KIMURA Toshikiro 木村聰城郎

… Alternative Names

木村聡城郎キムラトシキロウ

木村聰城郎キムラトシキロウ

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Researcher Number	10025710
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2013: 岡山大学, 医歯(薬)学総合研究科, その他 2013: 岡山大学, 大学院医歯薬学総合研究科, 特命教授 2012: 岡山大学, 医歯(薬)学総合研究科, 教授 2011: 岡山大学, 医歯(薬)学総合研究科, 特命教授 2009 – 2011: Okayama University, 大学院・医歯薬学総合研究科, 特命教授 … More 2010: 岡山大学, 大学院・医歯薬学総合研究科, 教授 2005 – 2008: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 2006: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 2003 – 2004: 岡山大学, 薬学部, 教授 1996 – 2001: 岡山大学, 薬学部, 教授 1993 – 1994: 岡山大学, 薬学部, 教授 1988 – 1989: 岡山大学, 薬学部, 教授 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Physical pharmacy / 応用薬理学・医療系薬学 / Biological pharmacy Except Principal Investigator Medical pharmacy / Biological pharmacy / 応用薬理学・医療系薬学
Keywords	Principal Investigator 経口吸収 / 消化管吸収 / Streptozotocin / GITA model / BCS class II / Cyp3A / P-gp / griseofulvin / 難水溶性薬物 / 初回通過効果 … More / Cytochrome P450 3A / P-glycoprotein / 薬物吸収 / 口腔粘膜 / Plasma protein binding / Urinary excretion / Drug metabolism / Drug absorption / Diabetes / streptozotocin / 血漿たん白結合 / 尿中排泄 / 薬物代謝 / 糖尿病 / in vitro dissolution study / prediction / poorly water-soluble drug / oral absorption / 吸収動態予測 / in vitro溶出試験 / 予測 / D-glucose transport / optimal culture condition / stratified cell layer / HaCaT cells / permeability evaluation / oral mucosa / D-glucose輸送系 / 最適培養条件 / 重層細胞 / HaCaT細胞 / 薬物透過性評価系 / transporter / facilitated diffusion / active transport / cultured stratified cell layer / dipeptide / D-glucose / human oral mucosal cells / トランスポータ / 促進拡散 / 能動輸送 / 培養重層細胞 / ジペプチド / D-グルコース / ヒト口腔粘膜上皮細胞 / 小腸抽出率 / 吸収クリアランス / 発現タンパク量 / quinidine / 経口窒収 / 経口投与 / SMEDDS製剤 / 補助界面活性剤 / 界面活性剤 / 油脂成分 / 自己乳化型マイクロエマルション / ムチン層 / グリセオフルビン / 放出 / 膵リパーゼ / 胆汁 / 自己乳化型マイクロエマルション製剤 / 自己乳化型マイクロエマルション製剤(SMEDDS) / 難溶解性薬物 / in vivo溶解挙動 / 小腸内移行性 / 胃排出 / PEPT1 / 代謝学 / 薬物動態 / 特殊輸送機構 / 角質層脂質 / 薬物透過障壁 / 吸収促進剤 / 非攪拌水層 / 親油性依存性 / 分子サイズ依存性 / 大腸 … More Except Principal Investigator P-glycoprotein / enteric nervous system / cephalexin / epinephrine / Western blot / 腸神経系 / clonidine / rhodamine123 / adrenaline / trafficking / PepT1 / 筋層間神経叢 / 粘膜下神経叢 / アドレナリン作動性神経系 / quinidine / 5-HT / oligopeptide transporter / enteric nerve system / myenteric plexus / 吸収促進 / 単純拡散 / 消化管吸収 / bethanechol / 刷子縁膜 / セロトニン / ベタネコール / 胆汁排泄 / cMOAT / P-450 / brush border membrane / dibutyryl cAMP / 腸管・血管同時灌流 / rhodamine 123 / submucosal plexus / colchicine / glycyl-sarcosine / cAMP / dobutamine / P-glycoproteir / absorption enhancement / gastrointestinal absorption / Voltage-clamp / p-chlorophenylalanine / serotonin(5-HT) / 消化管分泌 / cholinergic neuron / adrenergic neuron / 非アドレナリン作動性-非コリン作動性伝達物質 / 一酸化窒素 / 吸収抑制 / 交感神経系 / Auerbach神経叢 / Bethanechol / Epinephrine / Enteric nervous system / アウエルバッハ神経叢 / エピネフリン / コリン作動性神経 / アドレナリン作動性神経 / Caco-2 / 消化器疾患 / Ussing type chamber / 有機アニオン系薬物 / 発現タンパク / Mrp2 / BCRP / MRP2 / ラット単離小腸粘膜 / Caco-2細胞 / 分泌 / 有機アニオン系化合物 / antipyrine / FITC-dextran / クロム親和性細胞 / セロトニン異常 / モノアミンオキシダーゼA / ローダミン123 / P-糖タンパク / 小腸粘膜 / トラフィッキンク / セロトニン症候群 / クロルギリン / P-糖タンパク質 / 経細胞経路 / 細胞間隙経路 / 受動拡散 / アドレナリン / 薬物間相互作用 / CYPアイソザイム / 薬物速度論 / 薬物代謝 / 尿中排泄 / 輸送担体 / cDNAクローニング / oatp / 生理学的薬物速度論 / 薬物輸送担体 / 代替法 / 遺伝子診断法 / 遺伝的多型 / 遺伝子発現の調節機構 / 酵素の多様性 / 薬物代謝酵素 Less

