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SEISHIMA Mitsuru  清島 満

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Researcher Number 10171315
Other IDs
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Affiliation (based on the past Project Information) *help 2015 – 2019: 岐阜大学, 大学院医学系研究科, 教授
2012 – 2015: 岐阜大学, 医学(系)研究科(研究院), 教授
2013: 岐阜大学, 医学系研究科, 教授
2012: 岐阜大学, 医学系研究科, 医学系研究科
2011: 岐阜大学, 医学研究科, 教授 … More
2010 – 2011: 岐阜大学, 医学系研究科, 教授
2009: Gifu University, 大学院・医学系研究科, 教授
2008: 岐阜大学, 医学研究科, 教授
2007: Gifu University, Graduate School of Medicine, Professor
2006: 岐阜大学, 大学院医学系研究科, 教授
2005: GIFU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学系研究科, 教授
2004: 岐阜大学, 大学院・医学研究科, 教授
1997 – 2003: Gifu University, School of Medicine, Professor, 医学部, 教授
1996: Div.Central Lab.Gifu Univ.School.Med.Assis.Prof., 医学部・附属病院, 講師
1995 – 1996: 岐阜大学, 医学部附属病院, 講師
1993 – 1994: 岐阜大学, 医学部, 講師
1991 – 1993: 岐阜大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Laboratory medicine / Laboratory medicine / Gastroenterology
Except Principal Investigator
Laboratory medicine / Laboratory medicine / Orthopaedic surgery / 食品科学・栄養科学 / Circulatory organs internal medicine / Gastroenterology / Gastroenterology / Metabolomics / Neurochemistry/Neuropharmacology / Eating habits
Keywords
Principal Investigator
Atherosclerosis / アポA-IV / Apo A-IV / Cytokine / Bone marrow transplantation / Knockout mouse / スタチン製剤 / 筋障害 / 細胞内カルシウム / リアノジン受容体 … More / 遺伝子解析 / フローサイトメトリー / FACS / CPTII遺伝子 / B型肝炎ウイルス / インドールアミン酸素添加酵素 / 細胞傷害性T細胞 / 急性肝炎 / 肝炎ウイルス / 細胞障害性T細胞 / 遺伝子多型性 / 高脂血症 / Polymorphism / Hyperlipidemia / 脂肪酸 / CaCo-2cell / CaCoー2cell / Fatty acids / CaCo-2 cell / Lipid-free apolipoprotein / Coronary heart desease / pre β HDL / Coronary heart disease / ELISA / preβ HDL / Lipid-free-free apolipoprotein / Corobary heart disease / pre βHDL / Cytokines / Apoptosis / 臨床プロテオーム / バイオマーカー / 臨床検査 / 質量分析 / プロテオーム / clinical proteome / biomarker / clinical test … More
Except Principal Investigator
TNF-α / サイトカイン / 動脈硬化 / ノックアウトマウス / コレステロール / HepG2 / cholesterol / Atherosclerosis / TNF / インドールアミン酸素添加酵素 / Lp(a)表現型 / 虚血性心疾患 / ラテックス免疫比濁法 / ELISA法 / BRM / 慢性関節リウマチ / ポリフェノール / アポリポタンパク質A-I / ゲニステイン / Caco-2細胞 / ラット / 大豆イソフラボン / apolipoprotein A-I / genistein / encephalomyocarditis virus / interferon-γ / tumor necrosis factor-α / interleukin-1 / knockout mice / マクロファージ / ICAM-1 / VCAM-1 / MCP-1 / Macrophage / AIDS / 胆汁酸 / NF-κB / NF-kB / 骨髄移植 / 急性肝障害モデル / IL-6 / ガラクトースアミン / LPS / 