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OHYA Keiichi  大谷 啓一

ORCIDConnect your ORCID iD *help
Researcher Number 10126211
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2015: 東京医科歯科大学, 歯学部, 名誉教授
2015: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2014: 東京医科歯科大学, 歯学部, 非常勤講師
2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 名誉教授
2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 … More
2010 – 2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 教授
2009: Tokyo Medical and Dental University, 医歯学総合研究科, 教授
2007 – 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授
2006: Tokyo Medical and Dental University, Graduate School, Hard Tissue Engineering/Pharmacology, Professor, 大学院医歯学総合研究科, 教授
2000 – 2005: Tokyo Medical and Dental University, Graduate School, Division of Biomatrix, Department of Hard Tissue Engineering, Section of Pharmacology, Professor, 大学院・医歯学総合研究科, 教授
2002: 東京医科歯科大学, 大学院・医歯学総合研究科, 助教授
1996 – 1999: 東京医科歯科大学, 歯学部, 教授
1994: Tokyo Medical and Dental University Faculty of Dentistry, Professor, 歯学部, 教授
1993: 東京医科歯科大学, 歯学部・歯科薬理学講座, 助教授
1988 – 1993: Associate Professor, Faculty of Dentistry, Tokyo Medical and Dental University, 歯学部, 助教授
1988: Dept. of Pharmacol., School of Dent., Tokyo Med. Dent. Univ. Associate Professor, 歯学部歯科薬理学教室, 助教授
1987: 東京医科歯科大学, 歯科部, 助教授
1986: 医科歯科大, 歯学部, 助教授
1986: 東京医科歯科大学, 歯学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Functional basic dentistry / Functional basic dentistry
Except Principal Investigator
Functional basic dentistry / Educational technology / Surgical dentistry / Conservative dentistry / 補綴理工系歯学 / 病態科学系歯学(含放射線系歯学) / 外科・放射線系歯学
Keywords
Principal Investigator
破骨細胞 / 骨吸収 / TNF / bisphosphonates / 歯周病 / RANKL / RANK / 低Ca食 / BONE RESORPTION / 骨粗鬆症 … More / osteoclasts / periodontitis / bone resorption / Walker 256 / ラット / OSTEOCLAST / 骨吸収抑制薬 / 低カルシウム食 / リウマチ / ナノゲル / 骨形成 / 骨芽細胞 / NF-kB / NF-κB / Mini-pump / Nano-gel / Rheumatoid Arthritis / NF-kβ / ミニポンプ / ナノ・ゲル / inhibitroy drugs for bone resorption / s carcinoma cells / osteoblasts / osteoporosis / Walker256 / s癌細胞 / Biphosphinates / confocal laser-scanning microscope / bone mineral density / intracellular calcium / distraction osteogenesis / hyper-tension / osteoclast / high salt intake / a low calcium diet / 骨形態計測 / ウサギ / 骨塩素測定 / 共焦点レーザー走査顕微鏡 / 骨塩量測定 / 細胞内カルシウム / 仮骨延長法 / 高血圧症 / 高食塩摂取 / BISPHOSPHONATES / MECHANICAL STRESS / TURNOVER IN BONE METABOLISM / LOW CALCIUM DIET / INTRACELLULARpH / OSTEOCLASTS / 骨リモデリング活性 / oH / H^+交換体 / NA^+ / SNAFL-calcein / pH / mechanical stress / 骨代謝回転 / 細胞内pH / CONFOCAL LASER SCANNING MICROSCOPY / GOLGI-LYSOSOMAL SYSTEM / CYTOSKELETON / IN SITU HYBRIDIZATION / GENE EXPRESSION / BONE / 共焦点レーザースキャン顕微鏡 / golgi-lysosome系システム / 共焦点レーザー顕微鏡 / golgi-lysosomeシステム / 細胞骨格 / in situ hybridization / 遺伝子発現 / 骨 / ANTI-BONE RESORBING DRUG / ALVEOLAR BONE / BISPHOSPHONATE / LOW Ca DIET / bisphosphonate / 歯槽骨 / 鉄分泌 / Ca輸送 / microtubules / 微小管 / エナメル / エナメル芽細胞 / LPS / 炎症 / TNF2型受容体 / ペプチドアンタゴニスト / BMP / ペプチド薬 / DDS / 抗炎症 / 骨形成促進 / 骨吸収阻害薬 / 炎症性疾患 / 硬組織 / TNF拮抗薬 / 炎症性骨吸収治療薬 / NF-kB inducing kinase / 大理石骨病 / Alyマウス / Aly / 低Ca食飼育食マウス / 骨吸収阻害 / TNF受容体 / 細胞内情報伝達 / 分子モデリング / 表面プラズモン共鳴装置 / RANK-RANKL / calvaria / マウス / ブラジキニン / 上皮成長因子(EGF) / プロスタグランジン / アスピリン / サリチル酸 / 非ステロイド性抗炎症薬 … More
Except Principal Investigator
破骨細胞 / 骨吸収 / 低カルシウム食 / 歯学教育 / 教材開発 / コンピュータシミュレーション / Polyphosphate / Bisphosphonate / RANK / RANKL / SSI / BMD / pQCT / 歯槽骨吸収 / Osteoclast / Bone Resorption / Alveolar Bone / osteoporosis / 骨形態計測 / 歯槽骨 / 教育システム / e-learning / 臨床教育 / 歯学 / Anti-calculus agent / 歯石形成抑制 / Hexametaphosphate / ピロリン酸 / Anti-calculus agents / agents / Anti-calculus / Palyphosphate / 歯石 / Parathyroid Hormone / Low-Calcium Diet / 血漿アルカリフォスファターゼ / 血漿イオン化カルシウム / 血漿カルシウム / 歯槽骨吸収病態モデル / カルシトニン / パラサイロイドホルモン / 細胞運動 / 形態計測 / 歯槽骨吸収動物実験モデル / 副甲状腺ホルモン / osteoclasts / bone resorption / TNFα antagonistic peptide / 浸透圧ポンプ / TNFαペプチドアンタゴニスト / Distraction Osteogenesis / 顎顔面変形症 / PQCT / 仮骨延長法 / maxilla / mandible / bone mineral density / tpptj extraction / aging / DEXA / 下顎骨 / ラット / エストロゲン欠乏 / 抜歯 / 歯 / 骨粗鬆症 / 骨塩量 / 顎骨 / 老化 / Standard test / Endurance / Biomaterials / Oromaxillofacia region / Hard tissue desease / Tropical climate / インプラント / メッケル軟骨 / 重症歯周病 / 顎矯正 / 歯の発生 / チタン / 保管 / 梱包 / 規格試験 / 歯科材料 / 熱帯 / 歯科臨床 / clinicostatistical study / rat calvaria / bone fracture healing / insulin / organ culture / bone-forming factors / 臨床統計 / ラット頭蓋骨 / 骨折治癒 / インシュリン / 器官培養 / 骨形成因子 / IN SITU HYBRIDIZATION / OSTEOPONTIN / MINERALIZATION / INTRACELLULAR CALCIUM / OSTEOCLAST / LOW Ca DIET / BONE RESORPTION / プロテインカイネ-スC / 細胞力Ca / in situ hybridization / オステオポンチン / 石灰化 / 細胞内Ca / Colchicine / Microtubules / Bone Histomorphometry / Low Ca Diet / コルヒチン / 微小管 / 低Ca食 / コンピュータ支援学習 / eラーニング / 臨床 / 歯科衛生士 / 口腔保健学教育 / オンデマンド / ICT活用教育 / マルチメディア / コンピュータ / シミュレーション / 教育学 / 科学教育 Less
  • Research Projects

