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Fujii Masayuki  藤井 正幸

ORCIDConnect your ORCID iD *help
Researcher Number 00867575
Other IDs
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help 2025: 慶應義塾大学, 医学部(信濃町), 准教授
2020 – 2024: 慶應義塾大学, 医学部(信濃町), 講師
Review Section/Research Field
Principal Investigator
Basic Section 55020:Digestive surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords
Principal Investigator
オルガノイド / シングルセル解析 / 大腸がん / 転移 / がん / 細胞個性 / エピゲノム / がん進化 / 異種移植 / 大腸癌 … More / 遺伝子編集 / 発がん / 遺伝子変異 / 異種移植モデル / 再発 / 遺伝子スクリーニング / 浸潤 … More
Except Principal Investigator
オルガノイド / 肺癌 Less
  • Research Projects

    (4 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (8 People)
  •  治療抵抗性肺癌オルガノイドライブラリーを用いた獲得耐性機構の本態解明

    • Principal Investigator
      安田 浩之
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Keio University
  •  Re-defining human tumor evolution based on cellular identity plasticity and its therapeutic applicationPrincipal Investigator

    • Principal Investigator
      藤井 正幸
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Keio University
  •  Multi-layered decoding and therapeutic co-option of the metastatic checkpoint in human colorectal cancerPrincipal Investigator

    • Principal Investigator
      藤井 正幸
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Keio University
  •  Deep phenotyping of human colorectal cancer evolution using adult stem cell organoids and CRISPR-Cas9 technologyPrincipal Investigator

    • Principal Investigator
      Fujii Masayuki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Keio University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

  • [Journal Article] Decoding the basis of histological variation in human cancer2023

    • Author(s)
      Fujii Masayuki、Sekine Shigeki、Sato Toshiro
    • Journal Title

      Nature Reviews Cancer

      Volume: 24 Issue: 2 Pages: 141-158

    • DOI

      10.1038/s41568-023-00648-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22H04995, KAKENHI-PROJECT-23K27677
  • [Journal Article] Cell-matrix interface regulates dormancy in human colon cancer stem cells2022

    • Author(s)
      Ohta Yuki、Fujii Masayuki、Takahashi Sirirat、Takano Ai、Nanki Kosaku、Matano Mami、Hanyu Hikaru、Saito Megumu、Shimokawa Mariko、Nishikori Shingo、Hatano Yoshiko、Ishii Ryota、Sawada Kazuaki、Machinaga Akihito、Ikeda Wataru、Imamura Takeshi、Sato Toshiro
    • Journal Title

      Nature

      Volume: 608 Issue: 7924 Pages: 784-794

    • DOI

      10.1038/s41586-022-05043-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22H04995, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-22KJ2666, KAKENHI-PROJECT-20K08340
  • [Journal Article] Identification of Quiescent LGR5+ Stem Cells in the Human Colon2022

    • Author(s)
      Ishikawa K, Sugimoto S, Oda M, Fujii M, Toshimitsu K, Sawada K, Shimokawa M, Saito M, Kawasaki K, Ishii R, Taniguchi K, Sato T.
    • Journal Title

      Gastroenterology.

      Volume: 163 Issue: 5 Pages: 1391-1406

    • DOI

      10.1053/j.gastro.2022.07.081

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-22H04995, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-22KJ2666, KAKENHI-PROJECT-20K08340, KAKENHI-PROJECT-21K19540, KAKENHI-PROJECT-15K21775, KAKENHI-PROJECT-20H03758
  • [Journal Article] Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer2022

    • Author(s)
      Toshimitsu Kohta、Takano Ai、Fujii Masayuki、Togasaki Kazuhiro、Matano Mami、Takahashi Sirirat、Kanai Takanori、Sato Toshiro
    • Journal Title

      Nature Chemical Biology

      Volume: - Issue: 6 Pages: 605-614

    • DOI

      10.1038/s41589-022-00984-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20J12287, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-20K08340
  • [Journal Article] Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening2021

    • Author(s)
      Ebisudani Toshiki、Sugimoto Shinya、Haga Kei、Mitsuishi Akifumi、Takai-Todaka Reiko、Fujii Masayuki、Toshimitsu Kohta、Hamamoto Junko、Sugihara Kai、Hishida Tomoyuki、Asamura Hisao、Fukunaga Koichi、Yasuda Hiroyuki、Katayama Kazuhiko、Sato Toshiro
    • Journal Title

