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SHIMADA Shinji  島田 眞路

ORCIDConnect your ORCID iD *help
… Alternative Names

島田 眞路  シマダ シンジ

島田 真路  シマダ シンジ

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Researcher Number 10114505
External Links
Affiliation (Current) 2025: 山梨大学, その他部局等, 学長
Affiliation (based on the past Project Information) *help 2015 – 2016: 山梨大学, その他部局等, 学長
2015: 山梨大学, その他部局等, その他
2014 – 2015: 山梨大学, 総合研究部, 教授
2011 – 2013: 山梨大学, 医学工学総合研究部, 教授
2008 – 2012: University of Yamanashi, 大学院・医学工学総合研究部, 教授 … More
2010: 山梨大学, 医学部附属病院, 教授
2009: 山梨大学, 医学工学総合研究部, 教授
2006: University of Yamanashi, Department of Research Interdisciplinary Graduate School of Medicine and Engineering, Professor, 大学院医学工学総合研究部, 教授
2005: 山梨大学, 大学院・医学工学総合研究部, 教授
2003: University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Professor, 大学院・医学工学総合研究部, 教授
2002: 山梨大学, 医学部, 教授
1996 – 2002: 山梨医科大学, 医学部, 教授
2000 – 2001: 山梨医科大学, 教授
1992 – 1994: 東京大学, 医学部(分), 助教授
1989 – 1991: 山梨医科大学, 医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Dermatology / Dermatology
Except Principal Investigator
Dermatology / Dermatology
Keywords
Principal Investigator
Toll-like receptor / ランゲルハンス細胞 / マスト細胞 / 自然免疫 / 抗菌ペプチド / HIV / T cell receptor / Herpes simplex virus / Fas / Fas L … More / co-stimulation / SLAM / heat shock protein / IL-2 / Killer T cell / rat / nude mouse / ケラチノサイト / 経皮感染 / HSV / 創傷治癒 / 肥満細胞 / 樹状細胞 / 免疫療法 / cytokines / PCR / γδT細胞 / T細胞レセプタ- / Acquired immunity / Innate immunity / Mast cell / 獲得免疫 / Homeostasis / Endothelin / Skin / Mast cells / エンドリン / 恒常性 / エンドセリン / 皮膚 / Dermal fibroblast / Koebner Phenomenon / Retinoid / Apoptosis / Immuneprivilege site / Immune privilege / 線維芽細胞 / immune priviledge / 皮膚線維芽細胞 / ケブネル現象 / レチノイド / アポトーシス / immune privilege / 免疫特権臓器 / T cell activation / T細胞活性化 / Aly mouse / Fc receptor / zeta-chain / T cell antigen receptor / dendritic epidermal T cells / gamma delta T cells / FACS / 熱ショックタンパク / 樹枝状表皮下細胞 / PPD / FcεRI / intraepithelial lymphocyte / シクロスポリン / Fc レセプター / 3 chain / dendritic epidermal T cell / Aly マウス / サイトカイン / Fcレセプター / ζ鎖 / T細胞レセプター / dendritic epidermal Tcells / Perforin / T cell receptor gamma delta / Thy-1^+ dendritic epidermal cell / パ-フォリン / ヌ-ドマウス / CD_3 complex / T細胞レセプタ-γδ / Thy-1陽性樹枝状表皮細胞 / T cell receptor γδ / ILー2 / Killer T Cell / perforin / T Cell receptor γδ / T Cell receptor / Thyー1^+dendritic epidermal Cell / 治療抵抗性 / Timp3 / Nupr1 / メラノーマ / AID / Alarmin / innate immunity / mast cell / herpes simplex virus / IL-33 / アラーミン / ヘルペスウイルス / HIV / HSV / 性行為HIV感染 / HIV感染 / HSV-2 / 性行為感染症 / 上皮間葉転換 / 亜鉛 / 亜鉛欠乏 / 接触皮膚炎 / 腸性肢端皮膚炎 / 免疫抑制 / 治療 / ワクチン / 癌遺伝子 / 分子標的療法 / 分子標的薬 / 腫瘍ワクチン / 悪性黒色腫 / carcinoma / epithelioma / adenoma / Wnt遺伝子 / 石灰化上皮腫 / β-catenin / Wntシグナル / Fcγ chain / ζ chain / Dendritic epidermal T cells / γδT cells / Vγ,δレパ-トリ- / 接触温敏症 … More
Except Principal Investigator
マスト細胞 / HSV / 悪性黒色腫 / SAGE / 自然免疫 / 単純ヘルペスウイルス / 免疫療法 / IL-23 receptor / 乾癬 / 体内時計 / IL23receptor / imiquimod / psoriasis / IL23R / clock / circadian / regulatory T cell / autoimmunity / psoriasis vulgaris / 制御性T細胞 / アトピー性皮膚炎 / 尋常性乾癬 / fiber / cancer / peptide ligand / receptor / malignant melanoma / integrin / Gene therapy / Adenoviral vector / 悪性黒色癌 / ファイバー / がん / ペプチドリガンド / 受容体 / インテグリン / 遺伝子治療 / アデノウイルスベクター / DNA cloning / EST databases / cDNA profile / melanocyte / melanoma / 癌精巣抗原 / メラノソーム蛋白 / mRNAプロファイル / SAGE法 / EST / DNAクローニング / cDNAプロファイル / 色素細胞 / ESTデータベース / IL-33 / ウイルス / innate immunity / mast cell / 皮膚感染症 / ワクチン / 角層剥離皮膚 / ランゲルハンス細胞 / ペプチド / 細胞障害性T細胞 / 臨床試験 / 経皮免疫療法 / 悪性黒色種 Less
  • Research Projects

