KO TOSHIYUKI 候聡志

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Ko Toshiyuki 候聡志

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Researcher Number	00836059
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 特任助教
Affiliation (based on the past Project Information) *help	2025: 東京大学, 医学部附属病院, 特任助教 2020 – 2021: 東京大学, 医学部附属病院, 特任助教 2019: 東京大学, 医学部附属病院, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related Except Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator 系譜追跡 / 一細胞解析 / 空間的遺伝子発現解析 / シングルセル解析 / 心筋梗塞 / 心不全 Except Principal Investigator シングルセル解析 / 老化 / DNA損傷 / 心不全

心筋細胞DNA損傷と可塑性への介入による新規心不全治療戦略の開発Principal Investigator
- Principal Investigator
  
  候聡志
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
非分裂細胞である心筋細胞のDNA損傷と老化による心不全発症機序の解明
- Principal Investigator
  
  小室一成
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
Single-cell pathological dynamics in tissue repair and remodeling after myocardial infarctionPrincipal Investigator
- Principal Investigator
  
  Ko Toshiyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis2022
- Author(s)
  T. Ko, S. Nomura, K. Fujita, S. Yamada, T. Fujita, M. Satoh, C. Oka, M. Katoh, M. Ito, M. Katagiri, T. Sassa, B. Zhang, S. Hatsuse, T. Yamada, M. Harada, H. Toko, E. Amiya, M. Hatano, O. Kinoshita, K. Nawata, M. Ono, M. Ikeuchi, H. Morita, H. Aburatani, I. Komuro
- Journal Title
  
  Nature communications
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17587
[Journal Article] シングルセル解析に基づく循環器病態研究2021
- Author(s)
  候聡志、山田臣太郎、野村征太郎
- Journal Title
  
  Journal of JCS Cardiologists
  
  Volume: 30 Issue: 0 Pages: 43-50
- DOI
  10.1253/jjcsc.30.0_43
- NAID
  130008082135
- ISSN
  0918-9599, 2433-2852
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-19K17587
[Journal Article] Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure2021
- Author(s)
  Komai Kyoko、Ito Minako、Nomura Seitaro、Shichino Shigeyuki、Katoh Manami、Yamada Shintaro、Ko Toshiyuki、Iizuka-Koga Mana、Nakatsukasa Hiroko、Yoshimura Akihiko
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 763647-763647
- DOI
  10.3389/fimmu.2021.763647
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08891, KAKENHI-PROJECT-18K15129, KAKENHI-PROJECT-19K17587, KAKENHI-PUBLICLY-21H00432, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-21H04821, KAKENHI-PROJECT-21H02719, KAKENHI-PROJECT-19J40137, KAKENHI-PROJECT-20K07541, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19H03649
[Journal Article] Prediction of single-cell mechanisms for disease progression in hypertrophic remodelling by a trans-omics approach2021
- Author(s)
  Hamano M, Nomura S, Iida M, Komuro I, Yamanishi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1 Pages: 8112-8112
- DOI
  10.1038/s41598-021-86821-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-21H04821, KAKENHI-PROJECT-21H05045
[Journal Article] 特集心不全のすべて-増え続ける心不全患者にどう対峙するかトピックス心不全に対するprecision medicineの展望2021
- Author(s)
  候聡志
- Journal Title
  
  内科
  
  Volume: 128 Issue: 1 Pages: 121-124
- DOI
  10.15106/j_naika128_121
- ISSN
  0022-1961, 2432-9452
- Year and Date
  2021-07-01
- Data Source
  KAKENHI-PROJECT-19K17587
[Journal Article] CXCR7 ameliorates myocardial infarction as a β arrestin-biased receptor2021
- Author(s)
  Ishizuka et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 3426-3426
- DOI
  10.1038/s41598-021-83022-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08510, KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-19K17587, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-19J13042, KAKENHI-PROJECT-19K17667
[Journal Article] Author Correction: CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor2021
- Author(s)
  Ishizuka Masato、Harada Mutsuo、Nomura Seitaro、Ko Toshiyuki、et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 3426-3426
- DOI
  10.1038/s41598-021-91788-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17587
[Journal Article] New Vision, Mission, and Values of the Japanese Circulation Society2021
- Author(s)
  Ishida M, Matsumoto C, Kida K, Fukuda M, Kagiyama N, Kusunose K, Matsumoto S, Nomura S, Okumura T, Shiono Y, Taniguchi T, Mizuno A, Kishi T, Node K, Komuro I, Hirata KI; Directors of the Japanese Circulation Society.
- Journal Title
  
