Ogawa Akiko 小川亜希子

Researcher Number	00868565
Other IDs
Affiliation (Current)	2025: 東北大学, 薬学研究科, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 48040:Medical biochemistry-related / Biological Sciences / Basic Section 56060:Ophthalmology-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 48020:Physiology-related / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator RNA修飾 / 代謝 / 核酸医学 / 修飾ヌクレオシド / 酵素 / 液性因子 / COVID19 / ワクチン / COVID-19 / エピトランスクリプトミクス … More / アデノシン / エピトランスクリプトーム / 核酸代謝 / AMPK / メタボライト / 核酸医薬 / オートファジー / 線維化 / 緑内障 … More Except Principal Investigator RNA修飾 / CAR-T細胞療法 / 同種造血幹細胞移植 / サイトカイン放出症候群 / 移植片対宿主病 / 造血幹細胞移植 / 免疫細胞療法 / 免疫応答 / 受容体 / 核酸代謝 / GPCR / RNA / エネルギー代謝 / 硫黄 / 代謝 / ミトコンドリア Less

次世代RNA医薬の基盤創生への挑戦Principal Investigator
- Principal Investigator
  
  小川亜希子
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University
Molecular basis of RNA modification in immune response after transplantation and cell therapy and novel biomarkers
- Principal Investigator
  
  大西康
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
Investigation of the mechanism of autophagy pathway by novel metabolites derived from modified RNA.Principal Investigator
- Principal Investigator
  
  小川亜希子
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
A synthetic metabolic network based on RNA modification for biological homeostasisPrincipal Investigator
- Principal Investigator
  
  小川亜希子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tohoku University
Explore novel RNA modification physiology
- Principal Investigator
  
  魏范研
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Tohoku University
Modulation of mitochondrial function by reactive sulfur signaling
- Principal Investigator
  
  Wei Fan-Yan
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku University
The emerging role of RNA modifications in the regulation of glaucoma pathologyPrincipal Investigator
- Principal Investigator
  
  Ogawa Akiko
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tohoku University

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Pathological mutations promote proteolysis of mitochondrial tRNA-specific 2-thiouridylase 1 (MTU1) via mitochondrial caseinolytic peptidase (CLPP)2023
- Author(s)
  Ahmad Raja Norazireen?Raja、Zhang Long-Teng、Morita Rikuri、Tani Haruna、Wu Yong、Chujo Takeshi、Ogawa Akiko、Harada Ryuhei、Shigeta Yasuteru、Tomizawa Kazuhito、Wei Fan-Yan
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 52 Issue: 3 Pages: 1341-1358
- DOI
  10.1093/nar/gkad1197
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18088, KAKENHI-PROJECT-23K14113, KAKENHI-PROJECT-23K16989, KAKENHI-PROJECT-21K06094, KAKENHI-PROJECT-22KJ0156, KAKENHI-PUBLICLY-22H04628, KAKENHI-PROJECT-23K21370, KAKENHI-PROJECT-21H02731, KAKENHI-PROJECT-23K24075
[Journal Article] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.2023
- Author(s)
  Ogawa A, Ohira S, Kato Y, Ikuta T, Yanagida S, Mi X, Ishii Y, Kanda Y, Nishida M, Inoue A, Wei - FY
- Journal Title
  
  Communications Biology, in press
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Journal Article] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction2023
- Author(s)
  Ogawa Akiko、Ohira Seiya、Kato Yuri、Ikuta Tatsuya、Yanagida Shota、Mi Xinya、Ishii Yukina、Kanda Yasunari、Nishida Motohiro、Inoue Asuka、Wei Fan-Yan
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-023-04888-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18088, KAKENHI-PROJECT-22K19395, KAKENHI-PUBLICLY-22H04628, KAKENHI-PLANNED-21H05269, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-23K24035, KAKENHI-PROJECT-23K24075
[Journal Article] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.2023
- Author(s)
  Ogawa A, Ohira S, Kato Y, Ikuta T, Yanagida S, Mi X, Ishii Y, Kanda Y, Nishida M, Inoue A, Wei FY
- Journal Title
  
