SHIMIZU Motomu 清水本武

… Alternative Names

清水本武シミズモトム

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Researcher Number	10124463
Affiliation (based on the past Project Information) *help	2008: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 主任研究員 2007 – 2008: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 主任研究員 2001 – 2003: Tokyo Metropolitan Organization for Medical Research, Medical R&D center, Senior Researcher, 東京都臨床医学総合研究所, 主任研究員 2000: 東京都臨床総合研究所, 主任研究員 1999: Department of Cancer Therapeutics, Tokyo Metropolitan Institute of Medical Science, Chief Researcher, 化学療法部, 主任研究員 1995: 都臨床医学総合研究所, 研究員
Review Section/Research Field	Principal Investigator Experimental pathology Except Principal Investigator General surgery
Keywords	Principal Investigator 血管新生阻害作用 / インターロイン27 / 血管新生阻害 / IL-27 / インターロイキン27 / 抗腫瘍作用 / 免疫学 / 癌 Except Principal Investigator アポトーシス / Apoptosis … More / Fas / Cancer gene therapy / 抗Fas抗体 / がん遺伝子療法 / Anti-tumor effect / FasL(CD95L)-transfected tumor cell / Fasリガンド発現腫瘍 / 抗腫瘍効果 / anti-Fas mAb / cDNA methylation / cDNA depletion / Mutation frequency / Resistant cells / 抗体療法 / DNAメチル化 / DNA欠落 / cDNAメチル化 / cDNA欠落 / 耐性腫瘍の出現頻度 / 耐性 / Chemokine / Liposome / Gene delivery / Nonviral vector / Cancer Gene therapy / 好中球 / マクロファージ / Fasリガンド / ケモカイン / 抗腫瘍免疫 / リポソーム / 遺伝子導入 / 非ウイルス性ベクター / Resistant tumor / Anti-Fas antibody / MH134 hepatoma / Neutrophil infiltration / MH134 / FasL発現腫瘍 / 肝癌MH134 / 抗腫瘍作用 / 耐性腫瘍 / MH134肝癌 / 好中球浸潤 / 癌遺伝子療法 / FasL(CD95L)導入癌細胞 / Murine mammary tumor / Murine hepatoma / FasL system / マウス乳癌 / マウス肝癌 / Fas-FasLシステム / 癌遺伝子治療 / 遺伝子治療 / 癌治療 / 肝癌 / gld / lpr Less

Analysis of antitumor effect by antiangiogenic activity of interleukin-27Principal Investigator
- Principal Investigator
  
  SHIMIZU Motomu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Basic study for Analysis of Intractable Resistant Tumor Cells and their Overcoming in Cancer Gene Therapy
- Principal Investigator
  
  TAKEDA Yasutaka
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Clinical Application of Tumor-specific Anti-tumor Immunity Induced by Tumor Cells Expressing Fas (CD95) Ligand
- Principal Investigator
  
  TAKEDA Yasutaka
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Basic study for. Cancer Gene Therapy by Antitumor Effects Using Fas-Fas Ligand-Mediated Apoptosis
- Principal Investigator
  
  TAKEDA Yasutaka
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
A study for cancer gene therapy through Fas-mediated apoptosis
- Principal Investigator
  
  TAKEDA Yasutaka
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
FAS-FASリガンド実験系を用いたアポトーシスによる癌治療の基礎的研究
- Principal Investigator
  
  MATSUZAWA Akio
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo

All 2008 2007

All Journal Article Presentation

[Journal Article] SAR oriented novel discovery of substituted phenylpropanoic acid-PPAR panagonist with 4-adamantylphenyl group as a hydrophobic tail part.2008
- Author(s)
  J. Kasuga, D. Yamasaki, K. Ogura, M. Shimizu M. Sato, M. Makishima, T. Doi, Y. Hashimoto, H. Miyachi
- Journal Title
  
