MIWA Masao 三輪匡男

… Alternative Names

三輪匡雄ミワマサオ

三輪匡男

Less

Researcher Number	10046287
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2008 – 2011: University of Shizuoka, 薬学部, 名誉教授 2008: University of Shizuoka, 薬学部, 客員教授 1998 – 2007: 静岡県立大学, 薬学部, 教授 1996: School of Pharmaceutical Sciences, University of Shizuoka, Professor, 薬学部, 教授 1995: 静岡県立大学, 薬学部, 助教授 … More 1991 – 1992: University of Shizuoka, School of Pharmaceutical Science, Associate Professor, 薬学部, 助教授 1991: 静岡立大学, 薬学部, 助教授 1988 – 1990: 静岡県立大学, 薬学部, 講師 1986: 静岡薬科大学, 薬学部(生化学), 講師 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Medical pharmacy / Biological pharmacy / Laboratory medicine Except Principal Investigator Biological pharmacy / Digestive surgery / Biological pharmacy
Keywords	Principal Investigator PAF / 血小板活性化因子 / Y27632 / Y24180 / Platelet-Activating Factor / シグナル伝達 / 核内受容体 / 転写調節 / PAF遊離因子 / Asthma … More / Autosomal Recessive Heredity / Enzyme Deficiency / Acetylhydrolase / 免疫化学的測定法 / 血清PAFアセチルハイドロラーゼ欠損 / アセチルハイドロラーゼ / 喘息 / 常染色体性劣性遺伝 / アセチルヒドロラ-ゼ / 小児喘息 / 酵素欠損 / PAFアセチルヒドロラ-ゼ / cell signalling / Platelet disaggregation / Guanylate cyclase / PAF receptor / Platelet activating factor (PAF) / Platelet / Rho kinase阻害剤 / cGMP / 脱凝集 / 血小板脱凝集反応 / 細胞内情報伝達 / PAF脱凝集反応 / グアニルシクラーゼ / PAF受容体 / 血小板活性化因子(PAF) / 血小板 / oxidized phospholipid / arteriosclerosis obliterans / renal failure / genetic disposition / PAF acetylhydrolase / PAFアセチルヒドロラーゼ / PAF・アセチルヒドロラーゼ / 酸化脂質 / 閉塞性動脈硬化症 / 腎不全 / 遺伝素因 / PAFアセチルヒドラローゼ / monoclonal antibody / adhesion molecule / platelet / aggregation / platelet-activating factor / 細胞接着因子 / 血小板凝集 / PAF-releasing factor / Serum PAF-acetylhydrolase deficient / PAF-binding protein / Serum PAF-acetylhydrolase / PAF-carrier protein / PAF結果蛋白質 / 血清PAFアセチルヒドロラ-ゼ欠損 / PAF結合蛋白質 / 血清PAFアセチルヒドロラ-ゼ / PAFキャリア-蛋白質 / シグナル伝逹 / CDK 2 / 発現制御 / 肝薬物代謝酵素 / 細胞周期 / CDK2 / 薬物代謝酵素 / サイクリン依存性キナーゼ / 糖毒性 / 転写調節因子 / 解毒酵素 / 溶血性尿毒症 / 腎障害 / アクアポリン2 / 水チャンネル / 病原性大腸菌 / ベロ毒素 / 関節液 / PAF結合活性 / PMNs / 好中球 … More Except Principal Investigator UGT1A1 / CAR / 核内受容体 / グルクロン酸抱合酵素 / Clinical medicine / Bloloey / Stress / Surgery / 術後合併症 / 遺伝子多型 / 肝不全 / 肝切除 / 血小板活性化因子 / 臨床 / 生態学 / ストレス / 外科 / Growth factor / Transcriptional cofactor / Drug-metabolizing enzyme / Cell cycle / Nuclear receptor / CYP2B6 / コファクター / A1 / グルクロン酸抱合酵素UGT / constitutive androstane receptor(CAR) / 増殖因子 / 転写コファクター / 薬物代謝酵素 / 細胞周期 / flavonoids / nuclear receptor / single nucleotide polymorphism(SNP) / bilirubin / hyperbilirubinemia / Gilbert's syndrome / bilirubin LIDP-glucuronosyltransferase(UGT1A1) / プロモーター遺伝子 / フラボノイド / SNP / 遺伝子変異 / ビリルビン / 高ビリルビン血症 / 体質性黄疸 / Calcium blocker / Protein kinase inhibitor / phosphatase inhibitor / disaggregation / P-selectin / PAF / platelet-activating factor / Platelet / PAFアセチルヒドロラーゼ / 接直因子 / 血小板活性化因子(PAF) / カルシウム拮抗剤 / リン酸化酵素阻害剤 / ホスファターゼ阻害剤 / 脱凝集 / P-セレクチン / 血小板 / 血小板活性化因子(PDF) / 二次元定量 / イメージング装置 / シンチレータ / 微弱β線 / 生体切片 / 超高感度テレビカメラシステム / プロテインキナ-ゼ / トロンビン / 内皮細胞 / リゾレシチンアシルトランスフェラ-ゼ / EORF(内皮由来弛緩因子) / 内皮依存性弛緩反応 / 冠動脈 / LDL Less