  Communications Biology, in press
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24075
[Journal Article] Urinary excretion of modified nucleosides after COVID-19 vaccination2022
- Author(s)
  小川亜希子、松尾紀孝、齋藤一創、魏范研
- Journal Title
  
  Gout and Uric & Nucleic Acids
  
  Volume: 46 Issue: 2 Pages: 105-113
- DOI
  10.14867/gnamtsunyo.46.2_105
- ISSN
  2435-0095
- Year and Date
  2022-12-20
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04628, KAKENHI-PROJECT-23K24075
[Journal Article] Protocol for preparation and measurement of intracellular and extracellular modified RNA using liquid chromatography-mass spectrometry2021
- Author(s)
  Ogawa Akiko、Wei Fan-Yan
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 4 Pages: 100848-100848
- DOI
  10.1016/j.xpro.2021.100848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18371, KAKENHI-PUBLICLY-20H05309
[Journal Article] Potential roles of the IL-6 family in conjunctival fibrosis2021
- Author(s)
  Watanabe-Kitamura Fumika、Ogawa Akiko、Fujimoto Tomokazu、Iraha Satoshi、Inoue-Mochita Miyuki、Watanabe Takahiro、Takahashi Eri、Tanihara Hidenobu、Inoue Toshihiro
- Journal Title
  
