Rashad Sherif ＲａｓｈａｄＳｈｅｒｉｆ

Researcher Number	00824088
Other IDs
Affiliation (Current)	2025: 東北大学, 医工学研究科, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 医工学研究科, 准教授 2020 – 2022: 東北大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56010:Neurosurgery-related / Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator tRNA / Glioma / mRNA translation / Ferroptosis / Chemotherapy / CRISPR / tRNA modifications / Codon bias / Epigenetics / Mass spectrometry … More / Bioinformatics / LC-MS / Codon usage / Cell stress / Cell Stress / translation / Stroke / tRNA cleavage / oxidative stress … More Except Principal Investigator RNF213 / もやもや病 / Muse細胞 / 脊髄損傷 / iPS細胞 / 血管平滑筋 / 血管内皮 / 数値流体力学 / 内皮細胞 / 血流 / 細胞治療 / 認知症 / 幹細胞 Less

Elucidation of the pathogenesis of moyamoya disease through Endothelial-Smooth Muscle Interaction and RNF213
- Principal Investigator
  
  新妻邦泰
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tohoku University
Elucidating the role of tRNA epitranscriptome in Glioma pathology and development of novel therapiesPrincipal Investigator
- Principal Investigator
  
  Rashad Sherif
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
慢性期脊髄損傷に対するMuse細胞を用いた新規治療法の開発
- Principal Investigator
  
  遠藤俊毅
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Elucidation of moyamoya disease pathophysiology through an interaction of hemodynamics and endothelial cells
- Principal Investigator
  
  Tominaga Teiji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tohoku University
Studying the dynamics of a novel small RNA (tiRNA) generation in glioma; possible new therapyPrincipal Investigator
- Principal Investigator
  
  Rashad Sherif
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
tRNA epitranscriptome in regulating glioma therapeutic resistancePrincipal Investigator
- Principal Investigator
  
  RASHAD Sherif
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Development of Muse cell therapy for dementia
- Principal Investigator
  
  Niizuma Kuniyasu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tohoku University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Translational response to mitochondrial stresses is orchestrated by tRNA modifications2024
- Author(s)
  Sherif Rashad, Shadi Al-Mesitef, Abdulrahman Mousa, Yuan Zhou, Daisuke Ando, Guangxin Sun, Tomoko Fukuuchi, Yuko Iwasaki, Jingdong Xiang, Shane R Byrne, Jingjing Sun, Masamitsu Maekawa, Daisuke Saigusa, Thomas J Begley, Peter C Dedon, Kuniyasu Niizuma
- Journal Title
  
  Biorxiv preprint
  
  Volume: 00 Pages: 00-00
- DOI
  10.1101/2024.02.14.580389
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27432
[Journal Article] Angiogenin regulates mitochondrial stress and function via tRNA-derived fragments generation and impacting tRNA modifications2024
- Author(s)
  Shadi Al-Mesitef, Keita Tominaga, Abdulrahman Mousa, Thomas J Begley, Peter C Dedon, Sherif Rashad, Kuniyasu Niizuma
- Journal Title
  
  Biorxiv preprint
  
  Volume: 00 Pages: 00-00
- DOI
  10.1101/2024.02.13.580206
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27432
[Journal Article] Accumulation of m6A exhibits stronger correlation with MAPT than beta-amyloid pathology in an APP NL-GF/MAPT P301S mouse model of Alzheimer's disease2023
- Author(s)
  Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Alper Kilci, Matthew Jenkins, Sherif Rashad, Jingjing Sun, Peter Dedon, Sarah Anne Daley, Weiming Xia, Alejandro Rondon Ortiz, Luke Dorrian, Takaomi C Sado, Takashi Saido, Benjamin Wolozin
- Journal Title
  