Cyclin-dependent kinase 2 down-regulates expression of drug-metabolizing enzymes UGT1A1 and CYP3A4 through phosphorylation of nuclear receptor PXRPrincipal Investigator
- Principal Investigator
  
  MIWA Masao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Mechanism of carbohydrate toxicity induction and its association with transcription factors involved in expression of xenobiotics-metabolizing enzymesPrincipal Investigator
- Principal Investigator
  
  MIWA Masao
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Relationship between the Platelet Activating Factor Acetylhydaulase Gene Polymorphism, Enzymatic Activity and Postoverative Clinical Course afher Liver Surgery
- Principal Investigator
  
  SAKAGUCHI Takanori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Hamamatsu University School of Medicine
Induction of CAR and the nuclear localization are promoted in HepG2 hepatoma cells arrested at G_1 phase of cell cycle : Association with gene expression of UGT1A1 and Gadd45β
- Principal Investigator
  
  SUGATANI Junko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
Guanylate cyclase-cyclic GMP signaling pathway in platelet disaggregation associated with dissociation of PAF-receptor complexPrincipal Investigator
- Principal Investigator
  
  MIWA Masao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
Study on defect in human UGTIAI gene promoter associated with hyperbilirubinemia and mechanism of the UGTIAI in duction
- Principal Investigator
  
  SUGATANI Junko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
病原性大腸菌毒素Stxによる腎水チャンネル(アクアポリン)障害検査法の開発Principal Investigator
- Principal Investigator
  
  三輪匡男
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  University of Shizuoka
Identification of major plasma PAF acetylhydrolase and study on its gene mutation as a risk factor in allergic diseases.Principal Investigator
- Principal Investigator
  
  MIWA Masao
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
Study on mechanism of newly found reverse signaling system in platelets
- Principal Investigator
  
  SUGATANI Junko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
Study on platelet adhesion molecule to inhibit aggregation.Principal Investigator
- Principal Investigator
  
  MIWA Masao
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
血小板活性化因子(PAF)の生体内動態と血清PAF遊離因子の免疫化学的機能解析Principal Investigator
- Principal Investigator
  
  三輪匡男
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
LDL(低比重リポ蛋白)による冠動脈内皮依存性弛緩反応の抑制機構
- Principal Investigator
  
  富田多嘉子
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Shizuoka
Study of platelet-activating factor (PAF) carrier protein in human serum.Principal Investigator
- Principal Investigator
  
  MIWA Masao
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
Immunological study on human serum PAF(platelet-activating factor) acetylhydrolase deficiencyPrincipal Investigator
- Principal Investigator
  
  MIWA Masao
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
生体切片等の^3H,^<14>Cの超高感度テレビカメラシステムによる短時間二次元定量法の
- Principal Investigator
  
  岡田昌二
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Shizuoka College of Pharmacy