  Circ J
  
  Volume: 85 Issue: 12 Pages: 2248-2251
- DOI
  10.1253/circj.CJ-21-0822
- NAID
  130008119954
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2021-11-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04821, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19H03649
[Journal Article] Single-Cardiomyocyte RNA Sequencing to Dissect the Molecular Pathophysiology of the Heart.2021
- Author(s)
  Katoh M, Nomura S, Yamada S, Aburatani H, Komuro I.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2320 Pages: 183-192
- DOI
  10.1007/978-1-0716-1484-6_18
- ISBN
  9781071614839, 9781071614846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04821, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19H03649
[Journal Article] Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury2021
- Author(s)
  Hasegawa S, Inoue T, Nakamura Y, Fukaya D, Uni R, Wu CH, Fujii R, Peerapanyasut W, Taguchi A, Kohro T, Yamada S, Katagiri M, Ko T, Nomura S, Nakanishi Ozeki A, Susaki EA, Ueda HR, Akimitsu N, Wada Y, Komuro I, Nangaku M, Inagi R.
- Journal Title
  
  J Am Soc Nephrol.
  
  Volume: - Issue: 7 Pages: 1599-1615
- DOI
  10.1681/asn.2020121723
- NAID
  120007174517
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-19J11928, KAKENHI-PROJECT-19K22679, KAKENHI-PROJECT-19K17587, KAKENHI-PROJECT-21H04821, KAKENHI-PROJECT-19H03413, KAKENHI-PROJECT-21H02824, KAKENHI-PROJECT-21K19439, KAKENHI-PROJECT-21K16159, KAKENHI-PROJECT-21H05045
[Journal Article] Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice2021
- Author(s)
  Fujiwara Takayuki、Takeda Norifumi、Hara Hironori、Ishii Satoshi、Numata Genri、Tokiwa Hiroyuki、Maemura Sonoko、Suzuki Takaaki、Takiguchi Hiroshi、Kubota Yoshiaki、Seo Kinya、Sakata Asuka、Nomura Seitaro、Hatano Masaru、Ueda Kazutaka、Komuro Issei
- Journal Title
  
  Circulation
  
  Volume: 144 Issue: 17 Pages: 1452-1455
- DOI
  10.1161/circulationaha.121.056219
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08096, KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-21H04821, KAKENHI-PROJECT-21K16110, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-21K08023, KAKENHI-PROJECT-21H02908
[Journal Article] Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart2020
- Author(s)
  Toko Haruhiro、Morita Hiroyuki、Katakura Masanori、Hashimoto Michio、Ko Toshiyuki、Bujo Satoshi、Adachi Yusuke、Ueda Kazutaka、Murakami Haruka、Ishizuka Masato、Guo Jiaxi、Zhao Chunxia、Fujiwara Takayuki、Hara Hironori、Takeda Norifumi、Takimoto Eiki、Shido Osamu、Harada Mutsuo、Komuro Issei
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 15553-15553
- DOI
  10.1038/s41598-020-72686-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-19K17587, KAKENHI-PROJECT-19K17667
[Journal Article] Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure2020
- Author(s)
  Yamaguchi Toshihiro、Sumida Tomokazu S.、Nomura Seitaro、Satoh Masahiro、Higo Tomoaki、Ito Masamichi、Ko Toshiyuki、Fujita Kanna、Sweet Mary E.、Sanbe Atsushi、Yoshimi Kenji、Manabe Ichiro、Sasaoka Toshikuni、Taylor Matthew R. G.、Toko Haruhiro、Takimoto Eiki、Naito Atsuhiko T.、Komuro Issei
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4364-4364
- DOI
  10.1038/s41467-020-18128-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-19K17587, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-19H03662, KAKENHI-PROJECT-18K15881
[Journal Article] 特集循環器疾患バイオマーカー　有用性と可能性治す12 DNA 損傷評価に基づく拡張型心筋症患者の精密医療2020
- Author(s)
  候　聡志
- Journal Title
  
  Heart View
  
  Volume: 24 Issue: 10 Pages: 994-1000
- DOI
  10.18885/HV.0000000322
- ISSN
  1342-6591
- Year and Date
  2020-10-09
- Data Source
  KAKENHI-PROJECT-19K17587
[Journal Article] Quantification of DNA damage in heart tissue as a novel prediction tool for therapeutic prognosis of patients with dilated cardiomyopathy.2019
- Author(s)
  Ko T, Fujita K, Nomura S, Uemura Y, Yamada S, Tobita T, Katoh M, Satoh M, Ito M, Domoto Y, Hosoya Y, Amiya E, Hatano M, Morita H, Fukayama M, Aburatani H, Komuro I.
- Journal Title
  