    (23 results)
  • Research Products

    (55 results)
  • Co-Researchers

    (39 People)
  •  The alarmin IL-33 derived from HSV-2-infected keratinocytes triggers mast cell-mediated antiviral innate immunityPrincipal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  HSV感染防御におけるマスト細胞の役割の解明

    • Principal Investigator
      青木 類
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  Development of an innovative, simple system to detect the critical gene mutations of skin cancersPrincipal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice

    • Principal Investigator
      ANDO Noriko
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  The role of mast cells on host defense against lethal herpes simplex virus infection

    • Principal Investigator
      AOKI Rui
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  The elucidation of the early immune system in percutaneous infection of HSV and HIV and the development of novel methods to prevent their cutaneous infectionPrincipal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  Examination of the participation in HIV infection of the VitaminD3 and HSV-2 using the humanized mousePrincipal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  The role of mast cells on host defense against lethal herpes simplex virus infection

    • Principal Investigator
      AOKI Rui
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  Novel therapeutic approach to melanoma-bearing hosts with protein-transduction technologyPrincipal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  表皮の恒常性維持における亜鉛の役割の解明Principal Investigator

    • Principal Investigator
      島田 眞路
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  Immunotherapy with percutaneous peptide immunization in human melanoma

    • Principal Investigator
      TAKIGAWA Masahiro
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Dermatology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Roles of mast cells on viral infection and mast cell-based immunotherapyPrincipal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
  •  Dysfunctional Blood and Target Tissue CD4^+CD25^<high> Regulatory T Cells in Psoriasis.

    • Principal Investigator
      SUGIYAMA Hideaki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering
  •  The effects of endothelin-1 on degranulation, cytokine and growth factor production by skin-derived mast cells.Principal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      University of Yamanashi
      山梨医科大学
  •  Selective Upregulation of Fibroblast Fas Ligand Expression, and Prolongation of Fas/Fas Ligand-Mediated Skin Allograft Survial, by Retinoic Acid: the Skin as a Retinoide-Inducible Immune Privilege SitePrincipal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Yamanashi Medical University
  •  Systematic isolation of genes encoding candidate proteins for human melanoma antigens using serial analysis of gene expression (SAGE) and EST database

    • Principal Investigator
      KAWAKAMI Yutaka
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Targeted gene therapy for malignant melanoma

    • Principal Investigator
      HAMADA Hirofumi
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Sapporo Medical University
  •  皮膚腫瘍におけるWntシグナル構成分子の発現異常の検討および遺伝子導入による治療Principal Investigator

    • Principal Investigator
      島田 眞路
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      山梨医科大学
  •  The functional role of SLAM,a new co-stimulatory molecules, on T cell activation for the basis of gene therapyPrincipal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      YAMANASHI MEDICAL UNIVERSITY
  •  γδT細胞の活性化機序Principal Investigator