All 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] Transcriptional regulation of human bilirubin : UDP-glucuronosyltransferase UGT1A1 gene and implication of defects in the UGT1A1 gene promoter in "Bilirubin : Chemistry, Regulation and Disorder" (Jakub F.Novotny and Florian Sedlacek eds)2012
- Author(s)
  J.Sugatani, M.Miwa
- Total Pages
  27
- Publisher
  NOVA Science Publishers
- Data Source
  KAKENHI-PROJECT-21590170
[Book] Transcriptional regulation of human bilirubin : UDP-glucuronosyltransferase UGT1A1 gene and implication of defects in the UGT1A1 gene promoter in "Bilirubin : Chemistry, Regulation and Disorder"2011
- Author(s)
  Junko Sugatani and Masao Miwa
- Publisher
  NOVA Science Publishers
- Data Source
  KAKENHI-PROJECT-21590170
[Book] 酵素ハンドブック(第3版)2008
- Author(s)
  菅谷純子, 三輪匡男
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-19590151
[Book] 加水分解酵素3.1.4.39-3.1.4.51、4.6.1.14「酵素ハンドブック(第3版)」(八木達彦、福井俊郎、一島英治、鏡山博行、虎谷哲夫編集)2008
- Author(s)
  菅谷純子, 三輪匡男
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-19590151
[Book] 茶の効能と応用開発 Health beneficial functions and development of tea goods - 血小板凝集抑制.2006
- Author(s)
  菅谷純子, 三輪匡男
- Total Pages
  9
- Publisher
  シーエムシー出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Book] 茶の効能と応用開発 Health beneficial functions and development of tea goods-血小板凝集抑制2006
- Author(s)
  菅谷純子, 三輪匡男
- Total Pages
  9
- Publisher
  シーエムシー出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet2012
- Author(s)
  Sugatani J, Sadamitsu S, Wada T, Yamazaki Y, Ikari A, Miwa M
- Journal Title
  
  Nutr. Metab
  
  Volume: 9 Issue: 1 Pages: 23-46
- DOI
  10.1186/1743-7075-9-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590170, KAKENHI-PROJECT-22590068
[Journal Article] Diet-induced lipid accumlation in liver enhances ATP-biding cassette transporter g5/g8 expression in bile canaliculi. Drug Metab2011
- Author(s)
  Yamazaki Y, Hashizume T, Morioka H, Sadamitsu S, Ikari A, Miwa M, Sugatani J
- Journal Title
  
  Pharmacokinet
  
  Volume: 208 Pages: 442-450
- URL
  http://www.jstage.jst.go.jp/article/dmpk/26/5/26_442/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590170
[Journal Article] Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 22010
- Author(s)
  Sugatani J, Osabe M, Kurosawa M, Kitamura N, Ikari A, Miwa M
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 38 Issue: 1 Pages: 177-186
- DOI
  10.1124/dmd.109.029785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590170, KAKENHI-PROJECT-22590068
[Journal Article] Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells2010
- Author(s)
  Ikari A, Sanada A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M
- Journal Title
  
  J Cell Physiol
  
  Volume: 222 Issue: 3 Pages: 481-487
- DOI
  10.1002/jcp.21988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590170
[Journal Article] Nutritional status affects fluvastatinnduced hepatotoxicity and myopathy in rats2010
- Author(s)
  Sugatani J, Sadamitsu S, Kurosawa M, Ikushiro S, Sakaki T, Ikari A, Miwa M
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 38 Issue: 10 Pages: 1655-1664
- DOI
  10.1124/dmd.110.034090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590170, KAKENHI-PROJECT-22590068
[Journal Article] Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress2009
- Author(s)
  Makoto Osabe, Junko Sugatani, Akiko Takemura, Masatoshi Kurosawa, Yasuhiro Yamazaki, Akira Ikari, Masao Miwa
- Journal Title
  
  FEBS Letters 583(5)[IF 3.263]
  
  Pages: 885-889
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress2009
- Author(s)
  Osabe M, Sugatani J, Takemura A, Kurosawa M, Yamazaki Y, Ikari A, Miwa M
- Journal Title
  
  FEBS Lett
  
  Volume: 583 Pages: 885-889
- URL
  http://dx.doi.org/10.1016/j.febslet.2009.01.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590170
[Journal Article] Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells. Biochem. Biophys2009
- Author(s)
  Ikari A, Atomi K, Takiguchi A, Yamazaki Y, Miwa M, Sugatani J
- Journal Title
  
  Res. Commun
  
  Volume: 384 Pages: 306-310
- URL
  http://dx.doi.org/10.1016/j.bbrc.2009.04.120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590170
[Journal Article] TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells2008
- Author(s)
  A. Ikari, C. Okude, H. Sawada, Y. Yamazaki, J. Sugatani, M. Miwa
- Journal Title
  
  Biochem. Biophys. Res. Commun 369(4)[IF 2.855]
  
  Pages: 1129-1133
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs : implication of defects in the UGT1A1 gene promoter2008
- Author(s)
  J. Sugatani, K. Mizushima, M. Osabe, K. Yamakawa, S. Kakizaki, H. Takagi, M. Mori, A. Ikari, M. Miwa
- Journal Title
  
