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HIGASHI Hideho  東 英穂

ORCIDConnect your ORCID iD *help
Researcher Number 10098907
External Links
Affiliation (based on the past Project Information) *help 1994 – 2006: Kurume University School of Medicine Professor, 医学部, 教授
2001: Kurume Univ. Sch. of Med. Professor, 医学部, 講師
1986 – 1993: 久留米大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies / Neurophysiology and muscle physiology / General physiology / General physiology / Neurochemistry/Neuropharmacology
Except Principal Investigator
Neurophysiology and muscle physiology / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / 神経・脳内生理学 / 麻酔学 … More / Biological Sciences / General physiology / 生理学一般 / Anesthesiology/Resuscitation studies Less
Keywords
Principal Investigator
脳虚血 / 海馬錐体細胞 / Necrosis / Hippocampal CA 1 neurons / 細胞内Ca濃度 / ATP依存性Kチャネル / NMDA受容体 / IPSP / EPSP / 海馬 … More / Rapid depolarization / Brain ischemia / 急峻脱分極電位 / 細胞内情報伝達系 / Ca依存性Kチャネル / Non-NMDA antagonists / NMDA antagonists / Ca antagonists / Intracellular ATP / Intracellular Ca / Hippocampal neurones / Cell death / CNS neurones / 細胞内自由Ca濃度 / Na@Ca交換機構 / Caポンプ / Naポンプ / 膜電位 / 無グルコース液潅流 / 無酸素状態(アノキシア) / 誘起Ca拮抗薬 / Ca誘起生Ca遊離 / 脳保護薬 / 有機性Ca拮抵薬 / Ca誘起性Ca遊離 / 細胞死 / 低酸素症(ハイポキシア) / Ischemia / Chondroitin sulfate / Heparan sulfate / Cytoplasmic Ca^<2+> concentration / Extracellular K^+ concentration / Hippocampus / Proteoglycan / Astrocyte / 細胞構築 / 細胞内Ca^<2+>濃度 / グリア / CA1錐体細胞 / 中枢神経系 / 虚血 / コンドロイチン硫酸 / ヘパラン硫酸 / 細胞質Ca^<2+>濃度 / 細胞外K^+濃度 / プロテオグリカン / アストロサイト / adenosine / A_1 receptor / lidocaine / epilepsy / hippocampus / neural network / アデノシン1受容体 / 海馬CA3領域 / 海馬歯状回 / 抑制性シナプス後電位 / 興奮性シナプス後電位 / イオン透過型グルタミン酸受容体 / GABA_A受容体 / 海馬CA1領域 / 局麻薬 / てんかん様放電 / A_1受容体 / アデノシン / リドカイン / 神経回路網 / てんかん様発作放電 / Synaptic responses / Ca^<2+> antagonists / Cell swelling / Small blebs / glutamate / superoxide dismutase / NO scavengers / NO / 低温環境 / biocytin / 細胞膨化 / CA^<2+>蓄積 / small blebs / NO synthase阻害薬 / Ca^<2+>拮抗薬 / 細胞内Ca^<2+>蓄積 / シナプス応答 / ネクローシス / ATP-sensitive K^+ channel / Electrogenic Na^+ pump / Slow depolarization / Initial hyperpolarization / Glutamate拮抗薬 / 興奮性アミノ酸 / Baclofen / Muscimol / Slow IPSP / Fast IPSP / East EPSP / GABA受容体 / 興奮性アミノ酸受容体 / Terminal deporarizaiton / Glutamate antagonist / Calmodulin kinase II / C kinase / Calmodulin Kinase II / Internal Ca^<2+> concentration / Signal transduction system / ATP-sensitive K^+ channels / Ca^<2+> -dependent K^+ channels / Anoxic hyperpolarization / Fura-2 / Ckinase / Calmoduline Kinase II / Tolbutamide / Glybenclamide / Nicorandil / Diazoxide / 海馬錘体細胞 / 低酸素誘起過分極電位 / C-kinase / Catmodulin kinaseII / 低酸素負荷 … More
Except Principal Investigator