    (25 results)
  • Research Products

    (111 results)
  • Co-Researchers

    (54 People)
  •  New bone resrption inhibitor based on agonistic function for TNF type 2 receptorPrincipal Investigator

    • Principal Investigator
      OHYA Keiichi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Standardization and Evaluation of Computer-assisted Education System on Clinical Simulation in Dental and Interprofessional Education.

    • Principal Investigator
      Kinoshita Atsuhiro
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Educational technology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of TNF-receptor Antagonists which have both Anti-inflammatory Action and Bone Formation Activity and Apply Them for the Treatment of Periodontal Diseases.Principal Investigator

    • Principal Investigator
      OHYA Keiichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Development and Evaluation of Computer-assisted Education System on Clinical Simulation in Dental Education.

    • Principal Investigator
      KINOSHITA Atsuhiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Educational technology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of new therapeutic drugs for inflammatory bone destruction by the CIAM compound, a new TNF receptor antagonist.Principal Investigator

    • Principal Investigator
      OHYA Keiichi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  破骨細胞のRANKオルタネイティブ・シグナル伝達を修飾するペプチドの創成Principal Investigator

    • Principal Investigator
      大谷 啓一
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Utilization and Evaluation of Computer-Assisted Education System on Simulation for Dental Practice Training

    • Principal Investigator
      KINOSHITA Atsuhiro
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Educational technology
    • Research Institution
      Tokyo Medical and Dental University
  •  破骨細胞のRANK-TRAF6結合を阻害する新規機能ペプチドの創成Principal Investigator

    • Principal Investigator
      大谷 啓一
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of New Hybrid-type Drugs Targeted to the Mechanism of Bone RemodelingPrincipal Investigator

    • Principal Investigator
      OHYA Keiichi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  The development of a new drug TNFα antagonistic peptide that inhibits bone destruction by cancer cells

    • Principal Investigator
      YOSHIMASU Hidemi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Tokyo medical anc Dental University
  •  Search for the new target points of bisphosphonates in bone cells: Their inhibitory actions on bone resorption and the stimulatory actions on bone formationPrincipal Investigator

    • Principal Investigator
      OHYA Keiichi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Regulation of bone resorption in jaw by the drug administration. Analysis by the 3D-bone histomorphometry and by the measurement of bone mineral density.Principal Investigator

    • Principal Investigator
      OHYA Keiichi
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Non-invasive Densitometric and Histomorphometric Study of the Regenerated Bone in the Distraction Gap in Rabbits.

    • Principal Investigator
      YOSHIMASU Hidemi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  DEVELOPMENT OF DRUG WHICH REGULATES BONE RESORPTION ACTIVITY IN OSTEOCLASTS VIA CYTOSKELTON AND SIGNAL TRANSDUCTION SYSTEMPrincipal Investigator

    • Principal Investigator
      OHYA Keiichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Study of Hard Tissue Diseases in Oromaxillofacial Region

    • Principal Investigator
      NISHIMURA Fumio
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      TOKYO MEDICAL AND DENTAL UNIVERSITY
  •  Effect of aging and a tooth defect on the shape of mandible

    • Principal Investigator
      OHYAMA Takashi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      補綴理工系歯学
    • Research Institution
      Tokyo Medical and Dental University
  •  DRUG REGULATIONS OF BONE RESORPTION IN ALVEOLAR BONE AND ITS MECHANISM OF ACTIONPrincipal Investigator

    • Principal Investigator
      OHYA Keiichi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      TOKYO MEDICAL AND DENTAL UNIVERSITY
  •  Study of bone-forming factors and their clinical evaluation

    • Principal Investigator
      AMAGASA Teruo
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      外科・放射線系歯学
    • Research Institution
      Tokyo Medical and Dental University
  •  MOLECULAR BIOLOGY OF THE INTERRELATIONSHIP BETWEEN BONE CELLS IN THE LOW CALCIUM ENVIRONMENT

    • Principal Investigator
      OGURA Hideaki
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      TOKYO MEDICAL AND DENTAL UNIVERSITY
  •  A STUDY OF THE NEW INHIBITORY DRUG FOR BONE RESORPTION, BISPHOSPHONATES, ON THE ALVEOLAR BONE RESORPTION PROCESS.Principal Investigator

    • Principal Investigator
      OHYA Keiichi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      TOKYO MEDICAL AND DENTAL UNIVERSITY
  •  非ステロイド性抗炎症薬による歯槽骨吸収抑作用に関する基礎的研究Principal Investigator

    • Principal Investigator
      大谷 啓一
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Experimental Pharmacologic Studies on the Alveolar Bone Resorption and its Recovery Mechanism.

    • Principal Investigator
      OGURA Hideaki
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Experimental Pharmacologic Study on the Mechanism of Alveolar Bone Resorption

    • Principal Investigator
      OGURA Hideaki
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Anti-calculus effect of bisphosphonates and its application for the prevention of periodontal diseases.

