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Ishiko Akira  石河 晃

ORCIDConnect your ORCID iD *help
… Alternative Names

石河 晃  イシコウ アキラ

ISHIKO Akira  石河 晃

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Researcher Number 10202988
Other IDs
Affiliation (Current) 2021: 東邦大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2015 – 2017: 東邦大学, 医学部, 教授
2011 – 2013: 東邦大学, 医学部, 教授
2010: Keio University, 医学部, 講師
2007 – 2009: Keio University, School of Medicine, Associate Professor
2006: 慶應義塾大学, 医学部, 助教授 … More
2004 – 2005: Keio University, School of Medicine, Assistant Professor, 医学部, 講師
2000 – 2004: 慶應義塾大学, 医学部, 専任講師
2000: 慶応義塾大学, 医学部, 専任講師
1993 – 1994: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Dermatology / Dermatology
Except Principal Investigator
Dermatology / Dermatology
Keywords
Principal Investigator
免疫電顕 / デスモソーム / 免疫電顕法 / 水疱症 / 天疱瘡 / デスモグレイン / 電子顕微鏡 / immunoelectron microscopy / 自己免疫性水疱症 / 自己免疫 … More / 棘融解 / BPAG2 / 細胞接着 / desmosome / desmoglein / 線状IgA水疱性皮膚症 / エピリグリン / 全コロイド / 皮膚基底膜 / 自己抗体 / 自己抗原 / デスモグレイン3 / VII型コラーゲン / 先天性表皮水疱症 / ラミニン5 / 基底膜 / 遺伝子変異 / type VII collagen / epidermolysis bullosa / laminin 5 / basement membrane / mutation analysis / 尋常性天疱瘡 / デスモプラキン / プラコグロビン / モデルマウス / 自己免疫疾患 / pemphigus vulgaris / desmoplakin / plakoglobin / model mouse / cell adhision / 病理学 / デスモソース / pemphigus / electron microscopy / cell adhesion / acantholysis / bullous disease … More
Except Principal Investigator
天疱瘡 / 自己抗体 / 自己免疫 / カドヘリン / モデルマウス / デスモグレイン / 細胞接着 / Autoantibody / desmoglein / Autoimmune / Model mouse / pemphigus / Pemphigus / cadherin / X染色体 / 遺伝子多型性 / クローナリティー / マイクロダイセクション / HUMARA法 / HUMURA法 / 免疫寛容 / 皮膚疾患 / 皮膚生理学 / 再生医学 / 毛嚢 / 皮膚幹細胞 / バルジ / 毛乳頭 / 組織再構成 / 幹細胞 / 遺伝子 / 病理学 / 基底膜 / ラミニン332 / 表皮水疱症 / 免疫電顕 / 表皮水庖症 / エピトープ / 水疱症 / ノックアウトマウス / epitope / bullous disease / knockout mouse / 免疫抑制 / 治療 / 天庖瘡 / Immune suppression / Therapy / 皮膚感染症 / 黄色ブドウ球菌 / autoimmune / skin infection / Staphylococcus aureus / autoantibody / model mouse / ケラチン / アデノウイルス / 細胞骨格 / Cell adhesion / Desmoglein / Cadherin / Keratin / Adenovirus / Cytoskeleton Less
  • Research Projects

    (16 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (23 People)
  •  Mechanisms of blister formation in pemphigus foliacues analyzed by anti-Dsg1 monoclonal antibodies

    • Principal Investigator
      ISHII Ken
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Toho University
  •  Analysis of pathomechanism of blister formation in pemphigus vulgaris using post-embedding immuno-electron microscopyPrincipal Investigator

    • Principal Investigator
      ISHIKO Akira
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Toho University
  •  Immunoelectron microscopic analysis of in vivo interaction of basement membrane components using human skin lacking laminin 5.

    • Principal Investigator
      MASUNAGA Takuji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Analysis of mechanism for blister formation in pemphigus foliaceus using novel monoclonal antibody with pathogenic activityPrincipal Investigator

    • Principal Investigator
      ISHIKO Akira
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Experimental regeneration of human hair follicles using CD200 positive bulge cells

    • Principal Investigator
      OHYAMA Manabu
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Analysis of pathophysiology of pemphigus foliaceus by using immunoelectron microscopyPrincipal Investigator

    • Principal Investigator
      ISHIKO Akira
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Elucidation of tolerance mechanism against peripheral target antigens in autoimmune diseases

    • Principal Investigator
      AMAGAI Masayuki
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Molecular basis of keratinocyte desmosomes and acantholysis using imunoelectron microscopyPrincipal Investigator

    • Principal Investigator
      ISHIKO Akira
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  X染色体遺伝子多型性を用いた皮膚腫瘍性疾患のクローナリティー判定法の確立

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Real-time imaging analysis of cell adhesion molecules of epidermal keratinocytes

