Kaku Kohei 加来浩平

… Alternative Names

KAKU Kohei 加来浩平

加来浩平カクコウヘイ

KAKU Konei

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Researcher Number	10116709
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 特任研究員
Affiliation (based on the past Project Information) *help	2014 – 2016: 川崎医科大学, 医学部, 教授 2009 – 2011: Kawasaki Medical School, 医学部, 教授 2006 – 2007: 川崎医科大学, 医学部, 教授 2001 – 2004: 川崎医科大学, 医学部, 教授 1995: 山口大学, 医学部, 助教授 1989 – 1993: 山口大学, 医学部, 助教授 1990: Yamaguchi Umiversity School of Medicine Assoc. Prof.
Review Section/Research Field	Principal Investigator Metabolomics / 内分泌・代謝学 / Metabolomics Except Principal Investigator 内分泌・代謝学
Keywords	Principal Investigator pioglitazone / 膵β細胞機能 / db / diazoxide / アディポネクチン / LCM法 / 膵ラ氏島遺伝子発現 / dbマウス / PCR-SSCP / NIDDM … More / glucose transporter gene / RFLP / 糖輸送担体遺伝子 / β-cell restoration / β-cell mass / oxidative stress / diet therapy / LCM method / impaired β-cell function / db gene / 肥満2型糖尿病モデル / db遺伝子ヘテロ接合体マウス / db遺伝子ホモ接合体マウス / 膵β細胞機能保護 / 膵β細胞量 / 酸化ストレス / ピオグリタゾン / 食事介入 / 膵β細胞機能不全 / db遺伝子 / islet gene expression / Laser Capture Microdissection / β cell function / db mice / 膵ラ島内中性脂肪含量 / β細胞比率 / %膵ラ氏島面積 / 遺伝子発現プロファイリング / 糖・脂肪毒性 / 膵ラ氏島 / glucolipotoxicity / glucose tozicity / β- cell dysfunction / db + mice / db + / diabetes mellitus / KATPチャンネル開口薬 / 膵ラ氏島組織 / 肥満糖尿病モデル / 脂肪毒性 / 糖毒性 / 膵β細胞機能障害 / db+マウス / db+ / 2型糖尿病 / promoter activity / sequence variation / direct sequencing / genetic markers / glucokinase gene / PCR / CA繰り返し部位 / グルコキナ-ゼ遺伝子 / 糖輸送担体遺伝子(GLUT) / 発症遺伝子 / II型糖尿病(NIDDM) / シーケンスバリエーション / GLUT1遺伝子 / 遺伝子マーカー / グルコキーゼ遺伝子 / プロモーター活性 / シーケンス変異 / 直接シーケンス / グルコキナーゼ遺伝子 / GLUT-4 / GLUT-2 / GLUT-1 / type II diabetes (NIDDM) / RFLPs / 遺伝子ハプロタイプ / GLUTー4 / GLUTー2 / GLUTー1 / II型糖尿病 / endosome / インスリン / グルカゴン / GKラット / GLP-1R / GLP-1産生細胞 / 膵ラ氏島α細胞 / 糖尿病GKラット / 膵ラ氏島GLP-1のparacrine機構 / 膵ラ氏島GLP-1のautocrine機構 / 膵GLP-1受容体 / 膵GLP-1分泌 / autocrine作用 / GLP-1受容体 / GLP-1 / 膵α細胞 / 膵インクレチン / 膵灌流 / 膵ラ氏島機能 / 糖尿病 / 脂肪細胞小型化 / VEGF / db/dbマウス / VCAM1 / HIF1 / 内臓脂肪 / 骨格筋 / インスリン抵抗性 / 血管新生 / 高血糖マウス / 血管内皮細胞特異的PDK1欠損 / メタボリックシンドローム / sib-pair解析 / cdx-3 / IPF-1 / 転写因子 / 遺伝 / インスリン非依存型糖尿病 … More Except Principal Investigator PEPCK / AD-4833 / 6Phosphofructo-2-kinase / NIDDM / glucokinase / Wistar Fatty rats / 高インスリン血症 / 6-フォスフォフルクト-2-キナーゼ / グルコキナーゼ(GK) / 肥満 / WFラット / 6Phosphofructo-2-Kinase / AD4833 / グルコキナーゼ / Wistar Fattyラット / Gluconeogenesis / Glycolysis / Phosphenolpyruvate carboxykinase / Fructose-2,6-bisphosphate / Tolbutamide / Glibenclamide / Sulfonylurea / Liver / CS-045 / スルフォニルウレア / フォスフォエノールピルビン酸カルボキシナーゼ / スルフォニル尿素剤 / 糖新生 / 解糖系 / フォスフォエノールピルビン酸カルボキシキナーゼ / フルクトース-2,6-二リン酸 / トルブタミド / グリベンクラミド / スルフォニルウレア剤 / 肝 Less

