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Nanaura Hitoki  七浦 仁紀

… Alternative Names

NANAURA HITOKI  七浦 仁紀

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Researcher Number 00827909
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-0934-7065
Affiliation (Current) 2025: 奈良県立医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2025: 奈良県立医科大学, 医学部, 助教
2020 – 2023: 奈良県立医科大学, 医学部, 助教
2018 – 2019: 奈良県立医科大学, 医学部附属病院, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 52020:Neurology-related / 0902:General internal medicine and related fields
Except Principal Investigator
Basic Section 52020:Neurology-related
Keywords
Principal Investigator
神経変性疾患 / 液-液相分離 / 前頭側頭型認知症 / 筋萎縮性側索硬化症 / ALS / FTD / 精神神経疾患 / 相分離シャペロン / RNA結合タンパク質 / 遺伝性神経疾患 … More / アミロイド / シャペロン / パーキンソン病 / 中脳 / ドパミン / 神経細胞 / 脳オルガノイド … More
Except Principal Investigator
RAN翻訳 / リピート病 / オルガノイド / laser micro-irradiation / ポリペプチド / 脊髄小脳変性症 / 脳幹オルガノイド / DNA修復 / 核内封入体病 / ALS / RAN translation / C9orf72 / FUS / 脳オルガノイド / 筋萎縮性側索硬化症 / 非翻訳領域リピート病 / 神経変性疾患 Less
  • Research Projects

    (5 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (10 People)
  •  遺伝性神経疾患における変性過程のダイナミクス理解とその制御Principal Investigator

    • Principal Investigator
      七浦 仁紀
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Nara Medical University
  •  タンパク質の制御機構からみたALS/FTDの病態解明Principal Investigator

    • Principal Investigator
      七浦 仁紀
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Nara Medical University
  •  Analyses for molecular chaperones regulating liquid-liquid phase separation in amyotrophic lateral sclerosisPrincipal Investigator

    • Principal Investigator
      Nanaura Hitoki
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Nara Medical University
  •  Pathophysiological analysis of repeat disease causing neurodegenerative disease using human brain organoids.

    • Principal Investigator
      Kiriyama Takao
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Nara Medical University
  •  Induction of midbrain-like organoids from human pluripotent stem cellsPrincipal Investigator

    • Principal Investigator
      NANAURA HITOKI
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0902:General internal medicine and related fields
    • Research Institution
      Nara Medical University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Serum Alkaline Phosphatase in Cryptogenic Stroke Cases with Active Cancer2022

    • Author(s)
      Izumi Tesseki、Nanaura Hitoki、Iguchi Naohiko、Ozaki Maki、Sugie Kazuma
    • Journal Title

      Intern. Med.

      Volume: 61 Issue: 5 Pages: 639-646

    • DOI

      10.2169/internalmedicine.7550-21

    • NAID

      130008165973

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2022-03-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16583
  • [Journal Article] C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response2022

    • Author(s)
      Shiota Tomo、Nagata Riko、Kikuchi Sotaro、Nanaura Hitoki、Matsubayashi Masaya、Nakanishi Mari、Kobashigawa Shinko、Isozumi Noriyoshi、Kiriyama Takao、Nagayama Kazuaki、Sugie Kazuma、Yamashiro Yoshito、Mori Eiichiro
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 10 Pages: 750829-750829

    • DOI

      10.3389/fcell.2022.750829

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07978, KAKENHI-PROJECT-19K17043, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-21K15032, KAKENHI-PROJECT-22K07725, KAKENHI-PROJECT-21H03804, KAKENHI-PROJECT-19K08150, KAKENHI-PROJECT-23K21373, KAKENHI-PROJECT-21K19881
  • [Journal Article] Anti-programmed cell death-1 (PD-1) monoclonal antibodies involve reversible cranial dura matter2021

    • Author(s)
      Kataoka Hiroshi、Shimada Daisuke、Nanaura Hitoki、Sugie Kazuma
    • Journal Title

      Oxford Medical Case Reports

      Volume: 2021 Issue: 9

    • DOI

      10.1093/omcr/omab077

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16583
  • [Journal Article] C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers2021

    • Author(s)
      Nanaura Hitoki、Aiba Yuichiro、Nakanishi Mari、Shiota Tomo、Hibino Masaki、Kikuchi Sotaro、Nagata Riko、Morikawa Naritaka、Iguchi Naohiko、Kiriyama Takao、Nagamori Shushi、Sugie Kazuma、Saio Tomohide、Yoshizawa Takuya、Mori Eiichiro et al.
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 5301-5301

    • DOI

      10.1038/s41467-021-25560-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07978, KAKENHI-PROJECT-19K16060, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-18H03984, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-20K06493, KAKENHI-PROJECT-20K06527, KAKENHI-PROJECT-20K06569, KAKENHI-PROJECT-20K06579, KAKENHI-PROJECT-21K15032, KAKENHI-PROJECT-19KK0071, KAKENHI-PROJECT-22KJ0024, KAKENHI-PLANNED-20H05925, KAKENHI-PROJECT-19H05648
  • [Journal Article] Zonisamide for the Efficacy of Sleep Abnormality in Parkinson's Disease (ZEAL Study): A Protocol for Randomized Controlled Trials2021