生存率 / 臨床検査医学 / 生理活性物質 / 炎症・免疫 / 臨床化学 / トリプトファン代謝 / α-ガラクトシルセラミド / NKT細胞免疫療法 / 腫瘍 / IDO / α- ガラクトシルセラミド / NKT細胞 / 腫瘍免疫 / 一酸化窒素 / 免疫抑制因子 / NKT細胞 / 癌転移 / 癌免疫療法 / 癌進展 / リポ蛋白(a) / 急性相反応 / インターロイキン-6 / 血液凝固線溶 / プラスミノーゲン / 血液凝固線溶系 / 組織修復 / リポ蛋白(a)[Lp(a)] / 糖尿病 / アポ(a)表現型 / トリグリセリド・リッチ・リポ蛋白 / イオン強度 / Lipoprotein(a) / Lp(a) phenotype / Coronary artery disease / Acute phase reactant / Interleukin-6 / Coagulation / Fibrinolysis / Plasminogen / アポ(a) / TIA法 / LIA法 / アポ(a)イソ型 / 表現型分類 / 遺伝型分類 / 制限酵素KpnI / 免疫比濁法 / ラテックス免疫凝集比濁法 / 自動分析装置 / パーソナルコンピューター / 表現型 / 遺伝型 / 自動化 / コンピュータ処理 / Apolipoprotein(a) / ELISA / TIA / LIA / Apo(a) isoform / Phenotype / Genotype / Restriction enzyme KpnI / 悪性骨腫瘍 / 抗癌剤 / 免疫化学療法 / 動注療法 / malignant bone tumor / anti-cancer agent / immunochemotherapy / intra-arterial infusion chemotherapy / レトロウィルス / 遺伝子解析 / インターロイキン2 / 可溶性L-selectin / 接着分子 / レトロウイルス / rheumatoid arthritis / soluble interleukin-2 receptor / lymphocyte phenotypes / retrovirus / immunotherapy / ヘスペレチン / 大豆ペプチド / キトサン / ラツト / リン脂質 / カゼイン / ワイン / 遺伝子プロモーター / polyphenol / hesperetin / soy peptides / chitosan / rat / ウイルス心筋炎 / ウィルス心筋炎 / interleukin-6 / IFN-γ / INF-α / IL-1β / viral myocarditis / cytokine / アポトーシス / Fas蛋白 / 慢性関節リウマチ(RA) / Rheumatoid arthritis / Apoptosis / Soluble Fas / Cytokine / アポリポ蛋白E / Apolipoprotein E / Knockout Mice / 大豆 / アポリポプロテインA-I / イソフラボン / エストロゲン / エストロゲン受容体 / HDL / soybean / isoflavonoid / estrogen / estrogen receptor / 痴呆 / indoleamine-2,3-dioxygenase / NO合成酵素 / 炎症性脳神経疾患 / 脳神経疾患 / トキソプラズマ / dementia / indoleamine-2, 3-dioxygenase / NO synthase / inflammatory neurological disorders / β-ラクトグロブリン / マウス / コレステロール7α-水酸化酵素 / HMG-CoA還元酵素 / 牛乳 / 遺伝子 / コレステロール輸送担体 / β-lactoglobulin / mouse / CYP7A1 / HMG-CoAreductase / bile acid / milk / 再灌流傷害 / トランスジェニックマウス / 炎症細胞浸潤 / 接着因子 / ケモカイン / 心筋虚血 / 再灌流障害 / 好中球 / ischemia / reperfusion injury / transgenic mice / NE-κB / inflammatory cell infiltration / cell adhesion molecules / chemokines / プロテオミクス / proteomics / macrophage / Proteomics / 炎症性腸疾患 / TNFR-KOマウス / プロテオーム解析 / 炎症性腸モデル / Trinitrobenzene suiphonic acid (TNBS) / 実験的大腸炎モデル / TNFRノックアウトマウス / Inflammatory Bowel Disease / TNFR-KO mouse / Proteome / 高脂血症 / スタチン系薬剤 / 横紋筋融解症 / hyperlipidemia / statin drugs / rhabdomvosis / HBV / 小動物疾患モデル / 宿主免疫応答 / 抗HBV剤 / HSV-TK / 動物モデル / B型肝炎 / HSV-TKマウス / 肝障害 / HSV-Tkマウス / 免疫学 / ペプチド / FP / IIAEK / アルカリフォスファターゼ / ラクトスタチン / 大豆β-コングリシニン / Caco-2 / ペプチドアレイ / 脂質ラフト / β-コングリシニン / ソイスタチン / ミセル Less
  • Research Projects