Analysis of drug absorption behavior in the enteric nervous system-related gastrointestinal diseases
- Principal Investigator
  
  HIGAKI Kazutaka
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Analysis of dissolution kinetics and first-pass elimination of orally administered drugs and its application to prediction of absorption behavior after oral administrationPrincipal Investigator
- Principal Investigator
  
  KIMURA Toshikiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Systematic analysis of ENS-regulation of drug absorption
- Principal Investigator
  
  HIGAKI Kazutaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Analysis of first-pass effect in small intestinal mucosa and its application to prediction of drug absorption behavior after oral administrationPrincipal Investigator
- Principal Investigator
  
  KIMURA Toshikiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Regulation of drug absorption by enteric nervous system: Studies on drug secretion via specialized mechanisms.
- Principal Investigator
  
  HIGAKI Kazutaka
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Analysis of physiological factors regulating oral absorption behaviors of drugs and its application to prediction of plasma concentration-time profilePrincipal Investigator
- Principal Investigator
  
  KIMURA Toshikiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Regulation of drug absorption and secretion from gastrointestinal via specialized mechanisms by enteric nervous system
- Principal Investigator
  
  HIGAKI Kazutaka
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  OKAYAMA UNIVERSITY
Analysis of Drug Permeation Mechanism across Oral Mucosa Using Cultured Stratified Cell LayersPrincipal Investigator
- Principal Investigator
  
  KIMURA Toshikiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  OKAYAMA UNIVERSITY
Regulation of drug absorption from gastrointestinal tract by enteric nerve system
- Principal Investigator
  
  HIGAKI Kazutaka
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  OKAYAMA UNIVERSITY
Analysis of Carrier-Mediated Transport Systems in Drug Absorption from Oral MucosaPrincipal Investigator
- Principal Investigator
  
  KIMURA Toshikiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  OKAYAMA UNIVERSITY
異物解毒の分子基盤:代謝・排泄能の分子から個体への予測
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Effect of neurohumoral control on gastrointestinal absorption of drugs
- Principal Investigator
  
  OGAWARA Ken-ichi, 檜垣和孝
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Okayama University
薬物解毒(代謝・排泄)能力の予測:分子から個体へ
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
薬物動態の分子基盤:解毒(代謝・排泄)能力の予測
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
薬物吸収部位としての口腔粘膜の評価:薬物透過障壁能の物理科学的解析Principal Investigator
- Principal Investigator
  
  木村聰城郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Okayama University
薬物吸収部位としての大腸粘膜の評価:薬物透過障壁能の物理化学的解析Principal Investigator
- Principal Investigator
  
  木村聰城郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Okayama University
Experimental Analysis of Anomalous Pharmacokinetics in Disease State: Pharmacokinetics in DiabetesPrincipal Investigator
- Principal Investigator
  
  KIMURA Toshikiro
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Okayama University

All 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Sex differences in pharmacokinetics of cilostazol in rats2011
- Author(s)
  N. Kamada, K. Yamada, M. Odomi, T. Mukai, T. Nishibayashi, K. Ogawara, T. Kimura and K. Higaki
- Journal Title
  
  Xenobiotica
  
  Volume: 41(10) Pages: 903-913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590158
[Journal Article] 自己乳化型マイクロエマルション製剤2010
- Author(s)
  檜垣和孝、木村聰城郎
- Journal Title
  
  薬剤学 70
  
  Pages: 32-38
- NAID
  10029100674
- Data Source
  KAKENHI-PROJECT-21590158
[Journal Article] 自己乳化型マイクロエマルション製剤2010
- Author(s)
  檜垣和孝、木村聰城郎
- Journal Title
  