    • Principal Investigator
      SHINODA Hisashi
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Conservative dentistry
    • Research Institution
      Medical Research Institute, Tokyo Medical & Dental University.
  •  成熟期エナメル芽細胞の微小管の機能に関する実験薬理学的研究Principal Investigator

    • Principal Investigator
      大谷 啓一, 俣木 志郎
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokyo Medical and Dental University

All 2015 2014 2013 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] ビスフォスフォネート系薬剤との正しい付き合い方2008

    • Author(s)
      大谷啓一, 新井豊, 斎藤健一
    • Publisher
      DENTAL DIAMOND
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Book] ビスフォスフォネート製剤の現状2008

    • Author(s)
      大谷啓一
    • Publisher
      DENTAL DIAMOND Vol. 33(475)
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Book] ビスフォスフォネート製剤の現状2008

    • Author(s)
      大谷啓一
    • Publisher
      DENTAL DIAMOND
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Book] ビスフォスフォネート系薬剤との正しい付き合い方2008

    • Author(s)
      大谷啓一, 新井豊, 斎藤健一
    • Publisher
      DENTAL DIAMOND Vol. 33 (475)
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Book] ビスフォスフォネート製剤の現状2008

    • Author(s)
      大谷啓一
    • Publisher
      DENTAL DIAMOND Vol. 33 (475)
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Book] ビスフォスフォネート系薬剤との正しい付き合い方2008

    • Author(s)
      大谷啓一, 新井豊, 斎藤健一
    • Publisher
      DENTAL DIAMOND Vol. 33 (475)
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Book] 腫瘍壊死因子中和療法の新しい展開―WP9QYペプチドによる治療の可能性―2007

    • Author(s)
      青木和広, 大谷啓一
    • Publisher
      日本歯科評論 (The Nippon Dental Review)
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Book] 腫瘍壊死因子中和療法の新しい展開-WP9QYペプチドによる治療の可能性- 日本歯科評論(The Nippon Dental Review)Vol.67(7)2007

    • Author(s)
      青木和広, 大谷啓一.
    • Publisher
      株式会社ヒョーロンパブリッシャーズ
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Book] 腫瘍壊死因子中和療法の新しい展開-WP9QYペプチドによる治療の可能性-.日本歯科評論(The Nippon Dental Review)Vol.67(7)2007

    • Author(s)
      青木和広, 大谷啓一.
    • Publisher
      株式会社ヒョーロン・パブリッシャーズ
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Journal Article] Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model2015

    • Author(s)
      Toshimi Sato, Neil Alles, Masud Khan, Kenichi Nagano, Mariko Takahashi, Yukihiko Tamura, Asako Shimoda, Keiichi Ohya, Kazunari Akiyoshi, Kazuhiro Aoki
    • Journal Title

      International Journal of Nanomedicine

      Volume: 10 Pages: 3459-3473

    • DOI

      10.2147/ijn.s61566

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25670787, KAKENHI-PROJECT-25293377
  • [Journal Article] Use of a gelatin hydrogel membrane containing β-tricalcium phosphate for guided bone regeneration enhances rapid bone formation2014

    • Author(s)
      Noritake, K. Kuroda, S. Nyan, M. Atsuzawa, Y. Uo, M. Ohya, K. Kasugai, S
    • Journal Title

      Dent. Mater. J.

      Volume: 33 Issue: 5 Pages: 674-680

    • DOI

      10.4012/dmj.2014-123

    • NAID

      130004696774

    • ISSN
      0287-4547, 1881-1361
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390413, KAKENHI-PROJECT-25861882
  • [Journal Article] A disulfide bond-replacement strategy enables the efficient design of artificial therapeutic peptides2014

    • Author(s)
      Kazuhiro Aoki, Miki Maeda, Takashi Nakae, Yohei Okada, Keiichi Ohya, Kazuhiro Chiba
    • Journal Title

      Tetrahedron

      Volume: 70 Issue: 42 Pages: 7774-7779

    • DOI

      10.1016/j.tet.2014.05.079

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24380061, KAKENHI-PROJECT-24390413, KAKENHI-PROJECT-25293377, KAKENHI-PROJECT-25670787
  • [Journal Article] Gelatin hydrogel as a carrier of recombinant human fibroblast growth factor-2 during rat mandibular distraction.2014

    • Author(s)
      Kimura A, Kabasawa Y, Tabata Y, Aoki K, Ohya K, Omura K
    • Journal Title

      J Oral Maxillofac Surg.

      Volume: 72 Issue: 10 Pages: 2015-2031

    • DOI

      10.1016/j.joms.2014.03.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390413, KAKENHI-PROJECT-24591941, KAKENHI-PROJECT-25293377
  • [Journal Article] The local administration of TNF-α and RANKL antagonist peptide promotes BMP-2-induced bone formation.2013

    • Author(s)
      1. Khan, M. Alles, N. Soysa, N. Mamun, A. Nagano, K. Mikami, R. Furuya, Y. Yasuda, H. Ohya, K. Aoki
    • Journal Title

      J Oral Biosciences

      Volume: 55 Pages: 47-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670787
  • [Journal Article] Gelatin hydrogel carrier with the W9-peptide elicits synergistic effects on BMP-2-induced bone regeneration.2013

    • Author(s)
      Mamun, A.Khan, M. Alles, N. Matsui, M. Tabata, Y. Ohya, K. Aoki, K
    • Journal Title

      J Oral Biosciences

      Volume: 55 Pages: 217-223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Journal Article] Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity.2013

    • Author(s)
      Furuya Y, Inagaki A, Khan M, Mori K, Penninger JM, Nakamura M, Udagawa N, Aoki K, Ohya K, Uchida K, Yasuda H
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 8 Pages: 5562-5571

    • DOI

      10.1074/jbc.m112.426080

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23593054, KAKENHI-PROJECT-24390413, KAKENHI-PROJECT-24390417, KAKENHI-PROJECT-24593112, KAKENHI-PROJECT-25293377, KAKENHI-PROJECT-25670793
  • [Journal Article] Processing of the NF-β2 Precursor, p100, to p52 is Critical for RANKL-Induced Osteoclast Differentiation. published on 14^<th> December, 20092010

    • Author(s)
      Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, Doi T, Aoki K, Alles N, Ohya K, Hosokawa R, Jimi E.
    • Journal Title

      J Bone Miner Res. (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] The Pivotal role of the alternative NF-κB pathway in maintenance of basal bone homeostasis and osteoclastogenesis. Published on 14^<th> December, 20092010

    • Author(s)
      Soysa N, Alles N, Weih D, Lovas A, Mian H, Shimokawa H, Yasuda H, Weih F, Jimi E, Ohya K, Aoki K.
    • Journal Title

      J Bone Miner Res. (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Processing of the NF-β2 Precursor, p100, to p52 is Critical for RANKL-Induced Osteoclast Differentiation2009

    • Author(s)
      Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, Doi T, Aoki K, Alles N, Ohya K, Hosokawa R, Jimi E
    • Journal Title

      J Bone Miner Res published on 14^<th> December

    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Polysaccharide nanogel delivery of a TNF-α and RANKL antagonist peptide allows systemic prevention of bone loss.2009

    • Author(s)
      Alles N, Soysa N, Hussain A, Tomomatsu N, Saito H, Baron R, Morimoto N, Aoki K, Akiyoshi K, Ohya K.
    • Journal Title

      Eur J Pharm Sci. Vol.37

      Pages: 83-88

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Inhibition of the classical NF-kB pathway prevents OS teoclast bone-resorb ing activity2009

