ISHIKO Akira 石河晃

Researcher Number	10202988
Other IDs
Affiliation *help	2015 – 2018 : 東邦大学, 医学部, 教授 2011 – 2013 : 東邦大学, 医学部, 教授 2010 : Keio University, 医学部, 講師 2007 – 2009 : Keio University, School of Medicine, Associate Professor 2006 : 慶應義塾大学, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Dermatology / Dermatology Except Principal Investigator Dermatology / Dermatology
Keywords	Principal Investigator 免疫電顕 / デスモソーム / 水疱症 / デスモグレイン / 天疱瘡 / 電子顕微鏡 / 免疫電顕法 / immunoelectron microscopy / 自己免疫性水疱症 / 自己免疫 … More Except Principal Investigator 天疱瘡 / 自己抗体 / 自己免疫 / カドヘリン / デスモグレイン / モデルマウス / Autoantibody / 細胞接着 / desmoglein / cadherin / Model mouse / Pemphigus / Autoimmune / pemphigus / 免疫寛容 / 水疱症 / autoimmune / ケラチン / 免疫電顕 / 皮膚疾患 / Cell adhesion / Adenovirus / 皮膚感染症 / アデノウイルス / 皮膚幹細胞 / エピトープ / 表皮水庖症 / Desmoglein / Immune suppression / バルジ / 遺伝子多型性 / 基底膜 / 細胞骨格 / 治療 / Therapy / knockout mouse / Keratin / 病理学 / bullous disease / Cytoskeleton / 皮膚生理学 / ラミニン332 / 毛乳頭 / Staphylococcus aureus / 遺伝子 / 黄色ブドウ球菌 / 幹細胞 / skin infection / クローナリティー / 組織再構成 / Cadherin / 再生医学 / model mouse / 天庖瘡 / 免疫抑制 / epitope / 毛嚢 / autoantibody / HUMARA法 / ノックアウトマウス / HUMURA法 / 表皮水疱症 / マイクロダイセクション / X染色体 Less

落葉状天疱瘡モノクローナル抗体による棘融解性水疱形成機序の解明Ongoing
- Principal Investigator
  
  石井健
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Toho University
Analysis of pathomechanism of blister formation in pemphigus vulgaris using post-embedding immuno-electron microscopyPrincipal Investigator
- Principal Investigator
  
  ISHIKO Akira
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Toho University
Immunoelectron microscopic analysis of in vivo interaction of basement membrane components using human skin lacking laminin 5.
- Principal Investigator
  
  MASUNAGA Takuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Analysis of mechanism for blister formation in pemphigus foliaceus using novel monoclonal antibody with pathogenic activityPrincipal Investigator
- Principal Investigator
  
  ISHIKO Akira
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Experimental regeneration of human hair follicles using CD200 positive bulge cells
- Principal Investigator
  
  OHYAMA Manabu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Analysis of pathophysiology of pemphigus foliaceus by using immunoelectron microscopyPrincipal Investigator
- Principal Investigator
  
  ISHIKO Akira
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Elucidation of tolerance mechanism against peripheral target antigens in autoimmune diseases
- Principal Investigator
  
  AMAGAI Masayuki
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Molecular basis of keratinocyte desmosomes and acantholysis using imunoelectron microscopyPrincipal Investigator
- Principal Investigator
  
  ISHIKO Akira
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
X染色体遺伝子多型性を用いた皮膚腫瘍性疾患のクローナリティー判定法の確立
- Principal Investigator
  
  NISHIKAWA Takeji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Real-time imaging analysis of cell adhesion molecules of epidermal keratinocytes
- Principal Investigator
  
  NISHIKAWA Takeji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Clarification of pathophysiological mechanisms of autoimmune skin disease, pemphigus
- Principal Investigator
  
  AMAGAI Masayuki
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Basic studies for development of disease-specific therapeutic strategies against autoimmune diseases
- Principal Investigator
  
  NISHIKAWA Takeji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Evaluation of immune suppressive therapy using autoimmune model mouse
- Principal Investigator
  
  NISHIKAWA Takeji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Immunoelectron microscopic analysis of basement membrane components in type VII collagen knockout skinPrincipal Investigator
- Principal Investigator
  
  ISHIKO Akira
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
新しい免疫電顕法によるエピリグリンの皮膚基底膜部における微細局在部位の解明Principal Investigator
- Principal Investigator
  
  石河晃
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
新しい免疫電顕法による線状IgA水疱性皮膚症抗原の微細局在部位の解明Principal Investigator
- Principal Investigator
  
