Takeda Kazuki 武田一貴

Researcher Number	00896350
Other IDs	https://orcid.org/0000-0002-3265-4143
Affiliation (Current)	2025: 北里大学, 獣医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 北里大学, 獣医学部, 講師 2021 – 2022: 北里大学, 獣医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related Except Principal Investigator Medium-sized Section 63:Environmental analyses and evaluation and related fields / Medium-sized Section 64:Environmental conservation measure and related fields
Keywords	Principal Investigator AlphaFold / 分子ドッキング / 分子動力学 / 毒性予測 / 毒性評価 / シミュレーション / 環境化学物質 / 機械学習 / タンパク質立体構造 / 環境汚染 … More / 野生動物 / 医薬品 / 農薬 / AlphaFold2 / 中毒 / 化学物質感受性 / 動物種差 … More Except Principal Investigator シトクロムP450 / 薬物動態 / 薬物感受性 / 環境汚染物質 / アゾール系抗真菌薬 / 薬物相互作用 / 薬物代謝 / CYP / タンチョウ / 希少鳥類 / 金属 / 毒性学 / 重金属 / 農薬 / 環境毒性 / 環境汚染 / アフリカ / 化学物質代謝 / xenobiotics / 適応進化 / 硫酸抱合 / グルクロン酸抱合 / 環境適応 / 哺乳類 / 硫酸転移酵素 / グルクロン酸転移酵素 Less

Development of Off-Target Toxicity Prediction Method Using Comprehensive Binding SimulationPrincipal Investigator
- Principal Investigator
  
  武田一貴
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kitasato University
Development and clinical application of a non-invasive drug sensitivity assessment method for ex situ conservation of threatened avian species
- Principal Investigator
  
  久保田彰
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 64:Environmental conservation measure and related fields
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
アフリカの環境汚染によるヒトと動物の毒性学的影響とそのメカニズム解析
- Principal Investigator
  
  石塚真由美
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Hokkaido University
Adaptive evolution/change in mammals to exogenous chemicals (xenobiotics)
- Principal Investigator
  
  石塚真由美
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Hokkaido University
Establishment of an evaluation method of a chemical-susceptibility for wildlife using counter-QSAR and machine learningPrincipal Investigator
- Principal Investigator
  
  Takeda Kazuki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kitasato University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors.2024
- Author(s)
  K Khidkhan, F Yasuhira, A Saengtienchai, C Kasorndorkbua, R Sitdhibutr, Kohei Ogasawara, H Adachi, YWatanabe, K Saito, Hidefumi Sakai, Kazuo Horikoshi, Hajime Suzuki, Yusuke K. Kawai, Kazuki Takeda, Yared B. Yohannes, Y Ikenaka, BA Rattner, M Ishizuka, SMM Nakayama
- Journal Title
  
  Environmental Pollution.
  
  Volume: 341 Pages: 122837-122837
- DOI
  10.1016/j.envpol.2023.122837
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04919
[Journal Article] Estimating susceptibility of rodenticide by molecular dynamics & machine learning using 3D structures of vitamin k epoxide reductase2022
- Author(s)
  Kazuki Takeda, Nobuaki Yasuo, Kanami Watanabe, Ryo Sato, Ryo Kamata, Masakazu Sekijima
- Journal Title
  
  The Pure and Applied Chemistry International Conference 2022 (PACCON2022) “Frontiers in Chemical Sciences for Health, Energy, and Sustainability”
  
  Volume: 1 Pages: 971-975
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K14988
[Journal Article] Observation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase2022
- Author(s)
  Kamata Ryo、Okawa Yukiko、Hamaguchi Yuto、Tabata Soma、Terasaki Masanori、Takeda Kazuki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 19898-19898
- DOI
  10.1038/s41598-022-24547-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K14988
[Journal Article] Development of a sandwich enzyme-linked immunosorbent assay (ELISA) to quantify γ-glutamyl-carboxylated clotting factor IX and assess redox susceptibility of anticoagulant chemicals2022
- Author(s)
  SATO Ryo、WATANABE Kanami、KAMATA Ryo、TAKEDA Kazuki
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 84 Issue: 6 Pages: 804-808
- DOI
  10.1292/jvms.22-0079
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K14988
[Journal Article] Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon)2022
- Author(s)
  Takeda Kazuki、Manago Kosuke、Morita Ayuko、Kawai Yusuke K.、Yasuo Nobuaki、Sekijima Masakazu、Ikenaka Yoshinori、Hashimoto Takuma、Minato Ryuichi、Oyamada Yusuke、Horikoshi Kazuo、Suzuki Hajime、Ishizuka Mayumi、Nakayama Shouta M.M.
- Journal Title
  