    • Author(s)
      Kataoka Hiroshi、Isogawa Masahiro、Inoue Takashi、Hasebe Miyoko、Takashima Ryuzo、Kasama Shu、Nanaura Hitoki、Kiriyama Takao、Kasahara Masato、Sugie Kazuma
    • Journal Title

      Frontiers in Neurology

      Volume: 12

    • DOI

      10.3389/fneur.2021.741307

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-21K10284
  • [Journal Article] Brainstem organoids from human pluripotent stem cells2020

    • Author(s)
      Nobuyuki Eura, Takeshi K. Matsui, Joachim Luginbuhl, Masaya Matsubayashi, Hitoki Nanaura, Tomo Shiota, Kaoru Kinugawa, Naohiko Iguchi, Takao Kiriyama, Canbin Zheng, Tsukasa Kouno, Yan Jun Lan, Pornparn Kongpracha, Pattama Wiriyasermkul, Yoshihiko M. Sakaguchi, Riko Nagata, Tomoya Komeda, Naritaka Morikawa, et al.
    • Journal Title

      Frontiers in Neuroscience

      Volume: - Pages: 00538-00538

    • DOI

      10.3389/fnins.2020.00538

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23952, KAKENHI-PROJECT-19K21306, KAKENHI-PROJECT-19K07318, KAKENHI-PROJECT-19K07978, KAKENHI-PROJECT-19K08150, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-20K16606, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-18K06524, KAKENHI-PROJECT-19K16925, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H02770
  • [Journal Article] Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury2020

    • Author(s)
      Ozawa Shota、Matsubayashi Masaya、Nanaura Hitoki、Yanagita Motoko、Mori Kiyoshi、Asanuma Katsuhiko、Kajiwara Nobuyuki、Hayashi Kazuyuki、Ohashi Hiroshi、Kasahara Masato、Yokoi Hideki、Kataoka Hiroaki、Mori Eiichiro、Nakagawa Takahiko
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 47 Pages: 16002-16012

    • DOI

      10.1074/jbc.ra120.013721

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08682, KAKENHI-PROJECT-20K08633, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-18H02823, KAKENHI-PROJECT-20H03199
  • [Journal Article] 27‐Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action2020

    • Author(s)
      Matsubayashi M、Sakaguchi YM.、Sahara Y、Nanaura H、Kikuchi S、Asghari A、Bui L、Kobashigawa S、Nakanishi M、Nagata R、Matsui TK.、Kashino G、Hasegawa M、Takasawa S、Eriguchi M、Tsuruya K、Nagamori S、Sugie K、Nakagawa T、Takasato M、Umetani M、Mori E
    • Journal Title

      The FASEB Journal

      Volume: 35 Issue: 1

    • DOI

      10.1096/fj.202002077r

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08150, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-18H02770, KAKENHI-PROJECT-19H05648
  • [Journal Article] ATR inhibition enhances 5-fluorouracil sensitivity independent of non-homologous end-joining and homologous recombination repair pathway2020

    • Author(s)
      Ito SS, Nakagawa Y, Matsubayashi M, Sakaguchi YM, Kobashigawa S, Matsui TK, Nanaura H, Nakanishi M, Kitayoshi F, Kikuchi S, Kajihara A, Tamaki S, Sugie K, Kashino G, Takahashi A, Hasegawa M, Mori E
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2020.04.20.051318

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K08150, KAKENHI-PROJECT-19K21306
  • [Journal Article] Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways2020

    • Author(s)
      Ito Soichiro S.、Nakagawa Yosuke、Matsubayashi Masaya、Sakaguchi Yoshihiko M.、Kobashigawa Shinko、Matsui Takeshi K.、Nanaura Hitoki、Nakanishi Mari、Kitayoshi Fumika、Kikuchi Sotaro、Kajihara Atsuhisa、Tamaki Shigehiro、Sugie Kazuma、Kashino Genro、Takahashi Akihisa、Hasegawa Masatoshi、Mori Eiichiro、Kirita Tadaaki
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 37 Pages: 12946-12961

    • DOI

      10.1074/jbc.ra120.013726

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08150, KAKENHI-PROJECT-19K10272, KAKENHI-PROJECT-18K17234, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-18K07764, KAKENHI-PROJECT-18H02770
  • [Journal Article] Human URAT1/SLC22A12 gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements2019

    • Author(s)
      Matsubayashi M, Sakaguchi YM, Sahara Y, Nanaura H, Kikuchi S, Ashari A, Bui L, Kobashigawa S, Nakanishi M, Nagata R, Matsui TK, Kashino G, Hasegawa M, Takasawa S, Eriguchi M, Tsuruya K, Nagamori S, Sugie K, Nakagawa T, Takasato M, Umetani M, Mori E
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/827709