DARPP-32 / リン酸化 / ドーパミン / 線条体 / fast EPSP / 脳虚血 / 細胞内情報伝達 / phosphorylation / dopamine / Intracellular calcium / 細胞内カルシウム / 細胞内情報伝達系 / 脊髄側角ニューロン / fast IPSP / testosterone / 17β-estradiol / Cdk5 / striatum / Glutamate receptors / 神経伝達物質 / Brain ischemia / 脳損傷 / Ca依存性Kコンダクタンス / ノルアドレナリン / シグナルトランスダクション / 長期増強 / AMPA / NMDA / グルタミン酸受容体 / シナプス / ギャップ結合 / G protein / Protein kinase C / Signal transduction / Adrenoceptors / Slow EPSP and IPSP / Fast EPSP / Spinal lateral horn / ムスカリン性受容体 / 消化管内在神経細胞 / アルファ受容体 / 緩徐抑制性シナプス電位 / 速および緩徐興奮性シナプス電位 / プロテインキナ-ゼC / 速い経過のシスプス電位 / 興奮性アミノ酸 / 側角細胞 / 脊髄 / Gタンパク / プロティンキナ-ゼC / カテコ-ルアミン受容体 / グルタメイト受容体 / 遅い経過のシナプス電位 / 速い経過のシナプス電位 / 脊髄側角細胞 / Anti-ischemic activity / Brain injury / Membrane potential / Hypoxia / Hippocampus / Brain slice / 脳局所灌流 / 海馬CA1ニューロン / 麻酔薬 / Ca^<2+>流入 / Kチャンネル / 膜電位 / 低酸素 / cardiac ganglion cells / enteric submucous neurons / accumbens neurons / limbic neurons / Lateral horn cells / ムスカリン性シナプス電位 / マイスナー神経叢 / ニコチン性受容体 / ノイズ解析 / 心壁内神経節細胞 / 交感性節前線維 / ペプチド作動性ニューロン / 側坐核 / カテコールアミン / ドーパミン受容体 / 心臓内神経節細胞 / 腸管内在神経叢細胞 / 側坐核ニューロン / 辺縁系ニューロン / 脊髄側用ニューロン / sexsual specificity / medial preoptic area / medial amygdaloid nucleus / IPSP / EPSP / 後脱分極 / 内向き整流 / アンドロゲン受容体 / 内側核ニューロン / 扁桃体 / 性差 / 内側視索前野 / 内側扁桃核 / intracellular signal transduction / neurite outgrowth / synthetic oligosaccharide / chondroitin sulfate proteoglycan / dopaminergic neurons / コンドロイチン硫酸プロテオグリカン / コンドロイチン硫酸ブロテオグリカン / 神経突起伸長 / 合成糖鎖分子 / コンロドイチン硫酸プロテオグリカン / ドーパミン作動性神経 / nicotine / intracellular signaling / neostriatum / glutamate / ニコチン / グルタミン酸 / intracclular signaling / 線条件 / protein phosphatase-1 / プロテインホスファターゼ1 / Patch clamp / Na, K-pump / Culture cell / Astrocytes / Glia cell / パッチクランプ / Na,K-pump / 培養細胞 / アストロサイト / グリア細胞 / Postnatal development / Presynaptic terminals / Muscarinic receptors / Plasticity / Intracellular Ca^<2+> / Neurotransmitters / Synapses / 生後発達 / シナプス前終末 / マスカリン受容体 / 可塑性 / 細胞内Ca^<2+> / Nitric oxide / cDNA subtraction / Calcium binding protein / NMDA receptor / Calcium channel / Long term potentiation / 海馬 / 海馬スライス / アラキドン酸代謝系 / NO / NMDAレセプタ / 一酸化窒素 / cDNAサブトラクション法 / カルシウム結合タンパク / NMDAレセプター / カルシウムチャネル / Phosphorilation of protein / Second messenger / Cross talk / Hydrolysis of membrane lipid / Ion Channel / Receptor / 神経細胞 / 生体電気シグナル / cDNA / mRNA / 蛋白リン酸化 / 膜脂質代謝 / クロストーク / セカンドメッセンジャー / イオンチャネル / レセプター / tachykinin / serotonin / signal transduction / slow EPSP and IPSP / alpha_1 and alpha_2 receptor / presynaptic inhibition / sympathetic preganglionic neuron / マイスナ-神経叢細胞 / P物質 / 緩徐シナプス伝達 / 交感性節前ニュ-ロン / tachykinins / slow IPSP / slow EPSP / シグナル・トランスダクション / alpha_2受容体 / alpha_1受容体 / substance P / 緩徐シナプス電位 / タキキニン / セロトニン / slow EPSPとIPSP / α_1とα_2受容体 / シナプス前抑制 / 交感性節前ニューロン / Plastic change / cDNA cloning / Transmitter release / Glutamate receptor / Synapse / 長期抑圧 / GABA受容体 / 遺伝子クローニング / グリシン受容体 / CDNAクローニング / 可塑性変化 / cDNAクローニング / 伝達物質放出 / 細胞内記録 / 海馬錐体神経細胞 / 局所麻酔薬 / Ca電流 / whole cell patch recording / 脊髄神経節細胞 Less
  • Research Projects