  Naunyn Schmiedebergs Arch. Pharmacol 377(4-6)[IF 2.779]
  
  Pages: 597-605
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Constitutive androstane receptor and peroxisome proliferator-activated receptor a are activated in liver of male rats fed ahigh-fat and high-sucrose diet and the hepatic expression of UGT1A1 and UGT1A6 is enhanced.2008
- Author(s)
  M. Osabe, J. Sugatani, T. Fukuyama, S. Ikushiro, A. Ikari, M. Miwa.
- Journal Title
  
  Drug Metab. Dispos. 36
  
  Pages: 294-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high sucrose (cafeteria) diet2008
- Author(s)
  J. Sugatani, M. Osabe, T. Wada, K. Yamakawa, Y. Yamazaki, T. Takahashi, A. Ikari, M. Miwa
- Journal Title
  
  Eur. J. Nutr 47(4)[IF2.356]
  
  Pages: 192-200
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation2008
- Author(s)
  M. Osabe, J. Sugatani, A. Takemura, Y. Yamazaki, A. Ikari, N. Kitamura, M. Negishi, M. Miwa
- Journal Title
  
  Biochem. Biophys. Res. Commun 369(4)[IF 2.855]
  
  Pages: 1027-1033
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Downregulation of TRPM6-mediated magnesium influx by cyclosporine A2008
- Author(s)
  A, Ikari, C. Okude, H. Sawada, T. Takahashi, J. Sugatani, M. Miwa
- Journal Title
  
  Naunyn Schmiedebergs Arch. Pharmacol 377(4-6)[IF 2.779]
  
  Pages: 333-343
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Constitutive androstane receptor and peroxisome proliferator-activated receptor a are activated in liver of male rats fed a high-fat and high-sucrose diet and the hepatic expression of UGT1A1 and UGT1A6 is enhanced2008
- Author(s)
  M. Osabe, J. Sugatani, T. Fukuyama, S. Ikushiro, A. Ikari, M. Miwa
- Journal Title
  
  Drug Metab. Dispos 36(2)[IF 3.638]
  
  Pages: 294-302
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Claudin-16 is directly phosphorylated by protein kinase a independently of a vasodilator-stimulated phosphoprotein-mmediated pathway2008
- Author(s)
  A. Ikari, M. Ito, C. Okude, H. Sawada, H. Harada, M. Degawa, H. Sakai, T. Takahashi, J. Sugatani, M. Miwa
- Journal Title
  
  J. Cell Physiol 214(1)[IF3.638]
  
  Pages: 221-229
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Surface localization of the nuclear receptor CAR in influenza A virus-infected cells2008
- Author(s)
  T. Takahashi, Y. Moriyama, A. Ikari, J. Sugatani T. Suzuki, M. Miwa
- Journal Title
  
  Biochem. Biophys. Res. Commun 368(3)[IF 2.855]
  
  Pages: 550-555
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-162008
- Author(s)
  A. Ikari, C. Okude, H. Sawada, Y. Sasaki, Y. Yamazaki, J. Sugatani, M. Degawa, M. Miwa
- Journal Title
  
  Biochim. Biophys. Acta 1778(1)[IF 3.587]
  
  Pages: 283-290
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Comparison of enzymatically synthesized inulin, resisitant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high sucrose (cafeteria) diet.2008
- Author(s)
  J. Sugatani, M. Osabe, T. Wada, K. Yamakawa, Y. Yamazaki, T. Takahashi, A. Ikari, M. Miwa
- Journal Title
  
  Eurp. J. Nutr. 47
  
  Pages: 192-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590151
[Journal Article] Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet.2006
- Author(s)
  Kouichi Yoshinari, Shunsuke Takagi, Teruyasu Yoshimasa, Junko Sugatani, Masao Miwa
- Journal Title
  
  Pharmaceut. Res. DOI : 10. 1007/s 11095-006-
  
  Pages: 71-76
- NAID
  130004639309
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet.2006
- Author(s)
  Kouichi Yoshinari, Shunsuke Takagi, Teruyasu Yoshimasa, Junko Sugatani, Masao Miwa
- Journal Title
  
  Pharmaceut.Res. DOI : 10. 1007/sl 1095-006-0071-6
- NAID
  130004639309
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants.2006
- Author(s)
  Kouichi Yoshinari, Nao Okino, Takeshi Sato, Junko Sugatani, Masao Miwa
- Journal Title
  