  Ecotoxicology and Environmental Safety
  
  Volume: 243 Pages: 113971-113971
- DOI
  10.1016/j.ecoenv.2022.113971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00620, KAKENHI-PROJECT-21H04919, KAKENHI-PROJECT-21K14988
[Journal Article] Sensitivity of turtles to anticoagulant rodenticides: Risk assessment for green sea turtles (Chelonia mydas) in the Ogasawara Islands and comparison of warfarin sensitivity among turtle species2021
- Author(s)
  Yamamura Yoshiya、Takeda Kazuki、Kawai Yusuke K.、Ikenaka Yoshinori、Kitayama Chiyo、Kondo Satomi、Kezuka Chiho、Taniguchi Mari、Ishizuka Mayumi、Nakayama Shouta M.M.
- Journal Title
  
  Aquatic Toxicology
  
  Volume: 233 Pages: 105792-105792
- DOI
  10.1016/j.aquatox.2021.105792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14988
[Journal Article] The effects of fipronil on emotional and cognitive behaviors in mammals2021
- Author(s)
  Suzuki Tomohiro、Hirai Anri、Khidkhan Kraisiri、Nimako Collins、Ichise Takahiro、Takeda Kazuki、Mizukawa Hazuki、Nakayama Shouta M.M.、Nomiyama Kei、Hoshi Nobuhiko、Maeda Mizuki、Hirano Tetsushi、Sasaoka Kazuyoshi、Sasaki Noboru、Takiguchi Mitsuyoshi、Ishizuka Mayumi、Ikenaka Yoshinori
- Journal Title
  
  Pesticide Biochemistry and Physiology
  
  Volume: 3 Pages: 104847-104847
- DOI
  10.1016/j.pestbp.2021.104847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00645, KAKENHI-PROJECT-19K22933, KAKENHI-PROJECT-19H04277, KAKENHI-PROJECT-21K19846, KAKENHI-PROJECT-19K19406, KAKENHI-PROJECT-21K14988
[Presentation] Evaluation of Subchronic Toxicological Effects of Low Concentration Mixed Exposure of Nine Linear PFAS on Mice2023
- Author(s)
  Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Ryo Kamata
- Organizer
  6th International Chemical Hazard Symposium
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] AlphaFold2と分子シミュレーションを活用した天然記念物オガサワラオオコウモリの殺鼠剤感受性評価2023
- Author(s)
  武田一貴, 川合佑典, 安尾信明, 関嶋政和, 真砂皓大, 池中良徳, 堀越和夫, 鈴木　創, 石塚真由美, 中山翔太
- Organizer
  第2回環境化学物質3学会合同大会
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] AlphaFold2によるタンパク質立体構造予測を利用した毒性評価の試み2023
- Author(s)
  武田一貴
- Organizer
  第50回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] パーフルオロアルキル化合物（PFASs）のマウスへの低濃度混合曝露による毒性影響評価2022
- Author(s)
  武田一貴, 斎藤多喜, 佐々木さくら, 江口哲史, 鎌田亮
- Organizer
  環境化学物質3学会合同大会
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] 培養細胞法とAlphafold2による血液凝固第IX因子スプライシングバリアント2の機能解析2022
- Author(s)
  渡邉可菜実, 佐藤玲, 鎌田亮, 武田一貴
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] 分子シミュレーションを用いたヒトの一塩基多型から化学物質感受性の動物種差を予測する手法の構築2022
- Author(s)
  武田一貴, 安尾信明, 関嶋政和
- Organizer
  第49回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] AlphaFold2を用いた高精度タンパク質立体構造予測の毒性評価への応用可能性～環境汚染物質を例として～2022
- Author(s)
  武田一貴
- Organizer
  第5回医薬品毒性機序研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] 培養細胞発現系と AI による構造推定を用いた血液凝固第 IX 因子スプライシングバリアント 2 の機能解析2022
- Author(s)
  渡邉可菜実, 佐藤玲, 鎌田亮, 武田一貴
- Organizer
  第5回環境化学討論会北海道東北地区部会・中国四国地区部会合同シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] ESTIMATING SUSCEPTIBILITY OF RODENTICIDE BY MOLECULAR DYNAMICS & MACHINE LEARNING USING 3D STRUCTURES OF VITAMIN K EPOXIDE REDUCTASE2022
- Author(s)
  Kazuki Takeda, Nobuaki Yasuo, Kanami Watanabe, Ryo Sato, Ryo Kamata, Masakazu Sekijima
- Organizer
  The Pure and Applied Chemistry International Conference 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] 血液凝固第IX因子スプライシングバリアント2の機能解析2022
- Author(s)
  渡邉可菜実, 佐藤玲, 鎌田亮, 武田一貴
- Organizer
  第4回日本比較薬理学・毒性学会春季研究会
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] ゼブラフィッシュを用いた増感剤関連物質の芳香族炭化水素受容体（AhR）活性化能の評価2022
- Author(s)
  更田葵依, 武田一貴, 清水敬太, 寺崎正紀, 鎌田亮
- Organizer
  環境化学物質3学会合同大会
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] 水圏から見る抗凝血殺鼠剤散布～ウミガメにおける毒性評価の試み～2022
- Author(s)
  山村快哉、近藤理美、北山知代、武田一貴一瀬貴大、池中良徳、石塚真由美、中山翔太
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21H04919
[Presentation] インク由来化学物質群のゼブラフィッシュ胚への芳香族炭化水素受容体(AhR)を介する毒性影響評価2022
- Author(s)
  更田葵依, 武田一貴, 清水敬太, 寺崎正紀, 鎌田亮
- Organizer
  第165回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] 血液凝固第IX因子スプライシングバリアント2の機能解析2022
- Author(s)
  渡邉可菜実佐藤玲鎌田亮武田一貴
- Organizer
  第4回日本比較薬理学・毒性学会春季研究会
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] 培養細胞発現系と AI による構造推定を用いた血液凝固第 IX 因子スプライシングバリアント 2 の機能解析2022
- Author(s)
  渡邉可菜実佐藤玲鎌田亮武田一貴
- Organizer
  第5回環境化学討論会北海道東北地区部会・中国四国地区部会合同シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] Anticoagulant rodenticide in Bonin Islands, Japan “Galapagos of the Orient” - investigation of rodenticide-susceptibility of the endemic species by toxicokinetic analysis -2021
- Author(s)
  Kazuki Takeda, Shouta M.M. Nakayama, Kosuke Manago, Yoshiya Yamamura, Yusuke Kawai, Ayuko Morita, Yoshinori Ikenaka, Noriyuki Komatsu, Chiyo Kitayama, Satomi Kondo, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuo Horikoshi, and Mayumi Ishizuka
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)
- Data Source
  KAKENHI-PROJECT-21K14988
[Presentation] 分子動力学シミュレーションと機械学習によるビタミン K エポキシド還元酵素遺伝子多型からの殺鼠剤感受性の評価法の確立2021
- Author(s)
  武田一貴, 安尾信明, 渡邉可菜実, 佐藤玲, 鎌田亮, 関嶋政和
- Organizer
  第29回環境化学討論会
- Data Source
  KAKENHI-PROJECT-21K14988