    (28 results)
  • Research Products

    (52 results)
  • Co-Researchers

    (40 People)
  •  Fundamental study on the lipid lowering peptides derived from food proteins

    • Principal Investigator
      Nagaoka Satoshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Eating habits
    • Research Institution
      Gifu University
  •  Development of an HBV infection mouse model using HSV-TK-WT mouse

    • Principal Investigator
      Ito Hiroyasu
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Gifu University
  •  Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in cancer model

    • Principal Investigator
      Ito Hiroyasu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  The role of IDO in the HBV-related liver diseases.Principal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Gifu University
  •  The investigation of immune regulation by IDO in NKT cell-mediated immunotherapy

    • Principal Investigator
      HOSHI Masato
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Laboratory medicine
    • Research Institution
      Suzuka University of Medical Science
  •  Screening and gene analysis for the protection from muscle damage by statin drugsPrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  The pathophysiologic role of indoleamine 2, 3-dioxygenase in viral infectious diseases

    • Principal Investigator
      SAITOU Kuniaki
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyoto University
  •  Study on the mechanism of rhabdomyosis induced by statins and gene analysis of patients with rhalxiomyasis

    • Principal Investigator
      TAKEMURA Masao, 和田 久泰
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  Study on analytical system for the etiology of autoimmune disease using two-dimensional nano LC/MSPrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  The Role of the Tumor Necrosis Factor Receptor in 2,4,6-Trinitrobenzene Sulphonic Acid (TNBS)-induced Colitis in Mice

    • Principal Investigator
      KATO Tomohiro
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      GIFU UNIVERSITY
  •  マウス骨髄移植技術を用いた肝不全発症機構の解明とその臨床応用に関する研究

    • Principal Investigator
      YAMADA Yasuhiro
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Gifu University
  •  Mechanism of action of new hypocholesterolemic pentapeptidei

    • Principal Investigator
      NAGAOKA Satoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      食品科学・栄養科学
    • Research Institution
      Gifu University
  •  The role of proinflammatory cytokines in the generation of myocardial ischemia/reperfusion injury

    • Principal Investigator
      WADA Hisayasu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Gifu University
  •  Proteome analysis of human macrophage cells associated with atherosclerosis

    • Principal Investigator
      FUJII Hidehiko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  Study on the mechanism of atherosclerotic lesion formation using cytokine-knockout mousePrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  A mechanism of HIV-related dementia complex - relation between TNF-α and dementia -

    • Principal Investigator
      SAITO Kuniaki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Gifu University
  •  The analysis of the mechanism of the anti-atherogenic action of polyphenol utilizing new evaluation technology

    • Principal Investigator
      NAGAOKA Satoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      食品科学・栄養科学
    • Research Institution
      Gifu University
  •  The method for determination of serum lipid-free apolipoprotein concentration and its clinical applicationPrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  A study of the role of cytokines in the development of atherosclerosis using double knockout mice

    • Principal Investigator
      WADA Hisayasu, 藤井 秀比古
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Gifu University
  •  New screenings of the improving factors for lipid metabolism derived from foods and their functional evaluation

    • Principal Investigator
      NAGAOKA Satoshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      食品科学・栄養科学
    • Research Institution
      Gifu University
  •  The role of proinflammatory cytokines in the development and progression of viral myocarditis

    • Principal Investigator
      WADA Hisayasu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Gifu University
  •  Significance of soluble Fas and its related cytokines in serum of rheumatoid arthritis patients.