    • Principal Investigator
      島田 眞路
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      山梨医科大学
  •  Identification of the ligands of gamma delta T cellsPrincipal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      The University of Tokyo
  •  PCR法を用いたマウス接触過敏症におけるγδ型T細胞レパ-トリ-の解析Principal Investigator

    • Principal Investigator
      島田 眞路
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      山梨医科大学
  •  The Biochemical and Molecular Characterization of T Cell Receptor of Thy-1^+ Derdritic Epidermal Cells.Principal Investigator

    • Principal Investigator
      SHIMADA Shinji
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Yamanashi Medical College

All 2016 2015 2014 2013 2012 2011 2010 2009 2007 2006 2005 Other

All Journal Article Presentation Book

  • [Book] 癌と免疫  第2部 15,がん免疫における共刺激分子、共抑制分子と免疫チェックポイント2015

    • Author(s)
      猪爪隆史、島田眞路
    • Total Pages
      9
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-26670522
  • [Journal Article] Melanoma cells control anti-melanoma CTL responses via interaction between TIGIT and CD155 in the effector phase.2016

    • Author(s)
      Inozume T, Yaguchi T, Furuta F, Harada K, Kawakami Y, Shimada S.
    • Journal Title

      J Invest Dermatol.

      Volume: 136 Issue: 1 Pages: 255-263

    • DOI

      10.1038/jid.2015.404

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09783, KAKENHI-PROJECT-26221005, KAKENHI-PROJECT-25461687, KAKENHI-PROJECT-26670522
  • [Journal Article] The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity.2016

    • Author(s)
      Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Moriishi K, Nakao A, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 印刷中 Issue: 6 Pages: 1290-1292

    • DOI

      10.1016/j.jid.2016.01.030

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04864, KAKENHI-PROJECT-26670475, KAKENHI-PROJECT-26293256
  • [Journal Article] The role of human dendritic cells in HIV-1 infection.2015

    • Author(s)
      Ahmed Z, Kawamura T, Shimada S, Piguet V.
    • Journal Title

      J Invest Dermatol

      Volume: 135 Issue: 5 Pages: 1225-33

    • DOI

      10.1038/jid.2014.490

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293256
  • [Journal Article] Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice.2015

    • Author(s)
      Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A
    • Journal Title

      J Invest Dermatol

      Volume: 135 Issue: 12 Pages: 3001-3008

    • DOI

      10.1038/jid.2015.316

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19573, KAKENHI-PROJECT-26220201, KAKENHI-PROJECT-15H04864, KAKENHI-PROJECT-26461684, KAKENHI-PROJECT-26670475, KAKENHI-PROJECT-26860874, KAKENHI-PROJECT-26293087
  • [Journal Article] EFdA, a reverse transcriptase inhibitor , potently blocks HIV -1 ex vivo infection of Langerhans cells within epithelium2014

    • Author(s)
      Matsuzawa T, Kawamura T, Ogawa Y, Maeda K, Nakata H, Moriishi K, Koyanagi Y, Gatanaga H, Shimada S, Mitsuya H
    • Journal Title

      J Invest Dermatol

      Volume: 134(4) Issue: 4 Pages: 1158-61

    • DOI

      10.1038/jid.2013.467

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23390282, KAKENHI-PROJECT-23591641, KAKENHI-PLANNED-24115008, KAKENHI-PROJECT-26461510
  • [Journal Article] A case of oral mucosal fixed eruption caused by methacrylate2014

    • Author(s)
      Inozume T, Nakazawa R, Tanaka K, Harada K, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      Contact Dermatitis

      Volume: 70(6) Issue: 6 Pages: 387-8

    • DOI

      10.1111/cod.12183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282, KAKENHI-PROJECT-23591641
  • [Journal Article] Case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified, with characteristics of follicular helper T cells2014

    • Author(s)
      Takaki M, Inozume T, Matsuzawa T, Ando N, Y amaguchi M, Harada K, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      J Dermatol

      Volume: (In press) Issue: 6 Pages: 529-532

    • DOI

      10.1111/1346-8138.12493

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282, KAKENHI-PROJECT-23591614, KAKENHI-PROJECT-23591641
  • [Journal Article] Antimicrobial peptide LL-37 produced by HSV-2-infected keratinocytes enhances HIV infection of Langerhans cells2013