  J. Pharm. Sci. Technol.
  
  Volume: 70(1) Pages: 32-38
- NAID
  10029100674
- Data Source
  KAKENHI-PROJECT-21590158
[Journal Article] Effect of adrenergic stimulation on drug absorp- tion via passive diffusion in Caco-2 cells.2009
- Author(s)
  T.Kimoto, M.Takanashi, H.Mukai, K.Ogawara, T.Kimura, K.Higaki
- Journal Title
  
  Int.J.Pharm. 368(1-2)
  
  Pages: 31-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590145
[Journal Article] Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats2009
- Author(s)
  T. Hironaka, S. Itokawa, K. Ogawara, K. Higaki and T. Kimura
- Journal Title
  
  Pharm. Res. 26(1)
  
  Pages: 40-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590144
[Journal Article] Evaluation of in-vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug2008
- Author(s)
  Y. Fujioka, Y. Metsugi, K. Ogawara, K. Higaki and T. Kimura
- Journal Title
  
  Int. J. Pharm. 352(1-2)
  
  Pages: 36-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590144
[Journal Article] Regulation of drug absorption from small intestine by enteric nervous system : Studies on passive diffusion2007
- Author(s)
  T., Kimoto, M., Takanashi, M., Sasaki, K., Ogawara, T., Kimura, K., Higaki
- Journal Title
  
  Drug Metab. Rev 39(1)
  
  Pages: 94-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590142
[Journal Article] Regulation of P-glycoprotein function by enteric nervous system : Efflux activity and intracellular migration of P-glycoprotein in intestinal epithelial cells2007
- Author(s)
  H., Mukai, H., Hiraoka, K., Matsushita, K., Ogawara, T., Kimura, K., Higaki
- Journal Title
  
  Drug Metab. Rev 39(1)
  
  Pages: 274-275
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590142
[Journal Article] Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model : Utilization of a more suitable medium for in-vitro dissolution study.2007
- Author(s)
  Y.Fujioka, K.Kadono, Y.Fujie, Y.Metsugi, K.Ogawara, K.Higaki, T.Kimura
- Journal Title
  
  J. Control.Rel. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590124
[Journal Article] Upregulation of P-glycoprotein expression in small intestine under chronic serotonin-depleted conditions in rats.2005
- Author(s)
  H.Hiraoka, H.Kimura, Y.furukawa, K.Ogawara, T.Kimura, K.Higaki
- Journal Title
  
  J.Pharmacol.Exp.Ther. 312(1)
  
  Pages: 248-255
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590110
[Journal Article] Pharmacokinetic analysis of in-vivo dissolution and absorption behavior of poorly water-soluble drugs after oral administration.2005
- Author(s)
  Y.Fujioka, K.Kadono, Y.Fujie, Y.Metsugi, K.Ogawara, K.Higaki, T.Kimura
- Journal Title
  
  DrugMetab. Rev. 37 (supp. 2)
  
  Pages: 399-400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590124
[Journal Article] Regulation of drug transport via P-glycoprotein by enteric nervous system.2005
- Author(s)
  H.Hiraoka, H.Mukai, Matsushita, K.Ogawara, T.Kimura, K.Higaki
- Journal Title
  
  Drug Metab.Rev. 37(suppl 2)
  
  Pages: 79-80
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590110
[Journal Article] Regulation of drug absorption from small intestine by enteric nervous system : Studies on transport via PepT1 and passive diffusion.2005
- Author(s)
  T.Kimoto, Y.Furukawa, K.Ogawara, T.Kimura, K.Higaki
- Journal Title
  
  Drug Metab.Rev. 37(suppl 2)
  
  Pages: 291-291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590110
[Journal Article] Regulation of drug absorption from small intestine by enteric nervous system I : a poorly absorbable drug via passive diffusion.2004
- Author(s)
  K.Higaki, M.Sone, K.Ogawara, T.Kimura
- Journal Title
  
  Drug Metab.Pharmacokinet. 19(3)
  