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Clarification of pathophysiological mechanisms of autoimmune skin disease, pemphigus

    • Principal Investigator
      AMAGAI Masayuki
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Basic studies for development of disease-specific therapeutic strategies against autoimmune diseases

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Evaluation of immune suppressive therapy using autoimmune model mouse

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Immunoelectron microscopic analysis of basement membrane components in type VII collagen knockout skinPrincipal Investigator

    • Principal Investigator
      ISHIKO Akira
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  新しい免疫電顕法によるエピリグリンの皮膚基底膜部における微細局在部位の解明Principal Investigator

    • Principal Investigator
      石河 晃
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  新しい免疫電顕法による線状IgA水疱性皮膚症抗原の微細局在部位の解明Principal Investigator

    • Principal Investigator
      石河 晃
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Dermatology
    • Research Institution
      Keio University

All 2018 2017 2016 2015 2014 2012 2011 2010 2009 2008 2005 2004 2003 Other

All Journal Article Presentation Book

  • [Book] エキスパートに学ぶ皮膚病理診断学 棘融解を呈する代表的疾患の病理組織学的鑑別点2012

    • Author(s)
      石河 晃
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-23591629
  • [Journal Article] Splice site mutation in COL7A1 resulting in aberrant in-frame transcripts identified in a case of recessive dystrophic epidermolysis bullosa, pretibial2018

    • Author(s)
      Masunaga Takuji、Kubo Akiharu、Ishiko Akira
    • Journal Title

      The Journal of Dermatology

      Volume: 45 Pages: 306-307

    • DOI

      10.1111/1346-8138.14271

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09749
  • [Journal Article] Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering.2017

    • Author(s)
      Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Shiraishi K, Shirakata Y, Stanley JR, Ishiko A.
    • Journal Title

      Journal of Dermatological Science

      Volume: 85 Pages: 197-207

    • DOI

      10.1016/j.jdermsci.2016.12.010

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253065, KAKENHI-PROJECT-15K09749
  • [Journal Article] Alopecia developed in a transitional case from pemphigus foliaceus to pemphigus vulgaris2017

    • Author(s)
      Yoshida Kenji、Ishii Ken、Ishiko Akira
    • Journal Title

      The Journal of Dermatology

      Volume: 44

    • DOI

      10.1111/1346-8138.13957

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09749
  • [Journal Article] A Japanese-specificrecurrent mutation and a novel splice site mutation in the LAMC2 gene identified in two Japanese families with Herlitz junctional epidermolysis bullosa2011

    • Author(s)
      Michiyoshi Kouno, Rika Ko, Atsushi Shimizu, Takeshi Ouchi, Ko Sueoka, Takuji Masunaga, Akira Ishiko
    • Journal Title

      Clin Exp Dermatol 36

      Pages: 386-392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591327
  • [Journal Article] Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation2010

    • Author(s)
      Koji Nishifuji, Atsushi Shimizu, Akira Ishiko, Toshiroh Iwasaki, Masayuki Amagai
    • Journal Title

      J Dermatol Sci Sep 59(3)

      Pages: 184-191

    • NAID

      10027473355

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591329
  • [Journal Article] Desmosome splitting is a primary ultrastructural change in the acantholysis of pemphigus.2009

    • Author(s)
      W. Wang, M. Amagai, A. Ishiko
    • Journal Title

      J Dermatol Sci 54

      Pages: 59-61

    • NAID

      10025333258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591329
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T.
    • Journal Title

      J Invest Dermatol. 124

      Pages: 984-989

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T.
    • Journal Title

      J Invest Dermatol 124・5

      Pages: 984-989

    • Data Source
      KAKENHI-PROJECT-17109012
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T.
    • Journal Title

      J Invest Dermatol 124

      Pages: 984-989

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T
    • Journal Title

      J Invest Dermatol (In press)

    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T
    • Journal Title

      J Invest Dermatol (In press)

    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T
    • Journal Title

      J Invest Dermatol 124

      Pages: 984-989

    • Data Source
      KAKENHI-PROJECT-17109012
  • [Journal Article] IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model.2004

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M, Nishikawa T
    • Journal Title

      J Invest Dermatol 122

      Pages: 1145-1153

    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model.2004

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M, Nishikawa T.
    • Journal Title

      J Invest Dermatol 122

      Pages: 1145-1153

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] Immunomolecular mapping of adherens junction and desmosomal components in normal human epidermis2003

    • Author(s)
      Ishiko, et al.
    • Journal Title

      Exp Dermatol 12

      Pages: 747-754

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591192
  • [Journal Article] Immunomolecular mapping of adherens junction and desmosomal components in normal human epidermis2003

    • Author(s)
      Akira Ishiko, et al.
    • Journal Title

      Exp Dermatol 12

      Pages: 747-754

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591192
  • [Presentation] Desmoglein 1 clustering in pemphigus foliaceus patients’ skin.2017