      Cell Reports

      Volume: 35 Issue: 10 Pages: 109218-109218

    • DOI

      10.1016/j.celrep.2021.109218

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08610, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-21K08496, KAKENHI-PROJECT-20H03746
  • [Journal Article] An organoid-based organ-repurposing approach to treat short bowel syndrome2021

    • Author(s)
      Sugimoto S, Kobayashi E, Fujii M, Ohta Y, Arai K, Matano M, Ishikawa K, Miyamoto K, Toshimitsu K, Takahashi S, Nanki K, Hakamata Y, Kanai T, Sato T.
    • Journal Title

      Nature

      Volume: 592 Pages: 99-104

    • DOI

      10.1038/s41586-021-03247-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-23K20316
  • [Journal Article] Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases2021

    • Author(s)
      Fujii M, Sato T.
    • Journal Title

      Nat Mater

      Volume: 20 Issue: 2 Pages: 156-169

    • DOI

      10.1038/s41563-020-0754-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20H03757
  • [Journal Article] Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer2021

    • Author(s)
      Togasaki K, Sugimoto S, Ohta Y, Nanki K, Matano M, Takahashi S, Fujii M, Kanai T, Sato T.
    • Journal Title

      Gastroenterology

      Volume: 160 Issue: 3 Pages: 823-830

    • DOI

      10.1053/j.gastro.2020.10.047

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08340, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-20J12287, KAKENHI-PROJECT-23K20316
  • [Journal Article] Organoid Derivation and Orthotopic Xenotransplantation for Studying Human Intestinal Stem Cell Dynamics2020

    • Author(s)
      Shinya Sugimoto, Masayuki Fujii, Toshiro Sato
    • Journal Title

      Methods in Molecular Biology

      Volume: 2171 Pages: 303-320

    • DOI

      10.1007/978-1-0716-0747-3_21

    • ISBN
      9781071607466, 9781071607473
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757
  • [Journal Article] Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages2020

    • Author(s)
      Sato T, Ishikawa S, Asano J, Yamamoto H, Fujii M, Sato T, Yamamoto K, Kitagaki K, Akashi T, Okamoto R, Ohteki T.
    • Journal Title

      Nat Cell Biol

      Volume: 22 Issue: 8 Pages: 919-926

    • DOI

      10.1038/s41556-020-0545-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-18K07062
  • [Journal Article] Linking human intestinal scaffolds and organoids to combat intestinal failure2020

    • Author(s)
      Masayuki Fujii, Shinya Sugimoto, Toshiro Sato
    • Journal Title

      Nature Medicine

      Volume: 26 Issue: 10 Pages: 1517-1518

    • DOI

      10.1038/s41591-020-1096-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757
  • [Journal Article] An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping2020

    • Author(s)
      Kawasaki K、Toshimitsu K、Matano M、Fujita M、Kudo Atsushi、Kitagawa Y、Kanai T、Nakagawa H、Sato T, et.al.
    • Journal Title

      Cell

      Volume: 183 Issue: 5 Pages: 1420-1435

    • DOI

      10.1016/j.cell.2020.10.023

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09041, KAKENHI-PROJECT-20K08340, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-20H03533, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-18J21346, KAKENHI-PROJECT-20J12287, KAKENHI-PROJECT-23K20316
  • [Presentation] ヒト膵癌における系譜進化2024

    • Author(s)
      藤井正幸
    • Organizer
      第113回日本病理学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K27677
  • [Presentation] Understanding principles of cancer metastasis using patient-derived organoids2023

    • Author(s)
      Masayuki Fujii
    • Organizer
      第82回日本癌学会総会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27677
  • [Presentation] Organoid technology in the era of precision medicine2023

    • Author(s)
      藤井正幸
    • Organizer
      第62回日本癌治療学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K27677
  • [Presentation] Lessons from patient-derived organoid biobanks2023

    • Author(s)
      Masayuki Fujii
    • Organizer
      Sapporo International Symposium and Ohno Moonshot International Cancer Symposium, Cancer Organoid Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27677
  • [Presentation] Tumor environment drives epigenetic reprogramming of human pancreatic cancer2022

    • Author(s)
      Masayuki Fujii
    • Organizer
      The 81st Annual Meeting of the Japanese Cancer Association
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03757
  • [Presentation] Microenvironmental regulation of somatic evolution and tumorigenesis2020

    • Author(s)
      藤井正幸,佐藤俊朗
    • Organizer
      第79回日本癌学会学術総会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03757
  • 1.  安田 浩之 (70365261)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  浜本 純子 (40570239)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  MATANO Mami
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  佐藤 俊朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 7 results
  • 5.  杉本 真也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 6.  伊川 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  工藤 篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  南木 康作
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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