    • Author(s)
      Soysa N, Alles N, Shimokawa H. Jimi E, Aoki K, Ohya K.
    • Journal Title

      J Bone Miner Metab 27(2)

      Pages: 13-139

    • Data Source
      KAKENHI-PROJECT-19659486
  • [Journal Article] Three-dimensional characterization of osteoclast bone-resorbing activity in the resorption lacunae2009

    • Author(s)
      Soysa N, Alles N, Aoki K, Ohya K
    • Journal Title

      J Med & Dent Sci Vol. 56(2)

      Pages: 107-112

    • NAID

      130005420250

    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] LPS-Induced Inhibition of Osteogenesis Is TNF-α Dependent in a Murine Tooth Extraction Model2009

    • Author(s)
      Tomomatsu N, Aoki K, Alles N, Soysa N, Hussain A, Nakachi H, Kita S, Shimokawa H, Ohya K, Amagasa T
    • Journal Title

      J Bone Miner Res Vol. 24(10)

      Pages: 1770-1781

    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Three-dimensional characterization of osteoclast bone-resorbing activity in the resorption lacunae.2009

    • Author(s)
      Soysa N, Alles N, Aoki K, Ohya K.
    • Journal Title

      J Med & Dent Sci. Vol.56(2)

      Pages: 107-112

    • NAID

      130005420250

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Polysaccharide nanogel delivery of a TNF-α and RANKL antagonist peptide allows systemic prevention of bone loss2009

    • Author(s)
      Alles N, Soysa N, Hussain A, Tomomatsu N, Saito H, Baron R, Morimoto N, Aoki K, Akiyoshi K, Ohya K
    • Journal Title

      Eur J Pharm Sci Vol. 37

      Pages: 83-88

    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] LPS-Induced Inhibition of Osteogenesis Is TNF-α Dependent in a Murine Tooth Extraction Model2009

    • Author(s)
      Tomomatsu N, Aoki K, Alles N, Soysa N, Hussain A, Nakachi H, Kita S, Shimokawa H, Ohya K, Amagasa T.
    • Journal Title

      J Bone Miner Res. Vol.24(10)

      Pages: 1770-1781

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] The Pivotal role of the alternative NF-κB pathway in maintenance of basal bone homeostasis and osteoclastogenesis2009

    • Author(s)
      Soysa N, Alles N, Weih D, Lovas A, Mian H, Shimokawa H, Yasuda H, Weih F, Jimi E, Ohya K, Aoki K
    • Journal Title

      J Bone Miner Res, Published on 14^<th> December

    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] シミュレーション教材作成Faculty Developmentの実施と評価.2008

    • Author(s)
      大山篤, 吉岡隆知, 小長谷光, 俣木志朗, 荒木孝二, 大谷啓一, 木下淳博
    • Journal Title

      日本歯科医学教育学会雑誌 24

      Pages: 517-521

    • NAID

      10024177165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18300278
  • [Journal Article] Inhibition of the classical NF-kB pathway prevents osteoclast bone-resorbing activity2008

    • Author(s)
      Soysa N, Alles N, Shimokawa H, Jimi E, Aoki K, Ohya K.
    • Journal Title

      J Bone Miner Metab 27(2)

      Pages: 131-139

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis.2008

    • Author(s)
      Asagiri M, Hirai T, Kunigami T, Kamano S, Gober H-J. Okamoto K, Nishikawa K, Latz E, Golenbock D. T, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Rato S, Saftig P, Takayanagi H.
    • Journal Title

      Science Vol. 319

      Pages: 624-627

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthri tis.2008

    • Author(s)
      Asagiri M, Hirai T, KunigamiT, Kamano S, Gober H-J, Okamoto K, Nishikawa K, Latz E, Golenbock D. T, Aoki K, OhyaK, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H.
    • Journal Title

      Science Vol. 319

      Pages: 624-627

    • Data Source
      KAKENHI-PROJECT-19659486
  • [Journal Article] シミュレーション教材作成Faculty Developmentの実施と評価2008

    • Author(s)
      大山篤, 吉岡隆知, 小長谷光, 俣木志朗, 荒木孝二, 大谷啓一, 木下淳博
    • Journal Title

      日本歯科医学教育学会雑誌 24(1)

      Pages: 88-101

    • NAID

      10024177165

    • Data Source
      KAKENHI-PROJECT-18300278
  • [Journal Article] Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo.2008

    • Author(s)
      Mian MD, Saito H, Alles N, Shimokawa H, Aoki K, Ohya K.
    • Journal Title

      J Bone Miner Metab Vol. 26

      Pages: 469-477

    • NAID

      10024459458

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Inhibition of the classical NF-κB oathway prevents osteoclast bone-resorbing activity2008

    • Author(s)
      Soysa N, Alles N, Shimokawa H, Jimi E, Aoki K, Ohya K
    • Journal Title

      J Bone Miner Metab Vol. 27(2)

      Pages: 131-139

    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Lipopolysaccharide-induced bone resorption is increased in TNFtype 2 receptor-deficient mice in vivo.2008

    • Author(s)
      Mian MD, Saito H, Alles N, Shimokawa H, Aoki K, Ohya K.
    • Journal Title

      J Bone Miner Metab Vol. 26

      Pages: 469-477

    • NAID

      10024459458

    • Data Source
      KAKENHI-PROJECT-19659486
  • [Journal Article] Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo2008

    • Author(s)
      Mian MD, Saito H, Alles N, Shimokawa H, Aoki K, Ohya K
    • Journal Title

      J Bone Miner Metab Vol. 26

      Pages: 469-477

    • NAID

      10024459458

    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis2008

    • Author(s)
      Asagiri M, Hirai T, Kunigami T, Kamano S, Gober H-J, Okamoto K, Nishikawa K, Latz E, Golenbock D. T, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H
    • Journal Title

      Science Vol. 319

      Pages: 624-627

    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis.2007

    • Author(s)
      Saito H, Kojima T, Takahashi M, Horne WC, Baron R, Amagasa T, Ohya K, Aoki K.
    • Journal Title

      Arthritis and rheumatism 56

      Pages: 1164-1174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis2007

    • Author(s)
      Saito H, Kojima T, Takahashi M, Horne WC, Baron R, Amagasa T, Ohya K, Aoki K
    • Journal Title

      Arthritis Rheum 56

      Pages: 1164-1174

    • Data Source
      KAKENHI-PROJECT-19390471
  • [Journal Article] A tumor necrosis factor receptor loop peptide mimic inhibitsbone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis.2007

    • Author(s)
      Saito H, Kojima T, Takahashi M, Horne WC, Baron R, Amagasa T, Ohya K, Aoki K.
    • Journal Title