    • Author(s)
      Ogawa Y, Kawamura T, Matsuzawa T, Aoki R, Gee P, Yamashita A, Moriishi K, Yamasaki K, Koyanagi Y. Blauvelt A, Shimada S.
    • Journal Title

      Cell Host and Microbe

      Volume: 13 Issue: 1 Pages: 77-86

    • DOI

      10.1016/j.chom.2012.12.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05331, KAKENHI-PROJECT-22590724, KAKENHI-PROJECT-23390282, KAKENHI-PROJECT-23591637, KAKENHI-PROJECT-23591641, KAKENHI-PROJECT-24390112, KAKENHI-PROJECT-24591622, KAKENHI-PROJECT-24791144
  • [Journal Article] Antimicrobial Peptide LL-37 Produced by HSV-2-Infected Keratinocytes Enhances HIV Infection of Langerhans Cells2013

    • Author(s)
      Youichi Ogawa, Tatsuyoshi Kawamura, Takamitsu Matsuzawa, Rui Aoki, Peter Gee, Atsuya Yamashita, Kohji Moriishi, Kenshi Yamasaki, Yoshio Koyanagi, Andrew Blauvelt, and Shinji Shimada
    • Journal Title

      Cell Host and Microbe

      Volume: 13 Pages: 77-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659545
  • [Journal Article] Oral administration of the CCR5 inhibitor , maraviroc, blocks HIV ex vivo infection of Langerhans cells within the epithelium2013

    • Author(s)
      Matsuzawa T, Kawamura T, Ogawa Y, Takahashi M, Aoki R, Moriishi K, Koyanagi Y, Gatanaga H, Blauvelt A, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 133(12) Issue: 12 Pages: 2803-5

    • DOI

      10.1038/jid.2013.215

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282, KAKENHI-PROJECT-23591641, KAKENHI-PLANNED-24115008, KAKENHI-PROJECT-24390112, KAKENHI-PROJECT-24791143, KAKENHI-PROJECT-24791144
  • [Journal Article] Two cases of autosomal recessive woolly hair with LIPH gene mutations2013

    • Author(s)
      Harada K, Inozume T, Kawamura T, Shibagaki N, Kinoshita T, Deguchi N, Shimada S
    • Journal Title

      Int J Dermatol

      Volume: 52(5) Pages: 572-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282
  • [Journal Article] Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production2013

    • Author(s)
      Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Nakao A, Moriishi K, Nishiyama Y, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 133(9) Issue: 9 Pages: 2170-9

    • DOI

      10.1038/jid.2013.150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282, KAKENHI-PROJECT-23591641, KAKENHI-PROJECT-23659499, KAKENHI-PROJECT-24791144
  • [Journal Article] Antimicrobial Peptide LL-37 Produced by HSV-2-Infected Keratinocytes Enhances HIV Infection of2013

    • Author(s)
      小川陽一, 川村龍吉, 松澤高光, 青木類, Peter Gee, 山下篤哉, 森石恆司, 山崎研志, 小柳義夫, Andrew Blauvelt, 島田眞路
    • Journal Title

      Cell Host & Microbe

      Volume: 13 Pages: 77-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282
  • [Journal Article] Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-α and IL-6 Production.2013

    • Author(s)
      Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Nakao A, Moriishi K, Nishiyama Y, Shimada S.
    • Journal Title

      J Invest Dermatol.

      Volume: 133(9) Pages: 2170-2179

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791144
  • [Journal Article] A case of dermatomyositis accompanied by spontaneous intramuscular hemorrhage despite normal coagulability2013

    • Author(s)
      Hanawa F, Inozume T, Harada K, Andou N, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      Rheumatol Int

      Volume: 33(11) Issue: 11 Pages: 2949-50

    • DOI

      10.1007/s00296-012-2492-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282, KAKENHI-PROJECT-23591614, KAKENHI-PROJECT-23591641
  • [Journal Article] Case of mucous membrane pemphigoid characterized by circulating immunoglobulin A and immunoglobulin G autoantibodies to the gamma-2 subunit of laminin-3322012

    • Author(s)
      Hanawa F, Harada K, Andou N, Kawamura T, Shibagaki N, Fukuda S, Hashimoto T, Shimada S
    • Journal Title