    (23 results)
  • Co-Researchers

    (52 People)
  •  Do androgen receptors contribute to the expression of sex differences in the brain?

    • Principal Investigator
      TANAKA Eiichiro
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Kurume University
  •  Map of dopamine signaling in the neostriatum

    • Principal Investigator
      NISHI Akinori
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kurume University
  •  Elucidating the structure and function of chondrotin sulfate proteoglycan in differentitation, development and regeneration of dopaminergic neurons

    • Principal Investigator
      SOTOGAKU Naoki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kurume University
  •  Effects of proteoglycans on the membrane dysfunction produced by in vitro ischemia in the rat hippocampal CA1 neurons.Principal Investigator

    • Principal Investigator
      HIGASHI Hideho
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      KURUME UNIVERSITY
  •  Epileptic Discharges and the neural network in the hippocampus.Principal Investigator

    • Principal Investigator
      HIGASHI Hideho
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      KURUME UNIVERSITY
  •  ドーパミン情報伝達とシグナル統合細胞間分子回路

    • Principal Investigator
      西 昭徳
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kurume University
  •  Molecular mechanisms to amplify dopamine signaling in neostriatal neurons

    • Principal Investigator
      NISHI Akinori
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kurume University Scientifiv Research (C) (2)
  •  線条体神経細胞でのドーパミン情報伝達系、特にD1/D2レセプター相互作用の解析

    • Principal Investigator
      NISHI Akinori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kurume University
  •  Analysis of intracellular signaling cascades mediated by receptor activation and protein phosphorylation in neostriatal

    • Principal Investigator
      NISHI Akinori
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kurume Unuviersity
  •  Membrane dysfunction induced by in vitro ischemia in rat hippocampal CA1 pyramidal neuronsPrincipal Investigator

    • Principal Investigator
      HIGASHI Hideho
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kurume University
  •  Role of glia cell during brain ischemia

    • Principal Investigator
      YAMAMOTO Satoshi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      神経・脳内生理学
    • Research Institution
      Kurume University
  •  Physiological studies on the mechanisms of synaptic transmission.