      Arthritis and rheumatism 56

      Pages: 1164-1174

    • Data Source
      KAKENHI-PROJECT-19659486
  • [Journal Article] Three-Dimensional Measurements of Bone Resorption Lacunae Reveal Inhibition of Osteoclast Activity by TNF-α Antagonist In Vitro.2006

    • Author(s)
      Saito H, Soysa N, Alles N, Aoki K, Ohya K.
    • Journal Title

      Dentistry in Japan 42

      Pages: 35-37

    • NAID

      10019595335

    • Data Source
      KAKENHI-PROJECT-17659583
  • [Journal Article] A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.2006

    • Author(s)
      Aoki K., Saito H., Itzstein C., Ishiguro M., Shibata T., Blanque R., Mian AH., Takahashi M., Suzuki Y., Yoshimatsu M., Yamaguchi A., Deprez P., Mollat P., Murali R., Ohya K., Horne WC., Baron R.
    • Journal Title

      The Journal of Clinical Investigation 116 (6)

      Pages: 1525-1534

    • Data Source
      KAKENHI-PROJECT-17659583
  • [Journal Article] Three-Dimensional Measurements of Bone Resorption Lacunae Reveal Inhibition of Osteoclast Activity by TNF-α Antagonist In Vitro.2006

    • Author(s)
      Saito H, Soysa N, Alles N, Aoki K, Ohya K.
    • Journal Title

      Dentistry in Japan 42

      Pages: 35-37

    • NAID

      10019595335

    • Data Source
      KAKENHI-PROJECT-16209053
  • [Journal Article] Subcutaneous Injections of a TNF-α Antagonistic Peptide Inhibit Both Inflammation and Bone Resorption in Collagen-Induced Murine Arthritis.2005

    • Author(s)
      Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese BJ, Yoshimasu H, Baron R, Ohya K, Amagasa T
    • Journal Title

      Journal of Dental and Medical Sciences 52・1

      Pages: 91-99

    • NAID

      110001065281

    • Data Source
      KAKENHI-PROJECT-16209053
  • [Journal Article] Selective inhibition of NF-kB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo.2004

    • Author(s)
      Jimi F, Aoki K, Saito H, D'Acquisto F, May MJ, Nakamura I, Sudo T, Kojima T, Okamoto F, Fukushima H, Okabe K, Ohya K, Ghosh S
    • Journal Title

      Nature Medicine 10・6

      Pages: 617-624

    • Data Source
      KAKENHI-PROJECT-16209053
  • [Journal Article] A TNF-α antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalls infection in mice.

    • Author(s)
      Suzuki Y, Aoki K, Saito H, Umeda M, Nitta H, Baron R, Ohya K.
    • Journal Title

      Journal of Periodontal Research In Press

    • Data Source
      KAKENHI-PROJECT-16209053
  • [Presentation] NanoClikナノ粒子のペプチド徐放性の検討―NanoClikナノ粒子がW9の骨吸収抑制作用を助けるメカニズム―.2015

    • Author(s)
      佐藤俊三、田村幸彦、大谷啓一、青木和広
    • Organizer
      第35回日本歯科薬物療法学会学術大会
    • Place of Presentation
      鶴見大学(横浜市)
    • Year and Date
      2015-06-20
    • Data Source
      KAKENHI-PROJECT-25670787
  • [Presentation] An Osteoprotegerin-like Peptide Inhibits Bone Loss in Collagen Type II-Induced Murine Arthritis.2013

    • Author(s)
      Kato, G. Maeda, M. Alles, N. Mamun, A. Khan, M. Sugamori, Y. Takahashi, M. Tamura, Y. Murali, R. Ohya, K. Aoki, K.
    • Organizer
      IBMS/JSBMR第2回合同国際会議
    • Place of Presentation
      神戸/神戸コンベンションセンター・神戸ポートピアホテル
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Presentation] Bone resorption inhibitor peptides work as a bone formation stimulator.2013

    • Author(s)
      Aoki,K. Murali,R. Ohya,K.
    • Organizer
      The 3rd Tri-University Consortium on Oral Science and Education
    • Place of Presentation
      東京/東京医科歯科大学
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Presentation] CHPナノゲル担体のPEG架橋により骨吸収抑制ペプチドの作用は増強する-低Ca食飼育によるマウス骨吸収促進モデルにおける検討.2013

    • Author(s)
      佐藤 俊三、田村 幸彦、大谷 啓一、青木 和広.
    • Organizer
      第33回日本歯科薬物療法学会学術大会
    • Place of Presentation
      東京/東京医科歯科大学
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Presentation] An Osteoprotegerin-like Peptide Prevents Bone Loss in Collagen-Induced Murine Arthritis.2013

    • Author(s)
      Kato,G. Shimizu,Y. Mamun,M. Murali,R. Ohya,K. Aoki,K.
    • Organizer
      The 3rd Tri-University Consortium on Oral Science and Education
    • Place of Presentation
      東京/東京医科歯科大学
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Presentation] コンピュータシミュレーション教育システムによる診療模擬実習の展開2010

    • Author(s)
      木下淳博, 大谷啓一, 荒木孝二, 吉田直美, 小長谷光, 樺沢勇司, 大山篤, 近藤圭子, 須永昌代, 和達礼子, 中村輝保
    • Organizer
      2010年度ICT利用による教育改善研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-07
    • Data Source
      KAKENHI-PROJECT-21300303
  • [Presentation] 医歯学シミュレーション教育システムによる教材開発と活用2010

    • Author(s)
      須永昌代,山口久美子,窪田哲朗,大川淳,木下淳博,大谷啓一,荒木孝二,田中雄二郎
    • Organizer
      第4回医療系大学eラーニング全国交流会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21300303
  • [Presentation] 医歯学シミュレーション教育システムによる教材開発と活用.2010

    • Author(s)
      須永昌代, 山口久美子, 窪田哲朗, 大川淳, 木下淳博, 大谷啓一, 荒木孝二, 田中雄二郎
    • Organizer
      第4回医療系大学eラーニング全国交流会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-19
    • Data Source
      KAKENHI-PROJECT-21300303
  • [Presentation] コンピュータシミュレーション教育システムによる診療模擬実習の展開2010

    • Author(s)
      木下淳博,大谷啓一,荒木孝二,吉田直美,小長谷光,樺沢勇司,大山篤,近藤圭子,須永昌代,和達礼子,中村輝保
    • Organizer
      平成22年度ICT利用による教育改善研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-07
    • Data Source
      KAKENHI-PROJECT-21300303
  • [Presentation] 東京医科歯科大学での臨床検査技師卒前教育におけるe-learningシステムの利用について2010