    • Principal Investigator
      TAKEUCHI Shoji
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Gifu University
  •  The mechanism for synthesis and secretion of apo A-IV in CaCo-2 cellsPrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University School of Medicine
  •  Basic studies of immunotherapy in relation to the serum soluble interleukin-2 receptor determination in patients with rheumatoid arthritis

    • Principal Investigator
      TAKEUCHI Shoji
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Gifu University
  •  Study on apo A-IV polymorphism in patients with hyperlipidemia.Principal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  Clinical studies of adoptive immunochemotherapy combined with anti-cancer agents in the treatment of malignant bone tumor

    • Principal Investigator
      TAKTEUCHI Shoji
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Gifu University
  •  Developments and clinical evaluations of easy-to-perform and rapid measurements of serum Lp(a) concentrations and apo(a) isoforms.

    • Principal Investigator
      NOMA Akio
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  Study on the physiological and pathological significances of lipoprotein(a).

    • Principal Investigator
      NOMA Akio
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University

All 2015 2014 2013 2012 2011 2010 2009 2006

All Journal Article Presentation Book

  • [Book] 標準臨床検査医2012

    • Author(s)
      清島 満 標準臨床検査医学(高木 康・山田康幸編)
    • Publisher
      学医学書院, 東京
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Book] 病理学入門2011

    • Author(s)
      清島
    • Publisher
      昭和堂, 京都
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Book] 病理学入門2011

    • Author(s)
      清島満(分担執筆)内藤通孝編
    • Total Pages
      273
    • Publisher
      昭和堂
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in established murine cancer model.2015

    • Author(s)
      Ito H, Ando T, Seishima M.
    • Journal Title

      Oncotarget.

      Volume: 6(39) Pages: 41863-41874

    • DOI

      10.18632/oncotarget.6172

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Journal Article] Combination therapy with α-galactosylceramide and a Toll-like receptor agonist exerts an augmented suppressive effect on lung tumor metastasis in a mouse model.2015

    • Author(s)
      Ando T, Ito H, Arioka Y, Ogiso H, Seishima M.
    • Journal Title

      Oncol Rep.

      Volume: 33 Pages: 826-832

    • DOI

      10.3892/or.2014.3634

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Journal Article] Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model.2015

    • Author(s)
      Ito H, Ando T, Arioka Y, Saito K, Seishima M.
    • Journal Title

      Immunology

      Volume: 144(4) Pages: 621-630

    • DOI

      10.1111/imm.12413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Journal Article] Inhibition of induced nitric oxide synthase enhances the anti-tumor effects on cancer immunotherapy using TLR7 agonist in mice.2015

    • Author(s)
      Ito H, Ando T, Ogiso H, Arioka Y, Seishima M.
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 64(4) Pages: 429-436

    • DOI

      10.1007/s00262-014-1644-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Journal Article] Induction of HBsAg-specific cytotoxic T lymphocytes can be up-regulated by the inhibition of indoleamine 2, 3-dioxygenase activity2014

    • Author(s)
      Ito H, Ando T, Ando K, Ishikawa T, Saito K, Moriwaki H, Seishima M
    • Journal Title

      Immunology

    • DOI

      10.1111/imm.12274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-24659361
  • [Journal Article] Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis.2014

    • Author(s)
      Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1842(9) Pages: 1464-71

    • DOI

      10.1016/j.bbadis.2014.04.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-24659361, KAKENHI-PROJECT-26860376
  • [Journal Article] Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis2014

    • Author(s)
      Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M
    • Journal Title

      Biochim Biophys Acta

      Volume: S0925-4439(14) Pages: 102-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890270
  • [Journal Article] Resveratrol reverses remodeling in hearts with large, old myocardial infarction through enhanced autophagy-activating AMPK kinase pathway2013

    • Author(s)
      Kanamori H, Takemura G, Goto K, Tsujimoto A, Ogino A, Takeyama G, Kawaguchi T, Watanabe T, Morishita K, Kawasaki M, Mikami A, Fujiwara T, Fujiwara H, Seishima M, Minatoguchi S.
    • Journal Title