  石河晃
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Keio University

All 2017 2016 2015 2014 2012 2011 2010 2009 2008 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] エキスパートに学ぶ皮膚病理診断学　棘融解を呈する代表的疾患の病理組織学的鑑別点2012
- Author(s)
  石河　晃
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23591629
[Journal Article] Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering.2017
- Author(s)
  Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Shiraishi K, Shirakata Y, Stanley JR, Ishiko A.
- Journal Title
  
  Journal of Dermatological Science
  
  Volume : 85 Pages : 197-207
- DOI
  10.1016/j.jdermsci.2016.12.010
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26253065, KAKENHI-PROJECT-15K09749
[Journal Article] A Japanese-specificrecurrent mutation and a novel splice site mutation in the LAMC2 gene identified in two Japanese families with Herlitz junctional epidermolysis bullosa2011
- Author(s)
  Michiyoshi Kouno, Rika Ko, Atsushi Shimizu, Takeshi Ouchi, Ko Sueoka, Takuji Masunaga, Akira Ishiko
- Journal Title
  
  Clin Exp Dermatol 36
  
  Pages : 386-392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591327
[Journal Article] Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation2010
- Author(s)
  Koji Nishifuji, Atsushi Shimizu, Akira Ishiko, Toshiroh Iwasaki, Masayuki Amagai
- Journal Title
  
  J Dermatol Sci Sep 59(3)
  
  Pages : 184-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591329
[Journal Article] Desmosome splitting is a primary ultrastructural change in the acantholysis of pemphigus.2009
- Author(s)
  W. Wang, M. Amagai, A. Ishiko
- Journal Title
  
  J Dermatol Sci 54
  
  Pages : 59-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591329
[Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line2005
- Author(s)
  Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T
- Journal Title
  
  J Invest Dermatol (In press)
- Data Source
  KAKENHI-PROJECT-14370262
[Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005
- Author(s)
  Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T.
- Journal Title
  
  J Invest Dermatol. 124
  
  Pages : 984-989
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370262
[Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005
- Author(s)
  Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T
- Journal Title
  
  J Invest Dermatol 124
  
  Pages : 984-989
- Data Source
  KAKENHI-PROJECT-17109012
[Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005
- Author(s)
  Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T.
- Journal Title
  
  J Invest Dermatol 124・5
  
  Pages : 984-989
- Data Source
  KAKENHI-PROJECT-17109012
[Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line2005
- Author(s)
  Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T
- Journal Title
  
  J Invest Dermatol (In press)
- Data Source
  KAKENHI-PROJECT-13854017
[Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005
- Author(s)
  Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T.
- Journal Title
  
  J Invest Dermatol 124
  
  Pages : 984-989
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370262
[Journal Article] IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model.2004
- Author(s)
  Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M, Nishikawa T
- Journal Title
  
  J Invest Dermatol 122
  
  Pages : 1145-1153
- Data Source
  KAKENHI-PROJECT-14370262
[Journal Article] IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model.2004
- Author(s)
  Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M, Nishikawa T.
- Journal Title
  
  J Invest Dermatol 122
  
  Pages : 1145-1153
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370262
[Journal Article] Immunomolecular mapping of adherens junction and desmosomal components in normal human epidermis2003
- Author(s)
  Akira Ishiko, et al.
- Journal Title
  
  Exp Dermatol 12
  
  Pages : 747-754
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591192
[Journal Article] Immunomolecular mapping of adherens junction and desmosomal components in normal human epidermis2003
- Author(s)
  Ishiko, et al.
- Journal Title
  