  Drug Metab. Dispos. DOI : 10.1124/dmd
  
  Volume: 34 Issue: 7 Pages: 1081-1089
- DOI
  10.1124/dmd.105.007286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063, KAKENHI-PROJECT-16590056
[Journal Article] Physico-chemical characterization and biological effects of inulin enzymatically synthesized from sucrose.2005
- Author(s)
  Tadashi Wada, Junko Sugatani, Etsuko Terada, Masao Ohguchi, Masao Miwa
- Journal Title
  
  J.Agric.Food.Chem. 53
  
  Pages: 1246-1253
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Regulation of the human UGT1A1 gene by nuclear receptors CAR, PXR and GR. In "Conjugation Enzymes".2005
- Author(s)
  J.Sugatani, T.Sueyoshi, M.Negishi, M.Miwa
- Journal Title
  
  Methods in Enzymology, Elsevier Inc. (H.Sies, and L.Packer, eds.)
  
  Pages: 92-104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Regulation of the human UGT1A1 gene by nuclear receptors CAR, PXR and GR. In "Conjugation Enzymes".2005
- Author(s)
  J.Sugatani, T.Sueyoshi, M.Negishi, M.Miwa
- Journal Title
  
  Methods in Enzymology (H.Sies, L.Packer, eds.) Elsevier Inc
  
  Pages: 92-104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Transcriptional regulation of human UGT1A1 gene expression : Activated GR enhances CAR/PXR-mediated UGT1A1 regulation with GRIP1.2005
- Author(s)
  Junko Sugatani, Shinichi Nishitani, Kasurni Yamakawa, Kouichi Yoshinari, Tatsuya Sueyoshi, Masahiko Negishi, Masao Miwa
- Journal Title
  
  Mol.Pharmacol. 67(3)
  
  Pages: 845-855
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Transcriptional regulation of human UGT1A1 gene expression : Activated GR enhances CAR/PXR-mediated UGT1A1 regulation with GRIP1.2005
- Author(s)
  Junko Sugatani, Shinichi Nishitani, Kasumi Yamakawa, Kouichi Yoshinari, Tatsuya Sueyoshi, Masahiko Negishi, Masao Miwa
- Journal Title
  
  Mol.Pharmacol. 67(3)
  
  Pages: 845-855
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Physico-chemical characterization and biological effects of inulin enzymatically synthesized from sucrose.2005
- Author(s)
  Tadashi Wada, Junko Sugatani, Etsuko Terada, Masao Ohguchi, Masao Miwa
- Journal Title
  
  J.Agric.Food.Chem. 53
  
  Pages: 1246-1253
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] The induction of human bilirubin UDP-glucuronosyltransferase mediated through a distal enhancer module by flavonoids and xenobiotics.2004
- Author(s)
  Junko Sugatani, Kasumi Yamakawa, Eri Tonda, Shinichi Nishitani, Kouichi Yoshinari, Masakuni Degawa, Ikuro Abe, Hiroshi Noguchi, Masao Miwa
- Journal Title
  
  Biochem. Phalmacol. 67(5)
  
  Pages: 989-1000
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] The induction of human bilirubin UDP-glucuronosyltransferase mediated through a distal enhancer module by flavonoids and xenobiotics.2004
- Author(s)
  Junko Sugatani, Kasumi Yamakawa, Eri Tonda, Shinichi Nishitani, Kouichi Yoshinan, Masakuni Degawa, Ikuro Abe, Hiroshi Noguchi, Masao Miwa
- Journal Title
  
  Biochem.Phalmacol. 67(5)
  
  Pages: 989-1000
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue.2004
- Author(s)
  Kouichi Yoshinari, Takeshi Sato, Nao Okino, Junko Sugatani, Masao Miwa
- Journal Title
  
  J.Phalmacol.Exp Ther. 311
  
  Pages: 147-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Tea polyphenols inhibit acetyl-CoA : l-alkyl-sn-glycero-3- phosphocholine acetyltransferase (a key enzyme in PAF biosynthesis) and PAF- induced platelet aggregation.2004
- Author(s)
  Junko Sugatani, Nana Fukazawa, Kenji Ujihara, Kouichi Yoshinari, Ikuo Abe, Hiroshi Noguchi, Masao Miwa
- Journal Title
  
