Imai Hirotatsu 今井大達

Researcher Number	00866668
Other IDs
Affiliation (Current)	2026: 琉球大学, 医学(系)研究科(研究院), 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 琉球大学, 医学(系)研究科(研究院), 助教 2021 – 2022: 琉球大学, 医学(系)研究科(研究院), 特命助教
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related
Keywords	Principal Investigator RNA / リボソーム / 翻訳 / 統合的ストレス応答 / mRNA翻訳 / 近位依存ビオチン標識法 / リボソームストーク

統合的ストレス応答がリボソームを不活化する分子機構の解明Principal Investigator
- Principal Investigator
  
  今井大達
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  University of the Ryukyus
Investigation of translational factor pool formed around the ribosomal P-stalkPrincipal Investigator
- Principal Investigator
  
  Imai Hirotatsu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  University of the Ryukyus

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Metabolic RNA Labeling and Translating Ribosome Affinity Purification for Measurement of Nascent RNA Translation2024
- Author(s)
  Imai Hirotatsu、Yamashita Akio
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 14 Issue: 1355
- DOI
  10.21769/bioprotoc.5091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K02229, KAKENHI-PROJECT-24K18056
[Journal Article] Enhanced Broad-Spectrum Efficacy of an L2-Based mRNA Vaccine Targeting HPV Types 6, 11, 16, 18, with Cross-Protection Against Multiple Additional High-Risk Types2024
- Author(s)
  Tsukamoto Kosuke、Yamashita Akio、Maeki Masatoshi、Tokeshi Manabu、Imai Hirotatsu、Fukao Akira、Fujiwara Toshinobu、Okudera Koji、Mizuki Nobuhisa、Okuda Kenji、Shimada Masaru
- Journal Title
  
  Vaccines
  
  Volume: 12 Issue: 11 Pages: 1239-1239
- DOI
  10.3390/vaccines12111239
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00541, KAKENHI-PROJECT-23K23813, KAKENHI-PROJECT-24K02229, KAKENHI-PROJECT-23K08826, KAKENHI-PROJECT-24K18056
[Journal Article] Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification2023
- Author(s)
  Imai Hirotatsu、Utsumi Daisuke、Torihara Hidetsugu、Takahashi Kenzo、Kuroyanagi Hidehito、Yamashita Akio
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 1-33
- DOI
  10.1101/2023.02.15.525786
- Open Access
- Data Source
  KAKENHI-PROJECT-21K15015
[Journal Article] Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification2023
- Author(s)
  Imai Hirotatsu、Utsumi Daisuke、Torihara Hidetsugu、Takahashi Kenzo、Kuroyanagi Hidehito、Yamashita Akio
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 14 Pages: e76-e76
- DOI
  10.1093/nar/gkad545
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08387, KAKENHI-PROJECT-23K08826, KAKENHI-PROJECT-21K15015, KAKENHI-PROJECT-20H03181, KAKENHI-PROJECT-22H04925
[Journal Article] Recruitment of translation factors by the tentacles of ribosomes2022
- Author(s)
  今井大達
- Journal Title
  
  生化学
  
  Volume: 94 Issue: 5 Pages: 739-742
- DOI
  10.14952/SEIKAGAKU.2022.940739
- ISSN
  0037-1017
- Year and Date
  2022-10-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15015
[Journal Article] The flexible N-terminal motif of uL11 unique to eukaryotic ribosomes interacts with P-complex and facilitates protein translation2022
- Author(s)
  Yang Lei、Lee Ka-Ming、Yu Conny Wing-Heng、Imai Hirotatsu、Choi Andrew?Kwok-Ho、Banfield David?K、Ito Kosuke、Uchiumi Toshio、Wong Kam-Bo
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: 9 Pages: 5335-5348
- DOI
  10.1093/nar/gkac292
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15015
[Presentation] ナンセンス変異依存RNA分解を特異的に阻害する低分子化合物の探索と評価2024
- Author(s)
  今井大達、バトゥールナイマ、森下宗、久保田浩行、山下暁朗
- Organizer
  第47回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-24K18056
[Presentation] 小胞体ストレス応答におけるRNAの新規合成量と翻訳量の同時測定2023
- Author(s)
  今井大達、内海大介、鳥原英嗣、高橋健造、山下暁朗
- Organizer
  第46回日本分子生物学学会年会
- Data Source
  KAKENHI-PROJECT-21K15015
[Presentation] Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification2023
- Author(s)
  今井大達、内海大介、鳥原英嗣、高橋健造、山下暁朗
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-21K15015
[Presentation] Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification2023
- Author(s)
  Imai Hirotatsu、Utsumi Daisuke、Torihara Hidetsugu、Takahashi Kenzo、Kuroyanagi Hidehito、Yamashita Akio
- Organizer
  RNA2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15015
[Presentation] High-speed AFM visualizes translational GTPase factor pool formed around the ribosomal P-stalk2022
- Author(s)
  今井大達、内海利男、古寺哲幸
- Organizer
  第60回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15015

1. 山下暁朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 真栄城正寿

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 高橋建造

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 内海大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Imai Hirotatsu 今井 大達

Research Projects

Research Products

Co-Researchers

統合的ストレス応答がリボソームを不活化する分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of translational factor pool formed around the ribosomal P-stalkPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Metabolic RNA Labeling and Translating Ribosome Affinity Purification for Measurement of Nascent RNA Translation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced Broad-Spectrum Efficacy of an L2-Based mRNA Vaccine Targeting HPV Types 6, 11, 16, 18, with Cross-Protection Against Multiple Additional High-Risk Types2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recruitment of translation factors by the tentacles of ribosomes2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] The flexible N-terminal motif of uL11 unique to eukaryotic ribosomes interacts with P-complex and facilitates protein translation2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] ナンセンス変異依存RNA分解を特異的に阻害する低分子化合物の探索と評価2024

Author(s)

Organizer

Data Source

[Presentation] 小胞体ストレス応答におけるRNAの新規合成量と翻訳量の同時測定2023

Author(s)

Organizer

Data Source

[Presentation] Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification2023

Author(s)

Organizer

Data Source

[Presentation] Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification2023

Author(s)

Organizer

Data Source

[Presentation] High-speed AFM visualizes translational GTPase factor pool formed around the ribosomal P-stalk2022

Author(s)

Organizer

Data Source

Imai Hirotatsu 今井大達