      American Journal of Pathology

      Volume: 182 Pages: 701-13

    • DOI

      10.1016/j.ajpath.2012.11.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179, KAKENHI-PROJECT-24790751
  • [Journal Article] Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase2012

    • Author(s)
      Ogawa K, Hara T, Shimizu M, Ninomiya S, Nagano J, Sakai H, Hoshi M, Ito H, Tsurumi H, Saito K, Seishima M, Tanaka T, Moriwaki H
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 951-8

    • DOI

      10.1111/j.1349-7006.2012.02237.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590838, KAKENHI-PROJECT-24890270
  • [Journal Article] High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice2012

    • Author(s)
      Ohtaki H
    • Journal Title

      Sci Rep

      Volume: 2 Pages: 367-367

    • DOI

      10.1038/srep00367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790787, KAKENHI-PROJECT-24890270
  • [Journal Article] L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice.2012

    • Author(s)
      Hoshi M
    • Journal Title

      J Immunol.

      Volume: 188 Pages: 3980-3987

    • DOI

      10.4049/jimmunol.1100997

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179, KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-23790787, KAKENHI-PROJECT-24890270
  • [Journal Article] Pre-administration of L-tryptophan improved ADR-induced early renal failure in mice.2012

    • Author(s)
      Arioka Y
    • Journal Title

      Life Sci.

      Volume: 59 Pages: 100-106

    • DOI

      10.1016/j.lfs.2012.06.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179, KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-24890270
  • [Journal Article] Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection2012

    • Author(s)
      Murakami Y, Hoshi M, Hara A, Takemura M, Arioka Y, Yamamoto Y, Matsunami H, Funato T, Seishima M, Saito K
    • Journal Title

      Cytokine.

      Volume: 59(2) Pages: 245-51

    • DOI

      10.1016/j.cyto.2012.04.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-24890270
  • [Journal Article] -Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells2012

    • Author(s)
      Ogawa K, Hara T, Shimizu M, Nagano J, Ohno T, Hoshi M, Ito H, Tsurumi H, Saito K, Seishima M, Moriwaki H
    • Journal Title

      Oncol Lett

      Volume: 4(3) Pages: 546-550

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673646/

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890270
  • [Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression2011

    • Author(s)
      Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M
    • Journal Title

      FASEB J

      Volume: 25 Pages: 1133-44

    • DOI

      10.1096/fj.10-168351

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179, KAKENHI-PROJECT-22590728
  • [Journal Article] Indoleamine 2, 3-dioxygenase in tumor tissue indicates prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP2011

    • Author(s)
      Ninomiya S, Hara T, Tsurumi H, Hoshi M, Kanemura N, Goto N, Kasahara S, Shimizu M, Ito H, Saito K, Hirose Y, Yamada T, Takahashi T, Seishima M, Takami T, Moriwaki H.
    • Journal Title

      Ann Hematol.

      Volume: 90(4) Pages: 409-16

    • DOI

      10.1007/s00277-010-1093-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin2011

    • Author(s)
      Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 34800-34808

    • DOI

      10.1074/jbc.m111.235473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J06850, KAKENHI-PROJECT-20390167, KAKENHI-PROJECT-21390179
  • [Journal Article] Comparison of chemiluminescence enzyme immunoassay (CLEIA) with ELISA for the determination of anti-cyclic citrullinated peptide antibodies2010

    • Author(s)
      Tanaka R, Takemura M, Sato M, Yamada Y, Nakagawa T, Horibe T, Hoshi M, Ohtaki H, Ito H, Seishima M, Shimizu K.
    • Journal Title

      Clin Chim Acta

      Volume: 411 Pages: 22-5

    • DOI

      10.1016/j.cca.2009.09.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] リポ蛋白X2010

    • Author(s)
      清島満、伊藤弘康
    • Journal Title

      日本臨床

      Volume: 68 Pages: 46-49

    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] Serum concentration of L-kynureninepredicts the clinical outcome of patientswith diffuse large B-cell lymphoma treated with R-CHOP2010

    • Author(s)
      Yoshikawa T, Hara T, Tsurumi H, Goto N, Hoshi M, Kitagawa J, Kanemura N, Kasahara S, Ito H, Takemura M, Saito K, Seishima M, Takami T, Moriwaki H.
    • Journal Title

      Eur J Haematol.