  JACC: Basic to Translational Science
  
  Volume: 4(6) Pages: 670-680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17587
[Patent] 心筋梗塞・心不全の治療標的としての心保護因子Htra3の同定2021
- Inventor(s)
  野村征太郎、候聡志、油谷浩幸、小室一成
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-21H04821
[Presentation] Aberrant Interaction Between TEAD1 and Lamin A/C Impairs Cardiomyocyte Maturation in LMNA-related Cardiomyopathy2022
- Author(s)
  Toshiyuki Ko
- Organizer
  第86回日本循環器学会学術集会 Special Session「Single Cell Analysis in Cardiovascular Disease」
- Invited
- Data Source
  KAKENHI-PROJECT-19K17587
[Presentation] Cardiac Fibroblasts are Critically Involved in the Development of Heart Failure by Inducing Cardiomyocyte Senescence2021
- Author(s)
  Toshiyuki Ko
- Organizer
  米国心臓協会（American Heart Association）Scientific Sessions 2021, Melvin L. Marcus Early Career Investigator Award
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17587
[Presentation] Single-Cell Analysis to Explore the Molecular Pathology of Heart Failure2021
- Author(s)
  Toshiyuki Ko
- Organizer
  第85回日本循環器学会学術集会シンポジウム「Molecular mechanisms of heart failure」
- Invited
- Data Source
  KAKENHI-PROJECT-19K17587
[Presentation] Single-Cell Analysis to Explore the Molecular Pathology of Heart Failure2021
- Author(s)
  Toshiyuki Ko
- Organizer
  日本循環器学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17587
[Presentation] Single-cell multiomic analysis of both knock-in mouse and iPSCMs identifies the mechanism of maturation abnormality in heart caused by LMNA Q353R mutation2021
- Author(s)
  Toshiyuki Ko
- Organizer
  第38回国際心臓研究会日本部会 Young Investigator Award最優秀賞
- Data Source
  KAKENHI-PROJECT-19K17587
[Presentation] Mechanical Stress on Cardiac Fibroblasts Triggers Phenotypic Conversion in Cardiomyocytes Leading to Heart Failure2021
- Author(s)
  Toshiyuki Ko
- Organizer
  日本循環器学会
- Data Source
  KAKENHI-PROJECT-19K17587
[Presentation] Mechanical Stress on Cardiac Fibroblasts Triggers Phenotypic Conversion in Cardiomyocytes Leading to Heart Failure2021
- Author(s)
  Toshiyuki Ko
- Organizer
  第85回日本循環器学会学術集会 Young Investigator Award
- Data Source
  KAKENHI-PROJECT-19K17587
[Presentation] DNA傷害定量評価に基づく拡張型心筋症患者の治療予後予測2019
- Author(s)
  Toshiyuki Ko, Seitaro Nomura, Masaru Hatano, Issei Komuro
- Organizer
  第67回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17587
[Presentation] Single cell RNA-seq of human cardiomyocytes revealed DNA damage response as a novel predictor for therapeutic prognosis in heart failure patients with dilated cardiomyopathy2019
- Author(s)
  Toshiyuki Ko
- Organizer
  International Society for Heart Research World Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17587
[Presentation] Quantification of DNA Damage in Heart Tissue as A Novel Prediction Tool for Therapeutic Prognosis2019
- Author(s)
  Toshiyuki Ko, Seitaro Nomura, Masaru Hatano, Issei Komuro
- Organizer
  第23回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17587

1. 小室一成 (30260483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 野村征太郎 (10722118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 加藤愛巳 (60832045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 東口治弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 小賀麻菜(飯塚麻菜)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 上田和孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KO TOSHIYUKI 候 聡志

Ko Toshiyuki 候 聡志

Research Projects

Research Products

Co-Researchers

心筋細胞DNA損傷と可塑性への介入による新規心不全治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

非分裂細胞である心筋細胞のDNA損傷と老化による心不全発症機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single-cell pathological dynamics in tissue repair and remodeling after myocardial infarctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis2022

Author(s)

Journal Title

Data Source

[Journal Article] シングルセル解析に基づく循環器病態研究2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prediction of single-cell mechanisms for disease progression in hypertrophic remodelling by a trans-omics approach2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 特集 心不全のすべて-増え続ける心不全患者にどう対峙するか トピックス 心不全に対するprecision medicineの展望2021

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] CXCR7 ameliorates myocardial infarction as a β arrestin-biased receptor2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Author Correction: CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New Vision, Mission, and Values of the Japanese Circulation Society2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Single-Cardiomyocyte RNA Sequencing to Dissect the Molecular Pathophysiology of the Heart.2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury2021

Author(s)

Journal Title

KO TOSHIYUKI 候聡志

Ko Toshiyuki 候聡志

[Journal Article] 特集心不全のすべて-増え続ける心不全患者にどう対峙するかトピックス心不全に対するprecision medicineの展望2021

[Journal Article] 特集循環器疾患バイオマーカー　有用性と可能性治す12 DNA 損傷評価に基づく拡張型心筋症患者の精密医療2020