  Bioorg.Med.Chem.Lett. 18
  
  Pages: 1110-1115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590418
[Journal Article] SAR oriented novel discovery of substituted phenylpropanoic acid-PPAR pan agonist with 4-adamantylphenyl group as a hydrophobic tail part.2008
- Author(s)
  J. Kasuga, D. Yamasaki, K. Ogura, M. Shimizu, M. Sato, M. Makishima, T. Doi, Y. Hashimoto, H. Miyachi
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 1110-1115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590418
[Journal Article] Anti-proliferative activity of IL-27 on melanoma2008
- Author(s)
  T. Yoshimoto, N. Morishima, I. Mizoguchi, M. Shimizu, H. Nagai, S. Oniki, M. Oka, C. Nishigori, J. Mizuguchi,
- Journal Title
  
  J.Immunol. 180
  
  Pages: 6527-6535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590418
[Journal Article] Anti-proliferative activity of IL-27 on melanoma.2008
- Author(s)
  T. Yoshimoto, N. Morishima, I. Mizoguchi, M. Shimizu, H. Nagai, S. Oniki, M. Oka, C. Nishigori, J. Mizuguchi
- Journal Title
  
  J. Immunol. 180
  
  Pages: 6527-6535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590418
[Journal Article] 正電荷ポリマーによる乳癌細胞に対する遺伝子導入の基礎研究. 査読有2007
- Author(s)
  武田泰隆、榮光子、善本隆之、森本純司、清水本武、柳衛広宣
- Journal Title
  
  乳癌基礎研究 16
  
  Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590418
[Journal Article] IL-27の血管新生抑制作用2007
- Author(s)
  清水本武, 島村眞里子, 善本隆之
- Journal Title
  
  臨床免疫 47
  
  Pages: 298-302
- Data Source
  KAKENHI-PROJECT-19590418
[Journal Article] 正電荷ポリマーによる乳癌細胞に対する遺伝子導入の基礎研究2007
- Author(s)
  武田泰隆, 栄光子, 善本隆之, 森本純司, 清水本武, 柳衛広宣
- Journal Title
  
  乳癌基礎研究 16
  
  Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590418
[Journal Article] Design,synthesis,and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase(HDAC)inhibitors2007
- Author(s)
  S. Lee, C. Shinji, K. Ogura, M. Shimizu, S. Maeda, M. Sato, M. Yoshida, Y. Hashimoto, Miyachi, H
- Journal Title
  
  Bioorg.Med.Chem.Lett. 17
  
  Pages: 4895-4900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590418
[Journal Article] Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.2007
- Author(s)
  S. Lee, C. Shinji, K. Ogura, M. Shimizu, S. Maeda, M. Sato, M. Yoshida, Y. Hashimoto, H. Miyachi
- Journal Title
  
  Bioorg. Med. Chem. Lett. 17
  
  Pages: 4895-4900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590418
[Journal Article] IL-27の血管新生抑制作用2007
- Author(s)
  清水本武, 島村眞理子, 善本隆之
- Journal Title
  