Physiological role of pancreatic incretin on the functional regulation of pancreatic islet cellsPrincipal Investigator
- Principal Investigator
  
  Kaku Kohei
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Molecular mechanism of visceral obesity controlled by endothelial cell-related growth factors and the search for a new strategy of adipogenecity controlPrincipal Investigator
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Research for molecular mechanism of diabetes development in obese type 2 diabetes model db/db micePrincipal Investigator
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Mechanism of pancreatic β cell dysfunction in obese diabetes model db/db micePrincipal Investigator
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School, Faculty of Medicine
Mechanism of pancreatic β-cell dusfunction in db/db mice and approach for protection of the cell functionPrincipal Investigator
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KAWASAKI MEDICAL SCHOOL
II型糖尿病の発症機構におけるインスリン遺伝子転写因子の役割Principal Investigator
- Principal Investigator
  
  加来浩平
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamaguchi University
Mechanisms of extra-pancreatic effects of oral anti-diabetic agents
- Principal Investigator
  
  INOUE Yasushi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamaguchi University, School of Medicine
Elucidation of mechanism for diabetogenesis in Wistar Fatty rats
- Principal Investigator
  
  MATSUTANI Akira
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamaguchi University, School of Medicine
Analysis of genes involved in the susceptibility to type 2 diabetesPrincipal Investigator
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamaguchi University School of Medicine
Polymorphisms of Glucose Transporter Genes Associated with Type II DiabetesPrincipal Investigator
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamaguchi University

All 2016 2015 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation Book

[Book] 食後高血糖の自己管理2007
- Author(s)
  加来浩平
- Total Pages
  75
- Publisher
  (株)医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice.2016
- Author(s)
  Okauchi S, Shimoda M, Obata A, Kimura T, Hirukawa H, Kohara K, Mune T, Kaku K, Kaneto H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 470 Issue: 3 Pages: 772-782
- DOI
  10.1016/j.bbrc.2015.10.109
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461350, KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes.2015
- Author(s)
  Kimura T, Kaneto H, Shimoda M, Hirukawa H, Okauchi S, Kohara K, Hamamoto S, Tawaramoto K, Hashiramoto S, Kaku K
- Journal Title
  
  Mol Cell Endocrinol
  
  Volume: 400 Pages: 78-89
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461350
[Journal Article] GLP-1 stimulates insulin secretion by PKC-dependentTRPM4 and TRPM5 activation.2015
- Author(s)
  Shigeto M ,Ramracheya R, Tarasov AI, Cha C-Y, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PVR, Kaku K, Ladds G, and Rorsman P
- Journal Title
  
  J Clin Invest
  
  Volume: 125 Issue: 12 Pages: 1-15
- DOI
  10.1172/jci81975
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460113, KAKENHI-PROJECT-26461350
[Journal Article] Dietary restriction preserves the mass and function of pancreatic β cells via cell kinetic regulation and suppression of oxidative/ER stress in diabetic mice.2015
- Author(s)
  Kanda Y, Hashiramoto M, Shimoda M, Hamamoto S, Tawaramoto K, Kimura T, Hirukawa H, Nakajima K, Kaku K
- Journal Title
  
  J Nutr Biochem
  
  Volume: 26 Pages: 219-226
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461350
[Journal Article] Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression.2015
- Author(s)
  Hirukawa H, Kaneto H, Shimoda M, Kimura T, Okauchi S, Obata A, Kohara K, Hamamoto S, Tawaramoto K, Hashiramoto M, Kaku K
- Journal Title
  
