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YOSHIDA Naofumi  吉田 尚史

… Alternative Names

Yoshida Naofumi  吉田 尚史

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Researcher Number 00846321
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3949-0089
Affiliation (Current) 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
Affiliation (based on the past Project Information) *help 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
2019 – 2022: 神戸大学, 医学研究科, 医学研究員
Review Section/Research Field
Principal Investigator
Basic Section 53020:Cardiology-related / 0902:General internal medicine and related fields
Except Principal Investigator
Basic Section 53020:Cardiology-related
Keywords
Principal Investigator
質量分析 / lipid A / 動脈硬化 / リポ多糖 / 腸内細菌 / 循環器疾患
Except Principal Investigator
リポ多糖 / マイクロRNA / リポポリサッカライド / OMV … More / 循環器疾患 / 好中球細胞外トラップ / 外膜小胞 / LPS / 炎症 / 動脈硬化 / メッセージ物質 / 腸内細菌 Less
  • Research Projects

    (3 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (5 People)
  •  CRISPRスクリーニングを用いたY染色体喪失機構の解明Principal Investigator

    • Principal Investigator
      吉田 尚史
    • Project Period (FY)
      2025 – 2026
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Clarifying the function of gut microbial message molecules and their association with cardiovascular diseases

    • Principal Investigator
      Hirata Ken-ichi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Kobe University
  •  Impact of gut microbial LPS on cardiovascular diseasesPrincipal Investigator

    • Principal Investigator
      Yoshida Naofumi
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0902:General internal medicine and related fields
    • Research Institution
      Kobe University

All 2023 2022 2021 2020 2019

All Journal Article Presentation Book Patent

  • [Book] ICUとCCU2022

    • Author(s)
      山下 智也, 江本 拓央, 斉藤 克寛, 吉田 尚史, 平田 健一
    • Total Pages
      62
    • Publisher
      医学図書出版
    • ISBN
      9784865175110
    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Book] Precision Medicine2021

    • Author(s)
      吉田尚史
    • Total Pages
      5
    • Publisher
      北隆館
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Book] 医学のあゆみ2020

    • Author(s)
      吉田尚史、山下智也、平田健一
    • Total Pages
      7
    • Publisher
      医歯薬出版株式会社
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Book] PROGRESS IN MEDICINE2020

    • Author(s)
      山下智也、吉田尚史、林友鴻、田畑論子、江本拓央、平田健一
    • Total Pages
      7
    • Publisher
      メディカルオンライン
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Book] Pharma Medica2020

    • Author(s)
      吉田尚史、山下智也、平田健一
    • Total Pages
      4
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Book] ヒトマイクロバイオーム Vol.22020

    • Author(s)
      吉田尚史、山下智也、平田健一
    • Total Pages
      4
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Book] 循環器ジャーナル2020

    • Author(s)
      吉田尚史、山下智也、平田健一
    • Total Pages
      4
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Book] 医学の歩み2019

    • Author(s)
      吉田尚史、山下智也、平田健一
    • Total Pages
      6
    • Publisher
      医歯薬出版株式会社
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Journal Article] 今月の特集 マイクロバイオーム Microbiomeと心血管系疾患2022

    • Author(s)
      山下 智也, 吉田 尚史, 平田 健一
    • Journal Title

      臨床検査

      Volume: 66 Issue: 11 Pages: 1346-1351

    • DOI

      10.11477/mf.1542203170

    • ISSN
      0485-1420, 1882-1367
    • Year and Date
      2022-11-15
    • Data Source
      KAKENHI-PROJECT-22K19708, KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676
  • [Journal Article] Structural differences in bacterial lipopolysaccharides determine atherosclerotic plaque progression by regulating the accumulation of neutrophils.2022

    • Author(s)
      Saito Y, Yamashita T, Yoshida N, Emoto T, Takeda S, Tabata T, Shinohara M, Kishino S, Sugiyama Y, Kitamura N, Yamamoto H, Takaya T, Ogawa J, Hirata K
    • Journal Title

      Atherosclerosis.

      Volume: 358 Pages: 1-11

    • DOI

      10.1016/j.atherosclerosis.2022.08.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676
  • [Journal Article] Gut Microbiota Influence the Development of Abdominal Aortic Aneurysm by Suppressing Macrophage Accumulation in Mice.2022

    • Author(s)
      Shinohara R, Nakashima H, Emoto T, Yamashita T, Saito Y, Yoshida N, Inoue T, Yamanaka K, Okada K, Hirata K
    • Journal Title

      Hypertension

      Volume: 79 Issue: 12 Pages: 2821-2829

    • DOI

      10.1161/hypertensionaha.122.19422

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676
  • [Journal Article] Two Gut Microbiota-Derived Toxins Are Closely Associated with Cardiovascular Diseases: A Review.2021

    • Author(s)
      Yamashita T, Yoshida N, Emoto T, Saito Y, Hirata K
    • Journal Title