  臨床免疫 47
  
  Pages: 298-302
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Analysis of antitumor activity of IL-2.2008
- Author(s)
  Shimizu, M., Sato, M., Ogura, K., Nishito, Y., Takeda, Y., Mizuguchi, J, Yoshimoto, T.
- Organizer
  The 67^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Effects of Hgs on metastasis ability of mouse melanoma B16 cells.2008
- Author(s)
  Ogura, K., Kawashima, I., Sato, M., Shimizu, M.
- Organizer
  The 33rd FEBS Congress & 11th IUBMB Conference
- Place of Presentation
  Athens (Greece)
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Comprehensive gene expression analysis of melanoma B16 cells that Hgs expression level changed metastasis activity.2008
- Author(s)
  Ogura, K., Kawashima, I., Ishikawa, Y-I., Sato, M., Shimizu, M.
- Organizer
  The 67^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] A novel PPAR alpha/beta/gamma-pan agonist inhibits cell growth in human pancreatic cancer cell lines2008
- Author(s)
  Sato, M., Yajima Y., Ogura, K., Shimizu. M., Nishitho, Y., Miyachi H
- Organizer
  The 67^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya, Nagoya Congress Center
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] TIPP-703, A peroxisome proliferator-activated receptor pan agonist, induces a G1-phase arrest in human pancreatic carcinoma cell lines2008
- Author(s)
  Sato, M., Yajima Y., Ogura, K., Shimizu. M.
- Organizer
  The 33rd FEBS Congress-11th IUBMB Conference
- Place of Presentation
  Athens (Greece)
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] TIPP-703, A peroxisome proliferator-activated receptor pan agonist, induces a G1-phase arrest in human pancreatic carcinoma cell lines.2008
- Author(s)
  Sato, M., Yajima Y., Ogura, K., Shimizu, M., Miyachi H.
- Organizer
  The 33rd FEBS Congress - 11th IUBMB Conference "Biochemistry of Cell Regulation"
- Place of Presentation
  Athens (Greece)
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Analysis of in vivo antitumor activity of IL-27 against melanoma2008
- Author(s)
  Shimizu. M., Mizuguchi, J, Yoshimoto, T
- Organizer
  The 38^<th> Annual Meeting of the Japanese society for immunology
- Place of Presentation
  Kyoto, Kyoto International Conference Center
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] 正電荷ポリマーを用いたFasリガンド(FasL)遺伝子導入による乳癌遺伝子治療に向けた基礎的研究2008
- Author(s)
  武田泰隆, 榮光子, 善本隆之, 森本純司, 清水本武, 柳衛宏宣, 螺良愛朗
- Organizer
  第18回乳癌基礎研究会
- Place of Presentation
  福島
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Effects of Hgs on metastasis ability of mouse melanoma B16 cells2008
- Author(s)
  Ogura, K., Kawashima, I., Sato, M., Shimizu. M.
- Organizer
  The 33rd FEBS Congress & 11th IUBMB Conference
- Place of Presentation
  Athens (Greece)
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Comprehensive gene expression analysis of melanoma B16 cells that Hgs expression level changed metastasis activity2008
- Author(s)
  Ogura, K., Kawashima, I., Ishikawa, Y-I., Sato, M., Shimizu. M
- Organizer
  The 67^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya, Nagoya Congress Center
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Analysis of in vivo antitumor activity of IL-27 against melanoma.2008
- Author(s)
  Shimizu, M., Mizuguchi, J, Yoshimoto, T.
- Organizer
  The 38^<th> Annual Meeting of the Japanese society for immunology.
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Analysis of antitumor activity of IL-272008
- Author(s)
  Shimizu, M., Sato, M., Ogura, K. Nishito, Y., Takeda, Y., Mizuguchi, J, Yoshimoto, T
- Organizer
  The 67^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya, Nagoya Congress Center
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] A novel PPAR alpha/beta/gamma-pan agonist inhibits cell growth in human pancreatic cancer cell lines.2008
- Author(s)
  Sato, M., Yajima Y., Ogura, K., Shimizu, M., Nishitho, Y., Miyachi H.
- Organizer
  67th Annual Meeting of the Japanese cancer association.
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Role of chemokines in antitumor activity of Fas ligand (CD95L)-expressing tumor.2007
- Author(s)
  Shimizu, M., Mizuguchi, J., Yoshimoto, T.
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Novel PPAR α,γ dual agonists induce a Gl-phase arrest in pancreatic cancer cells2007
- Author(s)
  Sato, M., Ogura, K., Shimizu. M., Kunimasa, K., Ohta, T., Kaji, K., Miyachi, H
- Organizer
  The 66^<th>Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] L-carnosine, an endogenous bioactive dipeptide inhibits angiogenesis and tumor metastasis.2007
- Author(s)
  Shimamura, M., Ashino, H., Shimizu, M., Yamamoto, Y., Minamikawa-Tachino, R., Takahashi, S.
- Organizer
  The 66^<th> Annual Meeting of the Japanese Cancer Association.
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Effects of RNA Interference of GEF-1/Hgs on Metastasis of Mouse Melanoma B16 cells2007
- Author(s)
  Ogura, K., Horiguchi, S., Sato, M., Shimizu, M.
- Organizer
  The 66^<th>Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Role of macrophages and neutrophils in antitumor activity of Fas lig and (CD95L)-expressing tumor2007
- Author(s)
  Shimizu. M., Sato, M., Ogura, K. Takeda, Y., Mizuguchi J., Yoshimoto
- Organizer
  The 66^<th>Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] L-carnosine,an endogenous bioactive dipeptide inhibits angiogenesis and tumor metastasis2007
- Author(s)
  Shunamura, M., Ashino, H., Shimizu, M., Yamamoto, Y., Minamikawa-Tachino, R., Takahashi, S
- Organizer
  The 66^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Hgs高発現および抑制マウスメラノーマB16細胞の遺伝子発現プロファイリング2007
- Author(s)
  小倉潔, 佐藤眞友美, 清水本武
- Organizer
  第30回日本分子生物学会年会・第80回生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Effects of RNA Interference of GEF-1/Hgs on Metastasis of Mouse Melanoma B16 cells.2007
- Author(s)
  Ogura, K., Horiguchi, S., Sato, M., Shimizu, M.
- Organizer
  The 66^<th> Annual Meeting of the Japanese Cancer Association.
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Novel PPAR α, γ dual agonists induce a G1-phase arrest in pancreatic cancer cells.2007
- Author(s)
  Sato, M., Ogura, K., Shimizu, M., Kunimasa, K., Ohta, T., Kaji, K., Miyachi, H.
- Organizer
  The 66^<th> Annual Meeting of the Japanese Cancer Association.
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Role of macrophages and neutrophils in antitumor activity of Fas ligand (CD95L)-expressing tumor.2007
- Author(s)
  Shimizu, M., Sato, M., Ogura, K., Takeda, Y., Mizuguchi, J, Yoshimoto, T.
- Organizer
  The 66^<th> Annual Meeting of the Japanese Cancer Association.
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590418
[Presentation] Role of chemokines in antitumor activity of Fas ligand (CD95L)-expressing tumor2007
- Author(s)
  Shimizu, M., Sato, M., Ogura, K., Takeda, Y., Mizuguchi, J., Yoshimoto
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590418