  Mol Cell Endocrinol
  
  Volume: 413 Pages: 49-60
- DOI
  10.1016/j.mce.2015.06.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461350
[Journal Article] Self-inducible secretion ofglucagon-like peptide-1(GLP-1) that allows MIN6 cells to maintain insulin secretion and insure cell survival2012
- Author(s)
  Nakashima K, Shimoda M, Hamamoto S, Tatsumi F, Hirukawa H, Tawaramoto K, Kanda Y, Kaku K
- Journal Title
  
  Mol Cell Endocrinol
  
  Volume: 349(2) Pages: 281-288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Ablationof 3-phosphoinositide-dependent protein kinase 1(PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis2012
- Author(s)
  Tawaramoto K, Sakaue H, et al
- Journal Title
  
  Mol Endocrinol
  
  Volume: Vol.26 Issue: 1 Pages: 95-109
- DOI
  10.1210/me.2010-0412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591151, KAKENHI-PROJECT-21591153, KAKENHI-PLANNED-22126011, KAKENHI-PUBLICLY-23126520, KAKENHI-PROJECT-24591333
[Journal Article] The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes2011
- Author(s)
  Shimoda M, Kanda Y, Hamamoto S, Tawaramoto K, Hashiramoto M, Matsuki M, Kaku K
- Journal Title
  
  Diabetologia
  
  Volume: 54(5) Issue: 5 Pages: 1098-1108
- DOI
  10.1007/s00125-011-2069-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes.2010
- Author(s)
  Kaku K, et al
- Journal Title
  
  Diabetes Obes Metab
  
  Volume: 12 Pages: 341-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Molecular mechanism by which pioglitazone preserves pancreatic β cells in obese diabetic mice : Evidence for acute and chronic actions as a PPARγ agonist2010
- Author(s)
  Kanda Y, Shimoda M, Hamamoto S, Tawaramoto K, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 298(2) Issue: 2 Pages: 278-286
- DOI
  10.1152/ajpendo.00388.2009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Molecular Analysis of db Gene-related Pancreatic beta Cell Dysfunction ; Evidence for a Compensatory Mechanism Inhibiting Development of Diabetes in the db Gene Heterozygote2009
- Author(s)
  Kanda Y, Shimoda M, Tawaramoto K, Hamamoto S, Tatsumi F, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K
- Journal Title
  
  Endocr J
  
  Volume: 56(8) Pages: 997-1008
- URL
  https://www.jstage.jst.go.jp/article/endocrj/56/8/56_K09E-028/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Long-term effects of pioglitazone in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity2009
- Author(s)
  Kaku K, et al
- Journal Title
  
  Curr Med Res Opin. 25
  
  Pages: 2925-2932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8 and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.2008
- Author(s)
  Omori S, Kaku K, et. al.
- Journal Title
  
  Diabetes 57
  
  Pages: 791-795
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Association of CDKAL1,IGF2BP2,CDKN2A/B,HHEX,SLC30A8 and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population2008
- Author(s)
  Omori S, Kaku K, et. al.
- Journal Title
  
  Diabetes 57
  
  Pages: 791-795
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Analysis of waist circumference in Japanese subjects with type 2 diabetes mellitus : Lack of propriety to define the current criteria of metabolic syndrome.2007
- Author(s)
  Kanda Y, Kaku K, et. al.
- Journal Title
  
  Diab Res Clin Pract 77
  
  Pages: 220-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Polymorphisms in the 3'UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy.2007
- Author(s)
  Kamiyama M, Kaku K, et. al.
- Journal Title
  
  Hum Genet. 122
  
  Pages: 397-407
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum.2007
- Author(s)
  Shigeto M, Kaku K, et. al.
- Journal Title
  
  J Pharmacol Experimental Therapeutics 322
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Nateglinide and mitiglinide,but not sulfonylureas,induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum2007
- Author(s)
  Shigeto M, Kaku K, et. al.
- Journal Title
  
  J Pharmacol Experimental Therapeutics 322
  
  Pages: 1-7
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in Japanese population.2007
- Author(s)
  Hayaishi T, Kaku K, et. al.
- Journal Title
  
  Diabetologia 50
  
  Pages: 980-984
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] A novel complex deletion-insertion mutation mediated by Alu repeutitive elements leads to lipoprotein lipase deficiency2007
- Author(s)
  Okubo M, Kaku K, et. al.
- Journal Title
  
