YOSHIDA Naofumi 吉田尚史

… Alternative Names

Yoshida Naofumi 吉田尚史

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Researcher Number	00846321
Other IDs	https://orcid.org/0000-0003-3949-0089
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2019 – 2022: 神戸大学, 医学研究科, 医学研究員
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / 0902:General internal medicine and related fields Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator CRISPRスクリーニング / Y染色体喪失 / 体細胞変異 / 質量分析 / lipid A / 動脈硬化 / リポ多糖 / 腸内細菌 / 循環器疾患 Except Principal Investigator リポ多糖 … More / マイクロRNA / リポポリサッカライド / OMV / 循環器疾患 / 好中球細胞外トラップ / 外膜小胞 / LPS / 炎症 / 動脈硬化 / メッセージ物質 / 腸内細菌 Less

CRISPRスクリーニングを用いたY染色体喪失機構の解明Principal Investigator
- Principal Investigator
  
  吉田尚史
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Clarifying the function of gut microbial message molecules and their association with cardiovascular diseases
- Principal Investigator
  
  Hirata Ken-ichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kobe University
Impact of gut microbial LPS on cardiovascular diseasesPrincipal Investigator
- Principal Investigator
  
  Yoshida Naofumi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Kobe University

All 2023 2022 2021 2020 2019

All Journal Article Presentation Book Patent

[Book] ICUとCCU2022
- Author(s)
  山下智也, 江本拓央, 斉藤克寛, 吉田尚史, 平田健一
- Total Pages
  62
- Publisher
  医学図書出版
- ISBN
  9784865175110
- Data Source
  KAKENHI-PROJECT-20H03676
[Book] Precision Medicine2021
- Author(s)
  吉田尚史
- Total Pages
  5
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-19K23944
[Book] 医学のあゆみ2020
- Author(s)
  吉田尚史、山下智也、平田健一
- Total Pages
  7
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19K23944
[Book] PROGRESS IN MEDICINE2020
- Author(s)
  山下智也、吉田尚史、林友鴻、田畑論子、江本拓央、平田健一
- Total Pages
  7
- Publisher
  メディカルオンライン
- Data Source
  KAKENHI-PROJECT-19K23944
[Book] Pharma Medica2020
- Author(s)
  吉田尚史、山下智也、平田健一
- Total Pages
  4
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-19K23944
[Book] ヒトマイクロバイオーム Vol.22020
- Author(s)
  吉田尚史、山下智也、平田健一
- Total Pages
  4
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-19K23944
[Book] 循環器ジャーナル2020
- Author(s)
  吉田尚史、山下智也、平田健一
- Total Pages
  4
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19K23944
[Book] 医学の歩み2019
- Author(s)
  吉田尚史、山下智也、平田健一
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19K23944
[Journal Article] 今月の特集マイクロバイオーム Microbiomeと心血管系疾患2022
- Author(s)
  山下智也, 吉田尚史, 平田健一
- Journal Title
  
  臨床検査
  
  Volume: 66 Issue: 11 Pages: 1346-1351
- DOI
  10.11477/mf.1542203170
- ISSN
  0485-1420, 1882-1367
- Year and Date
  2022-11-15
- Data Source
  KAKENHI-PROJECT-22K19708, KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676
[Journal Article] Structural differences in bacterial lipopolysaccharides determine atherosclerotic plaque progression by regulating the accumulation of neutrophils.2022
- Author(s)
  Saito Y, Yamashita T, Yoshida N, Emoto T, Takeda S, Tabata T, Shinohara M, Kishino S, Sugiyama Y, Kitamura N, Yamamoto H, Takaya T, Ogawa J, Hirata K
- Journal Title
  
  Atherosclerosis.
  
