NIE YUNZHONG 聶運中

Researcher Number	00831330
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京大学, 医科学研究所, 助教 2018 – 2020: 横浜市立大学, 医学研究科, 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / 0905:Surgery of the organs maintaining homeostasis and related fields Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator hiPSC / disease modeling / liver / Vascular / Kupffer cells / Air-liquid interface / LSEC / Hepatic stellate cells / Kupffer cell / NASH … More / tissue structure / Mini liver tissue / Transplantation / Genetic liver disorders / Liver repopulation / Hepatoblast / progenitor cells / liver disease / progenitor / liver organoid / Massive production / Progenitor / Liver reconsturction / Liver organoid / Liver regenration / Stem cell … More Except Principal Investigator iPS細胞 / 肝臓 / オルガノイド / 三次元培養 / ヒトiPS細胞 / NASH / 肝硬変 / カニクイザル / ips細胞 Less

新規大量培養法による高機能化ヒトiPS細胞由来肝臓オルガノイドの創出
- Principal Investigator
  
  岡本理志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Keio University
Development of a novel human NASH model using human iPS cell-derived liver organoids
- Principal Investigator
  
  上野康晴
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokyo
Development of transplantation therapy for genetic liver disorders with hiPSC-derived proliferative hepatoblastPrincipal Investigator
- Principal Investigator
  
  聶運中
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokyo
Generation of mini liver tissue with complex cellular and architectural properties for disease modeling and drug screeningPrincipal Investigator
- Principal Investigator
  
  NIE YUNZHONG
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokyo
The development of human iPSC derived proliferative progenitors for the effectively massive production of liver organoidPrincipal Investigator
- Principal Investigator
  
  NIE YUNZHONG
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0905:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  The University of Tokyo
Liver organoid derived from iPSCs transplant to Cynomolgus monkey with liver cirrhosis
- Principal Investigator
  
  Taniguchi Hideki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  The University of Tokyo
  Yokohama City University

All 2022 2021 2020

All Journal Article Presentation Patent

[Journal Article] Improving the repopulation capacity of elderly human hepatocytes by decoding aging-associated hepatocyte plasticity.2022
- Author(s)
  Nie YZ, Zheng YW, Taniguchi H
- Journal Title
  
  Hepatology
  
  Volume: 0 Issue: 4 Pages: 0-0
- DOI
  10.1002/hep.32443
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04830, KAKENHI-PROJECT-21K16377, KAKENHI-PROJECT-20K22946
[Journal Article] A novel orthotopic liver cancer model for creating human-like tumor microenvironment.2021
- Author(s)
  Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.
- Journal Title
  
  Cancers(Basel)
  
  Volume: 13 Issue: 16 Pages: 3997-3997
- DOI
  10.3390/cancers13163997
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04830, KAKENHI-PROJECT-19H03733, KAKENHI-PROJECT-21K08208, KAKENHI-PROJECT-21K16377, KAKENHI-PROJECT-20K22946
[Journal Article] Human Pluripotent Stem Cell-Derived Hepatocyte-Like Cells and Organoids for Liver Disease and Therapy2021
- Author(s)
  Li Y, Yang X, Plummer R, Hayashi Y, Deng XS, Nie YZ, Taniguchi H
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 19 Pages: 10471-10471
- DOI
  10.3390/ijms221910471
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04830, KAKENHI-PROJECT-21K16377, KAKENHI-PROJECT-20K22946
[Patent] 肝細胞の可塑性誘導法2020
- Inventor(s)
  谷口英樹,聶運中,鄭允文
- Industrial Property Rights Holder
  谷口英樹,聶運中,鄭允文
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K22946
[Presentation] Decoding hepatocyte plasticity in aging with human induced pluripotent stem cells2022
- Author(s)
  Nie YZ, Hideki T
- Organizer
  東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K16377
[Presentation] ヒトiPS細胞を用いて老化に伴う肝細胞可塑性変化メカニズムの解明2022
- Author(s)
  聶　運中、谷口　英樹
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K16377
[Presentation] In-vitro generation of a functional and vascularized liver organoid from human iPS cells.2021
- Author(s)
  Plummer RT, Nie YZ, et al.,
- Organizer
  ISSCR Tokyo 2021 International Symposium.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22946
[Presentation] Recapitulation of hepatic hematopoiesis with human liver organoids2021
- Author(s)
  Li Y, Nie YZ, et al.,
- Organizer
  ISSCR 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16377
[Presentation] In-vitro generation of a functional and vascularized liver organoid from human iPS cells.2021
- Author(s)
  Plummer RT, Nie YZ, et al.,
- Organizer
  ISSCR Tokyo 2021 International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16377
[Presentation] Recapitulation of hepatic hematopoiesis with human liver organoids.2021
- Author(s)
  Li Y, Nie YZ, et al.,
- Organizer
  ISSCR 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22946
[Presentation] Generation of quiescent hepatic stellate cells from human induced pluripotent stem cells.2021
- Author(s)
  Yang X, Nie YZ, et al.,
- Organizer
  ISSCR 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22946
[Presentation] Generation of quiescent hepatic stellate cells from human induced pluripotent stem cells.2021
- Author(s)
  Yang X, Nie YZ, et al.,
- Organizer
  ISSCR 2021 Virtual Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16377
[Presentation] Ex vivo evaluation of human hepatocyte plasticity2020
- Author(s)
  Yun-Zhong Nie, Yun-Wen Zheng, Hideki Taniguchi
- Organizer
  The International Society for Stem Cell Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22946

1. Taniguchi Hideki (70292555)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 村田聡一郎 (40436275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 鄭允文 (80404995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 久世祥己 (70837806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 上野康晴 (60375235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 岡本理志 (50509106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NIE YUNZHONG 聶 運中

Research Projects

Research Products

Co-Researchers

新規大量培養法による高機能化ヒトiPS細胞由来肝臓オルガノイドの創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel human NASH model using human iPS cell-derived liver organoids

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of transplantation therapy for genetic liver disorders with hiPSC-derived proliferative hepatoblastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of mini liver tissue with complex cellular and architectural properties for disease modeling and drug screeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of human iPSC derived proliferative progenitors for the effectively massive production of liver organoidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Liver organoid derived from iPSCs transplant to Cynomolgus monkey with liver cirrhosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Improving the repopulation capacity of elderly human hepatocytes by decoding aging-associated hepatocyte plasticity.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel orthotopic liver cancer model for creating human-like tumor microenvironment.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human Pluripotent Stem Cell-Derived Hepatocyte-Like Cells and Organoids for Liver Disease and Therapy2021

Author(s)

Journal Title

DOI

Data Source

[Patent] 肝細胞の可塑性誘導法2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] Decoding hepatocyte plasticity in aging with human induced pluripotent stem cells2022

Author(s)

Organizer

Data Source

[Presentation] ヒトiPS細胞を用いて老化に伴う肝細胞可塑性変化メカニズムの解明2022

Author(s)

Organizer

Data Source

[Presentation] In-vitro generation of a functional and vascularized liver organoid from human iPS cells.2021

Author(s)

Organizer

Data Source

[Presentation] Recapitulation of hepatic hematopoiesis with human liver organoids2021

Author(s)

Organizer

Data Source

[Presentation] In-vitro generation of a functional and vascularized liver organoid from human iPS cells.2021

Author(s)

Organizer

NIE YUNZHONG 聶運中