  Mol Genet Metab 92
  
  Pages: 229-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Replication study for the association of TCF7L2 with susceptibility,to type 2 diabetes in Japanese population2007
- Author(s)
  Hayaishi T, Kaku K, et. al.
- Journal Title
  
  Diabetologia 50
  
  Pages: 980-984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in Japanese population2007
- Author(s)
  Hayaishi T, Kaku K, et. al.
- Journal Title
  
  Diabetologia 50
  
  Pages: 980-984
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Nateglinide and mitiglinide,but not sulfonylureas,induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum2007
- Author(s)
  Shigeto M, Kaku K, et. al.
- Journal Title
  
  J Pharmacol Experimantal Therapeutics 322
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.2007
- Author(s)
  Hayaishi T, Kaku K et al.
- Journal Title
  
  Diabetologia 50(4)
  
  Pages: 980-984
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] A novel complex deletion-insertion mutation mediated by Alu repetitive elements leads to lipoprotein lipase deficiency.2007
- Author(s)
  Okubo M, Kaku K, et. al.
- Journal Title
  
  Mol Genet Metab. 92
  
  Pages: 229-233
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Knockout of PDK1 in vascular endothelial cells protects against pbesity and insulin resistance2006
- Author(s)
  Tawaramoto K, Kaku K et al.
- Journal Title
  
  Diabetes 55(suppl 1)
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Molecular mechanism of db gene induced pancreatic b cell dysfunction : Evideno for compensatory mechanism to reduce susceptibility to diabaetes in bd gem heterozygote.2006
- Author(s)
  Kanda Y, Kaku K et al.
- Journal Title
  
  Diabetologia 49(suippl 1)
  
  Pages: 315-315
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] The relative contributions of insulin resistance nad beta-cell failure to the transformation from normal to impaired glucose tolerance varies in different ethnic groups2006
- Author(s)
  Abdul-Ghani M, Kaku K et al.
- Journal Title
  
  Diabetes 55(suppl 1)
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] First Phase of Glucose-Stimulated Insulin Secretion From MIN 6 Cells Does Not Always Require Extracellular Calcium Influx.2006
- Author(s)
  Shigeto M, Kaku K et al.
- Journal Title
  
  J Pharmacol Sci. 101(4)
  
  Pages: 293-302
- NAID
  10018236439
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] First Phase of Glucose-Stimulated Insulin Secretion From MIN 6 Cells Does Not Always Require Extracellular Calcium Influx.2006
- Author(s)
  Shigeto M, Katsura M, Matsuda M, Okuma S, Kaku K
- Journal Title
  
  J Pharmacol Sci. 101(4)
  
  Pages: 293-302
- NAID
  10018236439
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Plasma lipid levels and nutritional intake in childhood- and adolescenceonset type 1 diabetic patients.2006
- Author(s)
  Saito M, Kaku K et al.
- Journal Title
  
  Diab.Re.Clin.Pract 73(1)
  
  Pages: 18-34
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Retained capacity of glucose-mediated insulin secretion in patients with type 2 diabetes mellitus inversely correlates with the duration of diabetes.2004
- Author(s)
  Kaku K, et al.
- Journal Title
  
  Diab Res Clin Prac 64
  
  Pages: 221-224
- Data Source
  KAKENHI-PROJECT-15590962
[Journal Article] Retained capacity of glucose-mediated insulin secretion in patients with type 2 diabetes mellitus inversely correlates with the duration of diabetes.2004
- Author(s)
  Kaku K, et al.
- Journal Title
  
  Diab, Res.Clin.Pract 64
  
  Pages: 221-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590962
[Journal Article] Retained capacity of glucose-mediated insulin secretion in patients with type 2 diabetes mellitus inversely correlates with the duration of diabetes.2004
- Author(s)
  Kaku K, et al.
- Journal Title
  
