ISHIHARA Kazuhiko 石原和彦

Researcher Number	10104530
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2000 – 2006: 北里大学, 医療衛生学部, 教授 1998: Kitasato Univ.Sch.Allied Health Sci., Professor, 医療衛生学部, 教授 1995 – 1997: 北里大学, 医学部, 教授 1991 – 1992: 北里大学, 医学部, 助教授 1988 – 1989: 北里大学, 医学部, 助教授 1987: 北里大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / 物質生物化学 / Gastroenterology / Cell biology
Keywords	Principal Investigator mucin / monoclonal antibody / モノクローナル抗体 / immunohistochemistry / stomach / experimental ulcer / mucosal regeneration / ムチン / 胃粘液分泌 / ELISA … More / 抗ムチン抗体 / acidic oligosaccharide / mucosal damage / gastro-intestinal tract / 腸管寄生線虫 / シアロムチン / スルホムチン / 抗糖鎖抗体 / 粘膜障害 / 酸性糖鎖 / 粘膜傷害 / 消化管 / eperimental ulcer / monoclipnal antibody / carbohydrate antigen / mucus secretion / gastric mucin / anti-mucin antibody / 糖鐘抗原 / 糖鎮抗原 / 胃ムチン / Carbachol / Monoclonal antibody / Anti-mucin antibody / Hexosamine determination / Gastric mucin determination / Gastric mucus secretion / Ex-vivo gastric chamber / ラット胃粘膜 / 胃分泌機構 / 胃粘液 / Exーvivoガストリックチャンパ- / ヘキソサミン微量定量法 / 胃ムチン微量定量法 / carbachol / ヘキソサミン測定法 / 胃ムチン微量測定法 / Ex-vivoガストリックチャンバー … More Except Principal Investigator ムチン / calcitonin gene-related peptide / 実験潰瘍 / 免疫組織化学 / mucin / Gastric mucosa / 胃粘液 / 粘液細胞 / SV40 / 胃粘膜 / endoglycosidase / endo-alpha-N-acetylgalactosaminidase / mucin degradation enzyme / gastric mucus glycoprotein / エンドーN-アセチルガラクトサミニターゼ / エンドーNーアセチルガラクトサミニダーゼ / エンド-グリコシダ-ゼ / エンド-N-アセチルガラクトサミニダ-ゼ / エンドーグリコシダ-ゼ / エンドーNーアセチンガラクトサミニダ-ゼ / ムチン分解酵素 / 胃粘液糖タンパク質 / aging / gastrointestinal mucosa / neurotrophic factor / NT-3 / BDNF / NGF / TrkC / TrkB / TrkA / 表層粘液細胞 / 加齢 / 消化管 / 神経栄養因子 / experimental ulcer / mucus metabolism / anti-mucin monoclonal antibody / mucus cell / immunohistochemistry / vasoactive intestinal peptide / ペプチド作動性神経 / 抗ムチンモノクローナル抗体 / 粘液代謝 / 抗ムチンモノクロール抗体 / Dot-blot / Gastric mucus / Monoclonal antibody / Mucus gel / Helicobacter pylori / ドットブロット / ドットプロット / 粘液ゲル層 / モノクローナル抗体 / ヘリコバクター・ピロリ / GSM06 cells / large T-antigen / Transgenic mouse / Gastric epithelial cells / Hyaluronan / 胃表層粘液細胞 / モノクロナール抗体 / GSM06細胞 / large T-抗原 / トランスジェニックマウス / 胃上皮細胞 / ヒアルロナン Less

Function of gastro-intestinal mucin-derived acidic oligosaccharaides recognized by anti-mucin monoclonal antibodiesPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Kazuhiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
Neurotrophic factors and gastrointestinal mucosa
- Principal Investigator
  
  ICHIKAWA Takafumi
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  KITASATO UNIVERSITY
Homeostasis of gastric mucosa and effects of peptidergic nerve on mucus metabolism
- Principal Investigator
  
  ICHIKAWA Takafumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
A systematic development of monoclonal antibodies against mucins of digestive tract and their application to pathophysiological studiesPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Kazuhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
Role of the gastric mucus on the Helicobacter pylori infection.
- Principal Investigator
  
  HOTTA Kyoko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  KITASATO UNIVERSITY
Mucus secretion studies using anti-gastric mucin monoclonal antibodiesPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Kazuhiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
How dose the gastric surface mucus cell line derived from transgenic mouse synthesize and secrete mucins?
- Principal Investigator
  