  Volume: 358 Pages: 1-11
- DOI
  10.1016/j.atherosclerosis.2022.08.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676
[Journal Article] Gut Microbiota Influence the Development of Abdominal Aortic Aneurysm by Suppressing Macrophage Accumulation in Mice.2022
- Author(s)
  Shinohara R, Nakashima H, Emoto T, Yamashita T, Saito Y, Yoshida N, Inoue T, Yamanaka K, Okada K, Hirata K
- Journal Title
  
  Hypertension
  
  Volume: 79 Issue: 12 Pages: 2821-2829
- DOI
  10.1161/hypertensionaha.122.19422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676
[Journal Article] Two Gut Microbiota-Derived Toxins Are Closely Associated with Cardiovascular Diseases: A Review.2021
- Author(s)
  Yamashita T, Yoshida N, Emoto T, Saito Y, Hirata K
- Journal Title
  
  Toxin
  
  Volume: 13 Pages: 297-297
- NAID
  120007041605
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03676
[Journal Article] Gut microbiota-derived toxins and metabolites in cardiovascular diseases2021
- Author(s)
  Yamashita Tomoya、Yoshida Naofumi、Emoto Takuo、Saito Yoshihiro、Hirata Ken‐ichi
- Journal Title
  
  Toxins
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23944
[Journal Article] Unraveling the Effects of Trimethylamine N-Oxide on Stroke: “The lower, the better?”2021
- Author(s)
  Yamashita Tomoya、Yoshida Naofumi、Emoto Takuo、Hirata Ken-ichi
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 28 Issue: 4 Pages: 314-316
- DOI
  10.5551/jat.ED142
- NAID
  130008014044
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2021-04-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23944
[Journal Article] Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity2021
- Author(s)
  Yoshida Naofumi、Yamashita Tomoya、Osone Tatsunori、Shinohara Masakazu、Kitahama Seiichi、Sasaki Kengo、Sasaki Daisuke、Emoto Takuo、Saito Yoshihiro、Kitaura Yasuyuki、Shimomura Yoshiharu、Kondo Akihiko、Kajimura Shingo、Inagaki Takeshi、Yamada Takuji、Hirata Ken-ichi
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 11 Pages: 103342-103342
- DOI
  10.1016/j.isci.2021.103342
- NAID
  120007179184
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676, KAKENHI-PROJECT-18K11013, KAKENHI-PROJECT-21K08548, KAKENHI-PROJECT-20K22647, KAKENHI-PROJECT-20H03729, KAKENHI-PROJECT-21H03355
[Journal Article] Two Gut Microbiota-Derived Toxins Are Closely Associated with Cardiovascular Diseases: A Review2021
- Author(s)
  Yamashita Tomoya、Yoshida Naofumi、Emoto Takuo、Saito Yoshihiro、Hirata Ken-ichi
- Journal Title
  
  Toxins
  
  Volume: 13 Issue: 5 Pages: 297-297
- DOI
  10.3390/toxins13050297
- NAID
  120007041605
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03676, KAKENHI-PROJECT-20K21603, KAKENHI-PROJECT-19H03653
[Journal Article] Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs2020
- Author(s)
  Tabata Tokiko、Yamashita Tomoya、Hosomi Koji、Park Jonguk、Hayashi Tomohiro、Yoshida Naofumi、Saito Yoshihiro、Fukuzawa Koji、Konishi Kana、Murakami Haruka、Kawashima Hitoshi、Mizuguchi Kenji、Miyachi Motohiko、Kunisawa Jun、Hirata Ken-ichi
- Journal Title
  
  Heart and Vessels
  
  Volume: 36 Issue: 1 Pages: 105-114
- DOI
  10.1007/s00380-020-01669-y
- NAID
  120006952752
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20207, KAKENHI-PROJECT-19K23944, KAKENHI-PROJECT-19H03653
[Journal Article] Metabolic alterations in plasma after laparoscopic sleeve gastrectomy2020
- Author(s)
  Yoshida Naofumi、Kitahama Seiichi、Yamashita Tomoya、Hirono Yasuko、Tabata Tokiko、Saito Yoshihiro、Shinohara Ryohei、Nakashima Hitomi、Emoto Takuo、Hirota Yushi、Takahashi Tetsuya、Ogawa Wataru、Hirata Ken‐ichi
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 12 Issue: 1 Pages: 123-129
- DOI
  10.1111/jdi.13328
- NAID
  120006952753
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23944
[Journal Article] 今注目されている腸内細菌の話題2020
- Author(s)
  山下智也, 吉田尚史, 斎藤克寛, 田畑論子, 江本拓央, 平田健一
- Journal Title
  