      J Dermatol

      Volume: 39(11) Pages: 962-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282
  • [Journal Article] Case of rheumatoid papules : is this a link between vasculitis and rheumatoid nodules?2012

    • Author(s)
      Inozume T, Ando N, Sano S, Harada K, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      J Dermatol

      Volume: 39(12) Pages: 1091-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282
  • [Journal Article] Gutter method : noninvasive management of ingrown nails caused by epidermal growth factor inhibitor treatment2012

    • Author(s)
      Harada K, Y amaguchi M, Miyajima S, Kawamura T, Shibagaki S, Shimada S
    • Journal Title

      Clin Exp Dermatol

      Volume: 37(6) Pages: 703-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282
  • [Journal Article] Neutrophilic panniculitis with non-caseating granulomas in a Crohn's disease patient2012

    • Author(s)
      Ogawa Y, Aoki R, Harada K, Matsuzawa T, Inozume T, Shibagaki N, Kawamura T, Shimada S
    • Journal Title

      Eur J Dermatol

      Volume: 22(3) Issue: 3 Pages: 404-5

    • DOI

      10.1684/ejd.2012.1737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390282, KAKENHI-PROJECT-23591641
  • [Journal Article] Protein-transduction domainを用いた抗原性の増強2011

    • Author(s)
      柴垣直孝、島田眞路
    • Journal Title

      臨床免疫アレルギー科 55巻

      Pages: 255-261

    • Data Source
      KAKENHI-PROJECT-20390306
  • [Journal Article] Sev ere dermatitis with loss of epidermal Langerh ans cells in human and mouse zinc deficiency.2011

    • Author(s)
      Kawamura T, Ohta Y, et al.
    • Journal Title

      The Journal of Clinical Investigation

      Volume: 84 Issue: 2 Pages: 722-732

    • DOI

      10.1172/jci58618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22310117, KAKENHI-PROJECT-22700309, KAKENHI-PROJECT-23390282, KAKENHI-PROJECT-23591641, KAKENHI-PROJECT-24500360, KAKENHI-PROJECT-24659529
  • [Journal Article] CD70 is Selectively Expressed on Th1 but Not on Th2 Cells and Is Required for Th1-Type Immune Responses2011

    • Author(s)
      Kawamura T, Ogawa Y, Shimozato O, Ando T, Nakao A, Kobata T, Okumura K, Yagita H, Shimada S
    • Journal Title

      J Invest Dermatol. 131(6)

      Pages: 1252-1261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791068
  • [Journal Article] Novel immunotherapeutic approaches to skin cancer treatments using protein transduction technology2011

    • Author(s)
      N Shibagaki, Okamoto, H Mitsui, T.Inozume, M.kanzaki, S Shimada
    • Journal Title

      Journal of Dermatological Science 61

      Pages: 153-161

    • NAID

      10030890246

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390306
  • [Journal Article] A case of Lymphoepithelioma-like Carcinoma of the Skin associated with Epstein-Barr virus infection2010

    • Author(s)
      Rui Aoki, Hiroshi Mitsui, Kazutoshi Harada, Tatsuyoshi Kawamura, Naotaka Shibagaki, Katsuhiko Tsukamoto, Shin-ichi Murata, Shinji Shimada
    • Journal Title

      Journal of the American Academy of Dermatology. 62(4)

      Pages: 681-684

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791068
  • [Journal Article] A novel immunotherapeutic approach to melanoma-bearing mice hosts with protein-transduction domain containing immunogenic foreign antigens2010

    • Author(s)
      M Kanzaki, T Okamoto, H Mitsui, N Shibagaki, S Shimada
    • Journal Title

      Journal of Dermatological Science 60

      Pages: 84-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390306
  • [Journal Article] Overexpression of GRIM-19 in cancer cells suppresses STAT3-mediated signal transduction and cancer growth2010

    • Author(s)
      T.Okamoto, T.Inozume, H.Mitsui, M.kanzaki, K.Harada, N Shibagaki, S Shimada
    • Journal Title

      Molecular Cancer Therapeutics 9

      Pages: 2333-2343

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390306
  • [Journal Article] Intradermal injiections of polyarginin-containing immunogenic antigens preferentially elicit Tc1 and Th1 activation and antitumor immunity2010