  Pages: 198-205
- NAID
  80016771596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590110
[Presentation] セロトニン症候群発症時における薬物の経口吸収挙動に関する基礎的研究2012
- Author(s)
  中島駿、岩本武晴、高梨雅史、大河原賢一、木村聰城郎、檜垣和孝
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸国際会議場,神戸
- Data Source
  KAKENHI-PROJECT-23590181
[Presentation] 有機アニオン性化合物の経口吸収挙動に及ぼすセロトニン枯渇の影響2011
- Author(s)
  三木朋子、橋本賢太、大河原賢一、木村聰城郎、檜垣和孝
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀, 東京
- Data Source
  KAKENHI-PROJECT-23590181
[Presentation] 有機アニオン性化合物の経口吸収挙動に及ぼすセロトニン枯渇の影響2011
- Author(s)
  三木朋子、橋本賢太、大河原賢一、木村聰城郎、檜垣和孝
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀,東京
- Data Source
  KAKENHI-PROJECT-23590181
[Presentation] Regulation of Drug Absorption from Small Intestine by Enteric Nervous System : Studies on Passive Diffusion2007
- Author(s)
  Takahiro, Kimoto, Masashi, Takanashi, Moeko, Sasaki, Ken-ichi Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  Sendai International Center, Sendai, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590142
[Presentation] Regulation of P-glycoprotein Function by Enteric Nervous System : Efflux Activity and Intracellular Migration of P-glycoprotein in Intestinal Epithelial Cells2007
- Author(s)
  Hironori, Mukai, Hideo, Hiraoka, Kotaro, Matsushita, Kenichi, Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  Sendai International Center, Sendai, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590142
[Presentation] Regulation of drug absorption from small intestine by enteric nervous system : Studies on passive diffusion and P-gp function2007
- Author(s)
  Takahiro, Kimoto, Hideo, Hiraoka, Hironori, Mukai, Moeko, Sasaki, Kenichi, Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
- Organizer
  4th Pharmaceutical Sciences World Congress
- Place of Presentation
  RAI Congress Center, Amsterdam, Netherlands
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590142
[Presentation] Improvement of oral absorption behavior of poorly water-soluble drug using SMEDDS: Pharmacokinetic analysis and prediction based on GITA model2007
- Author(s)
  T. Kimura
- Organizer
  34th Annual Meeting and Exposition of the Controlled Release Society
- Place of Presentation
  Long Beach, California, USA
- Data Source
  KAKENHI-PROJECT-19590144
[Presentation] Improvement of oral absorption behavior of poorly watersolubledrug using SMEDDS : Pharmacokinetic analysis and prediction based on GITA model2007
- Author(s)
  T. Kimura
- Organizer
  34^<th> Annual meeting and exposition of the controlled releasesociety
- Place of Presentation
  Long Beach, California, USA
- Data Source
  KAKENHI-PROJECT-19590144
[Presentation] Regulation of drug transport via P-glycoprotein by enteric nervous system in Caco-2 monolayers2006
- Author(s)
  Hironori, Mukai, Hideo, Hiraoka, Kotaro, Matsushita, Kenichi, Ogawara, Toshikiro,Kimura, Kazutaka, Higaki
- Organizer
  21st Japanese Society for the Study of Xenobiotics Annual Meeting
- Place of Presentation
  Tower Hall Funabori, Tokyo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590142
[Presentation] Regulation of drug absorption via passive diffusion from small intestine by enteric nervous system2006
- Author(s)
  Takahiro, Kimoto, Moeko, Sasaki, Ken-ichi, Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
- Organizer
  21st Japanese Society for the Study of Xenobiotics Annual Meeting
- Place of Presentation
  Tower Hall Funabori, Tokyo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590142

1. OOGAWARA Kenichi (30291470)

# of Collaborated Projects: 12 results

# of Collaborated Products: 20 results
2. HIGAKI Kazutaka (60284080)

# of Collaborated Projects: 11 results

# of Collaborated Products: 22 results
3. KAWAI Keiichi (30204663)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 杉山雄一 (80090471)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 石崎高志 (50158747)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 乾賢一 (70034030)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 辻彰 (10019664)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 粟津荘司 (60012621)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results

KIMURA Toshikiro 木村 聰城郎

木村 聡城郎 キムラ トシキロウ

木村 聰城郎 キムラ トシキロウ

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Analysis of dissolution kinetics and first-pass elimination of orally administered drugs and its application to prediction of absorption behavior after oral administrationPrincipal Investigator

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Principal Investigator

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Analysis of first-pass effect in small intestinal mucosa and its application to prediction of drug absorption behavior after oral administrationPrincipal Investigator

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Principal Investigator

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Analysis of physiological factors regulating oral absorption behaviors of drugs and its application to prediction of plasma concentration-time profilePrincipal Investigator

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Analysis of Drug Permeation Mechanism across Oral Mucosa Using Cultured Stratified Cell LayersPrincipal Investigator

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Analysis of Carrier-Mediated Transport Systems in Drug Absorption from Oral MucosaPrincipal Investigator

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KIMURA Toshikiro 木村聰城郎

木村聡城郎キムラトシキロウ

木村聰城郎キムラトシキロウ