      Toxin

      Volume: 13 Pages: 297-297

    • NAID

      120007041605

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Journal Article] Gut microbiota-derived toxins and metabolites in cardiovascular diseases2021

    • Author(s)
      Yamashita Tomoya、Yoshida Naofumi、Emoto Takuo、Saito Yoshihiro、Hirata Ken‐ichi
    • Journal Title

      Toxins

      Volume: -

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Journal Article] Unraveling the Effects of Trimethylamine N-Oxide on Stroke: “The lower, the better?”2021

    • Author(s)
      Yamashita Tomoya、Yoshida Naofumi、Emoto Takuo、Hirata Ken-ichi
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 28 Issue: 4 Pages: 314-316

    • DOI

      10.5551/jat.ED142

    • NAID

      130008014044

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2021-04-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Journal Article] Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity2021

    • Author(s)
      Yoshida Naofumi、Yamashita Tomoya、Osone Tatsunori、Shinohara Masakazu、Kitahama Seiichi、Sasaki Kengo、Sasaki Daisuke、Emoto Takuo、Saito Yoshihiro、Kitaura Yasuyuki、Shimomura Yoshiharu、Kondo Akihiko、Kajimura Shingo、Inagaki Takeshi、Yamada Takuji、Hirata Ken-ichi
    • Journal Title

      iScience

      Volume: 24 Issue: 11 Pages: 103342-103342

    • DOI

      10.1016/j.isci.2021.103342

    • NAID

      120007179184

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676, KAKENHI-PROJECT-18K11013, KAKENHI-PROJECT-21K08548, KAKENHI-PROJECT-20K22647, KAKENHI-PROJECT-20H03729, KAKENHI-PROJECT-21H03355
  • [Journal Article] Two Gut Microbiota-Derived Toxins Are Closely Associated with Cardiovascular Diseases: A Review2021

    • Author(s)
      Yamashita Tomoya、Yoshida Naofumi、Emoto Takuo、Saito Yoshihiro、Hirata Ken-ichi
    • Journal Title

      Toxins

      Volume: 13 Issue: 5 Pages: 297-297

    • DOI

      10.3390/toxins13050297

    • NAID

      120007041605

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03676, KAKENHI-PROJECT-20K21603, KAKENHI-PROJECT-19H03653
  • [Journal Article] Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs2020

    • Author(s)
      Tabata Tokiko、Yamashita Tomoya、Hosomi Koji、Park Jonguk、Hayashi Tomohiro、Yoshida Naofumi、Saito Yoshihiro、Fukuzawa Koji、Konishi Kana、Murakami Haruka、Kawashima Hitoshi、Mizuguchi Kenji、Miyachi Motohiko、Kunisawa Jun、Hirata Ken-ichi
    • Journal Title

      Heart and Vessels

      Volume: 36 Issue: 1 Pages: 105-114

    • DOI

      10.1007/s00380-020-01669-y

    • NAID

      120006952752

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K20207, KAKENHI-PROJECT-19K23944, KAKENHI-PROJECT-19H03653
  • [Journal Article] Metabolic alterations in plasma after laparoscopic sleeve gastrectomy2020

    • Author(s)
      Yoshida Naofumi、Kitahama Seiichi、Yamashita Tomoya、Hirono Yasuko、Tabata Tokiko、Saito Yoshihiro、Shinohara Ryohei、Nakashima Hitomi、Emoto Takuo、Hirota Yushi、Takahashi Tetsuya、Ogawa Wataru、Hirata Ken‐ichi
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 12 Issue: 1 Pages: 123-129

    • DOI

      10.1111/jdi.13328

    • NAID

      120006952753

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Journal Article] 今注目されている腸内細菌の話題2020

    • Author(s)
      山下 智也, 吉田 尚史, 斎藤 克寛, 田畑 論子, 江本 拓央, 平田 健一
    • Journal Title

      循環器内科

      Volume: 87 Pages: 734-740

    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Journal Article] 9.腸内細菌由来LPSと循環器疾患2020

    • Author(s)
      吉田 尚史, 山下 智也, 平田 健一
    • Journal Title

      Precision Medicine

      Volume: 4 Pages: 151-155

    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Journal Article] Circulating intermediate monocytes and toll-like receptor 4 correlate with low-voltage zones in atrial fibrillation2020

    • Author(s)
      Suehiro Hideya、Fukuzawa Koji、Yoshida Naofumi、Kiuchi Kunihiko、Takami Mitsuru、Akita Tomomi、Tabata Tokiko、Takemoto Makoto、Sakai Jun、Nakamura Toshihiro、Yatomi Atsusuke、Takahara Hiroyuki、Sonoda Yusuke、Nakasone Kazutake、Yamamoto Kyoko、Suzuki Atsushi、Yamashita Tomoya、Hirata Ken-ichi
    • Journal Title

      Heart and Vessels

      Volume: 35 Issue: 12 Pages: 1717-1726

    • DOI

      10.1007/s00380-020-01647-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08036, KAKENHI-PROJECT-19K23944
  • [Journal Article] The impact of antibiotics on the metabolic status of obese adults without bacterial infection: a systematic review and meta-analysis2020