    • Author(s)
      H.Mitsui, T.Okamoto, M.Kanzaki, T.Inozume, N Shibagaki, S Shimada
    • Journal Title

      British Journal of Dermatology 162

      Pages: 29-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390306
  • [Journal Article] Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation2009

    • Author(s)
      Ogawa Y, Kawamura T, Kimura T, Ito M, Blauvelt A, Shimada S
    • Journal Title

      Blood. 113(21)

      Pages: 5157-5166

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791068
  • [Journal Article] Human eosinophils have an intact Smad signaling pathway leading to a major transforming growth factor-β target gene expression.2007

    • Author(s)
      Kanzaki, M., Shibagaki, N., Hatsushika, K., Mitsui, H., Inozume, T., Okamoto, A., Dobashi, Y., Ogawa, H., Shimada, S., Nakao, A.
    • Journal Title

      Int Arch Allergy Immunol 142

      Pages: 309-317

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] CD4^+ CD25^<high> regulatory T cells are markedly decreased in blood of patients with pemphigus vulgaris.2007

    • Author(s)
      Sugiyama, H., Matsue, H., Nagasaka, A., Nakamura, Y., Tsukamoto, K., Shibagaki, N., Kawamura, T., Kitamura, R., Ando, N., Shimada, S.
    • Journal Title

      Dermatology 214

      Pages: 210-220

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] Gap junction-mediated intercellular communication between dendritic cells (DCs) is required for effective activation of DCs.2006

    • Author(s)
      Matsue, H., Yao, J., Matsue, K., Nagasaka, A., Sugiyama, H., Aoki, R., Kitamura, M., Shimada, S.
    • Journal Title

      J. Immunol. 176

      Pages: 181-190

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] Polyarginine-mediated protein delivery to dendritic cells presents antigen more efficiently onto MHC class I and class II and elicits superior antitumor immunity.2006

    • Author(s)
      Mitsui, H., Inozume, T., Kitamura, R., Shibagaki, N., Shimada, S.
    • Journal Title

      J Invest Dermatol 126

      Pages: 1804-1812

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles.2005

    • Author(s)
      Tanaka, K., Kobayashi, T., Kawamura, T., Shimada, S., Matsumoto, K., Saida, T.
    • Journal Title

      Int J Cancer 116

      Pages: 624-633

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] T細胞2005

    • Author(s)
      島田眞路
    • Journal Title

      皮膚免疫ハンドブック改訂2版

      Pages: 32-38

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] Dysfunctional blood and target tissue CD4^+ CD25^<high> regulatory T cells in psoriasis : Mechanism underlying unrestrained pathogenic effector T Cell proliferation2005

    • Author(s)
      Sugiyama, H., Gyulai, R., Toichi, E., Garaczi, E., Shimada, S., Stevens, SR., McCormick, TS., Cooper, KD.
    • Journal Title

      J Immunol. 174

      Pages: 164-173

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] The role of Langerhans cells in the sexual transmission of HIV.2005

    • Author(s)
      Kawamura, T., Kurtz, SE., Blauvelt, A., Shimada, S.
    • Journal Title

      J Dermatol. Sci. 40

      Pages: 147-155

    • NAID

      10018032522

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients.2005

    • Author(s)
      Inozume, T., Matsuzaki, Y., Kurihara, S.Fujita, T., Yamamoto, A., Aburatani, H., Shimada, S., Kawakami, Y.
    • Journal Title

      Int J Cancer 114

      Pages: 283-290

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] Carbonic anhydrase is a tumor vessel endothelium-associated antigen targeted by dendritic cell therapy.2005

    • Author(s)
      Yoshiura, K., Nakaoka, T., Nishishita, T., Sato, K., Yamamoto, A., Shimada, S., Saida, T., Kawakami, Y., Takahash, T., Fukuda, H., Imajoh-Ohmi, S., Oyaizu, N., Yamashita, N.
    • Journal Title

      Clinical Cancer Res. 11

      Pages: 8201-8207

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-Lymphoma2005

    • Author(s)
      Tanaka, K., Ito, A., Kobayashi, T., Kawamura, T., Shimada, S., Matsumoto, K., Saida, T., Honda, H.
    • Journal Title

      Biosci & Bioeng 100

      Pages: 112-115

    • NAID

      110002703752

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390310
  • [Journal Article] Intradermal Injection of Polyarginine-containing Immunogenic Antigens Preferentially Elicit Tel and Thl Activation and Antitumor Immunity