      Volume: 84(4) Pages: 304-309

    • DOI

      10.1111/j.1600-0609.2009.01393.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Ability of IDO to attenuate liver in juryin alpha-galactosylceramide-in duced hepatitis model2010

    • Author(s)
      Ito H, Hoshi M, Ohtaki H, Taguchi A, AndoK, Ishikawa T, Osawa Y, Hara A, Moriwaki H, Saito K, Seishima M.
    • Journal Title

      J Immunol.

      Volume: 185(8) Pages: 4554-60

    • DOI

      10.4049/jimmunol.0904173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Lp(a)2010

    • Author(s)
      清島満、金森寛充、服部高幸
    • Journal Title

      Medicina

      Volume: 47 Pages: 254-256

    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse2010

    • Author(s)
      Hoshi M, Saito K, Hara A, Taguchi A, OhtakiH, Tanaka R, Fujigaki H, Osawa Y, TakemuraM, Matsunami H, Ito H, Seishima M.
    • Journal Title

      J Immunol.

      Volume: 185(6) Pages: 3305-12

    • DOI

      10.4049/jimmunol.0901150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Changes in serum tryptophan catabolism as an indicator of disease activity in adult T-cell leukemia/lymphoma2009

    • Author(s)
      Hoshi M, Ito H, Fujigaki H, Takemura M, Takahashi T, Tomita E, Ohyama M, Tanaka R, Ohtaki H, Saito K, Seishima M.
    • Journal Title

      LeukLymphoma.

      Volume: 50(8) Pages: 1372-1374

    • DOI

      10.1080/10428190903045393

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Valpha14 NKT cells2009

    • Author(s)
      Ohtaki H, Ito H, Ando K, Ishikawa T, HoshiM, Tanaka R, Osawa Y, Yokochi T, MoriwakiH, Saito K, Seishima M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 389(2) Pages: 229-34

    • DOI

      10.1016/j.bbrc.2009.08.120

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Statin-induced Ca2+release wasincreased in B lymphocytes in patients who showed elevated serum creatine kinase during statin treatment.2009

    • Author(s)
      Hattori T, Saito K, Takemura M, Ito H, Ohta H, Wada H, Sei Y, Kawamura M,Seishima M.
    • Journal Title

      J Atheroscler Thromb

      Volume: 16 Pages: 870-7

    • URL

      https://www.jstage.jst.go.jp/browse/jat

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] Marked increases in hippocampal neuron indoleamine 2, 3-dioxygenase via IFN-gamma-independent pathway following transient global ischemia in mouse2009

    • Author(s)
      Hoshi M, Saito K, Murakami Y, Taguchi A, Fujigaki H, Tanaka R, Takemura M, Ito H, Hara A, Seishima M.
    • Journal Title

      Neurosci Res.

      Volume: 63(3) Pages: 194-198

    • DOI

      10.1016/j.neures.2008.12.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] The signal transducer and activator of trenscription 1α and interferon regulatory factor 1are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide : involvement of p38 mitogen-activated protein kinase and nuclear factor-κ B pathways, and synergistic effect of several proinflammatory cytokines.2006

    • Author(s)
      Fujigaki H, Saito K, Fujigaki S, Takemura M, Sudo K, lshiguro H, Seishima M.
    • Journal Title

      The Journal of Biochemistry 139(4)

      Pages: 655-662

    • Data Source
      KAKENHI-PROJECT-18590525
  • [Journal Article] Nitration and inactivation of IDO by peroxynitrite.2006

    • Author(s)
      Fujigaki H, Saito K, Lin F, Fujigaki S, Takahashi K, Martin BM, Chen CY, Masuda J, Kowalak J, Takikawa O, Seishima M, Markey SP.
    • Journal Title