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08150, KAKENHI-PROJECT-19K21306
  • [Journal Article] Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains.2019

    • Author(s)
      Nanaura H, Kawamukai H, Fujiwara A, Uehara T, Nakanishi M, Shiota T, Hibino M, Aiba Y, Wiriyasermkul P, Kikuchi S, Nagata R, Matsubayashi M, Nagamori S, Shoji O, Ishimori K, Matsumura H, Sugie K, Saio T*, Yoshizawa T*, Mori E
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/812099

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K21306, KAKENHI-PUBLICLY-19H04945
  • [Journal Article] Proteolytic Cleavage by Matriptase Exacerbating Kidney Injury: a Novel Therapeutic Target.2019

    • Author(s)
      Ozawa S, Matsubayashi M, Nanaura H, Yanagita M, Mori K, Asanuma K, Kajiwara N, Hayashi K, Ohashi H, Kasahara M, Yokoi H, Kataoka H, Mori E, Nakagawa T
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/843607

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K21306
  • [Presentation] Disease-associated mutations dysregulate phase separation of RBPs in neurodegenerative diseases.2023

    • Author(s)
      七浦 仁紀, 山岡 美奈子, 井口 直彦, 森 英一朗, 杉江 和馬
    • Organizer
      第64回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-22K15734
  • [Presentation] C9orf72 derived dipeptide repeat proteins associate with lysosome.2022

    • Author(s)
      山岡 美奈子, 塩田 智, 七浦 仁紀, 森 英一朗, 杉江 和馬
    • Organizer
      第63回日本神経学会学術大会 2022/5/18-5/21, 国内, ポスター
    • Data Source
      KAKENHI-PROJECT-22K15734
  • [Presentation] C9orf72-derived proline:arginine poly-dipeptides alter cytoskeleton and mechanical stress response.2022

    • Author(s)
      塩田 智, 七浦 仁紀, 山岡 美奈子, 森 英一朗, 杉江 和馬
    • Organizer
      第63回日本神経学会学術大会 2022/5/18-5/21, 国内, ポスター
    • Data Source
      KAKENHI-PROJECT-22K15734
  • [Presentation] Arginine-rich poly-dipeptides impede phase modifiers of RNA-binding proteins in C9-ALS/FTD.2022

    • Author(s)
      七浦 仁紀, 塩田 智, 山岡 美奈子, 森 英一朗, 杉江 和馬
    • Organizer
      第63回日本神経学会学術大会 2022/5/18-5/21, 国内, ポスター
    • Data Source
      KAKENHI-PROJECT-22K15734
  • [Presentation] The role of zinc finger domains for regulating biological phase separation.2022

    • Author(s)
      井口 直彦, 五十棲 規嘉, 七浦 仁紀, 森 英一朗, 杉江 和馬
    • Organizer
      第63回日本神経学会学術大会 2022/5/18-5/21, 国内, ポスター
    • Data Source
      KAKENHI-PROJECT-22K15734
  • [Presentation] Dysfunction of molecular chaperones for phase separating proteins in ALS2021

    • Author(s)
      七浦仁紀、塩田智、森英一朗、杉江和馬
    • Organizer
      第62回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-20K16583
  • [Presentation] C9orf72-derived PR poly-dipeptides target Kapβ2 through NLS binding site and dysregulate LLPS2020

    • Author(s)
      七浦 仁紀, 塩田 智, 森 英一朗, 杉江 和馬
    • Organizer
      第61回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-20K16583
  • [Presentation] Rapid induction of midbrain-like organoids from human pluripotent stem cells2019

    • Author(s)
      七浦仁紀、松井健、塩田智、江浦信之、森英一朗、杉江和馬
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K21306
  • [Presentation] A human cerebral organoid model for ZEB2-deficient Mowat-Wilson syndrome2019

    • Author(s)
      江浦信之、松井健、七浦仁紀、塩田智、森英一朗、杉江和馬
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K21306
  • [Presentation] Induction of electrophysiologically-active brain organoids showing human midbrain-specific structure2019

    • Author(s)
      Takeshi Ken Matsui, Nobuyuki Eura, Hitoki Nanaura, Tomo Shiota, Yasuhiko Saitoh, Kazuma Sugie, Eiichiro Mori
    • Organizer
      Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K21306
  • [Presentation] Human cerebral organoids recapitulate brain formation and genetic developmental disorders2019

    • Author(s)
      松井健、江浦信之、七浦仁紀、塩田智、森英一朗、杉江和馬
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K21306
  • [Presentation] Recapitulation of brain ischemia with human cerebral organoids2019

    • Author(s)
      塩田智、松井健、江浦信之、七浦仁紀、森英一朗、杉江和馬
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K21306
  • 1.  Kiriyama Takao (80571025)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  杉江 和馬 (60347549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  松井 健 (90528605)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  塩田 智 (70837062)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  井口 直彦 (50838232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  KASHINO Genro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 7.  小橋川 新子(菓子野新子)
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 8.  森 英一朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 9.  絹川 薫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  森 潔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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