1. YOSHIMOTO Takayuki (80202406)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
2. TAKEDA Yasutaka (40163422)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MATSUZAWA Akio (50012745)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TSUBURA Airo (90098137)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SHIMAMURA Mariko (00124462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. TAHARA Hideaki (70322071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YANAGIE Hironobu (30212278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ERIGUCHI Masazumi (10114406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMIZU Motomu 清水 本武

清水 本武 シミズ モトム

Research Projects

Research Products

Co-Researchers

Analysis of antitumor effect by antiangiogenic activity of interleukin-27Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic study for Analysis of Intractable Resistant Tumor Cells and their Overcoming in Cancer Gene Therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical Application of Tumor-specific Anti-tumor Immunity Induced by Tumor Cells Expressing Fas (CD95) Ligand

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic study for. Cancer Gene Therapy by Antitumor Effects Using Fas-Fas Ligand-Mediated Apoptosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study for cancer gene therapy through Fas-mediated apoptosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

FAS-FASリガンド実験系を用いたアポトーシスによる癌治療の基礎的研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] SAR oriented novel discovery of substituted phenylpropanoic acid-PPAR panagonist with 4-adamantylphenyl group as a hydrophobic tail part.2008

Author(s)

Journal Title

Data Source

[Journal Article] SAR oriented novel discovery of substituted phenylpropanoic acid-PPAR pan agonist with 4-adamantylphenyl group as a hydrophobic tail part.2008

Author(s)

Journal Title

Data Source

[Journal Article] Anti-proliferative activity of IL-27 on melanoma2008

Author(s)

Journal Title

Data Source

[Journal Article] Anti-proliferative activity of IL-27 on melanoma.2008

Author(s)

Journal Title

Data Source

[Journal Article] 正電荷ポリマーによる乳癌細胞に対する遺伝子導入の基礎研究. 査読有2007

Author(s)

Journal Title

Data Source

[Journal Article] IL-27の血管新生抑制作用2007

Author(s)

Journal Title

Data Source

[Journal Article] 正電荷ポリマーによる乳癌細胞に対する遺伝子導入の基礎研究2007

Author(s)

Journal Title

Data Source

[Journal Article] Design,synthesis,and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase(HDAC)inhibitors2007

Author(s)

Journal Title

Data Source

[Journal Article] Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.2007

Author(s)

Journal Title

Data Source

[Journal Article] IL-27の血管新生抑制作用2007

Author(s)

Journal Title

Data Source

SHIMIZU Motomu 清水本武

清水本武シミズモトム