    • Principal Investigator
      KUBA Kenji
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      神経・脳内生理学
    • Research Institution
      Nagoya University
      佐賀医科大学
  •  Experimental Brain Ischemia and Ion ChannelsPrincipal Investigator

    • Principal Investigator
      HIGASHI Hideho
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kurume University
  •  脊椎麻酔は下行大動脈遮断に伴う脊髄の虚血性障害を緩和できるか

    • Principal Investigator
      杉山 和英
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kurume University
  •  Mechanisms for hypoxia-induced hyperpolarization in the rat hippocampal CA 1 neurons in vitro.Principal Investigator

    • Principal Investigator
      HIGASHI Hideho
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kurume University
  •  THE CROSS TALK OF SIGNAL TRANSMISSION BETWEEN THE RECEPTOR AND THE CHANNEL

    • Principal Investigator
      AKAIKE Norio
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      生理学一般
    • Research Institution
      KYUSYU UNIVERSITY
      Tohoku University
  •  Pathophysiology and treatments of brain ischemia insighted from neuronal function, metabolism and molecular structure

    • Principal Investigator
      SHIMOJI Koki
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      麻酔学
    • Research Institution
      Niigata University
  •  Molecular and cellular basis of synaptic function

    • Principal Investigator
      OZAWA Seiji
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Gunma University
  •  Electrophysiological studies of synaptic transmission in the central and peripheral autonomic neurons.

    • Principal Investigator
      NISHI Syogoro
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Kurume University
  •  Synaptic Transmission and Modulation in the Autonomic Nervous System

    • Principal Investigator
      NISHI Syogoro
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Kurume University
  •  Effects of deprivation of oxygen and/or glucose on mammalian CNS neuronesPrincipal Investigator

    • Principal Investigator
      HIGASHI Hideho
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Kurume University School of Medicine
  •  The electrical property, chemoreceptivity and synaptic transmission of autonomic neurons

    • Principal Investigator
      NISHI Syogoro
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Kurume University
  •  Study on pathophysiology of cerebral hypoxia by means of the brain slice technique and the regional perfusion technique

    • Principal Investigator
      SHIMOJI Koki
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      麻酔学
    • Research Institution
      Niigata University
  • 1.  NISHI Akinori (50228144)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  INOKUCHI Hiroe (10080558)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  TANAKA Eiichiro (80188284)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  AKAIKE Noriko (30040182)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  YAMAMOTO Satoshi (60220464)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  NISHI Syogoro (00080557)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  YOSHIMURA Megumu (10140641)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  SOTOGAKU Naoki (60368884)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  AKASU Takashi (60113213)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  OZAWA Seiji (40049044)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  TAKAHASHI Tomoyuki (40092415)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  MIHARA Satoshi (40166103)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  KUBA Kenji (60080561)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  SHIMOJI Koki (30040158)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  矢野 秀樹 (60210308)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  ONODERA Kayoko (00053091)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  MISHINA Masayoshi (80144351)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KIYOHARA Toshikazu (50071874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  KITAZATO Hiroshi (20079700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  OKADA Yasunobu (10025661)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  INOUE Isao (80001973)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SATOH Masamichi (80025709)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  KUMANISHI Toshiro (40018601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  ASANO Takao (70090496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  TANAKA Masatoshi (10080954)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  WATANABE Yuka (80412542)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  NISHI Yoshihiro (20352122)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  MURAI Yoshinaka (40322820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  HOKARI Tamaki (10173577)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  HASHIBA Masao (30108047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  ENDOH Hiroshi (90168831)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  杉山 和英 (80140721)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  大石 一男 (70203700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  無敵 剛介 (60080917)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  山岸 俊一 (70014032)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  野間 昭典 (00132738)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  外崎 昭 (90004572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  富田 忠雄 (50078763)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  高橋 国太郎 (10010034)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  竹中 敏文 (00045999)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  反町 勝 (70036440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  瀬山 一正 (70034006)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  鈴木 光 (80037548)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  小林 春雄 (20074502)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  崎村 建司 (40162325)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  佐武 明 (70018589)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  平野 丈夫 (50181178)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  木島 博正 (30012397)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  福井 隆一 (00309791)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  聖川 孝介 (20080559)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  丸山 洋一 (00111724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 52.  MARUYAMA Yoichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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