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SASAKI Makoto  佐々木 實

ORCIDConnect your ORCID iD *help
Researcher Number 10080003
Other IDs
Affiliation (based on the past Project Information) *help 2001: Nagoya City University Medical School Professor, 医学部, 教授
1995 – 1999: 名古屋市立大学, 医学部, 教授
1986 – 1993: 名古屋市立大学, 医学部, 教授
1986: Nagoya City University Medical School, 医学部, 教授
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / 代謝生物化学 / Neuroscience in general
Except Principal Investigator
Pathological medical chemistry / 物質生物化学 / General medical chemistry / 代謝生物化学 / Structural biochemistry
Keywords
Principal Investigator
カルパイン / Calpain / NF-κB / Calpain inhibitor / Ischemia / 脳神経細胞死 / 神経細胞死 / 抗カルパイン抗体 / 虚血 / カルパインインヒビター … More / NF-κBの活性化 / Chemotactic factor / Inflammation / 免疫グロブリン / ロイコエグレッシン / アセチル化ペプチド / 走化性因子 / 炎症 / Signal peptidase / Cathepsin / Calpastatin / Kininogen / Proteinase inhibitor / Proteolysis / プロティナーゼの活性制御 / カテプシン / キニノーゲン / プロティナーゼインヒビター / シグナルペプチダーゼ / プレプロエンザイムの活性化 / プロテオリシス / Calciium chelate compound / Calcium infulx / Necrosis / Apoptosis / Neuronal death / Hypoxia / カルパスタチン / 脳虚血 / ethidium bromide法 / acridine orange / 虚血低酸素 / カルシウム拮抗剤 / カルシウムinflux / ネクローシス / アポトーシス / 低酸素 / Neuronal cell death / Anti-calpain antibody / NF-kappaB / Miocardial infarction / Reperfusion / NFχB / 心筋虚血再灌流 / 神経芽細胞腫 / μ-カルパイン前駆体 / 虚血再灌流 / 心筋梗塞 / カルパイン阻害剤 / 再潅流 / Antigen presentation / Intracellular protease transport / Amyloidogenic protease / Calpain activation due to inafarotion / Hematocyte coagulation factor / Thrombomodulin / 94K calpain / Limited proteolysis / ニュ-カッスル病ウイルス / 26Sプロテアソ-ム / T細胞エイズレセプタ- / カルパインペプチドの白血球遊走活性 / カルパインの活性化 / プレプロタキキニン遺伝子発現調節因子 / プロテア-ゼによる情報発現 / トランスゴルジ膜結合性プロセシングプロテアーゼ / カテプシンBの抗原阻囎への関与 / 心筋梗塞巣活性化カルパイン / プロガストリンの活性化 / 筋組織特異的カルパイン / カテプシン-インバリアント鎖による抗原提示の調節 / 筋組織特異的94Kカルバイン / カテプシンの抗原提示への関与 / カテプシンの細胞内選別輸送 / アミロイドジェニックプロテアーゼ / 脳梗塞巣活性化カルパイン / 血球内凝固因子 / スロンボモジュリンの発現調節 / 筋組織特異的94Kカルパイン / プロテアーゼによる情報発現 / 昆虫細胞Sf9 / basulovirus / リコンビナント蛋白質 / IκBα切断部位 / IκBα / Lactacystin / カルパインインヒビターI / GST-IκB / IκB切断部位 / IκB … More
Except Principal Investigator
プロテアーゼインヒビター / プロテアソ-ム / プロセシング / プロテアーゼ / gene expression / proteasome / cathepsin / calpain / Protease / ATPプロテアーゼ / カルシウムプロテアーゼ / 病態 / アテプシン / 遺伝子発現 / カテプシン / プロテア-ゼ / カルパイン / Ornitho-kinin / Rat T-kininogen / Protease inhibitor / Thiol-protease / Kininogen / Plasma kallikrein / Kinin / ラットΤ-キニノーゲン / キニンリセプター / モノクロナール抗体 / XII因子 / トリキニン / ラットTキニノーゲン / チオールプロテアーゼ / キニノーゲン / カリクレイン / キニン / High molecular weight protease / Multisubunit complex / Structural analysis / Multicatalytic protease / Proteasomes / 発生と分化 / cDNAクロ-ニング / 20S環状粒子 / 細胞内プロテア-ゼ / 多機能プロテア-ゼ複合体 / 分子遺伝学 / 高分子量プロテア-ゼ / 構造解析 / 多成分複合体 / 多機能プロテア-ゼ / 蛋白質分解に関する国際委員会 / 炎症 / 癌 / 細胞増殖 / Ca依存性プロテアーゼ / リソゾームプロテアーゼ / 内在性インヒビター / 細胞内プロテアーゼ / 進化 / MHC / LMP7 / プロテアソーム / 蛋白質分解 Less
  • Research Projects

