2023
- Author(s)
  Deneke Victoria E.、Lu Yonggang、Phan Clara、Draper Jonne、Vance Tyler、Blaha Andreas、Panser Karin、Stejskal Karel、Schleiffer Alexander、Kamoshita Maki、Lee Jeffrey、Ikawa Masahito、Pauli Andrea
- Organizer
  The 24th Gordon Research Conference (GRC) on Fertilization and Activation of Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15103

1. SATOUH Yuhkoh

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. KIYOZUMI Daiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 伊川正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 遠藤墾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. CASTANEDA JULIO

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Lu Yonggang Ｌｕ Ｙｏｎｇｇａｎｇ

Research Projects

Research Products

Co-Researchers

Deciphering the molecular networks underpinning mammalian sperm-egg fusionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deciphering the cellular and molecular mechanisms underlying mammalian sperm-egg fusionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of genes essential for male fertility using CRISPR/Cas9-based genome editing technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ADAD2 functions in spermiogenesis and piRNA biogenesis in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR/Cas9‐mediated genome editing reveals seven testis‐enriched transmembrane glycoproteins dispensable for male fertility in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eukaryotic fertilization and gamete fusion at a glance2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human sperm TMEM95 binds eggs and facilitates membrane fusion2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization2021

Lu Yonggang ＬｕＹｏｎｇｇａｎｇ