    • Author(s)
      Kenji Yoshida, Ken Ishii1, Mari Nakagawa, Akira Ishiko
    • Organizer
      Tne 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09749
  • [Presentation] p38MAPK contributes to loss of cell adhesion through clustering of desmoglein 1 but is not required for blistering in pemphigus foliaceus .2016

    • Author(s)
      Yoshida K , Ishii K, Shimizu A , Yokouchi M , Amagai M ,John R.Stanley, Ishiko A
    • Organizer
      第41回日本研究皮膚科学会学術大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-12-09
    • Data Source
      KAKENHI-PROJECT-15K09749
  • [Presentation] Polyclonal nature of pemphigus foliaceus IgG antibodies enhances pathogenic effect for blister formation in association with p38MAPK-dependent desmoglein 1 clustering.2016

    • Author(s)
      Yoshida K, Ishii K , Shimizu A , Yokouchi M , Amagai M ,John R.Stanley , Ishiko A
    • Organizer
      Pathogenesis of pemphigus and pemhigoid 2016 the open blister/mind meeting,
    • Place of Presentation
      ミュンヘン大学(ドイツ、ミュンヘン)
    • Year and Date
      2016-09-07
    • Data Source
      KAKENHI-PROJECT-15K09749
  • [Presentation] p38 MAPK signaling is necessary for desmoglein 1 clustering and enhances pathogenic effect, but is not required for blistering in pemphigus foliaceus2015

    • Author(s)
      Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Stanley JR, Ishiko A
    • Organizer
      45th Annual European Society of Dermatological Research Meeting
    • Place of Presentation
      オランダ、ロッテルダム
    • Year and Date
      2015-09-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09749
  • [Presentation] Combination of pemphigus foliaceus IgG monoclonal antibodies (mAbs) promotes desmoglein 1 clustering2014

    • Author(s)
      Kenji Yoshida, Ken Ishii, Atsushi Shimizu, Mariko Yokouchi, John Stanley, Akira Ishiko
    • Organizer
      73rd annual meeting of Society for Investigative Dermatology
    • Place of Presentation
      Alvuquerque, New Mexico, USA (Oral presentation)
    • Year and Date
      2014-05-09
    • Data Source
      KAKENHI-PROJECT-23591629
  • [Presentation] LAMC2遺伝子に変異を認めたHerlitz致死型接合部型先天性表皮水庖症の1例2008

    • Author(s)
      河野通良, 高理佳, 清水篤, 増永卓司, 石河晃
    • Organizer
      第32回日本小児皮膚科学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20591327
  • [Presentation] Desmosome splitting is a primary ultrastructural change in the acantholysis of pemphigus.2008

    • Author(s)
      A. Ishiko, W. Wang, M. Amagai
    • Organizer
      5th joint meeting of SSSR and SCUR
    • Place of Presentation
      大津市
    • Data Source
      KAKENHI-PROJECT-20591329
  • [Presentation] 水疱症の最新の話題

    • Author(s)
      石河 晃
    • Organizer
      第3回とちぎ皮膚免疫疾患研究会
    • Place of Presentation
      宇都宮グランドホテル(栃木県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591629
  • [Presentation] Combination of pemphigus foliaceus IgG monoclonal antibodies (mAbs) promotes desmoglein 1 clustering

    • Author(s)
      Kenji Yoshida, Ken Ishii, Atsushi Shimizu, Mariko Yokouchi, John Stanley, Akira Ishiko
    • Organizer
      73rd Society for Investigative Dermatology
    • Place of Presentation
      Albuquerque, New Mexico, USA
    • Data Source
      KAKENHI-PROJECT-23591629
  • [Presentation] 自己免疫性水疱症の最新の話題

    • Author(s)
      石河 晃
    • Organizer
      皮膚疾患フォーラム
    • Place of Presentation
      三鷹産業プラザ(東京都)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591629
  • 1.  AMAGAI Masayuki (90212563)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 9 results
  • 2.  NISHIKAWA Takeji (50051579)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 6 results
  • 3.  TANAKA Masaru (40188339)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  KOYASU Shigeo (90153684)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  ISHII Ken (50296670)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 6.  SAITO Masataka (30306774)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  OHYAMA Manabu (10255424)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  IWASAKI Toshiro (50262754)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  MASUNAGA Takuji (70424140)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 10.  KIMURA Yoshifumi (10306772)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  YOSHIDA Kenji
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 12.  KUWANA Masataka (50245479)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  FUNAKOSHI Takeru (80365353)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OUCHI Takeshi (30528419)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SHIMIZU Atsushi (60383733)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  ANZAI Hidemi (90276345)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  SHIMIZU Hiroshi (00146672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  SUZUKI Yosuke (90306845)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NAGAO Keisuke (40286521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  TAKAE Yujirou (00306367)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  泉 美貴 (30228655)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  鈴木 春己 (70235985)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  齋藤 京 (50286548)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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