    • Author(s)
      Mitsui H., Okamoto T., Kanzaki M., Inozume T., Shibagaki N., Shimada S.
    • Journal Title

      British Journal of Dermatology (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390306
  • [Presentation] Co-blockade of TIGIT and PD-1 signals in tumor-infiltrating cytotoxic T lymphocytes is an effective anti-melanoma therapy2015

    • Author(s)
      Takashi Inozume, Tomonori Yaguchi, Yutaka Kawakami, Shinji Shimada
    • Organizer
      The 40th annual meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      岡山コンベンションセンター, 岡山県、北区
    • Year and Date
      2015-12-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670522
  • [Presentation] マウスイミキド乾癬モデルにおける体内時計の関与2015

    • Author(s)
      安藤典子、川村龍吉、島田眞路、中尾篤人
    • Organizer
      第82回日本皮膚科学会山梨地方会
    • Place of Presentation
      セレス甲府(山梨・中巨摩郡昭和町)
    • Year and Date
      2015-12-05
    • Data Source
      KAKENHI-PROJECT-26860874
  • [Presentation] Circadian Gene Clock Regulates Psoriasis-like Skin Inflammation in Mice2015

    • Author(s)
      Noriko Ando, Yuki Nakamura, Rui Aoki, Kayoko Ishimaru, Shinji Shimada, Atsuhito Nakao
    • Organizer
      日本研究皮膚科学会 第40回 年次総会
    • Place of Presentation
      岡山コンベンションセンター(岡山・岡山)
    • Year and Date
      2015-12-11
    • Data Source
      KAKENHI-PROJECT-26860874
  • [Presentation] 皮膚ヘルペス感染におけるAlarminとしてのIL-33の重要性2015

    • Author(s)
      青木 類、川村龍吉、五島 典、小川陽一、中江 進、中尾篤人、島田眞路
    • Organizer
      第3回ケラチノサイトと免疫を勉強する会
    • Place of Presentation
      帝国ホテル(東京)
    • Year and Date
      2015-03-28
    • Data Source
      KAKENHI-PROJECT-26461684
  • [Presentation] Blockade for CD155-TIGIT interaction is an effective therapy for melanoma2015

    • Author(s)
      Takashi Inozume, Tomonori Yaguchi, Yutaka Kawakami, Shinji Shimada
    • Organizer
      Society for Investigative Dermatology, 2015, annual meeting
    • Place of Presentation
      Hilton Atlanta, Atlanta, Georgia
    • Year and Date
      2015-05-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670522
  • [Presentation] 皮膚の免疫学-山梨大学からの発信-皮膚科よもやま話2015

    • Author(s)
      島田眞路
    • Organizer
      第20回茨城皮膚・アレルギー懇話会
    • Place of Presentation
      つくば国際会議場, 茨城県、つくば市
    • Year and Date
      2015-02-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670522
  • [Presentation] Antimicrobial Peptide LL-37 Produced by HSV-2-Infected Keratinocytes Enhances HIV Infection of Langerhans Cells2013

    • Author(s)
      Youichi Ogawa, Tatsuyoshi Kawamura, Takamitsu Matsuzawa, Rui Aoki, Andrew Blauvelt, and Shinji Shimada
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh, Scotland
    • Year and Date
      2013-05-09
    • Data Source
      KAKENHI-PROJECT-23659545
  • [Presentation] Antimicrobial peptide LL-37 produced by HSV-2-infected keratinocytes enhances HIV infection of Langerhans cells2013

    • Author(s)
      小川陽一, 川村龍吉, 松澤高光, 青木類, Peter Gee, 山下篤哉, 森石恆司, 山崎研志, 小柳義夫, Andrew Blauvelt, 島田眞路
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      エジンバラ国際会議場(エジンバラ, スコットランド)
    • Data Source
      KAKENHI-PROJECT-23390282
  • [Presentation] Intratumoral injections of a novel STAT3 inhibitor (R9-GRIM19)enhance antitumor effects combined with cancer immunotherapy in melanoma-bearing mice2010