  Exp Dermatol 12
  
  Pages : 747-754
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591192
[Presentation] Polyclonal nature of pemphigus foliaceus IgG antibodies enhances pathogenic effect for blister formation in association with p38MAPK-dependent desmoglein 1 clustering.2016
- Author(s)
  Yoshida K, Ishii K , Shimizu A , Yokouchi M , Amagai M ,John R.Stanley , Ishiko A
- Organizer
  Pathogenesis of pemphigus and pemhigoid 2016 the open blister/mind meeting,
- Place of Presentation
  ミュンヘン大学（ドイツ、ミュンヘン）
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-15K09749
[Presentation] p38MAPK contributes to loss of cell adhesion through clustering of desmoglein 1 but is not required for blistering in pemphigus foliaceus .2016
- Author(s)
  Yoshida K , Ishii K, Shimizu A , Yokouchi M , Amagai M ,John R.Stanley, Ishiko A
- Organizer
  第41回日本研究皮膚科学会学術大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-15K09749
[Presentation] p38 MAPK signaling is necessary for desmoglein 1 clustering and enhances pathogenic effect, but is not required for blistering in pemphigus foliaceus2015
- Author(s)
  Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Stanley JR, Ishiko A
- Organizer
  45th Annual European Society of Dermatological Research Meeting
- Place of Presentation
  オランダ、ロッテルダム
- Year and Date
  2015-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09749
[Presentation] Combination of pemphigus foliaceus IgG monoclonal antibodies (mAbs) promotes desmoglein 1 clustering2014
- Author(s)
  Kenji Yoshida, Ken Ishii, Atsushi Shimizu, Mariko Yokouchi, John Stanley, Akira Ishiko
- Organizer
  73rd annual meeting of Society for Investigative Dermatology
- Place of Presentation
  Alvuquerque, New Mexico, USA (Oral presentation)
- Year and Date
  2014-05-09
- Data Source
  KAKENHI-PROJECT-23591629
[Presentation] Desmosome splitting is a primary ultrastructural change in the acantholysis of pemphigus.2008
- Author(s)
  A. Ishiko, W. Wang, M. Amagai
- Organizer
  5th joint meeting of SSSR and SCUR
- Place of Presentation
  大津市
- Data Source
  KAKENHI-PROJECT-20591329
[Presentation] LAMC2遺伝子に変異を認めたHerlitz致死型接合部型先天性表皮水庖症の1例2008
- Author(s)
  河野通良, 高理佳, 清水篤, 増永卓司, 石河晃
- Organizer
  第32回日本小児皮膚科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591327
[Presentation] Combination of pemphigus foliaceus IgG monoclonal antibodies (mAbs) promotes desmoglein 1 clustering
- Author(s)
  Kenji Yoshida, Ken Ishii, Atsushi Shimizu, Mariko Yokouchi, John Stanley, Akira Ishiko
- Organizer
  73rd Society for Investigative Dermatology
- Place of Presentation
  Albuquerque, New Mexico, USA
- Data Source
  KAKENHI-PROJECT-23591629
[Presentation] 自己免疫性水疱症の最新の話題
- Author(s)
  石河　晃
- Organizer
  皮膚疾患フォーラム
- Place of Presentation
  三鷹産業プラザ（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23591629
[Presentation] 水疱症の最新の話題
- Author(s)
  石河　晃
- Organizer
  第3回とちぎ皮膚免疫疾患研究会
- Place of Presentation
  宇都宮グランドホテル（栃木県）
- Invited
- Data Source
  KAKENHI-PROJECT-23591629

1. AMAGAI Masayuki (90212563)

# of Collaborated Projects : 8results

# of Collaborated Products : 9results
2. NISHIKAWA Takeji (50051579)

# of Collaborated Projects : 7results

# of Collaborated Products : 6results
3. TANAKA Masaru (40188339)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
4. KOYASU Shigeo (90153684)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
5. ISHII Ken (50296670)

# of Collaborated Projects : 3results

# of Collaborated Products : 6results
6. SAITO Masataka (30306774)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. OHYAMA Manabu (10255424)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. IWASAKI Toshiro (50262754)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. MASUNAGA Takuji (70424140)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
10. KIMURA Yoshifumi (10306772)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. KUWANA Masataka (50245479)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. FUNAKOSHI Takeru (80365353)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. OUCHI Takeshi (30528419)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. SHIMIZU Atsushi (60383733)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
15. ANZAI Hidemi (90276345)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. SHIMIZU Hiroshi (00146672)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. SUZUKI Yosuke (90306845)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. NAGAO Keisuke (40286521)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. TAKAE Yujirou (00306367)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. 泉美貴 (30228655)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. 鈴木春己 (70235985)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. 齋藤京 (50286548)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. YOSHIDA Kenji

# of Collaborated Projects : 1results

# of Collaborated Products : 2results

ISHIKO Akira 石河 晃

Research Projects

Research Products

Co-Researchers

落葉状天疱瘡モノクローナル抗体による棘融解性水疱形成機序の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pathomechanism of blister formation in pemphigus vulgaris using post-embedding immuno-electron microscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mechanism for blister formation in pemphigus foliaceus using novel monoclonal antibody with pathogenic activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pathophysiology of pemphigus foliaceus by using immunoelectron microscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of keratinocyte desmosomes and acantholysis using imunoelectron microscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunoelectron microscopic analysis of basement membrane components in type VII collagen knockout skinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ISHIKO Akira 石河晃

[Book] エキスパートに学ぶ皮膚病理診断学　棘融解を呈する代表的疾患の病理組織学的鑑別点2012