  Experimental Eye Research
  
  Volume: 210 Pages: 108708-108708
- DOI
  10.1016/j.exer.2021.108708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18371, KAKENHI-PROJECT-21K09703
[Journal Article] N6-methyladenosine (m6A) is an endogenous A3 adenosine receptor ligand2021
- Author(s)
  Ogawa Akiko、Nagiri Chisae、Shihoya Wataru、Inoue Asuka、Kawakami Kouki、Hiratsuka Suzune、Aoki Junken、Ito Yasuhiro、Suzuki Takeo、Suzuki Tsutomu、Inoue Toshihiro、Nureki Osamu、Tanihara Hidenobu、Tomizawa Kazuhito、Wei Fan-Yan
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 4 Pages: 674-674
- DOI
  10.1016/j.molcel.2020.12.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21243, KAKENHI-PROJECT-18H02094, KAKENHI-PROJECT-18H02599, KAKENHI-PROJECT-18H02865, KAKENHI-PROJECT-19J11256, KAKENHI-PROJECT-19K22246, KAKENHI-PROJECT-20K18371, KAKENHI-PUBLICLY-20H05309, KAKENHI-PROJECT-18H05272
[Presentation] COVID19治療薬レムデシビルはウロテンシン受容体を活性化することで心筋細胞の機能不全を引き起こす2023
- Author(s)
  小川亜希子
- Organizer
  第96回日本生化学会年会
- Data Source
  KAKENHI-PROJECT-23K18088
[Presentation] 修飾RNAの分解産物によるオートファジー経路の解明に向けて2023
- Author(s)
  小川　亜希子
- Organizer
  第15回オートファジー研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] COVID19治療薬レムデシビルはウロテンシン受容体を活性化することで心筋細胞の機能不全を引き起こす2023
- Author(s)
  小川　亜希子
- Organizer
  第96回日本生化学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] Extracellular modified nucleosides derived from RNA catabolism activates GPCR2023
- Author(s)
  小川亜希子、魏　范研
- Organizer
  The 28th Annual Meeting of the RNA SOCIETY (RNA2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21370
[Presentation] COVID19治療薬レムデシビルはウロテンシン受容体を活性化することで心筋細胞の機能不全を引き起こす2023
- Author(s)
  小川　亜希子
- Organizer
  第96回　日本生化学会年会
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] Modified adenosine metabolism safeguards energy balance2023
- Author(s)
  小川　亜希子
- Organizer
  第101回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] RNA修飾とその代謝シグナルが開拓する生体の病態生理学2023
- Author(s)
  小川　亜希子
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] Metabolic regulation of modified RNA in immunity and disease2023
- Author(s)
  Akiko Ogawa
- Organizer
  Karolinska Institutet and Tohoku University Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] Metabolic regulation of modified RNA in immunity and disease2023
- Author(s)
  Akiko Ogawa
- Organizer
  Karolinska Institutet and Tohoku University Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] Modified adenosine metabolism safeguards energy balance2023
- Author(s)
  小川　亜希子
- Organizer
  第24回日本RNA学会
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] Extracellular modified nucleosides derived from RNA catabolism activates GPCR2023
- Author(s)
  Akiko Ogawa
- Organizer
  第82回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] COVID19治療薬レムデシビルの副作用の機序解明2023
- Author(s)
  小川　亜希子
- Organizer
  第57回日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] 修飾RNAの分解産物によるオートファジー経路の解明に向けて2023
- Author(s)
  小川　亜希子
- Organizer
  第15回オートファジー研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] RNA由来修飾核酸の代謝酵素の同定2023
- Author(s)
  小川亜希子
- Organizer
  第56回　日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] RNA修飾とその代謝シグナルが開拓する生体の病態生理学2023
- Author(s)
  小川　亜希子
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] Modified adenosine metabolism safeguards energy balance2023
- Author(s)
  小川　亜希子
- Organizer
  第24回日本RNA学会
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] 緑内障病態におけるミトコンドリア特異的RNA修飾の機能2023
- Author(s)
  小川　亜希子
- Organizer
  第34回日本緑内障学会（学会長企画）
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] 緑内障病態におけるミトコンドリア特異的RNA修飾の機能2023
- Author(s)
  小川　亜希子
- Organizer
  第34回日本緑内障学会(学会長企画)
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] COVID19治療薬レムデシビルの副作用の機序解明2023
- Author(s)
  小川　亜希子
- Organizer
  第57回日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] Extracellular modified nucleosides derived from RNA catabolism activates GPCR2023
- Author(s)
  Akiko Ogawa
- Organizer
  第82回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] RNA由来修飾核酸の代謝酵素の同定2023
- Author(s)
  小川亜希子
- Organizer
  第56回日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] Modified adenosine metabolism safeguards energy balance2023
- Author(s)
  Akiko Ogawa
- Organizer
  第101回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] Extracellular modified nucleosides derived from RNA catabolism activates GPCR2023
- Author(s)
  Akiko Ogawa
- Organizer
  第82回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K18088
[Presentation] RNA修飾とその代謝シグナルが開拓する生体の病態生理学2023
- Author(s)
  小川亜希子
- Organizer
  第46回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K18088
[Presentation] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction2022
- Author(s)
  小川亜希子
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] Exploring the role of RNA modification in autophagy-related signaling2022
- Author(s)
  Akiko Ogawa
- Organizer
  The 10th International Symposium on Autophagy(ISA2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] 緑内障術後線維化における RNA 修飾の変動2022
- Author(s)
  小川亜希子
- Organizer
  第 25 回眼科分子生物学研究会
- Data Source
  KAKENHI-PROJECT-20K18371
[Presentation] 緑内障術後線維化における RNA 修飾の変動2022
- Author(s)
  小川亜希子
- Organizer
  第 25 回眼科分子生物学研究会
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] RNA修飾由来の新しい核酸型液性因子とその生理的意義について2022
- Author(s)
  小川亜希子
- Organizer
  第55回日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-20K18371
[Presentation] Metabolic regulation of modified RNA in immunity and disease2022
- Author(s)
  小川亜希子
- Organizer
  第23回日本RNA学会
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] Identification of novel sulfur RNA modification and investigation of its possible functions in physiology and pathology2022
- Author(s)
  Akiko Ogawa
- Organizer
  The 12th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] RNAモドミクスが開拓する新しい眼内病態生理学2022
- Author(s)
  小川亜希子
- Organizer
  第126回日本眼科学会総会　シンポジウム10 　オミクス解析によって開かれる新しい扉
- Invited
- Data Source
  KAKENHI-PROJECT-20K18371
[Presentation] Metabolic regulation of modified RNA in immunity and disease2022
- Author(s)
  小川亜希子
- Organizer
  第23回日本RNA学会
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] RNAモドミクスが開拓する新しい眼内病態生理学2022
- Author(s)
  小川亜希子
- Organizer
  第126回日本眼科学会総会シンポジウム10 オミクス解析によって開かれる新しい扉(招待講演)
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] Identification of novel sulfur RNA modification and investigation of its possible functions in physiology and pathology2022
- Author(s)
  Akiko Ogawa
- Organizer
  The 12th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction2022
- Author(s)
  小川亜希子
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] 緑内障術後線維化における RNA 修飾の変動2022
- Author(s)
  小川亜希子
- Organizer
  第 25 回眼科分子生物学研究会
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] Exploring the role of RNA modification in autophagy-related signaling2022
- Author(s)
  Akiko Ogawa
- Organizer
  The 10th International Symposium on Autophagy(ISA2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04628
[Presentation] RNAモドミクスが開拓する新しい眼内病態生理学2022
- Author(s)
  小川亜希子
- Organizer
  第126回日本眼科学会総会シンポジウム10 オミクス解析によって開かれる新しい扉
- Invited
- Data Source
  KAKENHI-PROJECT-23K24075
[Presentation] シグナル伝達液性因子としてのRNA修飾2021
- Author(s)
  小川亜希子
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K18371
[Presentation] N6-methyladenosine (m6A) is an endogenous A3 adenosine receptor ligand.2021
- Author(s)
  小川亜希子
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-20K18371
[Presentation] 濾過手術後の創傷治癒制御治療の可能性2021
- Author(s)
  小川亜希子
- Organizer
  第 31 回日本緑内障学会シンポジウム 11. 緑内障手術の術後管理と長期経過を検証しよう!
- Invited
- Data Source
  KAKENHI-PROJECT-20K18371
[Presentation] 緑内障術後線維化におけるRNA修飾の変動2021
- Author(s)
  小川亜希子
- Organizer
  第32回日本緑内障学会
- Data Source
  KAKENHI-PROJECT-20K18371
[Presentation] N6-methyladenosine (m6A) is an endogenous A3 adenosine receptor ligand2021
- Author(s)
  小川亜希子
- Organizer
  第22回日本RNA学会
- Data Source
  KAKENHI-PROJECT-20K18371