    • Author(s)
      長雄一郎, 千田俊雄, 齋藤良一, 窪田哲朗, 木下淳博, 大谷啓一, 田中雄二郎, 佐藤健次
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-11
    • Data Source
      KAKENHI-PROJECT-21300303
  • [Presentation] 東京医科歯科大学での臨床検査技師卒前教育におけるe-learningシステムの利用について2010

    • Author(s)
      長雄一郎,千田俊雄,齋藤良一,窪田哲朗,木下淳博,大谷啓一,田中雄二郎,佐藤健次
    • Organizer
      第57回日本臨床検査医学会学術集会.臨床病理
    • Place of Presentation
      ポスター,東京
    • Data Source
      KAKENHI-PROJECT-21300303
  • [Presentation] 薬理学実習への医歯学シミュレーション教材の導入と教育効果.2009

    • Author(s)
      大谷啓一, 田村幸彦, 高橋真理子, 木下淳博
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-17
    • Data Source
      KAKENHI-PROJECT-18300278
  • [Presentation] Inhibition of IKK-β blocks osteoclast formation and activity2009

    • Author(s)
      Ohya K, Soysa N, Alles N, Aoki K
    • Organizer
      1^<st> meeting of the IADR APR
    • Place of Presentation
      武漢 (中国)
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] Lack of precursor p100 of NFκB2 causes osteopenia in mice.2009

    • Author(s)
      Soysa N, Alles N, Aoki K, Ohya K.
    • Organizer
      The 29^<th> Japanese Society for Bone Morphometry(第29回骨形態計測学会)
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] TNF-α誘導の骨吸収に対するTNFR2の役割.2009

    • Author(s)
      永野健一、青木和広、Neil Alles、大谷啓一
    • Organizer
      第51回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] 薬理学実習への医歯学シミュレーション教材の導入と教育効果2009

    • Author(s)
      大谷啓一、田村幸彦、高橋真理子、木下淳博
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-07
    • Data Source
      KAKENHI-PROJECT-18300278
  • [Presentation] The control release of TNF-α is necessary to mimic the LPS-induced bone resorption on calvaria.2009

    • Author(s)
      Nagano K, Aoki K, Mian H, Alles N, Shimokawa H, Morimoto N, Akiyoshi K, Ohya K.
    • Organizer
      第82回日本薬理学会年会.
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] NF-κB非古典的経路における破骨細胞分化調節機構2009

    • Author(s)
      福島秀文, 進正史, 丸山俊正, 青木和広, 大谷啓一, 細川隆司, 自見英治郎
    • Organizer
      第51回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] 炎症時の抜歯後骨新生は、NBDペプチドにより亢進される-LPS投与抜歯窩骨新生モデルを用いた検討-2009

    • Author(s)
      中地浩之, 友松伸允, 天笠光雄, 大谷啓一
    • Organizer
      第29回日本歯科薬物療法学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] LPS投与による抜歯後の骨新生は、TNF-α依存的に抑制される.2009

    • Author(s)
      中地浩之、青木和広、友松伸允、永野健一、Neil Alles、Niroshani Soysa、下川仁彌太、天笠光雄、大谷啓一
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] TNF-α誘導の骨吸収に対するTNFR2の役割2009

    • Author(s)
      永野健一, 青木和広, Neil Alles, 大谷啓一
    • Organizer
      第51回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] Inhibition of IKK-β blocks osteoclast formation and activity.2009

    • Author(s)
      Ohya K, Soysa N, Alles N, Aoki K.
    • Organizer
      1^<st> meeting of the IADR APR.
    • Place of Presentation
      武漢(中国)
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] 東京医科歯科大学の臨床検査学教育におけるe-learningシステムについて.2009

    • Author(s)
      長雄一郎, 後藤明久, 中川内光江, 松尾敦子, 須永昌代, 木下淳博, 大谷啓一, 田中雄二郎, 窪田哲朗, 佐藤健次
    • Organizer
      第4回日本臨床検査学教育学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2009-08-20
    • Data Source
      KAKENHI-PROJECT-21300303
  • [Presentation] LPS投与による抜歯後の骨新生は、TNF-α依存的に抑制される2009

    • Author(s)
      中地浩之, 青木和広, 友松伸允, 永野健一, Neil Alles, Niroshani Soysa, 下川仁彌太, 天笠光雄, 大谷啓一
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] The control release of TNF-α is necessary to mimic the LPS-induced bone resorption on calvaria2009

    • Author(s)
      Nagano K, Aoki K, Mian H, Alles N, Akiyoshi K, Ohya K
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] The control release of TNF-α is necessary to mimic the LPS-induced bone resorption on calvaria.2009

    • Author(s)
      Nagano K, Aoki K, Mian H, Alles N, Shimokawa H, MoriiotoN, Akiyoshi K, Ohya K.
    • Organizer
      第82回日本薬理学会年会.
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] NF-kB非古典的経路における破骨細胞分化調節機構.2009

    • Author(s)
      福島秀文、進正史、丸山俊正、青木和広、大谷啓一、細川隆司、自見英治郎
    • Organizer
      第51回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] 東京医科歯科大学の臨床検査学教育におけるe-learningシステムについて2009

    • Author(s)
      長雄一郎,後藤明久,中川内光江,松尾敦子,須永昌代,木下淳博,大谷啓一,田中雄二郎,窪田哲朗,佐藤健次
    • Organizer
      第4回日本臨床検査学教育学会学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21300303
  • [Presentation] Lack of precursor p100 of NFκB2 causes osteopenia in mice2009

    • Author(s)
      Soysa N, Alles N, Aoki K, Ohya K
    • Organizer
      The 29^<th> Japanese Society for Bone Morphometry (第29回骨形態計測学会)
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] TNF-α-induced bone resorption model using CHP nanogel in mice.2008

    • Author(s)
      Nagano K, Aoki K, Mian A. H, Alles N, Shimoda A, Morimoto N, Akiyoshi R, Ohya K
    • Organizer
      Japanese Association for Dental Research 56th Annual Meeting
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] TNF-α-induced bone resorption model using CHP nanogel in mice2008

    • Author(s)
      Nagano K, Aoki K, Mian A. H, Alles N, Shimoda A, Morimoto N, Akiyoshi K, Ohya K
    • Organizer
      Japanese Association for Dental Research 56^<th> Annual Meeting
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] NIK MUTATION IN ALY/ALY MICE CAUSES OSTEOPETROSIS AND REDUCE RANKL INDUCED OSTEOCLASTOGENESIS.2008

    • Author(s)
      Soysa N, Alles N, Mian MD, Yasuda H, Jimi E, Shimokawa H, Aoki K, Ohya K.
    • Organizer
      2^<nd> International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Rhodes (Greece)
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] TNF-α-induced bone resorption model using CHP nanogel in mice.2008