      The Journal of Immunology 176(1)

      Pages: 372-379

    • Data Source
      KAKENHI-PROJECT-17390161
  • [Journal Article] Serum-soluble tumor factor receptor 2 (sTNF-R2) level determines clinical outcome in patients with aggressive non-Hodgkin's lymphoma.2006

    • Author(s)
      Goto N, Tsurumi H, Takemura M, Hara T, Sawada M, Kasahara S, Kanemura N, Yamada T, Shimizu M, Takahashi T, Tomita M, Seishima M, Takami T, Moriwaki H.
    • Journal Title

      European Journal of Haematology 77(3)

      Pages: 217-225

    • Data Source
      KAKENHI-PROJECT-17390161
  • [Journal Article] Nitration and inactivation of indoeamine 2,3-dioxygenase by peroxynitrite2006

    • Author(s)
      Fujigaki H, Saito K, Seishima M他
    • Journal Title

      J.Immunol 176

      Pages: 372-379

    • Data Source
      KAKENHI-PROJECT-17390161
  • [Journal Article] The signal transducer and activity of transcription 1a and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide2006

    • Author(s)
      Fujigaki H, Saito K, Seishima M他
    • Journal Title

      J.Biochem. (In Press)

    • Data Source
      KAKENHI-PROJECT-17390161
  • [Presentation] Toll様受容体アゴニストと一酸化窒素合成酵素の抑制を用いた抗腫瘍効果の検討2015

    • Author(s)
      伊藤弘康、安藤達也、小木曽英介、清島 満
    • Organizer
      第62回日本臨床検査医学会学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2015-11-20
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Presentation] インドールアミン酸素添加酵素の発現制御を用いたHBV特異的細胞障害性T細胞誘導効果の検討2013

    • Author(s)
      伊藤弘康、安藤達也、石川哲也、清島満
    • Organizer
      第60回日本臨床検査医学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] マウスB型急性肝炎モデルにおけるインドールアミン酸素添加酵素の解析2013

    • Author(s)
      伊藤弘康、大瀧博文、安藤達也、安藤量基、石川哲也、森脇久隆、清島満
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] インドールアミン酸素添加酵素の発現抑制によるHBV特異的細胞障害性T細胞誘導効果2013

    • Author(s)
      伊藤弘康、安藤量基、石川哲也、森脇久隆、清島満
    • Organizer
      第40回日本肝臓学会西部会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] Is the measurement of Ca2+-release inCD19+ B cells stimulated by statin useful for prediction of muscle damage as a side effect?2012

    • Author(s)
      Mori I, Hattori T, Osawa Y, Kanamori H, Kajita K, Morita H, Ishizuka T, Saito K, Ito H, Seishima M
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      福岡市
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 脂質異常症の治療~動脈硬化予防の戦略として~2012

    • Author(s)
      清島 満
    • Organizer
      第59回日本臨床検査医学会学術集会(招待講演)
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 検査情報を生かすための病態情報解析医学に学ぶ.2012

    • Author(s)
      清島 満
    • Organizer
      第4回日本臨床一般検査学会学術集会(招待講演)
    • Place of Presentation
      岐阜市
    • Year and Date
      2012-10-27
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 細胞障害性T細胞により誘発されるマウス劇症肝炎モデルにおける indoleamine 2, 3-dioxygenaseの解析2012

    • Author(s)
      安藤 達也、清島 満ら
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] 脂質異常症の治療~動脈硬化予防の戦略として~2012

    • Author(s)
      清島 満
    • Organizer
      第59回日本臨床検査医学学術集会
    • Place of Presentation
      京都市
    • Invited
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 検査情報を活かすための病態情報解析医学に学ぶ2012

    • Author(s)
      清島 満
    • Organizer
      第4回日本臨床一般検査学会学術集会
    • Place of Presentation
      岐阜市
    • Invited
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 細胞障害性T細胞により誘発されるマウス劇症肝炎モデルにおけるindoleamine 2, 3-dioxygenaseの解析2012