    • Author(s)
      岡本崇、柴垣直孝、島田眞路
    • Organizer
      第35回に本研究皮膚科学会
    • Place of Presentation
      和歌山
    • Year and Date
      2010-12-04
    • Data Source
      KAKENHI-PROJECT-20390306
  • [Presentation] 高頻度遺伝子変異導入システムを利用したメラノーマ治療の成否を左右する重要因子の検索

    • Author(s)
      猪爪隆史、原田和俊、島田眞路
    • Organizer
      第114回日本皮膚科学会総会
    • Place of Presentation
      パシフィコ横浜、神奈川県、横浜市
    • Year and Date
      2015-05-29 – 2015-05-31
    • Data Source
      KAKENHI-PROJECT-26670522
  • [Presentation] The IL-33/ST2 axis on mast cells contributes to protective immune responses to herpes simplex virus-2

    • Author(s)
      Rui Aoki, Tatsuyoshi Kawamura, Fumi Goshima, Youichi Ogawa, Susumu Nakae, Atsuhito Nakao and Shinji Shimada
    • Organizer
      EMBRN-COST International Mast Cell and Basophil Meeting
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26461684
  • [Presentation] The alarmin IL-33 derived from HSV-2-infected keratinocytes triggers mast cell-mediated antiviral innate immunity

    • Author(s)
      Rui Aoki, Tatsuyoshi Kawamura, Fumi Goshima, Youichi Ogawa, Susumu Nakae, Atsuhito Nakao and Shinji Shimada
    • Organizer
      The 11th Meeting of the German-Japanese Society of Dermatology, post congress
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2014-06-15 – 2014-06-16
    • Data Source
      KAKENHI-PROJECT-26461684
  • [Presentation] The IL-33/ST2 axis on mast cells contributes to protective immune responses to herpes simplex virus-2

    • Author(s)
      Rui Aoki, Tatsuyoshi Kawamura, Fumi Goshima, Youichi Ogawa, Susumu Nakae, Atsuhito Nakao and Shinji Shimada
    • Organizer
      The 39th Annual meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府)
    • Year and Date
      2014-12-12 – 2014-12-14
    • Data Source
      KAKENHI-PROJECT-26461684
  • [Presentation] The IL-33-ST2 pathway drives mast cell-dependent antiviral responses

    • Author(s)
      Rui Aoki, Tatsuyoshi Kawamura, Fumi Goshima, Youichi Ogawa, Susumu Nakae, Atsuhito Nakao and Shinji Shimada
    • Organizer
      44th Annual meeting of European Society for Dermatological Research
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2014-09-10 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-26461684
  • 1.  KAWAMURA Tatsuyoshi (70262657)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 25 results
  • 2.  SHIBAGAKI Naotaka (40262662)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 18 results
  • 3.  AOKI Rui (10377541)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 10 results
  • 4.  HARADA Kazutoshi (20324197)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 5.  HASHIZUME Hideo (50237921)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  YAGI Hiroaki (20242779)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  ITO Taisuke (90293638)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  SEO Naohiro (50283354)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  SUGIYAMA Hideaki (70301207)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  SAIDA Toshiaki (10010381)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  TAKIGAWA Masahiro (80115873)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TOKURA Yoshiki (00172156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SHIMAUCHI Takatoshi (90399204)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SHIBAKI Akihiko (40291231)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  OGAWA Yoichi (20377542)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  INOZUME Takashi (80334853)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 17.  OKAMOTO Takashi (30402043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  OHTAKE Naoto (40194188)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  KUBOTA Yasuo (10126047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KITAJIMA Toshiyuki (40303408)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KAWAKAMI Yutaka (50161287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 22.  SUZUKI Yuriko (40255435)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  SAKURAI Toshiharu (20101933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  FUJITA Tomonobu (20199334)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  HAMADA Hirofumi (00189614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  JINBO Koichi (30094238)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  MATSUE Hiroyuki (10250424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 28.  NAGASAKA Akiko (60377546)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 29.  NISHIYAMA Hiroyuki (60115615)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  ANDO Noriko (90345710)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 31.  NAKAO Atsuhito (80317445)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 32.  NAKAMURA Yuki (90580465)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 33.  齊藤 敦 (30225693)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  堀部 尚弘 (10306277)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  長田 厚 (60262656)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  山田 伸夫 (50230470)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  YAGUCHI Tomonori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  大田 佳宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  石丸 かよ子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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