    • Author(s)
      Yoshida Naofumi、Saito Yoshihiro、Tsujimoto Yasushi、Taito Shunsuke、Banno Masahiro、Kataoka Yuki、Yamashita Tomoya、Hirata Ken-ichi
    • Journal Title

      Annals of Translational Medicine

      Volume: 8 Issue: 17 Pages: 1059-1059

    • DOI

      10.21037/atm-20-1007a

    • NAID

      120006954855

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-19K23944
  • [Journal Article] A possible beneficial effect of Bacteroides on faecal lipopolysaccharide activity and cardiovascular diseases2020

    • Author(s)
      Yoshida Naofumi、Yamashita Tomoya、Kishino Shigenobu、Watanabe Hikaru、Sasaki Kengo、Sasaki Daisuke、Tabata Tokiko、Sugiyama Yuta、Kitamura Nahoko、Saito Yoshihiro、Emoto Takuo、Hayashi Tomohiro、Takahashi Tomoya、Shinohara Masakazu、Osawa Ro、Kondo Akihiko、Yamada Takuji、Ogawa Jun、Hirata Ken-ichi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 13009-13009

    • DOI

      10.1038/s41598-020-69983-z

    • NAID

      120006879534

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21603, KAKENHI-PROJECT-19H03653, KAKENHI-PROJECT-20H03676, KAKENHI-PROJECT-18K05487, KAKENHI-PROJECT-19K23944, KAKENHI-PROJECT-16H06279
  • [Patent] LIPOPOLYSACCHARIDE-REGULATED ENTERIC BACTERIA AND USE THEREOF2019

    • Inventor(s)
      山下智也、江本拓央、吉田尚史
    • Industrial Property Rights Holder
      山下智也、江本拓央、吉田尚史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2020
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Presentation] 腸内細菌を除去すると、脾臓での単球を減らし、大動脈瘤の発生を抑制する。2023

    • Author(s)
      篠原涼平, 江本拓央, 吉田尚史, 斉藤克寛, 山下智也, 平田健一
    • Organizer
      第86回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Presentation] Structural Differences in Bacterial LPS Determine Atherosclerotic Progression in Mice.2023

    • Author(s)
      斉藤克寛, 吉田尚史, 江本拓央, 篠原正和, 山下智也, 平田健一
    • Organizer
      第86回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Presentation] Structural differences in bacterial LPS lead to different immune responses and progression of atherosclerotic plaque lesions in mice2021

    • Author(s)
      Yoshihiro Saito, Tomoya Yamashita, Naofumi Yoshida, Takuo Emoto, Masakazu Shinohara, Ken-ichi Hirata
    • Organizer
      第5回日本循環器学会基礎研究フォーラム
    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Presentation] Manipulating BCKA catabolism in brown adipose tissue via gut microbiota modulation for treating obesity2021

    • Author(s)
      Naofumi Yoshida、Tomoya Yamashita、Masakazu Shinohara、Ken-ichi Hirata
    • Organizer
      第85回日本循環器学会YIA
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Presentation] Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure.2021

    • Author(s)
      Takuo Emoto, Tomoya Yamashita, Shintaro Takeda, Yoshihiro Saito, Naofumi Yoshida, Ken-ichi Hirata
    • Organizer
      第5回日本循環器学会基礎研究フォーラム
    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Presentation] Impact of gut microbial LPS on cardiovascular diseases2021

    • Author(s)
      Naofumi Yoshida, Yoshihiro Saito, Takuo Emoto, Tomoya Yamashita, Ken-ichi Hirata
    • Organizer
      第5回日本循環器学会基礎研究フォーラム
    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Presentation] Bacteroides Decrease Human Fecal Lipopolysaccharide Levels2020

    • Author(s)
      Naofumi Yoshida、Tomoya Yamashita、Tokiko Tabata、Yoshihiro Saito、Takuo Emoto、Tomohiro Hayashi、Masakazu Shinohara、Ken-ichi Hirata
    • Organizer
      第84回日本循環器学会YIA
    • Data Source
      KAKENHI-PROJECT-19K23944
  • [Presentation] 4.動脈硬化を予防するBacteroides 2菌種のリポ多糖(LPS)に着目した抗炎症作用機序の解明2020

    • Author(s)
      斉藤 克寛、山下 智也、吉田 尚史、田畑 論子、江本 拓央、篠原 正和、平田 健一
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-20H03676
  • [Presentation] Bacteroides Decrease Human Fecal Lipopolysaccharide Levels.2020

    • Author(s)
      Naofumi Yoshida, Tomoya Yamashita,Tokiko Tabata, Yoshihiro Saito, Takuo Emoto, Tomohiro Hayashi, Masakazu Shinohara, Ken-ichi Hirata.
    • Organizer
      第84回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03676
  • 1.  Hirata Ken-ichi (20283880)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 2.  YAMASHITA Tomoya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 3.  小西 可奈
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  福沢 公二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  木内 邦彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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