  HOTTA Kyoko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  KITASATO UNIVERSITY
Measurement of rat gastric mucus secretion using ex-vivo gastric chamber systemPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Kazuhiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
Biochemical studies of mucin cleaving enzyme and gastric mucus glycoprotein
- Principal Investigator
  
  HOTTA Kyoko
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Kitasato University

All 2007 2006 2005 2004 2003

All Journal Article Book Patent

[Book] 胃粘液バリアー2004
- Author(s)
  堀田恭子, 石原和彦監修
- Total Pages
  123
- Publisher
  メジカルビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590683
[Book] 胃粘液バリアー2004
- Author(s)
  堀田恭子, 石原和彦
- Total Pages
  123
- Publisher
  メジカルビュー
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Effects of a novel histamine H2-receptor antagonist, lafutidine, on the mucus barrier of human gastric mucosa2007
- Author(s)
  Ichikawa T, Ota T, Sugiyama A, Maruta F, Ikezawa T, Hotta K, Ishihara K.
- Journal Title
  
  J Gastroenterol Hepatol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] An anti-mucin monoclonal antibody, PGM34, against 6-sulfated blood-group H type 2 antigen on the carbohydrate moiety of mucin : Analysis of the epitope sequence and immunohistochemica 1 study.2007
- Author(s)
  Tsubokawa D, Goso Y, Sawaguchi A, Kurihara M, Ichikawa T, Sato N, Suganuma T, Hotta K, Ishihara K.
- Journal Title
  
  FEBS Journal 274
  
  Pages: 1833-1848
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] A monoclonal antibody, PGM34, against 6-sulfated blood-group H type 2 antigen on the carbohydrate moiety of mucin : Analysis of the epitope sequence and immunohistochemical study2007
- Author(s)
  D.Tsubokawa, T.Ichikawa, K.Ishihara et al.
- Journal Title
  
  FEBS J 274
  
  Pages: 1833-1848
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590683
[Journal Article] Protective effects of the whisky congeners on ethanol-induced gastric mucosal damage.2007
- Author(s)
  Goso Y, Ueno M, Hotta K, Ishihara K.
- Journal Title
  
  Alcohol ism : Clinical and Experimental Research 31 (3)
  
  Pages: 390-394
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Nitric oxide synthase activity in rat gastric mucosa contributes to mucin synthesis elicited by calcitonin gene-related peptide.2006
- Author(s)
  Ichikawa T, Kusakabe T, Gono Y, Shikama N, Hiruma H, Kawakami T, Ishihara K.
- Journal Title
  
  Biomedical Research 27 (3)
  
  Pages: 117-124
- NAID
  130004470657
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Analysis of mucin composition in gastric juices of chronic rheumatic patients with upper gastrointestinal damage2005
- Author(s)
  T.Ikezawa, T.Ichikawa, K.Ishihara et al.
- Journal Title
  
  Biomed Res 26・4
  
  Pages: 147-151
- NAID
  130004470645
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590683
[Journal Article] Effect of tea catechin administration on the change in gastro-intesttinal mucus in rats2005
- Author(s)
  Ito Y, Ichikawa T, Ikezawa T, Saegusa Y, Tsubokawa D, Kuruhara M, Goso Y, Okayasu I, Ishihara K.
- Journal Title
  
  WCOG Abstract, 13^<th> World Congress of Gastroenterology
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Analysis of mucin composition in gastric juices of chronic rheumatic patients with upper gastrointesitinal damage2005
- Author(s)
  Ikezawa T, Ichikawa T, Adachi K, Sugano S, Ojima T, Nakamura Y, Watanabe Y, Ishihara K.
- Journal Title
  
  Biomedical Research 26
  
  Pages: 147-151
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] 組成の異なる経管栄養剤3ヶ月使用による栄養状態の変化の検討 -微量栄養素添加の意義について-2005
- Author(s)
  伊東祐子, 石原和彦他
- Journal Title
  
  臨床栄養 (印刷中)
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Effect of Lafutidine, an H2-blocker, in the rat gastric mucosa regenetating from acetic acid-induced ulcer2005
- Author(s)
  Ikezawa T, Saegusa Y, Ichikawa T, Goso Y, Kuruhara M, Saigenji K, Okayasu I, Ishihara K.
- Journal Title
  
  WCOG Abstract, 13^<th> World Congress of Gastroenterology
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Characterization of oligosaccharide epitope recognized by anti-mucin monoclonal antibody, RGM21, using neoglycoconjugate technology2005
- Author(s)
  Goso Y, Endo M, Kuruhara M, Ishihara K.
- Journal Title
  