  循環器内科
  
  Volume: 87 Pages: 734-740
- Data Source
  KAKENHI-PROJECT-20H03676
[Journal Article] 9.腸内細菌由来LPSと循環器疾患2020
- Author(s)
  吉田尚史, 山下智也, 平田健一
- Journal Title
  
  Precision Medicine
  
  Volume: 4 Pages: 151-155
- Data Source
  KAKENHI-PROJECT-20H03676
[Journal Article] Circulating intermediate monocytes and toll-like receptor 4 correlate with low-voltage zones in atrial fibrillation2020
- Author(s)
  Suehiro Hideya、Fukuzawa Koji、Yoshida Naofumi、Kiuchi Kunihiko、Takami Mitsuru、Akita Tomomi、Tabata Tokiko、Takemoto Makoto、Sakai Jun、Nakamura Toshihiro、Yatomi Atsusuke、Takahara Hiroyuki、Sonoda Yusuke、Nakasone Kazutake、Yamamoto Kyoko、Suzuki Atsushi、Yamashita Tomoya、Hirata Ken-ichi
- Journal Title
  
  Heart and Vessels
  
  Volume: 35 Issue: 12 Pages: 1717-1726
- DOI
  10.1007/s00380-020-01647-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08036, KAKENHI-PROJECT-19K23944
[Journal Article] The impact of antibiotics on the metabolic status of obese adults without bacterial infection: a systematic review and meta-analysis2020
- Author(s)
  Yoshida Naofumi、Saito Yoshihiro、Tsujimoto Yasushi、Taito Shunsuke、Banno Masahiro、Kataoka Yuki、Yamashita Tomoya、Hirata Ken-ichi
- Journal Title
  