    (13 results)
  • Co-Researchers

    (27 People)
  •  カルパインによるNF-κB転写活性調整の解析Principal Investigator

    • Principal Investigator
      佐々木 實
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nagoya City University
  •  カルパインによるNF-κB転写活性調節の解析Principal Investigator

    • Principal Investigator
      佐々木 實
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nagoya City University
  •  Selective neuronal death induced by activation of pro μ-calpain under the hypoxic conditionsPrincipal Investigator

    • Principal Investigator
      SASAKI Makoto
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Neuroscience in general
    • Research Institution
      Nagoya City University
  •  プロテアソームの抗原提示に於ける役割の系統発生学的解析

    • Principal Investigator
      野中 勝
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya City University
  •  Studies on the tissue damage induced by activation of calpains under infarct/ischemiaPrincipal Investigator

    • Principal Investigator
      SASAKI Makoto
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagoya City University
  •  細胞内タンパク質の分解と生理的意義

    • Principal Investigator
      SUZUKI Koichi
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      The University of Tokyo
  •  Roles of proteases in signal transduction and their disordersPrincipal Investigator

    • Principal Investigator
      SASAKI Makoto
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagoys City Unversity Medcal School
  •  Structure and Cell Biology of a Novel Multicatalytic Proteinase Complex

    • Principal Investigator
      ICHIHARA Akira
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  Regulation and Pathology of Gene Expression of Intracellular Proteases Science, Dept. Mol. Biol., Director

    • Principal Investigator
      SUZUKI Koichi
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  細胞内プチテアーゼと内在性インヒビターの生理的先割とその病態

    • Principal Investigator
      勝沼 信彦
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      The University of Tokushima
  •  Roles of thiol proteases and kininogens in induction and regulation of inflammationPrincipal Investigator

    • Principal Investigator
      SASAKI Makoto
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagoya City University Medical School
  •  Biological Significance of Plasma Kallikrein-kinin System

    • Principal Investigator
      IWANAGA Sadaaki
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      物質生物化学
    • Research Institution
      Kyushu University
  •  Biological significance of proteolysis and its regulationPrincipal Investigator

    • Principal Investigator
      SASAKI Makoto
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      代謝生物化学
    • Research Institution
      Nagoya City University Medical School
  • 1.  SUZUKI Koichi (80011948)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  KUNIMATSU Mitoshi (70145746)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  KATUNUMA Nobuhiko (50035375)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  MURACHI Takashi (10089104)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  木南 英紀 (10035496)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  OZAKI Yasuhiko (50254280)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  TAKAHASHI Kenji (70011533)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  IWANAGA Sadaaki (90029942)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  SUGITA Hideo (80009951)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  ICHIHARA Akira (40035374)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  OHKUBO Iwao (80152073)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  TADA Toyohiro (20106230)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  ICHIHARA Akira (20035405)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  川島 誠一 (60008571)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  鮫島 達也 (50082772)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  野中 勝 (40115259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  YOKOSAWA Hideyoshi (90012765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  ISHIURA Shoichi (10158743)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  IKAI Atsushi (50011713)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  TANAKA Keiji (10108871)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  石川 勝利 (00008608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  HAYAKAWA Tomihiro (50172995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  NAGASAWA Shigeharu (70029958)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  SAKAMOTO Wataru (30001952)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  NAKANISHI Shigetada (20089105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  KATORI Makoto (50050365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  KATO Keitaro (70037571)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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