1. Wei Fan-Yan (90555773)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. 松田盛 (00884272)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 大西康 (10509574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 加藤浩貴 (50801677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUZUKI Takeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ogawa Akiko 小川 亜希子

Research Projects

Research Products

Co-Researchers

次世代RNA医薬の基盤創生への挑戦Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of RNA modification in immune response after transplantation and cell therapy and novel biomarkers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism of autophagy pathway by novel metabolites derived from modified RNA.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A synthetic metabolic network based on RNA modification for biological homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Explore novel RNA modification physiology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Modulation of mitochondrial function by reactive sulfur signaling

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The emerging role of RNA modifications in the regulation of glaucoma pathologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Pathological mutations promote proteolysis of mitochondrial tRNA-specific 2-thiouridylase 1 (MTU1) via mitochondrial caseinolytic peptidase (CLPP)2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.2023

Author(s)

Journal Title

Data Source

[Journal Article] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.2023

Author(s)

Journal Title

Data Source

[Journal Article] Urinary excretion of modified nucleosides after COVID-19 vaccination2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Protocol for preparation and measurement of intracellular and extracellular modified RNA using liquid chromatography-mass spectrometry2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential roles of the IL-6 family in conjunctival fibrosis2021

Author(s)

Journal Title

Ogawa Akiko 小川亜希子

[Presentation] COVID19治療薬レムデシビルはウロテンシン受容体を活性化することで心筋細胞の機能不全を引き起こす2023

[Presentation] COVID19治療薬レムデシビルはウロテンシン受容体を活性化することで心筋細胞の機能不全を引き起こす2023

[Presentation] COVID19治療薬レムデシビルはウロテンシン受容体を活性化することで心筋細胞の機能不全を引き起こす2023

[Presentation] COVID19治療薬レムデシビルの副作用の機序解明2023

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[Presentation] RNA修飾とその代謝シグナルが開拓する生体の病態生理学2023