  Intern.Arch.Allergy Immunol. 134
  
  Pages: 17-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Tea polyphenols inhibit acetyl-CoA : 1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in PAF biosynthesis) and PAF-induced platelet aggregation.2004
- Author(s)
  Junko Sugatani, Nana Fukazawa, Kenji Ujihara, Kouichi Yoshinari, Ikuo Abe, Hiroshi Noguchi, Masao Miwa
- Journal Title
  
  Intern.Arch.Allergy Immunol. 134
  
  Pages: 17-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue.2004
- Author(s)
  Kouichi Yoshinari, Takeshi Sato, Nao Okino, Junko Sugatani, Masao Miwa
- Journal Title
  
  J.Pharmacol.Exp Ther. 311
  
  Pages: 147-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Presentation] サイクリン依存性キナーゼ2は核内受容体PXRを介して薬物代謝酵素CYP3A42011
- Author(s)
  内田貴啓、黒澤雅俊、平川城太朗、山崎泰広、五十里彰、三輪匡男、菅谷純子
- Organizer
  UGT1A1の発現を負に調節する第75回日本生化学会中部支部シンポジウム
- Place of Presentation
  静岡
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] Cyclin-dependent kinase 2 down-regulates expression of drug-metabolizing enzymes UGT1A1 and CYP3A4 through phosphorylation of nuclear receptor PXR in S phase2011
- Author(s)
  内田貴啓、黒澤雅俊、平川城太朗、山崎泰広、五十里彰、三輪匡男、菅谷純子
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] 核内受容体PXRを介したUGT1A1発現調節機構の解析2011
- Author(s)
  内田貴啓、黒澤雅俊、山崎泰広、五十里彰、三輪匡男、菅谷純子
- Organizer
  第131年回日本薬学会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] サイクリン依存性キナーゼ2は核内受容体PXRを介して薬物代謝酵素CYP3A4、UGT1A1の発現を負に調節する2011
- Author(s)
  内田貴啓、黒澤雅俊、平川城太朗、山崎泰広、五十里彰、三輪匡男、菅谷純子
- Organizer
  第75回日本生化学会中部支部シンポジウム
- Place of Presentation
  静岡
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] Cyclin-dependent kinase 2 down-regulates expression of drug-metabolizing enzymes UGT1A1 and CYP3A4 through phosphorylation of nuclear receptor PXR in S phase2011
- Author(s)
  内田貴啓、黒澤雅俊、平川城太朗、山崎泰広、五十里彰、三輪匡男、菅谷純子
- Organizer
  第34回日本分子生物学会年会(横浜)
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] PAF受容体欠損マウスで見いだされた新規なPAF生理機能の解明2011
- Author(s)
  菅谷純子、定光慧、山崎泰広、黒澤雅俊、長澤孝真、杉山渉、五十里彰、渡辺達夫、三輪匡男、石井聡、清水孝雄
- Organizer
  第53回日本脂質生化学会
- Place of Presentation
  東京
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats : Association with the suppression of hepatic organic an ion transporting polypeptide 22011
- Author(s)
  Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Akira Ikari, Masao Miwa
- Organizer
  4^<th> International conference on health and longevity sciences
- Place of Presentation
  静岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats : Association with the suppression of hepatic organic anion transporting polypeptide 2.2010
- Author(s)
  Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Akira Ikari, Masao Miwa
- Organizer
  3^<nd> International conference on health and longevity sciences "Integrated food-pharmaceutical science"
- Place of Presentation
  静岡県立大学
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] Expression of UGT1A1 is regulated by cell signals associated with cell-cycle progression.2010
- Author(s)
  黒澤雅俊、内田貴啓、五十里彰、三輪匡男、菅谷純子
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] 酵素合成イヌリン添加食による脂肪肝増悪化抑制と連動した肝薬物代謝酵素発現変動の改善2010
- Author(s)
  定光慧、和田正、長澤孝真、平本洸貴、五十里彰、三輪匡男、菅谷純子
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] 細胞周期に依存した薬物代謝酵素の発現制御2010
- Author(s)
  黒澤雅俊, 定光慧, 山崎泰広, 五十里彰, 三輪匡男, 菅谷純子
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] 細胞周期に依存した薬物代謝酵素の発現抑制2010
- Author(s)
  黒澤雅俊、定光慧、山崎泰広、五十里彰、三輪匡男、菅谷純子
- Organizer
  第130年回日本薬学会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] CDKシグナル伝達系を介した核内受容体CAR発現調節機序の解明2010
- Author(s)
  黒澤雅俊、内田貴啓、五十里彰、三輪匡男、菅谷純子
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] CDKシグナル伝達系を介した核内受容体CAR発現調節機序の解明2010
- Author(s)
  黒澤雅俊、内田貴啓、五十里彰、三輪匡男、菅谷純子
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] Expression of UGT1A1 is regulated by cell signals associated with cell-cycle progression2010