  Biorxiv preprint
  
  Volume: - Pages: 111-112
- DOI
  10.1101/2023.03.28.534515
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0338
[Journal Article] Mammalian tissue specific translation regulation; role of tRNA epitranscriptome in regulating codon optimality patterns across tissues2023
- Author(s)
  Daisuke Ando, Sherif Rashad, Thomas J Begley, Hidenori Endo, Masashi Aoki, Peter C Dedon, Kuniyasu Niizuma
- Journal Title
  
  Biorxiv preprint
  
  Volume: 00 Pages: 00-00
- DOI
  10.1101/2023.10.24.563884
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27432
[Journal Article] Codon Usage and mRNA Stability are Translational Determinants of Cellular Response to Canonical Ferroptosis Inducers2022
- Author(s)
  Rashad Sherif、Byrne Shane R、Saigusa Daisuke、Xiang Jingdong、Zhou Yuan、Zhang Liyin、Begley Thomas J、Tominaga Teiji、Niizuma Kuniyasu
- Journal Title
  
  Neuroscience
  
  Volume: 501 Pages: 103-130
- DOI
  10.1016/j.neuroscience.2022.08.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03374, KAKENHI-PROJECT-20K16323, KAKENHI-PROJECT-20KK0338
[Journal Article] RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses2022
- Author(s)
  Zhang Liyin、Rashad Sherif、Zhou Yuan、Niizuma Kuniyasu、Tominaga Teiji
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 42 Issue: 11 Pages: 2107-2122
- DOI
  10.1177/0271678x221110679
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04835, KAKENHI-PROJECT-20K16323
[Journal Article] Epigenetic regulation of translation repression in ferroptosis, and a role of Alternative splicing and tRNA methylation2021
- Author(s)
  Sherif Rashad, Daisuke Saigusa, Yuan Zhou, Liyin Zhang, Teiji Tominaga, Kuniyasu Niizuma
- Journal Title
  
  Biorxiv preprint
  
  Volume: 00 Pages: 00-00
- DOI
  10.1101/2021.11.10.468143
- Data Source
  KAKENHI-PROJECT-20K16323, KAKENHI-PROJECT-20KK0338
[Journal Article] Mature Neurons’ sensitivity to oxidative stress is epigenetically programmed by alternative splicing and mRNA stability2021
- Author(s)
  Yuan Zhou, Sherif Rashad, Teiji Tominaga, Kuniyasu Niizuma
- Journal Title
  