  Diab, Res. Clin. Pract. 64
  
  Pages: 221-223
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590962
[Presentation] 糖尿病モデルラットのα細胞におけるGIP/GIP受容体の発現とGLP-1/GLP-1受容体との相違性2016
- Author(s)
  中島弘二、金藤秀明、木村友彦、下田将司、加来浩平
- Organizer
  第５９回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26461350
[Presentation] 糖尿病モデルラットのα細胞におけるGIP/GIP受容体の発現とGLP-1/GLP-1受容体との相違性2016
- Author(s)
  中島弘二、金藤秀明、木村友彦、下田将司、加来浩平
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26461350
[Presentation] 血管内皮特異的PDK1欠損における肝、骨格筋内血管面積の解析ー高血糖による影響2012
- Author(s)
  俵本和仁、柱本満、木村友彦、蛭川英典、辰巳文則、濱本純子、下田将司、小川渉、春日雅人、加来浩平
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-05-17
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of PDK1 in vascular endothelial cells in diabetic condition deteriorates vascularity only in skeletal muscles but not in liver2012
- Author(s)
  Tawaramoto K, Hashiramoto M, Kimura T, Hirukawa H, Shimoda M, Ogawa W, Kasuga M, Kaku K
- Organizer
  72^<nd> American Diabetes Association Scientific Session
- Place of Presentation
  Philadelphia
- Year and Date
  2012-06-11
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] 高血糖状態での血管内皮細胞PDK1欠損は骨格筋内血管数減少と全身インスリン感受性悪化を惹起する2011
- Author(s)
  俵本和仁、柱本満、蛭川英典、辰巳文則、濱本純子、下田将司、菅田有紀子、小谷光、小川渉、春日雅人、加来浩平
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of PDK1 in vascular endothelial cells deteriorates systemic insulin sensitivity and angiogenesis of skeletal muscles in STZ-induced hyperglycemic mice2011
- Author(s)
  Tawaramoto K, Hashiramoto M, Kotani K, Ogawa W, Hirukawa H, Tatsumi F, Hamamoto S, Shimoda M, Kanda Y, Kasuga M, Kaku K
- Organizer
  71^<st> American Diabetes Association Scientific Session
- Place of Presentation
  San Diego
- Year and Date
  2011-06-25
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of vascular endothelial phosphoinositide-dependent protein kinase 1 deteriorates the volume of blood flow in skeletal muscle2010
- Author(s)
  Tawaramoto K, Hashiramoto M, Kotani K, Ogawa W, Tatsumi F, Hamamoto S, Shimoda M, Kanda Y, Kasuga M, Kaku K
- Organizer
  46th European Association for the Study of Diabetes Annual Meeting
- Place of Presentation
  Stockholm
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of Vascular Endothelial PDK1 in Diabetic db/db Mice Further Deteriorates Insulin Sensitivity through Defects of Angiogenesis in Skeletal Muscle and Adipose Tissue2009
- Author(s)
  Tawaramoto K, Hashiramoto M, Kotani K, Ogawa W, Tatsumi F, Hamamoto S, Shimoda M, Kanda Y, Kasuga M, Kaku K
- Organizer
  69^<th> American Diabetes Association Scientific Session
- Place of Presentation
  New Orleans
- Year and Date
  2009-06-08
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] 肥満2型糖尿病での血管内皮細胞PDK1欠損は筋肉内血管新生を低下させ、全身インスリン抵抗性を増悪させる2009
- Author(s)
  俵本和仁、柱本満、小谷光、小川渉、辰巳文則、濱本純子、下田将司、菅田有紀子、春日雅人、加来浩平
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] 肥満2型糖尿病モデルでの血管内皮細胞PDK1欠損は筋肉内血管新生を低下させ、全身インスリン抵抗性を増悪させる2009
- Author(s)
  俵本和仁、柱本満、小谷光、小川渉、辰巳文則、濱本純子、下田将司、菅田有紀子、春日雅人、加来浩平
- Organizer
  第30回日本肥満学会
- Place of Presentation
  浜松
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Molecular mechanism of pioglitazone effect on the pancreatic beta cell preservation in diabetic db/db mice:evidence for direct action as PPARg agonist2007
- Author(s)
  Kanda Y, Kaku K, et. al.
- Organizer
  The 43rd Annual Meeting of European Association of the Study of Diabetes
- Place of Presentation
  Amsterdam,Holland
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] The siginificant role of calcium signaling on GLP-1-stimulated insulin secretion from MIN6 cells.2007
- Author(s)
  Shigeto M, Katsura M, Ohkuma S, Kaku K
- Organizer
  The 67th Scientific Sessions of American Diabetes Association.
- Place of Presentation
  Chicago, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] Molecular mechanism of pioglitazone effect on the pancreatic beta cell preservation in diabetic db/db mice : evidence for direct action as PPARg agonist.2007
- Author(s)
  Kanda Y, Kaku K, et. al.
- Organizer
  The 43rd Annual Meeting of European Association of the Study of Diabetes.
- Place of Presentation
  Amsterdam
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] Molecular mechanism of pioglitazone effect on the pancreatic beta cell preservation in diabetic db/db mice:evidence for direct action as PPARγ agonist2007
- Author(s)
  Kanda Y, Kaku K, et. al.
- Organizer
  The 43rd Annual Meeting of European Association of the Study of Diabetes.
- Place of Presentation
  Amsterdam,Holland
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] Common variants of the TCF7L2 are associated with susceptibility to type 2 diabetes, but not with the expression of TCF7L2 in the adipose or plasma GLP-1 concentrations in a Japanese population.2007
- Author(s)
  Hayashi T, Kaku K, et. al.
- Organizer
  The 67th Scientific Sessions of American Diabetes Association.
- Place of Presentation
  Chicago, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] Molecular mechanism of db gene induced pancreatic b cell dysfunction: Evidence for compensatory mechanism to reduce susceptibility to diabetes in bd gene heterozygote.2006
- Author(s)
  Kanda Y, Kaku K, et. al.
- Organizer
  The 42nd Annual Meeting of European Association of the Study of Diabetes.
- Place of Presentation
  Copenhagen, Denmark
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] 膵α細胞および消化管由来のGLP-1とGIPの分泌機構の相違性
- Author(s)
  中島弘二、下田将司、木村友彦、蛭川英典、岡内省三、加来浩平
- Organizer
  第５７回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26461350
[Presentation] 糖尿病モデルラット膵α細胞にはGLP-1受容体が発現しGLP-1のautocrine機構が存在する
- Author(s)
  中島弘二、木村友彦、岡内省三、下田将司、金藤秀明、加来浩平
- Organizer
  第５８回日本糖尿病学会年次学術集会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-05-21 – 2015-05-23
- Data Source
  KAKENHI-PROJECT-26461350