  Glycoconjugate Journal 22
  
  Pages: 347-347
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Analysis of mucin composition in gastric juices of chronic rheumatic patients with upper gastro-intestinal damage2005
- Author(s)
  Ikezawa T, Ichikawa T, Adachi K, Sugano S, Ojima T, Nakamura Y, Watanabe Y, Ishihara K.
- Journal Title
  
  Bimedical Research 26 (4)
  
  Pages: 147-151
- NAID
  130004470645
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Characterization of sulfated oligosaccharide epitope recognized by anti-mucin monoclonal antibody RGM212005
- Author(s)
  Tsubokawa D, Goso Y, Sawguchi A, Kuruhara M, Ichikawa T, Suganuma T, Hotta K, Ishihara K.
- Journal Title
  
  Glycoconjugate Journal 22
  
  Pages: 349-350
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Appearance of specific mucins recognized by monoclonal antibodies in rat gastric mucosa healing From HCl-induced gastric mucosal damage.2004
- Author(s)
  Ikezawa T, Goso Y, Ichikawa T, Hayashida H, Kurihara M, Okayasu I, Saigenji K, Ishihara K.
- Journal Title
  
  Journal of Gastroenterology 39
  
  Pages: 113-119
- NAID
  80016447984
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Appearance of specific mucins recognized by monoclonal antibodies in the rat gastric mucosa healing from HCl-induced gastric mucosal damage2004
- Author(s)
  T.Ikezawa, T.Ichikawa, K.Ishihara et al.
- Journal Title
  
  J Gastroenterol 39・2
  
  Pages: 113-119
- NAID
  80016447984
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590683
[Journal Article] Appearance of specific mucins recognized by monoclonal antibodies in rat gastric mucosa healing from HCL-induced gastric mucsal damage2004
- Author(s)
  Ikezawa T, Ishihara K et al.
- Journal Title
  
  Journal of Gastroenterology 39
  
  Pages: 113-119
- Data Source
  KAKENHI-PROJECT-16590629
[Journal Article] Characterization of rat gastric raucins using a monoclonal antibody, RGM23, recognizing surface mucous cell-type mucins2003
- Author(s)
  Y.Goso, K.Ishihara et al.
- Journal Title
  
  J Biochem 133・4
  
  Pages: 453-460
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590683
[Patent] 人工糖脂質2005
- Inventor(s)
  千室智之, 黒山浩之, 石原和彦他
- Industrial Property Rights Holder
  関東化学
- Filing Date
  2005-08-24
- Data Source
  KAKENHI-PROJECT-16590629

1. ICHIKAWA Takafumi (30245378)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
2. HOTTA Kyoko (10050402)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. GOSO Yukinobu (20112659)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KOMURO Yuichi (20215411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OHARA Susumu (90118795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOIZUMI Wasaburou (00195645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OKAYASU Isao (20014342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAMURA Takeshi (30050652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. IWASE Hitoo (60050663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HORIUCHI Tadashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ISHIHARA Kazuhiko 石原 和彦

Research Projects

Research Products

Co-Researchers

Function of gastro-intestinal mucin-derived acidic oligosaccharaides recognized by anti-mucin monoclonal antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neurotrophic factors and gastrointestinal mucosa

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Homeostasis of gastric mucosa and effects of peptidergic nerve on mucus metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A systematic development of monoclonal antibodies against mucins of digestive tract and their application to pathophysiological studiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of the gastric mucus on the Helicobacter pylori infection.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mucus secretion studies using anti-gastric mucin monoclonal antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

How dose the gastric surface mucus cell line derived from transgenic mouse synthesize and secrete mucins?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Measurement of rat gastric mucus secretion using ex-vivo gastric chamber systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biochemical studies of mucin cleaving enzyme and gastric mucus glycoprotein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 胃粘液バリアー2004

Author(s)

Total Pages

Publisher

Description

Data Source

[Book] 胃粘液バリアー2004

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Effects of a novel histamine H2-receptor antagonist, lafutidine, on the mucus barrier of human gastric mucosa2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] An anti-mucin monoclonal antibody, PGM34, against 6-sulfated blood-group H type 2 antigen on the carbohydrate moiety of mucin : Analysis of the epitope sequence and immunohistochemica 1 study.2007

Author(s)

Journal Title

Description

Data Source

ISHIHARA Kazuhiko 石原和彦