  Biorxiv preprint
  
  Volume: 00 Pages: 00-00
- DOI
  10.1101/2021.12.25.472549
- Data Source
  KAKENHI-PROJECT-20K16323, KAKENHI-PROJECT-20KK0338
[Journal Article] The cell and stress‐specific canonical and noncanonical tRNA cleavage2021
- Author(s)
  Sherif Rashad, Teiji Tominaga, Kuniyasu Niizuma
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 236 Issue: 5 Pages: 3710-3724
- DOI
  10.1002/jcp.30107
- Data Source
  KAKENHI-PROJECT-20K16323, KAKENHI-PROJECT-20KK0338
[Presentation] Ribosome collisions is targetable vulnerability inglioma during ferroptosis exposure2023
- Author(s)
  Tianxiang Zhang, Sherif Rashad , Kuniyasu Niizuma;
- Organizer
  Cell bio 2023 (American society for cell biology meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27432
[Presentation] Neuronal sensitivity to oxidative stress is an epi and post transcriptional consequence to neuronal differentiation.2023
- Author(s)
  Yuan Zhou, Sherif Rashad , Kuniyasu Niizuma;
- Organizer
  RNA Japan meeting 2023
- Data Source
  KAKENHI-PROJECT-23K27432
[Presentation] Translational regulation of mitochondrial stress response via the tRNA epitranscriptome.2023
- Author(s)
  Sherif Rashad
- Organizer
  RNA 2023 meeting Singapore (International RNA society meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27432
[Presentation] tRNA Queuosine modifications regulate translationalresponse to mitochondrial stress2023
- Author(s)
  Sherif Rashad , Shadi Al-Mesitef , Abdulrahman Mousa , Daisuke Saigusa , Thomas Begley , Peter Dedon , Kuniyasu Niizuma
- Organizer
  Cell bio 2023 (American society for cell biology meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27432
[Presentation] Neuronal sensitivity to oxidative stress is epi- and post-transcriptionally regulated2023
- Author(s)
  Sherif Rashad
- Organizer
  Brain Japan 2023 (Japan society for cerebral blood flow and metabolism meeting)
- Data Source
  KAKENHI-PROJECT-23K27432
[Presentation] SAMD4A regulates neuronal differentiation andsensitivity to oxidative stress via altering mRNA stability2023
- Author(s)
  Yuan Zhou, Sherif Rashad , Kuniyasu Niizuma;
- Organizer
  Cell bio 2023 (American society for cell biology meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27432
[Presentation] Neuronal sensitivity to oxidative stress is epitranscriptionally programmed2022
- Author(s)
  Sherif Rashad, Yuan Zhou, Kuniyasu Niizuma
- Organizer
  The Society for Redox Biology and Medicine's 29th Annual Conference (SfRBM 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0338
[Presentation] Codon usage and mRNA stability are translational determinants of cellular response to canonical ferroptosis inducers2022
- Author(s)
  Sherif Rashad
- Organizer
  The Society for Redox Biology and Medicine's 29th Annual Conference (SfRBM 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0338
[Presentation] Rnf213遺伝子変異による抗原提示能低下は抗原特異的T細胞応答の低下に寄与する2022
- Author(s)
  田代亮介、新妻邦泰、笠松純、奥山祐子、Sherif Rashad、菊池敦生、藤村幹、呉繁夫、石井直人、冨永悌二
- Organizer
  Stroke 2022
- Data Source
  KAKENHI-PROJECT-21H04835
[Presentation] RNF213 loss of function reshapes vascular transcriptome and spliceosome2022
- Author(s)
  Sherif Rashad, Liyin Zhang, Kuniyasu Niizuma, Teiji Tominaga
- Organizer
  Brain Japan 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04835

1. Niizuma Kuniyasu (10643330)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. Tominaga Teiji (00217548)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 坂田洋之 (80722305)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 伊藤明 (90867863)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 森戸大介 (20514251)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 下田由輝 (30815444)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 遠藤俊毅 (00535370)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 藤村幹 (00361098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 菅野新一郎 (10400417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 豊原敬文 (60594182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 阿部高明 (80292209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 正本和人 (60455384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 七谷圭 (00547333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 金森政之 (60420022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 三枝大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 富永悌二

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Rashad Sherif Ｒａｓｈａｄ Ｓｈｅｒｉｆ

Research Projects

Research Products

Co-Researchers

Elucidation of the pathogenesis of moyamoya disease through Endothelial-Smooth Muscle Interaction and RNF213

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the role of tRNA epitranscriptome in Glioma pathology and development of novel therapiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

慢性期脊髄損傷に対するMuse細胞を用いた新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of moyamoya disease pathophysiology through an interaction of hemodynamics and endothelial cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studying the dynamics of a novel small RNA (tiRNA) generation in glioma; possible new therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

tRNA epitranscriptome in regulating glioma therapeutic resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Muse cell therapy for dementia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Translational response to mitochondrial stresses is orchestrated by tRNA modifications2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angiogenin regulates mitochondrial stress and function via tRNA-derived fragments generation and impacting tRNA modifications2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accumulation of m6A exhibits stronger correlation with MAPT than beta-amyloid pathology in an APP NL-GF/MAPT P301S mouse model of Alzheimer's disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mammalian tissue specific translation regulation; role of tRNA epitranscriptome in regulating codon optimality patterns across tissues2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Codon Usage and mRNA Stability are Translational Determinants of Cellular Response to Canonical Ferroptosis Inducers2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic regulation of translation repression in ferroptosis, and a role of Alternative splicing and tRNA methylation2021

Author(s)

Journal Title

DOI

Rashad Sherif ＲａｓｈａｄＳｈｅｒｉｆ