1. HASHIRAMOTO Mitsuru (40346680)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. KANDA Yukiko (40351895)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
3. SHIMODA Masashi (60388957)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. MATSUTANI Akira (10190464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MATSUDA Masafumi (00199811)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHIGETO Masato (60368628)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. MATSUKI Michihiro (00165797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. TAWARAMOTO Kazuhito (70368629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
9. INOUE Yasushi (10176448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOTANI Ko (10388928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 谷澤幸生 (00217142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKASHIMA Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. KIMURA Tomohiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
14. HIRUKAWA Hidenori

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. OKAUCHI Seizo

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
16. OBATA Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. KANETO Hideaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
18. Rorsman Patrik

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 桂昌司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 阪上浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kaku Kohei 加来 浩平

KAKU Kohei 加来 浩平

加来 浩平 カク コウヘイ

KAKU Konei

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Physiological role of pancreatic incretin on the functional regulation of pancreatic islet cellsPrincipal Investigator

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Molecular mechanism of visceral obesity controlled by endothelial cell-related growth factors and the search for a new strategy of adipogenecity controlPrincipal Investigator

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Research for molecular mechanism of diabetes development in obese type 2 diabetes model db/db micePrincipal Investigator

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Mechanism of pancreatic β cell dysfunction in obese diabetes model db/db micePrincipal Investigator

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Mechanism of pancreatic β-cell dusfunction in db/db mice and approach for protection of the cell functionPrincipal Investigator

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II型糖尿病の発症機構におけるインスリン遺伝子転写因子の役割Principal Investigator

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Mechanisms of extra-pancreatic effects of oral anti-diabetic agents

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Elucidation of mechanism for diabetogenesis in Wistar Fatty rats

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Analysis of genes involved in the susceptibility to type 2 diabetesPrincipal Investigator

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Polymorphisms of Glucose Transporter Genes Associated with Type II DiabetesPrincipal Investigator

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[Book] 食後高血糖の自己管理2007

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[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice.2016

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[Journal Article] Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes.2015

Author(s)

Journal Title

Kaku Kohei 加来浩平

KAKU Kohei 加来浩平

加来浩平カクコウヘイ