    • Author(s)
      Nagano K, Aoki K, Mian A. H, Alles N, Shimoda A, Morimoto N, Akiyoshi K, Ohya K.
    • Organizer
      Japanese Association for Dental Research 56^<th> Annual Meeting
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] LPS-induced Inhibition of Osteogenesis is TNF-α Dependent.2008

    • Author(s)
      Totaoniatsu N, Aoki K, HussainMA, Alles N, Shimokawa H, Amagasa T, Ohya K.
    • Organizer
      30^<th> ASBMR Annual Meeting
    • Place of Presentation
      Montreal
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] LPS-induced Inhibition of Osteogenesis is TNF-α Dependent2008

    • Author(s)
      Tomomatsu N, Aoki K, Hussain MA, Alles N, Shimokawa H, Amagasa T, Ohya K
    • Organizer
      30^<th> ASBMR Annual Meeting
    • Place of Presentation
      Montreal
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] LPS投与による抜歯後骨新生の抑制はTNF-α依存的である2008

    • Author(s)
      友松伸允, 青木和広, Mian MD, 下川仁彌太, 天笠光雄, 大谷啓一
    • Organizer
      第28回日本骨形態計測学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] 破骨細胞機能抑制ペプチドによる臨床応用の可能性2008

    • Author(s)
      青木和広, Alles N, Soysa N, 自見英治郎, 下川仁彌太, 大谷啓一
    • Organizer
      第50回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] Defective Alternative Pathway of NF-κB Causes Mild Osteopetrosis in Mice.2008

    • Author(s)
      Soysa N, Alles N, Aoki K, Shimokawa H, Jimi E, Ohya K.
    • Organizer
      86^<th> General Session &Exhibition of the IADR
    • Place of Presentation
      Toronto
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] Defective Alternative Pathway of NF-κB Causes Mild Osteopetrosis in Mice2008

    • Author(s)
      Soysa N, Alles N, Aoki K, Shimokawa H, Jimi E, Ohya K
    • Organizer
      86^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      Toronto
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] 医歯学シミュレーション教材による薬理学実習の教育効果2008

    • Author(s)
      大谷啓一, 田村幸彦, 木下淳博
    • Organizer
      第27回日本歯科医学教育学会学術大会, プログラム・抄録集
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
    • Data Source
      KAKENHI-PROJECT-18300278
  • [Presentation] 医歯学シミュレーション教材による薬理学実習の教育効果2008

    • Author(s)
      大谷啓一, 田村幸彦, 木下淳博
    • Organizer
      第27回日本歯科医学教育学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
    • Data Source
      KAKENHI-PROJECT-18300278
  • [Presentation] Drug development for inflammatory bone disease.2008

    • Author(s)
      Aoki K, Ohya K.
    • Organizer
      The 81th Annual Meeting of the Japanese Pharmacological Society(第81回日本薬理学会年会).
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] NIK MUTATION IN ALY/ALY MICE CAUSES OSTEOPETROSIS AND REDUCE RANKL INDUCED OSTEOCLASTOGENESIS2008

    • Author(s)
      Soysa N, Alles N, Mian MD, Yasuda H, Jimi E, Shimokawa H, Aoki K, Ohya K
    • Organizer
      2^<nd> International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Rhodes (Greece)
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] LPS-induced Inhibition of Osteogenesis is TNF-a Dependent.2008

    • Author(s)
      Tomoiatsu N, Aoki K, Hussain MA, Alles N, Shimokawa H. Amagasa T, Ohya K.
    • Organizer
      30^<th> ASBMR Annual Meeting
    • Place of Presentation
      Montreal
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] NIK MUTATION IN ALY/ALY MICE CAUSES OSTEOPETROSIS AND REDUCE RANKL INDUCED OSTEOCLASTOGENESIS.2008

    • Author(s)
      Soysa N, Alles N, Mian MD, Yasuda H, Jimi E, Shimokawa H, Aoki R, Ohya K.
    • Organizer
      2nd International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Rhodes (Greece)
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] 破骨細胞機能抑制ペプチドによる臨床応用の可能性2008

    • Author(s)
      青木和広, Alles N, Soysa N, 自見英治郎, 下川仁彌太, 大谷啓一
    • Organizer
      第50回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] 機械的非荷重による骨量減少におけるNF-κβシグナルの役割.2007

    • Author(s)
      自見英治郎, 青木和広, 仲村一郎, 大谷啓一.
    • Organizer
      第25回日本骨代謝学会学術集会25th Annual Meeting of the Japanese Society for Bone and Mineral Research.
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] Canonical NF-κβ pathway mediates osteoclast boneresorption activity.2007

    • Author(s)
      Soysa N, Alles N, 青木和広, 自見英治郎, 大谷啓一.
    • Organizer
      第25回日本骨代謝学会学術集会25th Annual Meeting of the Japanese Society for Bone and Mineral Research.
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] 歯学部卒前学生による医歯学シミュレーション教育システムに対する評価2007

    • Author(s)
      吉岡隆知, 小長谷光, 吉田直美, 大山篤, 樺沢勇司, 南一郎, 長澤敏行, 須永昌代, 須田英明, 大谷啓一, 荒木孝二, 木下淳博
    • Organizer
      第26回日本歯科医学教育学会学術大会, プログラム・抄録集
    • Place of Presentation
      岐阜
    • Year and Date
      2007-07-06
    • Data Source
      KAKENHI-PROJECT-18300278
  • [Presentation] 機械的非荷重による骨量減少におけるNF-κB シグナルの役割2007

    • Author(s)
      自見英治郎, 青木和広, 仲村一郎, 大谷啓一
    • Organizer
      第25回日本骨代謝学会学術集会25th Annual Meeting of the Japanese Society for Bone and Mineral Research
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] 骨の最新情報-骨疾患治療薬の現状と未来.2007

    • Author(s)
      大谷啓一.
    • Organizer
      The 10th Special Meeting of Innovational Advanced Implant Association.
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] 骨の最新情報―骨疾患治療薬の現状と未来2007

    • Author(s)
      大谷啓一
    • Organizer
      The 10^<th> Special Meeting of Innovational Advanced Implant Association
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390471
  • [Presentation] 骨の最新情報-骨疾患治療薬の現状と未来.2007

    • Author(s)
      大谷啓一.
    • Organizer
      The 10th Special Meeting of Innovational Advanced Implant Association.
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] 歯学部卒前学生による医歯学シミュレーション教育システムに対する評価2007