  Annals of Translational Medicine
  
  Volume: 8 Issue: 17 Pages: 1059-1059
- DOI
  10.21037/atm-20-1007a
- NAID
  120006954855
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-19K23944
[Journal Article] A possible beneficial effect of Bacteroides on faecal lipopolysaccharide activity and cardiovascular diseases2020
- Author(s)
  Yoshida Naofumi、Yamashita Tomoya、Kishino Shigenobu、Watanabe Hikaru、Sasaki Kengo、Sasaki Daisuke、Tabata Tokiko、Sugiyama Yuta、Kitamura Nahoko、Saito Yoshihiro、Emoto Takuo、Hayashi Tomohiro、Takahashi Tomoya、Shinohara Masakazu、Osawa Ro、Kondo Akihiko、Yamada Takuji、Ogawa Jun、Hirata Ken-ichi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 13009-13009
- DOI
  10.1038/s41598-020-69983-z
- NAID
  120006879534
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21603, KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676, KAKENHI-PROJECT-18K05487, KAKENHI-PROJECT-19K23944, KAKENHI-PROJECT-16H06279
[Patent] LIPOPOLYSACCHARIDE-REGULATED ENTERIC BACTERIA AND USE THEREOF2019
- Inventor(s)
  山下智也、江本拓央、吉田尚史
- Industrial Property Rights Holder
  山下智也、江本拓央、吉田尚史
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K23944
[Presentation] 腸内細菌を除去すると、脾臓での単球を減らし、大動脈瘤の発生を抑制する。2023
- Author(s)
  篠原涼平, 江本拓央, 吉田尚史, 斉藤克寛, 山下智也, 平田健一
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03676
[Presentation] Structural Differences in Bacterial LPS Determine Atherosclerotic Progression in Mice.2023
- Author(s)
  斉藤克寛, 吉田尚史, 江本拓央, 篠原正和, 山下智也, 平田健一
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03676
[Presentation] Structural differences in bacterial LPS lead to different immune responses and progression of atherosclerotic plaque lesions in mice2021
- Author(s)
  Yoshihiro Saito, Tomoya Yamashita, Naofumi Yoshida, Takuo Emoto, Masakazu Shinohara, Ken-ichi Hirata
- Organizer
  第5回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-20H03676
[Presentation] Manipulating BCKA catabolism in brown adipose tissue via gut microbiota modulation for treating obesity2021
- Author(s)
  Naofumi Yoshida、Tomoya Yamashita、Masakazu Shinohara、Ken-ichi Hirata
- Organizer
  第85回日本循環器学会YIA
- Data Source
  KAKENHI-PROJECT-19K23944
[Presentation] Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure.2021
- Author(s)
  Takuo Emoto, Tomoya Yamashita, Shintaro Takeda, Yoshihiro Saito, Naofumi Yoshida, Ken-ichi Hirata
- Organizer
  第5回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-20H03676
[Presentation] Impact of gut microbial LPS on cardiovascular diseases2021
- Author(s)
  Naofumi Yoshida, Yoshihiro Saito, Takuo Emoto, Tomoya Yamashita, Ken-ichi Hirata
- Organizer
  第5回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-20H03676
[Presentation] Bacteroides Decrease Human Fecal Lipopolysaccharide Levels2020
- Author(s)
  Naofumi Yoshida、Tomoya Yamashita、Tokiko Tabata、Yoshihiro Saito、Takuo Emoto、Tomohiro Hayashi、Masakazu Shinohara、Ken-ichi Hirata
- Organizer
  第84回日本循環器学会YIA
- Data Source
  KAKENHI-PROJECT-19K23944
[Presentation] 4.動脈硬化を予防するBacteroides 2菌種のリポ多糖(LPS)に着目した抗炎症作用機序の解明2020
- Author(s)
  斉藤克寛、山下智也、吉田尚史、田畑論子、江本拓央、篠原正和、平田健一
- Organizer
  第52回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20H03676
[Presentation] Bacteroides Decrease Human Fecal Lipopolysaccharide Levels.2020
- Author(s)
  Naofumi Yoshida, Tomoya Yamashita,Tokiko Tabata, Yoshihiro Saito, Takuo Emoto, Tomohiro Hayashi, Masakazu Shinohara, Ken-ichi Hirata.
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03676

1. Hirata Ken-ichi (20283880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. YAMASHITA Tomoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
3. 小西可奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 福沢公二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 木内邦彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIDA Naofumi 吉田 尚史

Yoshida Naofumi 吉田 尚史

Research Projects

Research Products

Co-Researchers

CRISPRスクリーニングを用いたY染色体喪失機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarifying the function of gut microbial message molecules and their association with cardiovascular diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impact of gut microbial LPS on cardiovascular diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] ICUとCCU2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Precision Medicine2021

Author(s)

Total Pages

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Data Source

[Book] 医学のあゆみ2020

Author(s)

Total Pages

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[Book] PROGRESS IN MEDICINE2020

Author(s)

Total Pages

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Data Source

[Book] Pharma Medica2020

Author(s)

Total Pages

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Data Source

[Book] ヒトマイクロバイオーム Vol.22020

Author(s)

Total Pages

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Data Source

[Book] 循環器ジャーナル2020

Author(s)

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Data Source

[Book] 医学の歩み2019

Author(s)

Total Pages

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[Journal Article] 今月の特集 マイクロバイオーム Microbiomeと心血管系疾患2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] Structural differences in bacterial lipopolysaccharides determine atherosclerotic plaque progression by regulating the accumulation of neutrophils.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gut Microbiota Influence the Development of Abdominal Aortic Aneurysm by Suppressing Macrophage Accumulation in Mice.2022

Author(s)

Journal Title

DOI

YOSHIDA Naofumi 吉田尚史

Yoshida Naofumi 吉田尚史

[Journal Article] 今月の特集マイクロバイオーム Microbiomeと心血管系疾患2022