- Author(s)
  黒澤雅俊、内田貴啓、五十里彰、三輪匡男、菅谷純子
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] 細胞増殖抑制シグナル伝達系と連携したCYP2B62009
- Author(s)
  菅谷純子、長部誠、黒澤雅俊、山崎泰広、五十里彰、三輪匡男
- Organizer
  UGT1A1発現調節機構の解明第2回博多シンポジウム「内・外環境と生物応答」
- Place of Presentation
  博多
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] 細胞増殖抑制シグナル伝達系と連携したCYP2B6、UGT1A1発現調節機構の解明2009
- Author(s)
  菅谷純子, 長部誠, 黒澤雅俊, 山崎泰広, 五十里彰, 三輪匡男
- Organizer
  第2回博多シンポジウム「内・外環境と生物応答
- Place of Presentation
  九州大学
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] CDK2シグナル伝達系を介した薬物代謝酵素CYP2B6、UGT1A1発現調節機序の解明2009
- Author(s)
  黒澤雅俊、長部誠、喜多村直美、山崎泰広、五十里彰、三輪匡男、菅谷純子
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21590170
[Presentation] Comparison of enzymatically synthesized inulin, clofibrate and fluvastatin effects on biomarkers of metabolic disease and drug metabolism in rats fed standard and cafeteria diets2008
- Author(s)
  J. Sugatani, M. Osabe, S. Sadamitsu, M. Imanishi, Y. Yamazaki, A. Ikari, M. Miwa
- Organizer
  1^<st> International conference on health and longevity sciences, Yaku-shoku Dogen、'Medicine and food, sharing a common origin
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-19590151
[Presentation] 高カロリー食摂取ラットにおける肝コレステロールトランスポーターAbcg5/8発現変動の解析2008
- Author(s)
  山崎泰広、長部誠、松井久美子、鎌田修二、近江明大、竹村明子、五十里彰、菅谷純子、三輪匡男
- Organizer
  日本薬学会第128年会(講演要旨集3)
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590151
[Presentation] Comparison of enzymatically synthesized inulin, clofibrate and fluvastatin effects on biomarkers of metabolic disease and drug metabolism in rats fed standard and cafeteria diets2008
- Author(s)
  Junko Sugatani, Makoto Osabe, Satoshi Sadamitsu, Masaki Imanishi, Yasuhiro Yamazaki, Akira Ikari, Masao Miwa
- Organizer
  1^<st> International conference on health and longevity sciences, Yaku-shoku Dogen、'Medicine and food, sharing a common origin
- Place of Presentation
  University of Shizuoka
- Data Source
  KAKENHI-PROJECT-19590151
[Presentation] 酵素合成法によるイヌリンの抗肥満作用機構の解析2008
- Author(s)
  菅谷純子、和田正、長部誠、鎌田修二、近江明大、石川智子、山崎泰広、五十里彰、三輪匡男
- Organizer
  日本薬学会第128年会(講演要旨集3)(59)
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590151
[Presentation] 高脂肪高糖質食で飼育したラット肝薬物代謝酵素/トランスポーターの発現変動について2007
- Author(s)
  長部誠、菅谷純子、福山知哲、山崎泰広、高橋忠伸、五十里彰、三輪匡男
- Organizer
  第53回日本薬学会東海支部総会・大会(講演要旨集)(28)
- Place of Presentation
  名古屋
- Year and Date
  2007-07-07
- Data Source
  KAKENHI-PROJECT-19590151
[Presentation] 脂肪肝形成モデル動物の薬物動態-アセトアミノフェングルクロン酸抱合反応の亢進2007
- Author(s)
  長部誠、菅谷純子、福山知哲、山崎康広、五十里彰、三輪匡男
- Organizer
  第1回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-19590151
[Presentation] 高カロリー食の摂取により脂肪肝を形成したラット肝臓のグルクロン酸抱合酵素UGT1A1、UGT1A6の発現亢進は核内受容体CAR、PPARaの活性化に起因するBMB20072007
- Author(s)
  水嶋康介、菅谷純子、長部誠、福山知哲、山崎泰広、五十里彰、三輪匡男
- Organizer
  第80回日本生化学会大会(332)
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19590151
[Presentation] 脂肪肝形成モデル動物の薬物動態-アセトアミノフェングルクロン酸抱合反応の亢進2007
- Author(s)
  長部誠、菅谷純子、福山知哲、山崎泰広、五十里彰、三輪匡男
- Organizer
  第1回次世代を担う若手医療薬科学シンポジウム
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-19590151
[Presentation] 高カロリー食の摂取により脂肪肝を形成したラット肝臓のグルクロン酸抱合酵素UGT1A1、UGT1A6の発現亢進は核内受容体CAR、PPARαの活性化に起因する2007
- Author(s)
  水嶋康介、菅谷純子、長部誠、福山知哲、山崎康広、五十里彰、三輪匡男
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19590151
[Presentation] Dietary inulin alleviates hepatic steatosis and xenobiotics-induced liver injury in rats fed a high-fat and high-sucrose diet : Association with the suppression of hepatic cytochrome P450 and HNF4a expression2007
- Author(s)
  Makoto Osabe, Junko Sugatani, Tadashi Wada, Tadanobu Takahashi, Akira Ikari, Masao Miwa
- Organizer
  The 5th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects, International Receptor Symposium
- Place of Presentation
  Shizuoka, Japan
- Data Source
  KAKENHI-PROJECT-19590151