    • Author(s)
      吉岡隆知, 小長谷 光, 吉田直美, 大山 篤, 樺沢勇司, 南 一郎, 長澤敏行, 須永昌代, 須田英明, 大谷啓一, 荒木孝二, 木下淳博
    • Organizer
      第26回日本歯科医学教育学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2007-07-06
    • Data Source
      KAKENHI-PROJECT-18300278
  • [Presentation] Defective NIK Causes Impaired Osteoclastogenesis and Mild Osteopetrosis in Mice2007

    • Author(s)
      Soysa N, Alles N, Aoki K, Shimokawa H, Jimi E, Ohya K.
    • Organizer
      The 55th Annual Meeting of Japanese Association for Dental Research.
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] Canonical NF-κβ Pathway Mediates Osteoclast Bone Resorption Activity.2007

    • Author(s)
      Soysa N, Alles N, Aoki K, Jimi E, Ohya K.
    • Organizer
      ASBMR 29th Annual Meeting・
    • Place of Presentation
      Honolulu
    • Data Source
      KAKENHI-PROJECT-19659486
  • [Presentation] 医歯学シミュレーション教育システムの薬理学実習教材への応用2006

    • Author(s)
      大谷啓一、高橋真理子、田村幸彦、木下淳博
    • Organizer
      第25回日本歯科医学教育学会学術大会, プログラム・抄録集
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-18300278
  • [Presentation] 薬理学実習における医歯学シミュレーション教育システムの応用と評価

    • Author(s)
      高橋真理子,田村幸彦,青木和広,須永昌代,木下淳博,大谷啓一
    • Organizer
      第33回日本歯科医学教育学会
    • Place of Presentation
      北九州
    • Year and Date
      2014-07-04 – 2014-07-05
    • Data Source
      KAKENHI-PROJECT-24300280
  • [Presentation] RANKL結合ペプチドの骨吸収抑制作用と骨形成促進作用

    • Author(s)
      青木和広、菅森泰隆、加藤玄樹、上原智己、新井祐貴、Md.Zahirul Haq Bhuyan、Neil Alles、Masud Khan、高橋真理子、田村幸彦、若林則幸、大谷啓一
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-25670787
  • [Presentation] RANKL-binding peptides increased bone formation in a murine calvarial defect model

    • Author(s)
      Sugamori,Y. Honma,M. Kato,G. Tamura,Y. Furuya,Y. YasudaH, Tabata,Y. Udagawa,N. Ohya,K. Suzuki,H. Aoki,K
    • Organizer
      アメリカ骨代謝学会2014
    • Place of Presentation
      ヒューストン、アメリカ
    • Year and Date
      2014-09-12 – 2014-09-15
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Presentation] マウス骨吸収モデルにおいてPEG架橋したCHPナノゲルは合成ペプチドW9の骨量減少抑制効果を増強した

    • Author(s)
      佐藤俊三、青木和広、田村幸彦、大谷啓一
    • Organizer
      第34回日本歯科薬物療法学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-21 – 2014-06-22
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Presentation] RANKL結合ペプチドの骨吸収抑制作用と骨形成促進作用

    • Author(s)
      青木和広、菅森泰隆、加藤玄樹、上原智己、新井祐貴、Md.Zahirul Haq Bhuyan、Neil Alles、Masud Khan、高橋真理子、田村幸彦、若林則幸、大谷啓一
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Presentation] Ⅱ型ウシコラーゲン誘導のマウス関節リウマチモデルを用いたRANKL結合ペプチドの骨形成促進作用と骨吸収抑制作用

    • Author(s)
      加藤玄樹、清水康広、菅森泰隆、田村幸彦、小野卓史、大谷啓一、青木和広
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Presentation] RANKL結合ペプチドはマウス頭蓋骨欠損モデルの骨新生を促進する

    • Author(s)
      菅森泰隆、本間雅、加藤玄樹、田村幸彦、古屋優里子、保田尚孝、田畑泰彦、宇田川信之、大谷啓一、鈴木洋史、青木和広
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-24 – 2014-07-26
    • Data Source
      KAKENHI-PROJECT-24390413
  • [Presentation] RANKL結合ペプチドはマウス頭蓋骨欠損モデルの骨新生を促進する

    • Author(s)
      菅森泰隆、本間雅、加藤玄樹、田村幸彦、古屋優里子、保田尚孝、田畑泰彦、宇田川信之、大谷啓一、鈴木洋史、青木和広
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2014-07-24 – 2014-07-26
    • Data Source
      KAKENHI-PROJECT-25670787
  • 1.  AOKI Kazuhiro (40272603)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 80 results
  • 2.  TAKAHASHI Mariko (90334440)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 6 results
  • 3.  KASUGAI Shohei (70161049)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  OGURA Hideaki (20013831)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  SUMIKAWA Maki (10216492)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  KINOSHITA Atsuhiro (10242207)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 18 results
  • 7.  ARAKI Kouji (70167998)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 8.  KOHASE Hikaru (20251548)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 9.  KABASAWA Yuhji (10396963)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 10.  MINAMI Ichiro (70396951)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 11.  YOSHIDA Naomi (50282760)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 12.  OHYAMA Atsushi (50361689)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 13.  WADACHI Reiko (00334441)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 14.  YOSHIOKA Takatomo (60323698)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 15.  MARUKAWA Eriko (40419263)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  JIMI Eijiro (40276598)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 15 results
  • 17.  KONDO Keiko (20282759)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 18.  SUNAGA Masayo (90581611)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 19.  NIFUJI Akira (00240747)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 20.  MATAKI Shiro (80157221)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 21.  ISHIKAWA Isao (10014151)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 22.  YOSHIMASU Hidemi (70137933)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 23.  NAKAMURA Teruyasu (80396994)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 24.  ADACHI Toshiko (90420265)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  TAMURA Yukihiko (40188446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 26.  TAKEUCHI Yasuo (60396968)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  MATSUMOTO Akira (40064365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  AMAGASA Teruo (00014332)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  FUJII Eiji (20221541)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  NISHIMURA Fumio (10013856)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  KURODA Takayuki (10013939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  ETOH Kazuhiro (30014161)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  OHYAMA Takashi (50064366)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  MUKOHYAMA Hitoshi (00242214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  SHIMOKAWA Hitoyata (80014257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  SHINODA Hisashi (80014025)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  NOGUCHI Toshihide (50014262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  齋藤 広章 (00431966)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  田中 義浩 (20361719)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  天野 均 (90212571)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  柴田 達也 (90323708)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  根岸 明秀 (60270914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  俣木 志郎
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  IBRAHIM Elza
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  SOSROSOEDIRD バンバン イ
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  SOEKANTO Ang
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  PRAYITNO Sit
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  HOESIN Faruk
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  NISHIMURA Yoshie
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  西村 佳恵
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  NAKAMURA Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 52.  千葉 一裕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 53.  中村 美どり
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 54.  宇田川 信之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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