    • Author(s)
      安藤達也、大瀧博文、伊藤弘康、星雅人、石川哲也、斎藤邦明、清島満
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] Inhibition of acid sphingomyelinase causes hepatic glucose intolerance and insulin resistance2010

    • Author(s)
      Osawa Y, Ito H, Suetusgu A, Nagaki M, Moriwaki H, Seishima M
    • Organizer
      DDW 2010
    • Place of Presentation
      New Orlealls
    • Year and Date
      2010-05-03
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 高脂血症治療剤による培養細胞に対するCa^<2+>放出効果の基礎的検討2010

    • Author(s)
      服部高幸、竹村正男、太田浩敏、大澤陽介、金森寛充、伊藤弘康、斎藤邦明、清島満
    • Organizer
      第49回日本臨床検査医学会東海・北陸支部総会第320回日本臨床化学会東海北陸支部例会連合大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-03-14
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] Ca2+releasing effect of stains on human CD19+primary B cells.2010

    • Author(s)
      Hattori T, Saito K, Takemura M, Ito H, Ohta H, Wada H, Sei Y, Kawamura M, Seishima M
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-06-15
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] Inhibition of acid sphingomyelinasecauses hepatic glucose intolerance and insulin resistance2010

    • Author(s)
      Osawa Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Seishima M.
    • Organizer
      DDW 2010 New Orleans
    • Place of Presentation
      USA
    • Year and Date
      2010-05-03
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] Ca^<2+> releasing effect of statins on human CD19+ primary B cells2010

    • Author(s)
      Hattori T, Saito K, Takemura M, Ito H, Ohta H, Wada H, Sei Y, Kawamura M, Seishima M
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-06-15
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 高脂血症治療剤による培養細胞に対するCa2+放出効果の基礎的検討2010

    • Author(s)
      服部高幸、竹村正男、太田浩敏、 大澤陽介、金森寛充、伊藤弘康、斎藤邦明、清島 満
    • Organizer
      第49回日本臨床検査医学会東海・北陸支部総会 第320回日本臨床化学会東海・北陸支部例会 連合大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-03-14
    • Data Source
      KAKENHI-PROJECT-21390179
  • 1.  SAITOU Kuniaki (80262765)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 28 results
  • 2.  WADA Hisayasu (10283300)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 1 results
  • 3.  ITO Hiroyasu (80373075)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 31 results
  • 4.  YAMADA Yasuhiro (10324295)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  NOMA Akio (30208384)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  NAGAOKA Satoshi (50202221)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  FUJII Hidehiko (50301213)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  TAKTEUCHI Shoji (50021473)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  ABE Akira (30175898)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  MAKINO Kazuhiko (80181618)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  MORITA Toshiko (30242746)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  TAKEMURA Masao (80402155)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 13.  SEKIKAWA Kenji
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  YAMAMOTO Yasuko (00331869)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  FUNATO Tadao (70165455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  OSAWA Yousuke (60447787)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 17.  MORI Ichiro (40444327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 18.  KANAMORI Hiromitsu (20456502)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 19.  HOSHI Masato (40633996)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 20.  SHIRAKAMI Yohei (50632816)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  OKUNO Masataka (10204140)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SHIMOKAWA Kuniyasu (70021376)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MINATOGUCHI Shinya (20190697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  NABESHIMA Toshitaka (70076751)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KATO Tomohiro (40224521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  MORIWAKI Hisataka (50174470)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 27.  中村 容子 (90227950)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  石川 哲也 (10288508)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  松井 利郎 (20238942)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  上野 義仁 (20250467)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  本多 裕之 (70209328)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  YOSHIMURA Yoshimichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  TSUKADA Yutaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  SAITO Kazunori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  Kanbe Ayumu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  斎藤 和典
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  KODAMA Yuzo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  SHIMIZU Masahito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  HARA Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  MURAKAMI Yuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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