1. 石塚真由美 (50332474)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 川合佑典 (10709546)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 池中良徳 (40543509)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 中山翔太 (90647629)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 早川卓志 (00758493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山崎淳平 (20732902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 江口哲史 (70595826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 久保田彰 (60432811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 生城真一 (50244679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田上瑠美 (60767226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NOMIYAMA Kei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. SEKIJIMA Masakazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeda Kazuki 武田 一貴

Research Projects

Research Products

Co-Researchers

Development of Off-Target Toxicity Prediction Method Using Comprehensive Binding SimulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and clinical application of a non-invasive drug sensitivity assessment method for ex situ conservation of threatened avian species

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アフリカの環境汚染によるヒトと動物の毒性学的影響とそのメカニズム解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Adaptive evolution/change in mammals to exogenous chemicals (xenobiotics)

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of an evaluation method of a chemical-susceptibility for wildlife using counter-QSAR and machine learningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Estimating susceptibility of rodenticide by molecular dynamics & machine learning using 3D structures of vitamin k epoxide reductase2022

Author(s)

Journal Title

Data Source

[Journal Article] Observation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a sandwich enzyme-linked immunosorbent assay (ELISA) to quantify γ-glutamyl-carboxylated clotting factor IX and assess redox susceptibility of anticoagulant chemicals2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon)2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sensitivity of turtles to anticoagulant rodenticides: Risk assessment for green sea turtles (Chelonia mydas) in the Ogasawara Islands and comparison of warfarin sensitivity among turtle species2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effects of fipronil on emotional and cognitive behaviors in mammals2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Evaluation of Subchronic Toxicological Effects of Low Concentration Mixed Exposure of Nine Linear PFAS on Mice2023

Author(s)

Organizer

Data Source

[Presentation] AlphaFold2と分子シミュレーションを活用した天然記念物オ ガサワラオオコウモリの殺鼠剤感受性評価2023

Author(s)

Organizer

Data Source

[Presentation] AlphaFold2によるタンパク質立体構造予測を利用した毒性評価の試み2023

Author(s)

Takeda Kazuki 武田一貴

[Presentation] AlphaFold2と分子シミュレーションを活用した天然記念物オガサワラオオコウモリの殺鼠剤感受性評価2023

[Presentation] AlphaFold2を用いた高精度タンパク質立体構造予測の毒性評価への応用可能性～環境汚染物質を例として～2022

[Presentation] 培養細胞発現系と AI による構造推定を用いた血液凝固第 IX 因子スプライシングバリアント 2 の機能解析2022

[Presentation] 血液凝固第IX因子スプライシングバリアント2の機能解析2022

[Presentation] ゼブラフィッシュを用いた増感剤関連物質の芳香族炭化水素受容体（AhR）活性化能の評価2022

[Presentation] 血液凝固第IX因子スプライシングバリアント2の機能解析2022

[Presentation] 培養細胞発現系と AI による構造推定を用いた血液凝固第 IX 因子スプライシングバリアント 2 の機能解析2022