1. SUGATANI Junko (30098131)

# of Collaborated Projects: 9 results

# of Collaborated Products: 68 results
2. YOSHINARI Kouichi (60343399)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. HAYASHI Machiko (50137072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MAEDA Toshio (00137069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAKAGUCHI Takanori (70313955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAMURA Toshio (40283353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. INABA Keisuke (10397383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 富田多嘉子 (30046263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 池田雅彦 (20232176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 芳野恭士 (10211658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岡田昌二 (40046256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 松本亮 (70046241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 手塚雅勝 (00046294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 五島廉輔 (70046275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 大須賀慎二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIWA Masao 三輪 匡男

三輪 匡雄 ミワ マサオ

三輪 匡男

Research Projects

Research Products

Co-Researchers

Cyclin-dependent kinase 2 down-regulates expression of drug-metabolizing enzymes UGT1A1 and CYP3A4 through phosphorylation of nuclear receptor PXRPrincipal Investigator

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Mechanism of carbohydrate toxicity induction and its association with transcription factors involved in expression of xenobiotics-metabolizing enzymesPrincipal Investigator

Principal Investigator

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Relationship between the Platelet Activating Factor Acetylhydaulase Gene Polymorphism, Enzymatic Activity and Postoverative Clinical Course afher Liver Surgery

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Induction of CAR and the nuclear localization are promoted in HepG2 hepatoma cells arrested at G_1 phase of cell cycle : Association with gene expression of UGT1A1 and Gadd45β

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Guanylate cyclase-cyclic GMP signaling pathway in platelet disaggregation associated with dissociation of PAF-receptor complexPrincipal Investigator

Principal Investigator

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Study on defect in human UGTIAI gene promoter associated with hyperbilirubinemia and mechanism of the UGTIAI in duction

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病原性大腸菌毒素Stxによる腎水チャンネル(アクアポリン)障害検査法の開発Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Identification of major plasma PAF acetylhydrolase and study on its gene mutation as a risk factor in allergic diseases.Principal Investigator

Principal Investigator

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Study on mechanism of newly found reverse signaling system in platelets

Principal Investigator

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Study on platelet adhesion molecule to inhibit aggregation.Principal Investigator

Principal Investigator

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血小板活性化因子(PAF)の生体内動態と血清PAF遊離因子の免疫化学的機能解析Principal Investigator

Principal Investigator

Project Period (FY)

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LDL(低比重リポ蛋白)による冠動脈内皮依存性弛緩反応の抑制機構

Principal Investigator

Project Period (FY)

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Research Institution

Study of platelet-activating factor (PAF) carrier protein in human serum.Principal Investigator

Principal Investigator

Project Period (FY)

MIWA Masao 三輪匡男

三輪匡雄ミワマサオ

三輪匡男